Search Results - "CHINEN, YOSHIAKI"

Imaging flow cytometry-based multiplex FISH for three IGH translocations in multiple myeloma by Tsukamoto, Taku, Kinoshita, Masaki, Yamada, Kazuhiro, Ito, Hodaka, Yamaguchi, Toshikazu, Chinen, Yoshiaki, Mizutani, Shinsuke, Fujino, Takahiro, Kobayashi, Tsutomu, Shimura, Yuji, Inazawa, Johji, Kuroda, Junya

“…Three types of chromosomal translocations, t(4;14)(p16;q32), t(14;16)(q32;q23), and t(11;14)(q13;q32), are associated with prognosis and the decision making of…”
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EWSR1 overexpression is a pro-oncogenic event in multiple myeloma by Nishiyama, Daichi, Chinen, Yoshiaki, Isa, Reiko, Fujibayashi, Yuto, Kuwahara-Ota, Saeko, Yamaguchi, Junko, Takimoto-Shimomura, Tomoko, Matsumura-Kimoto, Yayoi, Tsukamoto, Taku, Shimura, Yuji, Kobayashi, Tsutomu, Horiike, Shigeo, Taniwaki, Masafumi, Handa, Hiroshi, Kuroda, Junya

“…Multiple myeloma (MM) is cytogenetically, genetically and molecularly heterogenous even among subclones in one patient, therefore, it is essential to identify…”
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Detection of novel and recurrent conjoined genes in non-Hodgkin B-cell lymphoma by Matsumoto, Yosuke, Tsukamoto, Taku, Chinen, Yoshiaki, Shimura, Yuji, Sasaki, Nana, Nagoshi, Hisao, Sato, Ryuichi, Adachi, Hiroko, Nakano, Masakazu, Horiike, Shigeo, Kuroda, Junya, Taki, Tomohiko, Tashiro, Kei, Taniwaki, Masafumi

“…For this study, we investigated comprehensive expression of conjoined genes (CGs) in non-Hodgkin B-cell lymphoma (B-NHL) cell line KPUM-UH1 by using paired-end…”
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Evaluation of the Influence of a History of Childhood Nocturnal Enuresis on Nighttime Urinary Frequency and the Causes of Nocturia in Adults by Miyazato, Minoru, Gakiya, Munehisa, Ashikari, Asuka, Kamijo, Tadanobu Chuyo, Kagawa, Haruo, Matsuo, Tomohiro, Miyata, Yasuyoshi, Oshiro, Yoshinori, Arai, Koji, Machida, Noriko, Shinzato, Hiroshi, Chinen, Yoshiaki, Iwata, Hiroyoshi, Ueda, Shinichiro, Saito, Seiichi

“…To examine whether a history of nocturnal enuresis affects nighttime urinary frequency and to evaluate nocturia etiologies in adults. A total of 143…”
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Clinical impacts of frailty, poor performance status, and advanced age in carfilzomib-containing treatment for relapsed/refractory multiple myeloma: post hoc investigation of the KOTOSG multicenter pilot prospective observational study by Kawaji-Kanayama, Yuka, Muramatsu, Ayako, Sasaki, Nana, Shimura, Kazuho, Kiyota, Miki, Fuchida, Shinichi, Isa, Reiko, Fujino, Takahiro, Matsumura-Kimoto, Yayoi, Tsukamoto, Taku, Chinen, Yoshiaki, Mizutani, Shinsuke, Nakao, Mitsushige, Kaneko, Hiroto, Kawata, Eri, Hirakawa, Koichi, Takahashi, Ryoichi, Shimazaki, Chihiro, Uchiyama, Hitoji, Uoshima, Nobuhiko, Shimura, Yuji, Kobayashi, Tsutomu, Taniwaki, Masafumi, Kuroda, Junya

“…We conducted a post hoc analysis of our previous pilot observational study on the efficacy and safety of carfilzomib (CFZ)-containing therapy in 50 patients…”
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Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2 by Takimoto-Shimomura, Tomoko, Tsukamoto, Taku, Maegawa, Saori, Fujibayashi, Yuto, Matsumura-Kimoto, Yayoi, Mizuno, Yoshimi, Chinen, Yoshiaki, Shimura, Yuji, Mizutani, Shinsuke, Horiike, Shigeo, Taniwaki, Masafumi, Kobayashi, Tsutomu, Kuroda, Junya

“…Summary Despite the recent therapeutic progress, the prognoses of diffuse large B-cell lymphomas (DLBCLs) that concomitantly overexpress c-MYC and BCL2, i.e.,…”
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Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma by Chinen, Yoshiaki, Kuroda, Junya, Shimura, Yuji, Nagoshi, Hisao, Kiyota, Miki, Yamamoto-Sugitani, Mio, Mizutani, Shinsuke, Sakamoto, Natsumi, Ri, Masaki, Kawata, Eri, Kobayashi, Tsutomu, Matsumoto, Yosuke, Horiike, Shigeo, Iida, Shinsuke, Taniwaki, Masafumi

“…Multiple myeloma is a cytogenetically/molecularly heterogeneous hematologic malignancy that remains mostly incurable, and the identification of a universal and…”
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Epstein-Barr virus-associated lymphoproliferative disease during imatinib mesylate treatment for chronic myeloid leukemia by Yamaguchi, Junko, Fujino, Takahiro, Isa, Reiko, Nishiyama, Daichi, Kuwahara-Ota, Saeko, Kawaji, Yuka, Tsukamoto, Taku, Chinen, Yoshiaki, Shimura, Yuji, Kobayashi, Tsutomu, Horiike, Shigeo, Kohno, Kei, Nakamura, Shigeo, Kuroda, Junya

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Recurrent intragenic exon rearrangements of SOBP and AUTS2 in non-Hodgkin B-cell lymphoma by Matsumoto, Yosuke, Chinen, Yoshiaki, Shimura, Yuji, Nagoshi, Hisao, Sasaki, Nana, Muramatsu, Ayako, Kuriyama, Kodai, Ohshiro, Muneo, Hirakawa, Yoshiko, Iwai, Toshiki, Uchiyama, Hitoji, Taki, Tomohiko, Horiike, Shigeo, Kuroda, Junya, Taniwaki, Masafumi

“…Expression of intragenic exon rearrangements (IERs) has reportedly been detected in both normal and cancer cells. However, there have been few reports of…”
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Aberrant BUB1 Overexpression Promotes Mitotic Segregation Errors and Chromosomal Instability in Multiple Myeloma by Fujibayashi, Yuto, Isa, Reiko, Nishiyama, Daichi, Sakamoto-Inada, Natsumi, Kawasumi, Norichika, Yamaguchi, Junko, Kuwahara-Ota, Saeko, Matsumura-Kimoto, Yayoi, Tsukamoto, Taku, Chinen, Yoshiaki, Shimura, Yuji, Kobayashi, Tsutomu, Horiike, Shigeo, Taniwaki, Masafumi, Handa, Hiroshi, Kuroda, Junya

“…Chromosome instability (CIN), the hallmarks of cancer, reflects ongoing chromosomal changes caused by chromosome segregation errors and results in whole…”
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Pretreatment serum level of interleukin-6 predicts carfilzomib-induced hypertension in relapsed/refractory multiple myeloma by Muramatsu, Ayako, Kobayashi, Tsutomu, Kawaji-Kanayama, Yuka, Uchiyama, Hitoji, Sasaki, Nana, Uoshima, Nobuhiko, Nakao, Mitsushige, Takahashi, Ryoichi, Shimura, Kazuho, Kaneko, Hiroto, Kiyota, Miki, Wada, Katsuya, Chinen, Yoshiaki, Hirakawa, Koichi, Fuchida, Shin-ichi, Shimazaki, Chihiro, Mizutani, Shinsuke, Tsukamoto, Taku, Shimura, Yuji, Taniwaki, Masafumi, Teramukai, Satoshi, Kuroda, Junya

“…Carfilzomib (CFZ) constitutes powerful combinatory therapy for relapsed/refractory multiple myeloma (RRMM); however, cardiovascular adverse events (CVAEs) have…”
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A novel method of amplified fluorescent in situ hybridization for detection of chromosomal microdeletions in B cell lymphoma by Mizuno, Yoshimi, Chinen, Yoshiaki, Tsukamoto, Taku, Takimoto-Shimomura, Tomoko, Matsumura-Kimoto, Yayoi, Fujibayashi, Yuto, Kuwahara-Ota, Saeko, Fujino, Takahiro, Nishiyama, Daichi, Shimura, Yuji, Kobayashi, Tsutomu, Horiike, Shigeo, Taniwaki, Masafumi, Kuroda, Junya

“…Chromosomal microdeletions frequently cause loss of prognostically relevant tumor suppressor genes in hematologic malignancies; however, detection of minute…”
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Intravascular lymphoma in a rheumatoid arthritis patient following short-term methotrexate treatment by Kida, Takashi, Kohno, Masataka, Chinen, Yoshiaki, Tominaga, Aiko, Seno, Takahiro, Tsukamoto, Taku, Kuroda, Junya, Kawahito, Yutaka

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Multiple myeloma: pathophysiology and progress in management by Kuroda, Junya, Chinen, Yoshiaki

“…There have been dramatic recent advances in understanding the basic pathophysiology and treatment strategies for multiple myeloma (MM). Research has shown both…”
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Extranodal NK/T-cell Lymphoma, Nasal Type Accompanied by PR3-ANCA-associated Glomerulonephritis by Tamoto, Yuta, Ishida, Ryo, Shiogama, Kazuya, Kado, Hiroshi, Kamezaki, Michitsugu, Chinen, Yoshiaki, Matsumoto, Yosuke, Kusaba, Tetsuro, Konishi, Eiichi, Tsutsumi, Yutaka, Tamagaki, Keiichi

“…A 62-year-old man exhibiting nasal obstruction and glomerulonephritis with proteinase 3-antineutrophil cytoplasmic antibodies (PR3-ANCAs) was diagnosed with…”
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Detection of chromosomal abnormalities by G-banding and prognostic impact in follicular lymphoma in the rituximab era by Tsukamoto, Taku, Kiyota, Miki, Kawata, Eri, Uoshima, Nobuhiko, Tatekawa, Shotaro, Chinen, Yoshiaki, Nagoshi, Hisao, Mizutani, Shinsuke, Shimura, Yuji, Yamamoto-Sugitani, Mio, Kobayashi, Tsutomu, Horiike, Shigeo, Yasukawa, Satoru, Yanagisawa, Akio, Taniwaki, Masafumi, Kuroda, Junya

“…Disease-specific cytogenetic abnormalities involving BCL2 gene rearrangement frequently co-exist with other cytogenetic abnormalities, contributing to disease…”
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Immunosuppressive therapy with rabbit antithymocyte globulin therapy for acquired aplastic anemia: a multi-institutional retrospective study in Japanese adult patients by Sasaki, Nana, Shimura, Kazuho, Yoshida, Mihoko, Uoshima, Nobuhiko, Kiyota, Miki, Hatsuse, Mayumi, Uchiyama, Hitoji, Chinen, Yoshiaki, Kobayashi, Tsutomu, Nakao, Mitsushige, Takahashi, Ryoichi, Nakano-Akamatsu, Sonoko, Kaneko, Hiroto, Kobayashi, Yutaka, Shimazaki, Chihiro, Taniwaki, Masafumi, Kuroda, Junya

“…We retrospectively analyzed efficacy and safety of therapy with rabbit antithymocyte globulin (rATG) in combination with cyclosporine A (CsA) in 30 Japanese…”
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Combined rituximab, bendamustine, and dexamethasone chemotherapy for relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma: a multicenter phase II study by Matsumoto, Yosuke, Kobayashi, Tsutomu, Shimura, Yuji, Kawata, Eri, Nagoshi, Hisao, Ohshiro, Muneo, Sugitani, Mio, Shimura, Kazuho, Iwai, Toshiki, Fuchida, Shin-ichi, Yoshida, Mihoko, Kiyota, Miki, Mizutani, Shinsuke, Chinen, Yoshiaki, Takimoto-Shimomura, Tomoko, Nakao, Mitsushige, Kaneko, Hiroto, Uchiyama, Hitoji, Uoshima, Nobuhiko, Nishigaki, Hikari, Kobayashi, Yutaka, Horiike, Shigeo, Shimazaki, Chihiro, Taniwaki, Masafumi, Kuroda, Junya

“…This multicenter phase II study (UMIN000008145) aims to investigate the efficacy and safety of six cycles of combination therapy (RBD) comprising rituximab,…”
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Monosomy 13 in metaphase spreads is a predictor of poor long-term outcome after bortezomib plus dexamethasone treatment for relapsed/refractory multiple myeloma by Kiyota, Miki, Kobayashi, Tsutomu, Fuchida, Shinichi, Yamamoto-Sugitani, Mio, Ohshiro, Muneo, Shimura, Yuji, Mizutani, Shinsuke, Nagoshi, Hisao, Sasaki, Nana, Nakayama, Ryuko, Chinen, Yoshiaki, Sakamoto, Natsumi, Uchiyama, Hitoji, Matsumoto, Yosuke, Horiike, Shigeo, Shimazaki, Chihiro, Kuroda, Junya, Taniwaki, Masafumi

“…We retrospectively investigated the prognostic impact of high-risk cytogenetic abnormalities (CAs) on the outcome of treatment with bortezomib plus…”
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Serine‐227 in the N‐terminal kinase domain of RSK2 is a potential therapeutic target for mantle cell lymphoma by Matsumura‐Kimoto, Yayoi, Tsukamoto, Taku, Shimura, Yuji, Chinen, Yoshiaki, Tanba, Kazuna, Kuwahara‐Ota, Saeko, Fujibayashi, Yuto, Nishiyama, Daichi, Isa, Reiko, Yamaguchi, Junko, Kawaji‐Kanayama, Yuka, Kobayashi, Tsutomu, Horiike, Shigeo, Taniwaki, Masafumi, Kuroda, Junya

“…RSK2 is a serine/threonine kinase downstream signaling mediator in the RAS/ERK signaling pathway and may be a therapeutic target in mantle cell lymphoma (MCL),…”
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