Healthy human pregnancy: inherently inflammatory or anti-inflammatory? (HUM1P.275)
Although much is known of immunity at the maternal-fetal interface, the innate immune status of women during healthy pregnancy remains unclear. Whether it exhibits a bias towards inflammatory phenotypes (transiently enhancing host defense) or anti-inflammatory phenotypes (reducing potential response...
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| Published in: | The Journal of immunology (1950) Vol. 194; no. 1_Supplement; pp. 52 - 52.24 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
01-05-2015
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| Online Access: | Get full text |
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| Summary: | Although much is known of immunity at the maternal-fetal interface, the innate immune status of women during healthy pregnancy remains unclear. Whether it exhibits a bias towards inflammatory phenotypes (transiently enhancing host defense) or anti-inflammatory phenotypes (reducing potential responses to the fetus) is controversial. Here, in a longitudinal study of >100 healthy women giving birth to full term healthy infants, systemic innate immune status was examined during the 2nd/3rd trimester and again, one or three years postpartum. Following REB approval and informed consent, pro and anti-inflammatory plasma biomarkers were quantified. Constitutive CCL2, CXCL10 and TNFa levels were sharply reduced (p<0.003 to 0.0001) in pregnancy. Several anti-inflammatory biomarkers were elevated (sTNFRI, sTNFRII, IL-1Ra p<0.0001). Plasma IL-10, expressed in >85% of this population, was not altered during/post pregnancy. Kinetic studies revealed that pro-inflammatory biomarker expression (CXCL10, CCL2, CXCL8, IL-18, TNFa) was independent of gestational age. Conversely, the intensity of anti-inflammatory cytokine antagonist production increased with gestational age (Spearman p<0.0003). In summary, among women experiencing healthy full term pregnancies, basal systemic immunity is characterized by an increasingly intense bias towards an anti-inflammatory innate immune phenotype that is resolved by one year postpartum. |
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| ISSN: | 0022-1767 1550-6606 |
| DOI: | 10.4049/jimmunol.194.Supp.52.24 |