Search Results - "CHILDS, Kay"

LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA by Childs, Kay S, Randall, Richard E, Goodbourn, Stephen

“…The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of…”
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Paramyxovirus V Proteins Interact with the RNA Helicase LGP2 To Inhibit RIG-I-Dependent Interferon Induction by CHILDS, Kay, RANDALL, Richard, GOODBOURN, Stephen

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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Trans-Encapsidation of Foot-and-Mouth Disease Virus Genomes Facilitates Escape from Neutralizing Antibodies by Childs, Kay, Jackson, Ben, Harvey, Yongjie, Seago, Julian

“…Foot-and-mouth disease is an economically devastating disease of livestock caused by foot-and-mouth disease virus (FMDV). Vaccination is the most effective…”
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Demonstration of Co-Infection and Trans-Encapsidation of Viral RNA In Vitro Using Epitope-Tagged Foot-and-Mouth Disease Viruses by Childs, Kay, Juleff, Nicholas, Moffat, Katy, Seago, Julian

“…Foot-and-mouth disease, caused by foot-and-mouth disease virus (FMDV), is an economically devastating disease affecting several important livestock species…”
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The Identification of Host Proteins That Interact with Non-Structural Proteins-1α and -1β of Porcine Reproductive and Respiratory Syndrome Virus-1 by Riccio, Sofia, Childs, Kay, Jackson, Ben, Graham, Simon P, Seago, Julian

“…Porcine reproductive and respiratory syndrome viruses (PRRSV-1 and -2) are the causative agents of one of the most important infectious diseases affecting the…”
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The African Swine Fever Virus DP71L Protein Recruits the Protein Phosphatase 1 Catalytic Subunit To Dephosphorylate eIF2α and Inhibits CHOP Induction but Is Dispensable for These Activities during Virus Infection by FUQUAN ZHANG, MOON, Alice, CHILDS, Kay, GOODBOURN, Stephen, DIXON, Linda K

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Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction by Iaconis, Gennaro, Jackson, Ben, Childs, Kay, Boyce, Mark, Goodbourn, Stephen, Blake, Neil, Iturriza-Gomara, Miren, Seago, Julian

“…Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells…”
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A missense mutation in TRAPPC6A leads to build-up of the protein, in patients with a neurodevelopmental syndrome and dysmorphic features by Mohamoud, Hussein Sheikh, Ahmed, Saleem, Jelani, Musharraf, Alrayes, Nuha, Childs, Kay, Vadgama, Nirmal, Almramhi, Mona Mohammad, Al-Aama, Jumana Yousuf, Goodbourn, Steve, Nasir, Jamal

“…Childhood onset clinical syndromes involving intellectual disability and dysmorphic features, such as polydactyly, suggest common developmental pathways link…”
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An Improved αvβ6-Receptor-Expressing Suspension Cell Line for Foot-and-Mouth Disease Vaccine Production by Harvey, Yongjie, Jackson, Ben, Carr, Brigid Veronica, Childs, Kay, Moffat, Katy, Freimanis, Graham, Tennakoon, Chandana, Juleff, Nicholas, Seago, Julian

“…Foot-and-mouth disease (FMD) is endemic in large parts of sub-Saharan Africa, Asia and South America, where outbreaks in cloven-hooved livestock threaten food…”
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Analysis of porcine bone marrow-derived macrophage cytokine responses to infection with PRRSV-1 strains of differing virulence by Jackson, Ben, Chrun, Tiphany, Childs, Kay, Wanasen, Nanchaya, Frossard, Jean-Pierre, Graham, Simon P., Seago, Julian

“…Porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) causes huge economic losses to the European pig industry. PRRSV-1 is divided into 3 subtypes…”
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Identification of novel co‐repressor molecules for Interferon Regulatory Factor‐2 by Childs, Kay S., Goodbourn, Stephen

“…We have identified two novel proteins that interact specifically with the C‐terminal repression domain of Interferon Regulatory Factor‐2 (IRF‐2). These…”
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Development of a quadrivalent foot-and-mouth disease vaccine candidate for use in East Africa by Childs, Kay, Harvey, Yongjie, Waters, Ryan, Woma, Timothy, Wilsden, Ginette, Sun, Hualu, Sun, Peng, Seago, Julian

“…•Efficacious quadrivalent foot-and-mouth disease vaccine for East Africa.•Recombinant chimeric foot-and-mouth disease virus vaccine.•Foot-and-mouth disease…”
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mda-5, but not RIG-I, is a common target for paramyxovirus V proteins by Childs, Kay, Stock, Nicola, Ross, Craig, Andrejeva, Jelena, Hilton, Louise, Skinner, Michael, Randall, Richard, Goodbourn, Stephen

“…Abstract The induction of IFN-β by the paramyxovirus PIV5 (formerly known as SV5) is limited by the action of the viral V protein that targets the cellular RNA…”
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The African Swine Fever Virus DP71L Protein Recruits the Protein Phosphatase 1 Catalytic Subunit To Dephosphorylate eIF2a and Inhibits CHOP Induction but Is Dispensable for These Activities during Virus Infection by Zhang, Fuquan, Moon, Alice, Childs, Kay, Goodbourn, Stephen, Dixon, Linda K

“…The African swine fever virus (ASFV) DP71L protein is present in all isolates as either a short form of 70 to 72 amino acids or a long form of about 184 amino…”
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The African Swine Fever Virus DP71L Protein Recruits the Protein Phosphatase 1 Catalytic Subunit To Dephosphorylate eIF2 and Inhibits CHOP Induction but Is Dispensable for These Activities during Virus Infection by Zhang, Fuquan, Moon, Alice, Childs, Kay, Goodbourn, Stephen, Dixon, Linda K

“…The African swine fever virus (ASFV) DP71L protein is present in all isolates as either a short form of 70 to 72 amino acids or a long form of about 184 amino…”
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LGP2 Plays a Critical Role in Sensitizing mda-5 to Activation by Double-Stranded RNA. e64202 by Childs, Kay S, Randall, Richard E, Goodbourn, Stephen

“…The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of…”
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A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with altered expression of bcl-2 family proteins by MARRIOTT, J. Blake, CLARKE, Ian A, DALGLEISH, Angus G, CZAJKA, Anna, DREDGE, Keith, CHILDS, Kay, MAN, Hon-Wah, SCHAFER, Peter, GOVINDA, Sowmya, MULLER, George W, STIRLING, David I

“…Thalidomide is clinically useful in a number of cancers. Antitumor activity may be related to a number of known properties, including anti-tumor necrosis…”
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The African swine fever virus DP71L protein recruits the protein phosphatase 1 catalytic subunit to dephosphorylate eIF2alpha and inhibits CHOP induction but is dispensable for these activities during virus infection by Zhang, Fuquan, Moon, Alice, Childs, Kay, Goodbourn, Stephen, Dixon, Linda K

“…The African swine fever virus (ASFV) DP71L protein is present in all isolates as either a short form of 70 to 72 amino acids or a long form of about 184 amino…”
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Telling women's stories: Women's experiences of being in established relationships in which the men developed erectile dysfunction by Childs, Kay Jeanine King

“…When a man in an established relationship develops erectile dysfunction, this may affect his wife/partner in ways beyond the sexual. The primary objectives of…”
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Telling women's stories: Women's experiences of being in established relationships in which the men developed erectile dysfunction by Childs, Kay Jeanine King

“…When a man in an established relationship develops erectile dysfunction, this may affect his wife/partner in ways beyond the sexual. The primary objectives of…”
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