Search Results - "CHIGNARD, Nicolas"

Bile Salts Control the Antimicrobial Peptide Cathelicidin Through Nuclear Receptors in the Human Biliary Epithelium by D'Aldebert, Emilie, Biyeyeme Bi Mve, Marie–Jeanne, Mergey, Martine, Wendum, Dominique, Firrincieli, Delphine, Coilly, Audrey, Fouassier, Laura, Corpechot, Christophe, Poupon, Raoul, Housset, Chantal, Chignard, Nicolas

“…Backgrounds & Aims Under normal conditions, the biliary tract is a microbial-free environment. The absence of microorganisms has been attributed to various…”
Get full text

Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells by BOISSAN, Mathieu, DE WEVER, Olivier, BRACKE, Marc, CHAVRIER, Philippe, GESPACH, Christian, LACOMBE, Marie-Lise, LIZARRAGA, Floria, WENDUM, Dominique, POINCLOUX, Renaud, CHIGNARD, Nicolas, DESBOIS-MOUTHON, Christèle, DUFOUR, Sylvie, NAWROCKI-RABY, Béatrice, BIREMBAUT, Philippe

“…Loss of NM23-H1 expression correlates with the degree of metastasis and with unfavorable clinical prognosis in several types of human carcinoma. However, the…”
Get full text

Vitamin D and the vitamin D receptor in liver pathophysiology by Zúñiga, Silvia, Firrincieli, Delphine, Housset, Chantal, Chignard, Nicolas

“…Summary Vitamin D through the vitamin D nuclear receptor (VDR) plays a key role in mineral ion homeostasis. The liver is central in vitamin D synthesis,…”
Get full text

Targeting Farnesoid X Receptor in Hepatic and Biliary Inflammatory Diseases by Chignard, Nicolas, PhD, Poupon, Raoul, MD

Get full text

Cleavage of Endoplasmic Reticulum Proteins in Hepatocellular Carcinoma: Detection of Generated Fragments in Patient Sera by Chignard, Nicolas, Shang, Sufen, Wang, Hong, Marrero, Jorge, Bréchot, Christian, Hanash, Samir, Beretta, Laura

“…Background & Aims: In the past decade, there has been a rising incidence of hepatocellular carcinoma (HCC) and a progressive increase in HCC-related mortality…”
Get full text

Expression patterns of nuclear receptors in parenchymal and non-parenchymal mouse liver cells and their modulation in cholestasis by Gonzalez-Sanchez, Ester, Firrincieli, Delphine, Housset, Chantal, Chignard, Nicolas

“…Nuclear receptors (NR), the largest family of transcription factors, control many physiological and pathological processes. To gain insight into hepatic NR and…”
Get full text

Nuclear receptors in acute and chronic cholestasis by Gonzalez-Sanchez, Ester, Firrincieli, Delphine, Housset, Chantal, Chignard, Nicolas

“…Nuclear receptors (NRs) form a family of 48 members. NRs control hepatic processes such as bile acid homeostasis, lipid metabolism and mechanisms involved in…”
Get more information

Hepatocyte Growth Factor and c-Met Inhibition by Hepatic Cell Hypoxia by Corpechot, Christophe, Barbu, Veronique, Wendum, Dominique, Chignard, Nicolas, Housset, Chantal, Poupon, Raoul, Rosmorduc, Olivier

“…Hepatic resection in cirrhotic patients is associated with impaired liver regeneration and poor clinical outcome. Because experimental cirrhosis is associated…”
Get full text

Cholangiopathy aggravation is caused by VDR ablation and alleviated by VDR-independent vitamin D signaling in ABCB4 knockout mice by Gonzalez-Sanchez, Ester, El Mourabit, Haquima, Jager, Marion, Clavel, Marie, Moog, Sophie, Vaquero, Javier, Ledent, Tatiana, Cadoret, Axelle, Gautheron, Jérémie, Fouassier, Laura, Wendum, Dominique, Chignard, Nicolas, Housset, Chantal

“…Cholangiopathies are chronic liver diseases in which damaged cholangiocytes trigger a proinflammatory and profibrotic reaction. The nuclear vitamin D receptor…”
Get more information

Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice by Firrincieli, Delphine, Zúñiga, Silvia, Rey, Colette, Wendum, Dominique, Lasnier, Elisabeth, Rainteau, Dominique, Braescu, Thomas, Falguières, Thomas, Boissan, Mathieu, Cadoret, Axelle, Housset, Chantal, Chignard, Nicolas

“…Alterations in apical junctional complexes (AJCs) have been reported in genetic or acquired biliary diseases. The vitamin D nuclear receptor (VDR),…”
Get full text

Reply by Debray, Dominique, Chignard, Nicolas, Housset, Chantal

Get full text

E-cadherin, guardian of liver physiology by Gonzalez-Sanchez, Ester, Vaquero, Javier, Fouassier, Laura, Chignard, Nicolas

“…Summary E-cadherin is a cell-to-cell adhesion molecule involved in epithelial cell behavior, tissue formation and cancer suppression. In the liver, E-cadherin…”
Get full text

Reply by Debray, Dominique, Chignard, Nicolas, Housset, Chantal

Get full text

Defects in Gallbladder Emptying and Bile Acid Homeostasis in Mice With Cystic Fibrosis Transmembrane Conductance Regulator Deficiencies by Debray, Dominique, Rainteau, Dominique, Barbu, Véronique, Rouahi, Myriam, El Mourabit, Haquima, Lerondel, Stéphanie, Rey, Colette, Humbert, Lydie, Wendum, Dominique, Cottart, Charles–Henry, Dawson, Paul, Chignard, Nicolas, Housset, Chantal

“…Background & Aims Patients with cystic fibrosis (CF) have poorly defined defects in biliary function. We evaluated the effects of cystic fibrosis transmembrane…”
Get full text

Phosphorylation of ABCB4 impacts its function: Insights from disease‐causing mutations by Gautherot, Julien, Delautier, Danièle, Maubert, Marie‐Anne, Aït‐Slimane, Tounsia, Bolbach, Gérard, Delaunay, Jean‐Louis, Durand‐Schneider, Anne‐Marie, Firrincieli, Delphine, Barbu, Véronique, Chignard, Nicolas, Housset, Chantal, Maurice, Michèle, Falguières, Thomas

“…The ABCB4 transporter mediates phosphatidylcholine (PC) secretion at the canalicular membrane of hepatocytes and its genetic defects cause biliary diseases…”
Get full text

Proteomics for hepatocellular carcinoma marker discovery by Chignard, Nicolas, Beretta, Laura

“…Refinements of serological markers and screening of patients at high risk for developing hepatocellular carcinoma (HCC) may lead to better HCC detection,…”
Get full text

Functions of the Gallbladder by Housset, Chantal, Chrétien, Yues, Debray, Dominique, Chignard, Nicolas

“…The gallbladder stores and concentrates bile between meals. Gallbladder motor function is regulated by bile acids via the membrane bile acid receptor, TGR5,…”
Get more information

Role of nuclear receptors in the biliary epithelium by Firrincieli, Delphine, Zuniga, Silvia, Poupon, Raoul, Housset, Chantal, Chignard, Nicolas

“…The biliary epithelium is organized as a single layer of biliary epithelial cells lining the biliary tree. Biliary epithelial cells have three major biological…”
Get more information

Ezrin-Radixin-Moesin-Binding Phosphoprotein (EBP50), an Estrogen-Inducible Scaffold Protein, Contributes to Biliary Epithelial Cell Proliferation by Fouassier, Laura, Rosenberg, Peter, Mergey, Martine, Saubaméa, Bruno, Clapéron, Audrey, Kinnman, Nils, Chignard, Nicolas, Jacobsson-Ekman, Gunilla, Strandvik, Birgitta, Rey, Colette, Barbu, Véronique, Hultcrantz, Rolf, Housset, Chantal

“…Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) anchors and regulates apical membrane proteins in epithelia. EBP50 is inducible by estrogen and may…”
Get full text

Altered hepatobiliary gene expressions in PFIC1 : ATP8B1 gene defect is associated with cftr downregulation by DEMEILLIERS, Christine, JACQUEMIN, Emmanuel, BARBU, Véronique, MERGEY, Martine, PAYE, Francois, FOUASSIER, Laura, CHIGNARD, Nicolas, HOUSSET, Chantal, LOMRI, Nour-Eddine

“…Recent reports in patients with PFIC1 have indicated that a gene defect in ATP8B1 could cause deregulations in bile salt transporters through decreased…”
Get full text