Search Results - "CHIESA, Mattia"

GARS: Genetic Algorithm for the identification of a Robust Subset of features in high-dimensional datasets by Chiesa, Mattia, Maioli, Giada, Colombo, Gualtiero I, Piacentini, Luca

“…Feature selection is a crucial step in machine learning analysis. Currently, many feature selection approaches do not ensure satisfying results, in terms of…”
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Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells by Buzzetti, Marta, Morlando, Sonia, Solomos, Dimitrios, Mehmood, Ammara, Cox, Alexander W. I., Chiesa, Mattia, D’Alessandra, Yuri, Garofalo, Michela, Topham, Caroline H., Di Leva, Gianpiero

“…Medulloblastoma (MB) is the most common aggressive paediatric brain tumour and, despite the recent progress in the treatments of MB patients, there is still an…”
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Whole blood transcriptome profile at hospital admission discriminates between patients with ST-segment elevation and non-ST-segment elevation acute myocardial infarction by Chiesa, Mattia, Piacentini, Luca, Bono, Elisa, Milazzo, Valentina, Campodonico, Jeness, Marenzi, Giancarlo, Colombo, Gualtiero I.

“…Whether ST-segment (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) should be regarded as distinct pathophysiological entities is a matter…”
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Patient-specific primary and pluripotent stem cell-derived stromal cells recapitulate key aspects of arrhythmogenic cardiomyopathy by Maione, Angela Serena, Meraviglia, Viviana, Iengo, Lara, Rabino, Martina, Chiesa, Mattia, Catto, Valentina, Tondo, Claudio, Pompilio, Giulio, Bellin, Milena, Sommariva, Elena

“…Primary cardiac mesenchymal stromal cells (C-MSCs) can promote the aberrant remodeling of cardiac tissue that characterizes arrhythmogenic cardiomyopathy (ACM)…”
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Multiomic Approaches to Uncover the Complexities of Dystrophin-Associated Cardiomyopathy by Gowran, Aoife, Brioschi, Maura, Rovina, Davide, Chiesa, Mattia, Piacentini, Luca, Mallia, Sara, Banfi, Cristina, Pompilio, Giulio, Santoro, Rosaria

“…Despite major progress in treating skeletal muscle disease associated with dystrophinopathies, cardiomyopathy is emerging as a major cause of death in people…”
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Omics Analyses of Stromal Cells from ACM Patients Reveal Alterations in Chromatin Organization and Mitochondrial Homeostasis by Lippi, Melania, Maione, Angela Serena, Chiesa, Mattia, Perrucci, Gianluca Lorenzo, Iengo, Lara, Sattin, Tommaso, Cencioni, Chiara, Savoia, Matteo, Zeiher, Andreas M, Tundo, Fabrizio, Tondo, Claudio, Pompilio, Giulio, Sommariva, Elena

“…Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder characterized by ventricular arrhythmias, contractile dysfunctions and fibro-adipose replacement of…”
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Plasmatic and chamber-specific modulation of cardiac microRNAs in an acute model of DOX-induced cardiotoxicity by Gioffré, Sonia, Ricci, Veronica, Vavassori, Chiara, Ruggeri, Clarissa, Chiesa, Mattia, Alfieri, Ivana, Zorzan, Silvia, Buzzetti, Marta, Milano, Giuseppina, Scopece, Alessandro, Castiglioni, Laura, Sironi, Luigi, Pompilio, Giulio, Colombo, Gualtiero I., D'Alessandra, Yuri

“…Doxorubicin (DOX) is a chemotherapeutic drug limited in its usefulness by an adverse side effect, cardiotoxicity. The mechanisms leading to this detrimental…”
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Gene Regulatory Network Analysis of Perivascular Adipose Tissue of Abdominal Aortic Aneurysm Identifies Master Regulators of Key Pathogenetic Pathways by Piacentini, Luca, Chiesa, Mattia, Colombo, Gualtiero Ivanoe

“…The lack of medical therapy to treat abdominal aortic aneurysm (AAA) stems from our inadequate understanding of the mechanisms underlying AAA pathogenesis. To…”
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Evaluation of Oxford Nanopore MinION RNA-Seq Performance for Human Primary Cells by Massaiu, Ilaria, Songia, Paola, Chiesa, Mattia, Valerio, Vincenza, Moschetta, Donato, Alfieri, Valentina, Myasoedova, Veronika A., Schmid, Michael, Cassetta, Luca, Colombo, Gualtiero I., D’Alessandra, Yuri, Poggio, Paolo

“…Transcript sequencing is a crucial tool for gaining a deep understanding of biological processes in diagnostic and clinical medicine. Given their potential to…”
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Cardiovascular magnetic resonance images with susceptibility artifacts: artificial intelligence with spatial-attention for ventricular volumes and mass assessment by Penso, Marco, Babbaro, Mario, Moccia, Sara, Guglielmo, Marco, Carerj, Maria Ludovica, Giacari, Carlo Maria, Chiesa, Mattia, Maragna, Riccardo, Rabbat, Mark G, Barison, Andrea, Martini, Nicola, Pepi, Mauro, Caiani, Enrico G, Pontone, Gianluca

“…Segmentation of cardiovascular magnetic resonance (CMR) images is an essential step for evaluating dimensional and functional ventricular parameters as…”
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Putative Circulating MicroRNAs Are Able to Identify Patients with Mitral Valve Prolapse and Severe Regurgitation by Songia, Paola, Chiesa, Mattia, Alfieri, Valentina, Massaiu, Ilaria, Moschetta, Donato, Myasoedova, Veronika, Valerio, Vincenza, Fusini, Laura, Gripari, Paola, Zanobini, Marco, Poggio, Paolo

“…Mitral valve prolapse (MVP) associated with severe mitral regurgitation is a debilitating disease with no pharmacological therapies available. MicroRNAs…”
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Multi-omics in thoracic aortic aneurysm: the complex road to the simplification by Rega, Sara, Farina, Floriana, Bouhuis, Silvia, de Donato, Silvia, Chiesa, Mattia, Poggio, Paolo, Cavallotti, Laura, Bonalumi, Giorgia, Giambuzzi, Ilaria, Pompilio, Giulio, Perrucci, Gianluca L

“…Thoracic aortic aneurysm (TAA) is a serious condition that affects the aorta, characterized by the dilation of its first segment. The causes of TAA (e.g., age,…”
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Diabetes Induces a Transcriptional Signature in Bone Marrow-Derived CD34 + Hematopoietic Stem Cells Predictive of Their Progeny Dysfunction by D'Alessandra, Yuri, Chiesa, Mattia, Vigorelli, Vera, Ricci, Veronica, Rurali, Erica, Raucci, Angela, Colombo, Gualtiero Ivanoe, Pompilio, Giulio, Vinci, Maria Cristina

“…Hematopoietic stem/progenitor cells (HSPCs) participate in cardiovascular (CV) homeostasis and generate different types of blood cells including lymphoid and…”
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MiR-320a as a Potential Novel Circulating Biomarker of Arrhythmogenic CardioMyopathy by Sommariva, Elena, D’Alessandra, Yuri, Farina, Floriana Maria, Casella, Michela, Cattaneo, Fabio, Catto, Valentina, Chiesa, Mattia, Stadiotti, Ilaria, Brambilla, Silvia, Dello Russo, Antonio, Carbucicchio, Corrado, Vettor, Giulia, Riggio, Daniela, Sandri, Maria Teresa, Barbuti, Andrea, Vernillo, Gianluca, Muratori, Manuela, Dal Ferro, Matteo, Sinagra, Gianfranco, Moimas, Silvia, Giacca, Mauro, Colombo, Gualtiero Ivanoe, Pompilio, Giulio, Tondo, Claudio

“…Diagnosis of Arrhythmogenic CardioMyopathy (ACM) is challenging and often late after disease onset. No circulating biomarkers are available to date. Given…”
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Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis by Myasoedova, Veronika A, Massaiu, Ilaria, Moschetta, Donato, Chiesa, Mattia, Songia, Paola, Valerio, Vincenza, Alfieri, Valentina, Capoulade, Romain, Trabattoni, Daniela, Andreini, Daniele, Mass, Elvira, Parisi, Valentina, Poggio, Paolo

“…Aortic stenosis (AS) is the most common valve disorder characterized by fibro-calcific remodeling of leaflets. Recent evidence indicated that there is a…”
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Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy by Sommariva, Elena, Stadiotti, Ilaria, Casella, Michela, Catto, Valentina, Dello Russo, Antonio, Carbucicchio, Corrado, Arnaboldi, Lorenzo, De Metrio, Simona, Milano, Giuseppina, Scopece, Alessandro, Casaburo, Manuel, Andreini, Daniele, Mushtaq, Saima, Conte, Edoardo, Chiesa, Mattia, Birchmeier, Walter, Cogliati, Elisa, Paolin, Adolfo, König, Eva, Meraviglia, Viviana, De Musso, Monica, Volani, Chiara, Cattelan, Giada, Rauhe, Werner, Turnu, Linda, Porro, Benedetta, Pedrazzini, Matteo, Camera, Marina, Corsini, Alberto, Tondo, Claudio, Rossini, Alessandra, Pompilio, Giulio

“…Arrhythmogenic cardiomyopathy (ACM) is hallmarked by ventricular fibro‐adipogenic alterations, contributing to cardiac dysfunctions and arrhythmias. Although…”
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Melanocortin-1 Receptor Positively Regulates Human Artery Endothelial Cell Migration by Saporiti, Federica, Piacentini, Luca, Alfieri, Valentina, Bono, Elisa, Ferrari, Fabrizio, Chiesa, Mattia, Colombo, Gualtiero I

“…Melanocortin receptors (MCRs) belong to a hormonal signalling pathway with multiple homeostatic and protective actions. Microvascular and umbilical vein…”
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EMID2 is a novel biotherapeutic for aggressive cancers identified by in vivo screening by Cappelletto, Ambra, Alfì, Edoardo, Volf, Nina, Vu, Thi Van Anh, Bortolotti, Francesca, Ciucci, Giulio, Vodret, Simone, Fantuz, Marco, Perin, Martina, Colliva, Andrea, Rozzi, Giacomo, Rossi, Matilde, Ruozi, Giulia, Zentilin, Lorena, Vuerich, Roman, Borin, Daniele, Lapasin, Romano, Piazza, Silvano, Chiesa, Mattia, Lorizio, Daniela, Triboli, Luca, Kumar, Sandeep, Morello, Gaia, Tripodo, Claudio, Pinamonti, Maurizio, Piperno, Giulia Maria, Benvenuti, Federica, Rustighi, Alessandra, Jo, Hanjoong, Piccolo, Stefano, Del Sal, Giannino, Carrer, Alessandro, Giacca, Mauro, Zacchigna, Serena

“…New drugs to tackle the next pathway or mutation fueling cancer are constantly proposed, but 97% of them are doomed to fail in clinical trials, largely because…”
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Human Cardiac Mesenchymal Stromal Cells From Right and Left Ventricles Display Differences in Number, Function, and Transcriptomic Profile by Stadiotti, Ilaria, Piacentini, Luca, Vavassori, Chiara, Chiesa, Mattia, Scopece, Alessandro, Guarino, Anna, Micheli, Barbara, Polvani, Gianluca, Colombo, Gualtiero Ivanoe, Pompilio, Giulio, Sommariva, Elena

“…Left ventricle (LV) and right ventricle (RV) are characterized by well-known physiological differences, mainly related to their different embryological origin,…”
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A Specific Circulating MicroRNA Cluster Is Associated to Late Differential Cardiac Response to Doxorubicin-Induced Cardiotoxicity In Vivo by Pompilio, Giulio, Colombo, Gualtiero I., D’Alessandra, Yuri, Pontremoli, Marta, Castiglioni, Laura, Scopece, Alessandro, Milano, Giuseppina, Buzzetti, Marta, Chiesa, Mattia, Gioffré, Sonia, Ruggeri, Clarissa, Sironi, Luigi

“…Background. Cardiotoxicity is a detrimental side effect of the anticancer drug doxorubicin (DOX), characterized by progressive heart dysfunction. Circulating…”
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