Search Results - "CHIDGEY, Ann P"

Multilineage Potential and Self-Renewal Define an Epithelial Progenitor Cell Population in the Adult Thymus by Wong, Kahlia, Lister, Natalie L., Barsanti, Marco, Lim, Joanna M.C., Hammett, Maree V., Khong, Danika M., Siatskas, Christopher, Gray, Daniel H.D., Boyd, Richard L., Chidgey, Ann P.

“…Thymic epithelial cells (TECs) are critical for T cell development and self-tolerance but are gradually lost with age. The existence of thymic epithelial…”
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Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging by Lepletier, Ailin, Hun, Michael L., Hammett, Maree V., Wong, Kahlia, Naeem, Haroon, Hedger, Mark, Loveland, Kate, Chidgey, Ann P.

“…A key feature of immune functional impairment with age is the progressive involution of thymic tissue responsible for naive T cell production. In this study,…”
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Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage by Hun, Michael Ly, Wong, Kahlia, Gunawan, Josephine Rahma, Alsharif, Abdulaziz, Quinn, Kylie, Chidgey, Ann P

“…One of the main consequences of thymus aging is the decrease in naïve T cell output. This condition accelerates at the onset of puberty, and presents as a…”
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Editorial: New Insights Into Thymic Functions During Stress, Aging, and in Disease Settings by van Oers, Nicolai S C, Su, Dong-Ming, Chidgey, Ann P, Dudakov, Jarrod

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Activation of Thymic Regeneration in Mice and Humans following Androgen Blockade by Sutherland, Jayne S, Goldberg, Gabrielle L, Hammett, Maree V, Uldrich, Adam P, Berzins, Stuart P, Heng, Tracy S, Blazar, Bruce R, Millar, Jeremy L, Malin, Mark A, Chidgey, Ann P, Boyd, Richard L

“…The thymus undergoes age-related atrophy, coincident with increased circulating sex steroids from puberty. The impact of thymic atrophy is most profound in…”
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Effects of Castration on Thymocyte Development in Two Different Models of Thymic Involution by Heng, Tracy S. P, Goldberg, Gabrielle L, Gray, Daniel H. D, Sutherland, Jayne S, Chidgey, Ann P, Boyd, Richard L

“…Age-associated thymic involution is accompanied by decreased thymic output. This adversely affects general immune competence and T cell recovery following…”
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Autoimmune-Mediated Thymic Atrophy Is Accelerated but Reversible in RelB-Deficient Mice by O'Sullivan, Brendan J, Yekollu, Suman, Ruscher, Roland, Mehdi, Ahmed M, Maradana, Muralidhara Rao, Chidgey, Ann P, Thomas, Ranjeny

“…Polymorphisms impacting thymic function may decrease peripheral tolerance and hasten autoimmune disease. The NF-κB transcription factor subunit, RelB, is…”
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Enhanced Immune System Regeneration in Humans Following Allogeneic or Autologous Hemopoietic Stem Cell Transplantation by Temporary Sex Steroid Blockade by SUTHERLAND, Jayne S, SPYROGLOU, Lisa, MUIRHEAD, Jennifer L, HENG, Tracy S, PRIETO-HINOJOSA, Adria, PRINCE, H. Miles, CHIDGEY, Ann P, SCHWARER, Anthony P, BOYD, Richard L

“…Purpose: To determine if temporarily blocking sex steroids prior to stem cell transplantation can increase thymus function and thus enhance the rate of T cell…”
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Redefining epithelial progenitor potential in the developing thymus by Rossi, Simona W, Chidgey, Ann P, Parnell, Sonia M, Jenkinson, William E, Scott, Hamish S, Boyd, Richard L, Jenkinson, Eric J, Anderson, Graham

“…Cortical and medullary epithelium represent specialised cell types that play key roles in thymocyte development, including positive and negative selection of…”
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Ablation and Regeneration of Tolerance-Inducing Medullary Thymic Epithelial Cells after Cyclosporine, Cyclophosphamide, and Dexamethasone Treatment by Fletcher, Anne L, Lowen, Tamara E, Sakkal, Samy, Reiseger, Jessica J, Hammett, Maree V, Seach, Natalie, Scott, Hamish S, Boyd, Richard L, Chidgey, Ann P

“…Immunosuppressive drugs and cytotoxic chemotherapy agents are designed to kill or suppress autoreactive, alloaggressive, or hyperinflammatory T cells, or…”
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The Lymphotoxin Pathway Regulates Aire-Independent Expression of Ectopic Genes and Chemokines in Thymic Stromal Cells by Seach, Natalie, Ueno, Tomoo, Fletcher, Anne L, Lowen, Tamara, Mattesich, Monika, Engwerda, Christian R, Scott, Hamish S, Ware, Carl F, Chidgey, Ann P, Gray, Daniel H. D, Boyd, Richard L

“…Medullary thymic epithelial cells (mTEC) play an important and unique role in central tolerance, expressing tissue-restricted Ags (TRA) which delete thymocytes…”
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The role of Tenascin C in the lymphoid progenitor cell niche by Ellis, Sarah L, Heazlewood, Shen Y, Williams, Brenda, Reitsma, Andrea J, Grassinger, Jochen, Borg, Judy, Heazlewood, Chad K, Chidgey, Ann P, Nilsson, Susan K

“…Hemopoietic stem cells (HSCs) are extrinsically controlled by the bone marrow (BM) microenvironment. Mice devoid of the extracellular matrix molecule…”
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Enhanced Hematopoietic Stem Cell Function Mediates Immune Regeneration following Sex Steroid Blockade by Khong, Danika M., Dudakov, Jarrod A., Hammett, Maree V., Jurblum, Marc I., Khong, Sacha M.L., Goldberg, Gabrielle L., Ueno, Tomoo, Spyroglou, Lisa, Young, Lauren F., van den Brink, Marcel R.M., Boyd, Richard L., Chidgey, Ann P.

“…Mechanisms underlying age-related defects within lymphoid-lineages remain poorly understood. We previously reported that sex steroid ablation (SSA) induced…”
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Getting back at nature: understanding thymic development and overcoming its atrophy by Heng, Tracy SP, Chidgey, Ann P, Boyd, Richard L

“…T cell development is a complex and tightly regulated process involving reciprocal interactions between the thymic stroma and differentiating thymocytes…”
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Native thymic extracellular matrix improves in vivo thymic organoid T cell output, and drives in vitro thymic epithelial cell differentiation by Hun, Michael, Barsanti, Marco, Wong, Kahlia, Ramshaw, John, Werkmeister, Jerome, Chidgey, Ann P

“…Abstract Although the thymus is a primary lymphoid organ, its function is compromised by an age-induced loss of resident epithelial cells, which results in…”
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Unbiased analysis, enrichment and purification of thymic stromal cells by Gray, Daniel H.D., Fletcher, Anne L., Hammett, Maree, Seach, Natalie, Ueno, Tomoo, Young, Lauren F., Barbuto, Jade, Boyd, Richard L., Chidgey, Ann P.

“…The microenvironment of the thymus consists of functionally discrete niches composed of distinct stromal cell subsets. Clinically relevant changes affecting…”
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Feeding the fire: the role of defective bone marrow function in exacerbating thymic involution by Dudakov, Jarrod A, Khong, Danika M.P, Boyd, Richard L, Chidgey, Ann P

“…Most of the steps of lymphopoiesis have been elucidated but contentious issues remain, particularly regarding the identity and function of the earliest…”
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Rewiring Immunity: Generating a Functional Thymus from hESCs… Are We There Yet? by Boyd, Richard L., Soh, Chew-Li, Boyd, Nicholas R., Stanley, Edouard G., Chidgey, Ann P.

“…Two papers in this issue of Cell Stem Cell have made a significant advance in solving one of the great challenges of modern immunology—resurrecting thymus…”
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Thymic involution: where endocrinology meets immunology by Calder, Adrienne E, Hince, Melanie N, Dudakov, Jarrod A, Chidgey, Ann P, Boyd, Richard L

“…The decline in immune function with aging represents a major clinical challenge in many disease conditions. It is manifest in many parameters but is…”
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The contribution of thymic stromal abnormalities to autoimmune disease by Fletcher, Anne L, Calder, Adrienne, Hince, Melanie N, Boyd, Richard L, Chidgey, Ann P

“…In essence, normal thymus function involves the production of a broad repertoire of αβT cells capable of responding to foreign antigens with low risk of…”
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