Search Results - "CHIBON, Frédéric"

Adult desmoid tumors: biology, management and ongoing trials by Penel, Nicolas, Chibon, Frédéric, Salas, Sébastien

“…To summarize the current knowledge about the biology and clinical management of adult desmoid tumors. In the past decade, we have learned that desmoid tumors…”
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Molecular prognostication of uterine smooth muscle neoplasms: From CGH array to CINSARC signature and beyond by Croce, Sabrina, Chibon, Frédéric

“…Uterine leiomyoma and leiomyosarcoma are located at the ends of the spectrum of smooth muscle lesions. Leiomyosarcoma belongs to the complex genomic sarcomas…”
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A Global and Integrated Analysis of CINSARC-Associated Genetic Defects by Lesluyes, Tom, Chibon, Frédéric

“…The Complexity Index in Sarcomas (CINSARC) signature is a transcriptomic marker that identifies high-risk soft-tissue sarcomas and is associated with high…”
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MED12 and uterine smooth muscle oncogenesis: State of the art and perspectives by Croce, Sabrina, Chibon, Frédéric

“…Abstract MED12 is a subunit of the multiprotein complex Mediator, an evolutionary-conserved regulator of transcription. Oncogenic mutations in exon 2 of MED12…”
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Acquisition of cancer stem cell capacities after spontaneous cell fusion by Merle, Candice, Lagarde, Pauline, Lartigue, Lydia, Chibon, Frédéric

“…Cancer stem/Initiating cell (CS/IC) hypothesis argues that CS/ICs are responsible of tumour initiation, drug resistance, metastasis or disease relapse. Their…”
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Grading of soft tissue sarcomas: from histological to molecular assessment by Neuville, Agnes, Chibon, Frédéric, Coindre, Jean-Michel

“…Several histological grading systems for soft tissue sarcomas have been described since the early 1980s. Their main objective is to select patients for…”
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Leiomyosarcomas: whole genome sequencing for a whole biology characterization by Chibon, Frédéric, Darbo, Elodie, Pérot, Gaëlle

“…PURPOSE OF REVIEWLeiomyosarcoma (LMS) is among the more aggressive sarcomas and still suffers from the lack of efficient systemic treatment after, or before,…”
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Genome remodeling upon mesenchymal tumor cell fusion contributes to tumor progression and metastatic spread by Lartigue, Lydia, Merle, Candice, Lagarde, Pauline, Delespaul, Lucile, Lesluyes, Tom, Le Guellec, Sophie, Pérot, Gaelle, Leroy, Laura, Coindre, Jean-Michel, Chibon, Frédéric

“…Cell fusion in tumor progression mostly refers to the merging of a cancer cell with a cell that has migration and immune escape capabilities such as…”
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Fluorescence in situ hybridization analysis is a helpful test for the diagnosis of dermatofibrosarcoma protuberans by Karanian, Marie, Pérot, Gaëlle, Coindre, Jean-Michel, Chibon, Frédéric, Pedeutour, Florence, Neuville, Agnès

“…Cytogenetically, most dermatofibrosarcoma protuberans are characterized by chromosomal rearrangements resulting in the collagen type-1 alpha 1…”
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The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms by Lesluyes, Tom, Delespaul, Lucile, Coindre, Jean-Michel, Chibon, Frédéric

“…We previously reported the CINSARC signature as a prognostic marker for metastatic events in soft tissue sarcomas, breast carcinomas and lymphomas through…”
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Special features of sarcomas developed in patients with Lynch syndrome: A systematic review by Poumeaud, François, Valentin, Thibaud, Vande Perre, Pierre, Jaffrelot, Marion, Bonnet, Delphine, Chibon, Frédéric, Chevreau, Christine, Selves, Janick, Guimbaud, Rosine, Fares, Nadim

“…Lynch syndrome (LS) is a genetic predisposition leading to colorectal and non-colorectal tumors such as endometrial, upper urinary tract, small intestine,…”
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Value of peri-operative chemotherapy in patients with CINSARC high-risk localized grade 1 or 2 soft tissue sarcoma: study protocol of the target selection phase III CHIC-STS trial by Filleron, Thomas, Le Guellec, Sophie, Chevreau, Christine, Cabarrou, Bastien, Lesluyes, Tom, Lodin, Sabrina, Massoubre, Angélique, Mounier, Muriel, Poublanc, Muriel, Chibon, Frédéric, Valentin, Thibaud

“…The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and…”
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Biology and signaling pathways involved in the oncogenesis of desmoid tumors by Salas, Sébastien, Chibon, Frédéric

“…Desmoid tumors (TDs) are derived from mesenchymal stem cells and their pathogenesis is strongly linked to the Wingless/Wnt cascade where the deregulation of…”
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YAP1 and VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas by Hélias-Rodzewicz, Zofia, Pérot, Gaëlle, Chibon, Frédéric, Ferreira, Céline, Lagarde, Pauline, Terrier, Philippe, Coindre, Jean-Michel, Aurias, Alain

“…In a series of 404 adult soft tissue sarcomas, analyzed by array‐CGH, we have observed in approximately 10% of them a genomic amplification of either…”
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Recurrent DMD Deletions Highlight Specific Role of Dp71 Isoform in Soft-Tissue Sarcomas by Mauduit, Olivier, Delcroix, Vanessa, Lesluyes, Tom, Pérot, Gaëlle, Lagarde, Pauline, Lartigue, Lydia, Blay, Jean-Yves, Chibon, Frédéric

“…Soft-tissue sarcomas (STS) are rare tumors whose oncogenesis remains unknown and for which no common therapeutic target has yet been identified. Analysis of…”
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PRIMA-1(MET) induces death in soft-tissue sarcomas cell independent of p53 by Grellety, Thomas, Laroche-Clary, Audrey, Chaire, Vanessa, Lagarde, Pauline, Chibon, Frédéric, Neuville, Agnes, Italiano, Antoine

“…The aim of this study was to explore the efficacy and define mechanisms of action of PRIMA-1(MET) as a TP53 targeted therapy in soft-tissue sarcoma (STS)…”
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Robust gene expression signature is not merely a significant P value by Brulard, Céline, Chibon, Frédéric

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Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 cases by Dreux, Nadège, Marty, Marion, Chibon, Frédéric, Vélasco, Valérie, Hostein, Isabelle, Ranchère-Vince, Dominique, Terrier, Philippe, Coindre, Jean-Michel

“…The high mobility group A ( HMGA2 ) gene encodes a protein that alters chromatin structure and regulates the transcription of many genes; it is implicated in…”
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Tetraploidization of Immortalized Myoblasts Induced by Cell Fusion Drives Myogenic Sarcoma Development with DMD Deletion by Merle, Candice, Thébault, Noémie, LeGuellec, Sophie, Baud, Jessica, Pérot, Gaëlle, Lesluyes, Tom, Delespaul, Lucile, Lartigue, Lydia, Chibon, Frédéric

“…Whole-genome doubling is the second most frequent genomic event, after alterations, in advanced solid tumors and is associated with poor prognosis…”
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PRIMA-1MET induces death in soft-tissue sarcomas cell independent of p53 by Grellety, Thomas, Laroche-Clary, Audrey, Chaire, Vanessa, Lagarde, Pauline, Chibon, Frñdñric, Neuville, Agnes, Italiano, Antoine

“…Background The aim of this study was to explore the efficacy and define mechanisms of action of PRIMA-1.sup.MET as a TP53 targeted therapy in soft-tissue…”
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