Search Results - "CHIBA, SHIGEKI"

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells by Jinushi, Masahisa, Chiba, Shigeki, Yoshiyama, Hironori, Masutomi, Kenkichi, Kinoshita, Ichiro, Dosaka-Akita, Hirotoshi, Yagita, Hideo, Takaoka, Akinori, Tahara, Hideaki

“…Recent evidence has unveiled the critical role of tumor cells with stem cell activities in tumorigenicity and drug resistance, but how tumor microenvironments…”
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Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1 by Chiba, Shigeki, Baghdadi, Muhammad, Akiba, Hisaya, Yoshiyama, Hironori, Kinoshita, Ichiro, Dosaka-Akita, Hirotoshi, Fujioka, Yoichiro, Ohba, Yusuke, Gorman, Jacob V, Colgan, John D, Hirashima, Mitsuomi, Uede, Toshimitsu, Takaoka, Akinori, Yagita, Hideo, Jinushi, Masahisa

“…The receptor TIM-3 was initially identified as a negative regulator of T helper type 1 responses. Jinushi and colleagues now show it has high expression by…”
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Altered expression of tight junction molecules in alveolar septa in lung injury and fibrosis by Ohta, Hiromitsu, Chiba, Shigeki, Ebina, Masahito, Furuse, Mikio, Nukiwa, Toshihiro

“…The dysfunction of alveolar barriers is a critical factor in the development of lung injury and subsequent fibrosis, but the underlying molecular mechanisms…”
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The protective effects of Ninjin’yoeito against liver steatosis/fibrosis in a non-alcoholic steatohepatitis model mouse by Takano, Kyohei, Kaneda, Marisa, Aoki, Yayoi, Fujita, Nina, Chiba, Shigeki, Michihara, Seiwa, Han, Li-Kun, Takahashi, Ryuji

“…Non-alcoholic steatohepatitis (NASH) is a progressive fibrotic form of non-alcoholic fatty liver disease. Liver fibrosis leads to liver cancer and cirrhosis,…”
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Impact of Ninjin’yoeito on frailty and short life in klotho-hypomorphic (kl/kl) mice by Amitani, Haruka, Chiba, Shigeki, Amitani, Marie, Michihara, Seiwa, Takemoto, Risa, Han, Likun, Fujita, Nina, Takahashi, Ryuji, Inui, Akio

“…With the recent aging of society, the prevention of frailty has become an important issue because people desire both a long and healthy lifespan…”
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Serial Cultivation of an MSC-Like Cell Line with Enzyme-Free Passaging Using a Microporous Titanium Scaffold by Sakisaka, Yukihiko, Ishihata, Hiroshi, Maruyama, Kentaro, Nemoto, Eiji, Chiba, Shigeki, Nagamine, Masaru, Hasegawa, Hiroshi, Hatsuzawa, Takeshi, Yamada, Satoru

“…In vitro studies on adherent cells require a process of passage to dissociate the cells from the culture substrate using enzymes or other chemical agents to…”
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Evaluation of Preosteoblast MC3T3-E1 Cells Cultured on a Microporous Titanium Membrane Fabricated Using a Precise Mechanical Punching Process by Zhang, Jingyu, Sakisaka, Yukihiko, Ishihata, Hiroshi, Maruyama, Kentaro, Nemoto, Eiji, Chiba, Shigeki, Nagamine, Masaru, Hasegawa, Hiroshi, Yamada, Satoru

“…The surface topography of Titanium (Ti) combined toughness and biocompatibility affects the attachment and migration of cells. Limited information of…”
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Conventional and Kampo Medicine Treatment for Mild-to-moderate COVID-19: A Multicenter, Retrospective, Observational Study by the Integrative Management in Japan for Epidemic Disease (IMJEDI Study-observation) by Takayama, Shin, Yoshino, Tetsuhiro, Koizumi, Sayaka, Irie, Yasuhito, Suzuki, Tomoko, Fujii, Susumu, Katori, Rie, Kainuma, Mosaburo, Kobayashi, Seiichi, Nogami, Tatsuya, Yokota, Kenichi, Yamazaki, Mayuko, Minakawa, Satoko, Chiba, Shigeki, Suda, Norio, Nakada, Yoshinobu, Ishige, Tatsuya, Maehara, Hirofumi, Tanaka, Yutaka, Nagase, Mahiko, Kashio, Akihiko, Komatsu, Kazuhisa, Nojiri, Makoto, Shimooki, Osamu, Nakamoto, Kayo, Arita, Ryutaro, Ono, Rie, Saito, Natsumi, Kikuchi, Akiko, Ohsawa, Minoru, Nakae, Hajime, Mitsuma, Tadamichi, Mimura, Masaru, Ishii, Tadashi, Nochioka, Kotaro, Chiu, Shih-Wei, Yamaguchi, Takuhiro, Namiki, Takao, Hisanaga, Akito, Mitani, Kazuo, Ito, Takashi

“…Objective Patients in whom coronavirus disease 2019 (COVID-19) was suspected or confirmed between January 1, 2020, and October 31, 2021, were enrolled from…”
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MFG-E8 regulates the immunogenic potential of dendritic cells primed with necrotic cell-mediated inflammatory signals by Baghdadi, Muhammad, Chiba, Shigeki, Yamashina, Tsunaki, Yoshiyama, Hironori, Jinushi, Masahisa

“…Dendritic cells (DC) manipulate tissue homeostasis by recognizing dying cells and controlling immune functions. However, the precise mechanisms by which DC…”
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Synthesis of new tricyclic thiolactams as potent antitumor agent for pancreatic cancer by Okada, Takuya, Minehira, Daisuke, Takada, Minetatsu, Urata, Hirokazu, Kato, Atsushi, Adachi, Isao, Kurashima, Yukiko, Kaji, Satoshi, Ogura, Tsutomu, Chiba, Shigeki, Esumi, Hiroyasu, Toyooka, Naoki

“…[Display omitted] We synthesized the novel tricyclic thiolactams 2a–d, 3d–k, having a benzyl or substituted benzyl substituent on the nitrogen of indole…”
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Two Cases of Pseudo-achalasia With Lung Cancer: Case Report and Short Literature Review by Hirano, Taizou, Miyauchi, Eisaku, Inoue, Akira, Igusa, Ryotaro, Chiba, Shigeki, Sakamoto, Kazuhiro, Sugiura, Hisatoshi, Kikuchi, Toshiaki, Ichinose, Masakazu

“…Abstract Pseudo-achalasia with lung cancer is a rare complication. We present 2 cases of pseudo-achalasia with lung cancer and summarize previous reports. The…”
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The human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene by Isomura, Hiroki, Stinski, Mark F, Murata, Takayuki, Nakayama, Sanae, Chiba, Shigeki, Akatsuka, Yoshiki, Kanda, Teru, Tsurumi, Tatsuya

“…Human cytomegalovirus (HCMV) can be reactivated under immunosuppressive conditions causing several fatal pneumonitis, hepatitis, retinitis, and…”
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Increased Prevalence of High Anti-Cladosporium Antibody Titers in Interstitial Lung Diseases by Watanuki, Zenta, Okada, Shinji, Chiba, Shigeki, Kamei, Katsuhiko, Suzuki, Yasuko, Yamada, Norihiro

“…Interstitial lung diseases (ILDs) represent a large group of different diseases, with a large part comprising idiopathic interstitial pneumonias…”
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Transient increases in p53-responsible gene expression at early stages of Epstein-Barr virus productive replication by Sato, Yoshitaka, Shirata, Noriko, Murata, Takayuki, Nakasu, Sho, Kudoh, Ayumi, Iwahori, Satoko, Nakayama, Sanae, Chiba, Shigeki, Isomura, Hiroki, Kanda, Teru, Tsurumi, Tatsuya

“…Expression of Epstein-Barr Virus BZLF1, a key protein initiating the switch from latent to lytic infection, is known to cause cell growth arrest by…”
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Cladosporium Species-Related Hypersensitivity Pneumonitis in Household Environments by Chiba, Shigeki, Okada, Shinji, Suzuki, Yasuko, Watanuki, Zenta, Mitsuishi, Yoichiro, Igusa, Ryotaro, Sekii, Takehiko, Uchiyama, Bine

“…Home-related chronic hypersensitivity pneumonitis (HP) is sometimes difficult to discriminate because patients do not have an obvious history of antigen…”
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Modeling of thermoregulation in the skunk cabbage in relation to meteorological factors by Takahashi, Ken, Ito, Takanori, Chiba, Shigeki, Ito, Kikukatsu, Osada, Hiroshi

“…A model is proposed to calculate the spadix temperature of the skunk cabbage Symplocarpus foetidus which regulates its internal temperature at around 20 °C…”
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The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema by Chiba, Shigeki, Ohta, Hiromitsu, Abe, Kyoko, Hisata, Shu, Ohkouchi, Shinya, Hoshikawa, Yasushi, Takashi, Kondo, Ebina, Masahito

“…The combined pulmonary fibrosis and emphysema (CPFE) was reported first in 1990, but it has been comparatively underestimated until recently. Although the…”
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A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography by Hisata, Shu, Kimura, Yuichiro, Shibata, Naoko, Ono, Shuichi, Kobayashi, Takao, Chiba, Shigeki, Ohta, Hiromitsu, Nukiwa, Toshihiro, Ebina, Masahito

“…Both SP-D and KL-6/MUC1 are established biomarkers of the interstitial pneumonias, including idiopathic pulmonary fibrosis (IPF), but the causes and clinical…”
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Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis by Makiguchi, Tomonori, Yamada, Mitsuhiro, Yoshioka, Yusuke, Sugiura, Hisatoshi, Koarai, Akira, Chiba, Shigeki, Fujino, Naoya, Tojo, Yutaka, Ota, Chiharu, Kubo, Hiroshi, Kobayashi, Seiichi, Yanai, Masaru, Shimura, Sanae, Ochiya, Takahiro, Ichinose, Masakazu

“…Idiopathic pulmonary fibrosis (IPF) is a disease with a poor prognosis. Although the median survival is 3 years, the clinical course varies to a large extent…”
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Validation of a diagnostic flowchart for tuberculous pleurisy in pleural fluid with high levels of adenosine deaminase by Shimoda, Masafumi, Tanaka, Yoshiaki, Ohe, Takashi, Ishiguro, Takashi, Suzuki, Atsushi, Kurahara, Yu, Shimatani, Yasuaki, Matsushima, Hidekazu, Kusano, Kenji, Ohta, Hiroki, Yanagisawa, Satoru, Kozu, Yuki, Yui, Takaya, Igarashi, Shunya, Kimizuka, Yoshifumi, Honda, Kojiro, Otani, Sakiko, Chiba, Shigeki, Xu, Dongjie, Mitsui, Miho, Waseda, Yuko, Ishii, Haruyuki

“…Adenosine deaminase (ADA) in pleural fluid is a useful marker for diagnosing tuberculous pleurisy. However, recent studies have reported a lower specificity of…”
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