Search Results - "CHIBA, Kazuhiro"

Electrochemical Total Synthesis of Pyrrolophenanthridone Alkaloids: Controlling the Anodically Initiated Electron Transfer Process by Okamoto, Kazuhiro, Chiba, Kazuhiro

“…Electrochemical intramolecular C­(sp2)–H cross-coupling and dehydrogenative indole synthesis were developed. Both reactions were initiated by anodic oxidation…”
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Biphasic electrochemical peptide synthesis by Nagahara, Shingo, Okada, Yohei, Kitano, Yoshikazu, Chiba, Kazuhiro

“…The large amount of waste derived from coupling reagents is a serious drawback of peptide synthesis from a green chemistry viewpoint. To overcome this issue,…”
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Aromatic "Redox Tag"-assisted Diels-Alder reactions by electrocatalysis by Okada, Yohei, Yamaguchi, Yusuke, Ozaki, Atsushi, Chiba, Kazuhiro

“…Electrocatalysis was employed to promote Diels-Alder reactions between electronically mismatched substrates. A catalytic amount of electricity was enough to…”
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Peptide Head‐to‐Tail Cyclization: A “Molecular Claw” Approach by Yamagami, Sayuri, Okada, Yohei, Kitano, Yoshikazu, Chiba, Kazuhiro

“…Both naturally occurring and artificial cyclic peptides are in high demand for a wide range of therapeutic applications due to the improvement of their…”
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Establishment of a suitable combination of serological markers to diagnose surgical site infection following spine surgery: A novel surgical site infection scoring system by Imabayashi, Hideaki, Miyake, Atsushi, Chiba, Kazuhiro

“…The accuracy rates of several effective serological markers of surgical site infection following spine surgery are unclear. We aimed to verify the accuracy of…”
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A novel approach for identifying serological markers indicative of surgical-site infection following spine surgery: Postoperative lymphopenia is a risk factor by Imabayashi, Hideaki, Miyake, Atsushi, Chiba, Kazuhiro

“…Postoperative lymphopenia (PL) after spine surgery is reported to be an indicator of surgical-site infection (SSI). PL without SSI is often encountered,…”
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Oxidation Potential Gap (ΔEox): The Hidden Parameter in Redox Chemistry by Okamoto, Kazuhiro, Shida, Naoki, Morizumi, Haruka, Kitano, Yoshikazu, Chiba, Kazuhiro

“…Oxidative biaryl coupling of aryls with different electronic features generally fails. However, this has not been systematically studied via theoretical…”
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Synthesis of Azanucleosides by Anodic Oxidation in a Lithium Perchlorate–Nitroalkane Medium and Diversification at the 4′‐Nitrogen Position by Shoji, Takao, Kim, Shokaku, Chiba, Kazuhiro

“…Azanucleosides, in which the 4′‐oxygen atom has been replaced with a nitrogen atom, have drawn much attention owing to their anticancer and antivirus activity,…”
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Electrochemical Amide Bond Formation from Benzaldehydes and Amines: Oxidation by Cathodic‐Generated Hydrogen Peroxide by Kurose, Yuma, Imada, Yasushi, Okada, Yohei, Chiba, Kazuhiro

“…Although amide bond formation from aldehydes and amines is a popular synthetic tool, most of the previously reported reactions depend on transition‐metal…”
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Condoliase chemonucleolysis for lumbar disc herniation: A post-hoc follow-up study of patients in previous clinical trials by Matsuyama, Yukihiro, Seo, Takayuki, Chiba, Kazuhiro

“…Chemonucleolysis with condoliase significantly improved clinical symptoms in patients with lumbar disc herniation. We evaluated the surgical intervention rate…”
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Observations using Phosphorus-31 nuclear magnetic resonance (31P-NMR) of structural changes in freeze-thawed hen egg yolk by Wakamatsu, Hiroki, Handa, Akihiro, Chiba, Kazuhiro

“…•31P-NMR can be used to detect structural changes in EY.•Granule collapse and freeze–thaw denaturation is easily monitored using 31P-NMR.•Granules show high…”
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Electrochemical Synthesis of Imino‐C‐Nucleosides by “Reactivity Switching” Methodology for in situ Generated Glycoside Donors by Okamoto, Kazuhiro, Tsutsui, Mizuki, Morizumi, Haruka, Kitano, Yoshikazu, Chiba, Kazuhiro

“…Redox‐induced regioselective C(sp3)‐H C‐glycosidation for unactivated prolinols was achieved by controlling the anomeric reactivity of electrochemically…”
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IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis by Mori, Tomoaki, Miyamoto, Takeshi, Yoshida, Hideyuki, Asakawa, Mayoko, Kawasumi, Miyuri, Kobayashi, Takashi, Morioka, Hideo, Chiba, Kazuhiro, Toyama, Yoshiaki, Yoshimura, Akihiko

“…Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes irreversible joint damage and significant disability. However, the fundamental…”
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Metal‐ and Reagent‐Free Dehydrogenative Formal Benzyl–Aryl Cross‐Coupling by Anodic Activation in 1,1,1,3,3,3‐Hexafluoropropan‐2‐ol by Imada, Yasushi, Röckl, Johannes L., Wiebe, Anton, Gieshoff, Tile, Schollmeyer, Dieter, Chiba, Kazuhiro, Franke, Robert, Waldvogel, Siegfried R.

“…A selective dehydrogenative electrochemical functionalization of benzylic positions that employs 1,1,1,3,3,3‐hexafluoropropan‐2‐ol (HFIP) has been developed…”
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Investigating radical cation chain processes in the electrocatalytic Diels-Alder reaction by Imada, Yasushi, Okada, Yohei, Chiba, Kazuhiro

“…Single electron transfer (SET)-triggered radical ion-based reactions have proven to be powerful options in synthetic organic chemistry. Although unique chain…”
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Biomechanical evaluation of fixation strength among different sizes of pedicle screws using the cortical bone trajectory: what is the ideal screw size for optimal fixation? by Matsukawa, Keitaro, Yato, Yoshiyuki, Imabayashi, Hideaki, Hosogane, Naobumi, Abe, Yuichiro, Asazuma, Takashi, Chiba, Kazuhiro

“…Background The cortical bone trajectory (CBT) has attracted attention as a new minimally invasive technique for lumbar instrumentation by minimizing…”
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Incidence and Risk Factors of Adjacent Cranial Facet Joint Violation Following Pedicle Screw Insertion Using Cortical Bone Trajectory Technique by Matsukawa, Keitaro, Kato, Takashi, Yato, Yoshiyuki, Sasao, Hiroshi, Imabayashi, Hideaki, Hosogane, Naobumi, Asazuma, Takashi, Chiba, Kazuhiro

“…STUDY DESIGN.Retrospective study evaluating cranial facet joint violation (FJV) by pedicle screws. OBJECTIVE.The aim of the study was to determine the…”
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Synthesis of Ribo‐Azanucleosides by Anodic Oxidation: Reactivity Control of Intermediate for Efficient Access to Pharmacophores by Okamoto, Kazuhiro, Shoji, Takao, Tsutsui, Mizuki, Shida, Naoki, Chiba, Kazuhiro

“…Azanucleosides, the sugar‐modified nucleoside analogues, have various biological activities, while their efficient synthetic strategy is still under…”
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Probing Electron Transfer Events in Radical Cation Cycloadditions: Intramolecular vs. Intermolecular Single Electron Transfer by Tanami, Shuhei, Hussaini, Syed R., Kitano, Yoshikazu, Chiba, Kazuhiro, Okada, Yohei

“…Although radical ion chain pathways have long been recognized in the field of synthetic organic chemistry and are expected to be operative in various…”
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C–C Bond Cleavage at the N-α Position Enabled by the Low-potential Electrochemical Oxidation of the 2,7-Dimethoxynaphthyl Electroauxiliary by OKAMOTO, Kazuhiro, IMADA, Yasushi, SHIDA, Naoki, KITANO, Yoshikazu, ATOBE, Mahito, CHIBA, Kazuhiro

“…Herein, we report that the 2,7-dimethoxynaphthyl (2,7-DMN) group is a novel electroauxiliary that is readily installed at the N-α position of a carbamate…”
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