Search Results - "CHIARELLI, Laurent R"

Burkholderia cenocepacia Infections in Cystic Fibrosis Patients: Drug Resistance and Therapeutic Approaches by Scoffone, Viola C, Chiarelli, Laurent R, Trespidi, Gabriele, Mentasti, Massimo, Riccardi, Giovanna, Buroni, Silvia

“…is an opportunistic pathogen particularly dangerous for cystic fibrosis (CF) patients. It can cause a severe decline in CF lung function possibly developing…”
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Antibiotics' Sustainability: Another Issue in the Fight against Antimicrobial Resistance by Buroni, Silvia, Chiarelli, Laurent R

“…The spread of antimicrobial resistance (AMR) is still a major threat to global health that is likely to worsen also as a consequence of the COVID-19 pandemic…”
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Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens by Scoffone, Viola Camilla, Trespidi, Gabriele, Chiarelli, Laurent R, Barbieri, Giulia, Buroni, Silvia

“…Cystic fibrosis (CF) is an autosomal recessive genetic disorder which leads to the secretion of a viscous mucus layer on the respiratory epithelium that…”
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Mycobacterium abscessus Infections in Cystic Fibrosis Individuals: A Review on Therapeutic Options by Recchia, Deborah, Stelitano, Giovanni, Stamilla, Alessandro, Gutierrez, Damaris L, Degiacomi, Giulia, Chiarelli, Laurent R, Pasca, Maria Rosalia

“…is an opportunistic pathogen that mainly colonizes and infects cystic fibrosis patients' lungs. is naturally resistant to many antibiotics such as rifamycin,…”
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Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery by Mori, Matteo, Villa, Stefania, Chiarelli, Laurent R, Meneghetti, Fiorella, Bellinzoni, Marco

“…MbtI from Mycobacterium tuberculosis (Mtb) is a Mg2+-dependent salicylate synthase, belonging to the chorismate-utilizing enzyme (CUE) family. As a fundamental…”
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Synthesis, Characterization, and Biological Evaluation of New Derivatives Targeting MbtI as Antitubercular Agents by Mori, Matteo, Stelitano, Giovanni, Chiarelli, Laurent R, Cazzaniga, Giulia, Gelain, Arianna, Barlocco, Daniela, Pini, Elena, Meneghetti, Fiorella, Villa, Stefania

“…Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains…”
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Improving Protection to Prevent Bacterial Infections: Preliminary Applications of Reverse Vaccinology against the Main Cystic Fibrosis Pathogens by Cocorullo, Mario, Chiarelli, Laurent R, Stelitano, Giovanni

“…Reverse vaccinology is a powerful tool that was recently used to develop vaccines starting from a pathogen genome. Some bacterial infections have the necessity…”
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Engineering of Helicobacter pylori L-asparaginase: characterization of two functionally distinct groups of mutants by Maggi, Maristella, Chiarelli, Laurent R, Valentini, Giovanna, Scotti, Claudia

“…Bacterial L-asparaginases have been used as anti-cancer drugs for over 4 decades though presenting, along with their therapeutic efficacy, several side effects…”
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Molecular insights on pathogenic effects of mutations causing phosphoglycerate kinase deficiency by Chiarelli, Laurent R, Morera, Simone M, Bianchi, Paola, Fermo, Elisa, Zanella, Alberto, Galizzi, Alessandro, Valentini, Giovanna

“…Phosphoglycerate kinase (PGK) catalyzes an important ATP-generating step in glycolysis. PGK1 deficiency is an uncommon X-linked inherited disorder, generally…”
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Expanding targets for a metabolic therapy of cancer: L-asparaginase by Covini, Daniele, Tardito, Saverio, Bussolati, Ovidio, Chiarelli, Laurent R, Pasquetto, Maria V, Digilio, Rita, Valentini, Giovanna, Scotti, Claudia

“…The antitumour enzyme L-asparaginase (L-asparagine amidohydrolase, EC 3.5.1.1, ASNase), which catalyses the deamidation of L-asparagine (Asn) to L-aspartic…”
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Editorial: Enzyme targeting for the development of novel antimicrobials by Salina, Elena G, Qiao, Chunhua, Chiarelli, Laurent R

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Synthesis and Assessment of the In Vitro and Ex Vivo Activity of Salicylate Synthase (Mbti) Inhibitors as New Candidates for the Treatment of Mycobacterial Infections by Mori, Matteo, Stelitano, Giovanni, Griego, Anna, Chiarelli, Laurent R, Cazzaniga, Giulia, Gelain, Arianna, Pini, Elena, Camera, Marina, Canzano, Paola, Fumagalli, Andrea, Scarpa, Edoardo, Cordiglieri, Chiara, Rizzello, Loris, Villa, Stefania, Meneghetti, Fiorella

“…Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains…”
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Targeting Siderophore-Mediated Iron Uptake in M. abscessus : A New Strategy to Limit the Virulence of Non-Tuberculous Mycobacteria by Mori, Matteo, Stelitano, Giovanni, Cazzaniga, Giulia, Gelain, Arianna, Tresoldi, Andrea, Cocorullo, Mario, Roversi, Martina, Chiarelli, Laurent R, Tomaiuolo, Martina, Delre, Pietro, Mangiatordi, Giuseppe F, Griego, Anna, Rizzello, Loris, Cassetta, Alberto, Covaceuszach, Sonia, Villa, Stefania, Meneghetti, Fiorella

“…Targeting pathogenic mechanisms, rather than essential processes, represents a very attractive approach for the development of new antimycobacterial drugs. In…”
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New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents by Chiarelli, Laurent R., Mori, Matteo, Beretta, Giangiacomo, Gelain, Arianna, Pini, Elena, Sammartino, Josè Camilla, Stelitano, Giovanni, Barlocco, Daniela, Costantino, Luca, Lapillo, Margherita, Poli, Giulio, Caligiuri, Isabella, Rizzolio, Flavio, Bellinzoni, Marco, Tuccinardi, Tiziano, Villa, Stefania, Meneghetti, Fiorella

“…Starting from the analysis of the hypothetical binding mode of our previous furan-based hit (I), we successfully achieved our objective to replace the nitro…”
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Structural and Energetic Basis of Protein Kinetic Destabilization in Human Phosphoglycerate Kinase 1 Deficiency by Pey, Angel L, Mesa-Torres, Noel, Chiarelli, Laurent R, Valentini, Giovanna

“…Protein kinetic destabilization is a common feature of many human genetic diseases. Human phosphoglycerate kinase 1 (PGK1) deficiency is a rare genetic disease…”
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Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug by Mori, Giorgia, Orena, Beatrice Silvia, Chiarelli, Laurent R, Degiacomi, Giulia, Riabova, Olga, Sammartino, José Camilla, Makarov, Vadim, Riccardi, Giovanna, Pasca, Maria Rosalia

“…Tuberculosis remains one of the leading causes of death from a single pathogen globally. It is estimated that 1/4 of the world's population harbors latent…”
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Chemical, Metabolic, and Cellular Characterization of a FtsZ Inhibitor Effective Against Burkholderia cenocepacia by Chiarelli, Laurent R, Scoffone, Viola Camilla, Trespidi, Gabriele, Barbieri, Giulia, Riabova, Olga, Monakhova, Natalia, Porta, Alessio, Manina, Giulia, Riccardi, Giovanna, Makarov, Vadim, Buroni, Silvia

“…There is an urgent need for new antimicrobials to treat the opportunistic Gram-negative , which represents a problematic challenge for cystic fibrosis…”
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Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study by Buroni, Silvia, Scoffone, Viola C, Fumagalli, Marco, Makarov, Vadim, Cagnone, Maddalena, Trespidi, Gabriele, De Rossi, Edda, Forneris, Federico, Riccardi, Giovanna, Chiarelli, Laurent R

“…Quorum sensing (QS) is a bacterial intercellular communication process which controls the production of major virulence factors, such as proteases,…”
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Crystal Structure, Hirshfeld Surface Analysis, In-Silico and Antimycotic Investigations of Methyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2-dihydropyrimidine-5-carboxylate by Huseynzada, Alakbar, Mori, Matteo, Meneghetti, Fiorella, Israyilova, Aygun, Guney, Elif, Sayin, Koray, Chiarelli, Laurent R., Demiralp, Mustafa, Hasanova, Ulviyya, Abbasov, Vagif

“…Herein, we report the preparation of methyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2-dihydropyrimidine-5-carboxylate 2, obtained by the regioselective oxidative…”
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Side Chain-Modified Benzothiazinone Derivatives with Anti-Mycobacterial Activity by Fan, Dongguang, Wang, Bin, Stelitano, Giovanni, Savková, Karin, Riabova, Olga, Shi, Rui, Wu, Xiaomei, Chiarelli, Laurent R, Mikušová, Katarína, Makarov, Vadim, Lu, Yu, Hong, Yuzhi, Qiao, Chunhua

“…Tuberculosis (TB) is a leading infectious disease with serious antibiotic resistance. The benzothiazinone (BTZ) scaffold PBTZ169 kills (Mtb) through the…”
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