Search Results - "CHIAM, Karen"

Circulating Serum Exosomal miRNAs As Potential Biomarkers for Esophageal Adenocarcinoma by Chiam, Karen, Wang, Tingting, Watson, David I., Mayne, George C., Irvine, Tanya S., Bright, Tim, Smith, Lorelle, White, Imogen A., Bowen, Joanne M., Keefe, Dorothy, Thompson, Sarah K., Jones, Michael E., Hussey, Damian J.

“…Background The poor prognosis and rising incidence of esophageal adenocarcinoma highlight the need for improved detection methods. The potential for…”
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Mutant p53 Mediates Sensitivity to Cancer Treatment Agents in Oesophageal Adenocarcinoma Associated with MicroRNA and SLC7A11 Expression by Eichelmann, Ann-Kathrin, Mayne, George C., Chiam, Karen, Due, Steven L., Bastian, Isabell, Butz, Frederike, Wang, Tingting, Sykes, Pamela J., Clemons, Nicholas J., Liu, David S., Michael, Michael Z., Karapetis, Christos S., Hummel, Richard, Watson, David I., Hussey, Damian J.

“…TP53 gene mutations occur in 70% of oesophageal adenocarcinomas (OACs). Given the central role of p53 in controlling cellular response to therapy we…”
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MicroRNA Profiling in Oesophageal Adenocarcinoma Cell Lines and Patient Serum Samples Reveals a Role for miR-451a in Radiation Resistance by Butz, Frederike, Eichelmann, Ann-Kathrin, Mayne, George C, Wang, Tingting, Bastian, Isabell, Chiam, Karen, Marri, Shashikanth, Sykes, Pamela J, Wijnhoven, Bas P, Toxopeus, Eelke, Michael, Michael Z, Karapetis, Christos S, Hummel, Richard, Watson, David I, Hussey, Damian J

“…Many patients with Oesophageal Adenocarcinoma (OAC) do not benefit from chemoradiotherapy treatment due to therapy resistance. To better understand the…”
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Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development by BIANCO-MIOTTO, Tina, CHIAM, Karen, HORVATH, Lisa G, KENCH, James G, STRICKER, Phillip D, MARSHALL, Villis R, SUTHERLAND, Robert L, HENSHALL, Susan M, GERALD, William L, SCHER, Howard I, RISBRIDGER, Gail P, CLEMENTS, Judith A, BUCHANAN, Grant, BUTLER, Lisa M, TILLEY, Wayne D, HORSFALL, David J, RICCIARDELLI, Carmela, JINDAL, Shalini, DAY, Tanya K, THOMAS, Mervyn, PICKERING, Marie A, O'LOUGHLIN, Melissa A, RYAN, Natalie K, RAYMOND, Wendy A

“…Epigenetic alterations are common in prostate cancer, yet how these modifications contribute to carcinogenesis is poorly understood. We investigated whether…”
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Making informed decisions about prostate cancer testing: Locally tailored factsheets on the burden of prostate cancer in Australia by Chiam, Karen, Crowe, Jane, Grogan, Paul, Vaneckova, Pavla, Kohar, Ankur, Mazariego, Carolyn, Nair-Shalliker, Visalini, Smith, David P

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GSTP1 DNA methylation and expression status is indicative of 5-aza-2'-deoxycytidine efficacy in human prostate cancer cells by Chiam, Karen, Centenera, Margaret M, Butler, Lisa M, Tilley, Wayne D, Bianco-Miotto, Tina

“…DNA methylation plays an important role in carcinogenesis and the reversibility of this epigenetic modification makes it a potential therapeutic target. To…”
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INPP4B is highly expressed in prostate intermediate cells and its loss of expression in prostate carcinoma predicts for recurrence and poor long term survival by Rynkiewicz, Natalie K., Fedele, Clare G., Chiam, Karen, Gupta, Ruta, Kench, James G., Ooms, Lisa M., McLean, Catriona A., Giles, Graham G., Horvath, Lisa G., Mitchell, Christina A.

“…BACKGROUND Phosphoinositide 3‐kinase (PI3K)/Akt pathway is frequently activated in prostate carcinoma due to the loss of tumor suppressor PTEN, which leads to…”
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Epigenetic biomarkers in prostate cancer: Current and future uses by Chiam, Karen, Ricciardelli, Carmela, Bianco-Miotto, Tina

“…Abstract Epigenome alterations are characteristic of nearly all human malignancies and include changes in DNA methylation, histone modifications and microRNAs…”
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The complex impact of COVID ‐19 on cancer outcomes in Australia by Canfell, Karen, Chiam, Karen, Nickson, Carolyn, Mann, G Bruce

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Benefits and harms of prostate specific antigen testing according to Australian guidelines by Caruana, Michael, Gulati, Roman, Etzioni, Ruth, Barratt, Alexandra, Armstrong, Bruce K., Chiam, Karen, Nair‐Shalliker, Visalini, Luo, Qingwei, Bang, Albert, Grogan, Paul, Smith, David P., O'Connell, Dianne L., Canfell, Karen

“…Guidelines for prostate specific antigen (PSA) testing in Australia recommend that men at average risk of prostate cancer who have been informed of the…”
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Family history, obesity, urological factors and diabetic medications and their associations with risk of prostate cancer diagnosis in a large prospective study by Nair-Shalliker, Visalini, Bang, Albert, Egger, Sam, Yu, Xue Qin, Chiam, Karen, Steinberg, Julia, Patel, Manish I., Banks, Emily, O’Connell, Dianne L., Armstrong, Bruce K., Smith, David P.

“…Background Prostate cancer (PC) aetiology is unclear. PC risk was examined in relation to several factors in a large population-based prospective study…”
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Use of multiparametric magnetic resonance imaging (mpMRI) in active surveillance for low-risk prostate cancer: a scoping review on the benefits and harm of mpMRI in different biopsy scenarios by Chiam, Karen, Carle, Chelsea, Hughes, Suzanne, Kench, James G., Woo, Henry H., Lord, Sally, Smith, David P.

“…Background There is uncertainty on how multiparametric MRI (mpMRI) and MRI-targeted biopsy (MRI-TB) can be best used to manage low-risk prostate cancer…”
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Characteristics Associated with the Use of Diagnostic Prostate Biopsy and Biopsy Outcomes in Australian Men by Chiam, Karen, Bang, Albert, Patel, Manish I, Nair-Shalliker, Visalini, O'Connell, Dianne L, Smith, David P

“…Population characteristics associated with the use of prostate biopsy are poorly understood. We described the use of diagnostic prostate biopsy and subsequent…”
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Descriptive analysis of prostate cancer pathology data from diagnosis and surgery in men from the 45 and Up Study by Gallagher, Benjamin D T, Chiam, Karen, Bang, Albert, Patel, Manish I, Kench, James G, Edwards, Sue, Nair-Shalliker, Visalini, Smith, David P

“…Information available from the New South Wales Cancer Registry (NSWCR) about the aggressiveness of prostate cancer is limited to the summary stage variable…”
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ASO Author Reflections: Predicting the Response of Esophageal Adenocarcinoma to Chemoradiotherapy Before Surgery Using MicroRNA Biomarkers Offers Hope to Improve Outcomes by Tailoring Treatment to Predicted Responses by Mayne, George C., Watson, David I., Chiam, Karen, Hussey, Damian J.

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Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus by Chiam, Karen, Mayne, George C, Wang, Tingting, Watson, David I, Irvine, Tanya S, Bright, Tim, Smith, Lorelle T, Ball, Imogen A, Bowen, Joanne M, Keefe, Dorothy M, Thompson, Sarah K, Hussey, Damian J

“…Circulating microRNAs (miRNAs) are potential biomarkers for many diseases. However, they can originate from non-disease specific sources, such as blood cells,…”
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An analysis of a multiple biomarker panel to better predict prostate cancer metastasis after radical prostatectomy by Zhang, Alison Y., Chiam, Karen, Haupt, Ygal, Fox, Stephen, Birch, Simone, Tilley, Wayne, Butler, Lisa M., Knudsen, Karen, Comstock, Clay, Rasiah, Krishan, Grogan, Judith, Mahon, Kate L., Bianco‐Miotto, Tina, Ricciardelli, Carmela, Böhm, Maret, Henshall, Susan, Delprado, Warick, Stricker, Phillip, Horvath, Lisa G., Kench, James G.

“…A plethora of individual candidate biomarkers for predicting biochemical relapse in localized prostate cancer (PCa) have been proposed. Combined biomarkers may…”
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Identification of microRNA Biomarkers of Response to Neoadjuvant Chemoradiotherapy in Esophageal Adenocarcinoma Using Next Generation Sequencing by Chiam, Karen, Mayne, George C., Watson, David I., Woodman, Richard J., Bright, Tim F., Michael, Michael Z., Karapetis, Christos S., Irvine, Tanya, Phillips, Wayne A., Hummel, Richard, Wang, Tingting, Pimlott, Letitia K., Marri, Shashikanth, Astill, David StJ, Ruszkiewicz, Andrew R., Thompson, Sarah K., Hussey, Damian J.

“…Background Clinical trials report improved overall survival following neoadjuvant chemoradiotherapy in patients undergoing surgery for esophageal…”
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Global review of COVID-19 mitigation strategies and their impact on cancer service disruptions by Shah, Richa, Loo, Ching Ee, Hanna, Nader Mounir, Hughes, Suzanne, Mafra, Allini, Fink, Hanna, McFerran, Ethna, Garcia, Montse, Acharya, Suryakanta, Langselius, Oliver, Frick, Clara, Niyigaba, Jean, Lasebikan, Nwamaka, Steinberg, Julia, Sullivan, Richard, Bray, Freddie, Ilbawi, André Michel, Ginsburg, Ophira, Chiam, Karen, Cylus, Jonathan, Caruana, Michael, David, Michael, Hui, Harriet, Canfell, Karen, Soerjomataram, Isabelle

“…During the COVID-19 pandemic, countries adopted mitigation strategies to reduce disruptions to cancer services. We reviewed their implementation across health…”
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An analysis of multiple biomarkers to better predict prostate cancer metastasis and death after radical prostatectomy by Zhang, Alison Yan, Chiam, Karen, Haupt, Ygal, Fox, Stephen B., Birch, Simone, Tilley, Wayne, Butler, Lisa, Knudsen, Karen E., Cornstock, Christopher, Rasiah, Krishan, Grogan, Judith, Mahon, Kate Lynette, Bianco-Miotto, Tina, Bohm, Maret, Henshall, Susan M., Delprado, Warick, Stricker, Phillip, Horvath, Lisa, Kench, James

“…Abstract only 54 Background: Identification of potentially lethal disease at the time of diagnosis with localized prostate cancer (PCa) remains a significant…”
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