Search Results - "CHI DUANMU"

Tubulin-dependent hydrolysis of guanosine triphosphate as a screening test to identify new antitubulin compounds with potential as antimitotic agents: application to carbamates of aromatic amines by CHI DUANMU, SHAHRIK, L. K, HO, H. H, HAMEL, E

“…Tubulin-dependent GTP hydrolysis was evaluated for its potential as a relatively simple screening assay for new antimitotic drugs. Carbamates of aromatic…”
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2,4-dichlorobenzyl Thiocyanate, an Antimitotic Agent that Alters Microtubule Morphology by Abraham, Irene, Dion, Robert L., Duanmu, Chi, Gottesman, Michael M., Hamel, Ernest

“…A compound of simple structure, 2,4-dichlorobenzyl thiocyanate (DCBT), is an antimitotic agent with a number of unusual properties. The drug causes an extreme…”
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Tubulin polymerization with ATP is mediated through the exchangeable GTP site by Duanmu, C, Lin, C M, Hamel, E

“…Glycerol-induced tubulin polymerization supported by non-guanine nucleotides was examined. The electrophoretically homogeneous tubulin was devoid of nucleoside…”
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Mechanism of action of the antimitotic drug 2,4-dichlorobenzyl thiocyanate: alkylation of sulfhydryl group(s) of beta-tubulin by Bai, R, Duanmu, C, Hamel, E

“…The compound, 2,4-dichlorobenzyl thiocyanate (DCBT) was previously shown to cause mitotic arrest, disruption of intracellular microtubules, and inhibition of…”
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