Search Results - "CHEUNG, Mui"

TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury by Balakrishna, Shrilatha, Song, Weifeng, Achanta, Satyanarayana, Doran, Stephen F, Liu, Boyi, Kaelberer, Melanie M, Yu, Zhihong, Sui, Aiwei, Cheung, Mui, Leishman, Emma, Eidam, Hilary S, Ye, Guosen, Willette, Robert N, Thorneloe, Kevin S, Bradshaw, Heather B, Matalon, Sadis, Jordt, Sven-Eric

“…The treatment of acute lung injury caused by exposure to reactive chemicals remains challenging because of the lack of mechanism-based therapeutic approaches…”
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Activating Transcription Factor 3 Diminishes Ischemic Cerebral Infarct and Behavioral Deficit by Downregulating Carboxyl-Terminal Modulator Protein by Kao, Mei-Han, Huang, Chien-Yu, Cheung, Wai-Mui, Yan, Yu-Ting, Chen, Jin-Jer, Ho, Yuan-Soon, Hsu, Chung Y, Lin, Teng-Nan

“…Activating transcription factor 3 (ATF3) is a stress-induced transcription factor and a familiar neuronal marker for nerve injury. This factor has been shown…”
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Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity by Kumar, Rakesh, Knick, Victoria B, Rudolph, Sharon K, Johnson, Jennifer H, Crosby, Renae M, Crouthamel, Ming-Chih, Hopper, Teresa M, Miller, Charles G, Harrington, Laura E, Onori, James A, Mullin, Robert J, Gilmer, Tona M, Truesdale, Anne T, Epperly, Andrea H, Boloor, Amogh, Stafford, Jeffrey A, Luttrell, Deirdre K, Cheung, Mui

“…With the development of targeted therapeutics, especially for small-molecule inhibitors, it is important to understand whether the observed in vivo efficacy…”
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Clinacanthus nutans Mitigates Neuronal Apoptosis and Ischemic Brain Damage Through Augmenting the C/EBPβ-Driven PPAR-γ Transcription by Wu, Jui-Sheng, Kao, Mei-Han, Tsai, Hsin-Da, Cheung, Wai-Mui, Chen, Jin-Jer, Ong, Wei-Yi, Sun, Grace Y., Lin, Teng-Nan

“…Clinacanthus nutans Lindau ( C. nutans ) is a traditional herbal medicine widely used in Asian countries for treating a number of remedies including snake and…”
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Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor by Harris, Philip A, Boloor, Amogh, Cheung, Mui, Kumar, Rakesh, Crosby, Renae M, Davis-Ward, Ronda G, Epperly, Andrea H, Hinkle, Kevin W, Hunter, Robert N, Johnson, Jennifer H, Knick, Victoria B, Laudeman, Christopher P, Luttrell, Deirdre K, Mook, Robert A, Nolte, Robert T, Rudolph, Sharon K, Szewczyk, Jerzy R, Truesdale, Anne T, Veal, James M, Wang, Liping, Stafford, Jeffrey A

“…Inhibition of the vascular endothelial growth factor (VEGF) signaling pathway has emerged as one of the most promising new approaches for cancer therapy. We…”
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Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4 by Cheung, Mui, Bao, Weike, Behm, David J, Brooks, Carl A, Bury, Michael J, Dowdell, Sarah E, Eidam, Hilary S, Fox, Ryan M, Goodman, Krista B, Holt, Dennis A, Lee, Dennis, Roethke, Theresa J, Willette, Robert N, Xu, Xiaoping, Ye, Guosen, Thorneloe, Kevin S

“…Transient Receptor Potential Vanilloid 4 (TRPV4) is a member of the Transient Receptor Potential (TRP) superfamily of cation channels. TRPV4 is expressed in…”
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Clinacanthus nutans Mitigates Neuronal Death and Reduces Ischemic Brain Injury: Role of NF-κB-driven IL-1β Transcription by Kao, Mei-Han, Wu, Jui-Sheng, Cheung, Wai-Mui, Chen, Jin-Jer, Sun, Grace Y., Ong, Wei-Yi, Herr, Deron R., Lin, Teng-Nan

“…Neuroinflammation has been shown to exacerbate ischemic brain injury, and is considered as a prime target for the development of stroke therapies. Clinacanthus…”
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2- and 4-Nitrobenzenesulfonamides: Exceptionally versatile means for preparation of secondary amines and protection of amines by Fukuyama, Tohru, Jow, Chung-Kuang, Cheung, Mui

“…2- and 4-Nitrobenzenesulfonamides, readily prepared from primary amines, undergo smooth alkylation by Mitsunobu reaction or by conventional methods to give…”
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In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1 by Lansing, Timothy J, McConnell, Randy T, Duckett, Derek R, Spehar, Glenn M, Knick, Victoria B, Hassler, Daniel F, Noro, Nobuhiro, Furuta, Masaaki, Emmitte, Kyle A, Gilmer, Tona M, Mook, Jr, Robert A, Cheung, Mui

“…Polo-like kinase 1 (PLK1) plays key roles in the regulation of mitotic progression, including mitotic entry, spindle formation, chromosome segregation, and…”
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Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1 by Cheung, Mui, Tangirala, Raghuram S, Bethi, Sridhar R, Joshi, Hemant V, Ariazi, Jennifer L, Tirunagaru, Vijaya G, Kumar, Sanjay

“…Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) plays an important role in triglyceride synthesis and is a target of interest for the treatment of metabolic…”
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Differential regulation of thrombospondin-1 and thrombospondin-2 after focal cerebral ischemia/reperfusion by LIN, Teng-Nan, KIM, Gyoeng-Moon, CHEN, Jean-Ju, CHEUNG, Wai-Mui, HE, Yong Y, HSU, Chung Y

“…Angiogenesis occurs after cerebral ischemia, and the extent of angiogenesis has been correlated with survival in stroke patients. However, postischemic…”
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Induction of secretory phospholipase A2 in reactive astrocytes in response to transient focal cerebral ischemia in the rat brain by Lin, Teng‐Nan, Wang, Qun, Simonyi, Agnes, Chen, Jean‐Ju, Cheung, Wai‐Mui, Y. He, Yong, Xu, Jan, Sun, Albert Y., Hsu, Chung Y., Sun, Grace Y.

“…Although mRNA expression of group IIA secretory phospholipase A2 (sPLA2‐IIA) has been implicated in responses to injury in the CNS, information on protein…”
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Discovery and Evaluation of 2-Anilino-5-aryloxazoles as a Novel Class of VEGFR2 Kinase Inhibitors by Harris, Philip A, Cheung, Mui, Hunter, Robert N, Brown, Matthew L, Veal, James M, Nolte, Robert T, Wang, Liping, Liu, Wendy, Crosby, Renae M, Johnson, Jennifer H, Epperly, Andrea H, Kumar, Rakesh, Luttrell, Deirdre K, Stafford, Jeffrey A

“…A series of derivatives of 2-anilino-5-phenyloxazole (5) has been identified as inhibitors of VEGFR2 kinase. Herein we describe the structure−activity…”
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Dynamic changes in cerebral blood flow and angiogenesis after transient focal cerebral ischemia in rats: Evaluation with serial magnetic resonance imaging by LIN, Teng-Nan, SUN, Shu-Wei, CHEUNG, Wai-Mui, FUHAI LI, CHEN CHANG

“…Angiogenesis occurs after cerebral ischemia, but the relationship between angiogenesis and cerebral hemodynamic change is unknown. The aim of the present study…”
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Development of a high-throughput screen to detect inhibitors of TRPS1 sumoylation by Brandt, Martin, Szewczuk, Lawrence M, Zhang, Hong, Hong, Xuan, McCormick, Patricia M, Lewis, Tia S, Graham, Taylor I, Hung, Sunny T, Harper-Jones, Amber D, Kerrigan, John J, Wang, Da-Yuan, Dul, Edward, Hou, Wangfang, Ho, Thau F, Meek, Thomas D, Cheung, Mui H, Johanson, Kyung O, Jones, Christopher S, Schwartz, Benjamin, Kumar, Sanjay, Oliff, Allen I, Kirkpatrick, Robert B

“…Small ubiquitin-like modifier (SUMO) belongs to the family of ubiquitin-like proteins (Ubls) that can be reversibly conjugated to target-specific lysines on…”
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Efficient and Regioselective Synthesis of 2-Alkyl-2H-indazoles by Cheung, Mui, Boloor, Amogh, Stafford, Jeffrey A

“…An efficient and regioselective synthesis of 2-methyl-2H-indazoles and 2-ethyl-2H-indazoles using trimethyloxonium tetrafluoroborate or triethyloxonium…”
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Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: Potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties by Rheault, Tara R., Donaldson, Kelly H., Badiang-Alberti, Jennifer G., Davis-Ward, Ronda G., Andrews, C. Webb, Bambal, Ramesh, Jackson, Jeffrey R., Cheung, Mui

“…Potent inhibitors of PLK1 with acceptable solubility, mouse iv clearance, and reduced CYP450 inhibition were identified. Drug-like properties were improved…”
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TLR2 agonism reverses chemotherapy-induced neutropenia in Macaca fascicularis by Laping, Nicholas J., DeMartino, Michael P., Cottom, Joshua E., Axten, Jeffrey M., Emery, John G., Guss, Jeffrey H., Burman, Miriam, Foley, James J., Cheung, Mui, Oliff, Allen, Kumar, Sanjay

“…Neutropenia is a common consequence of radiation and chemotherapy in cancer patients. The resulting immunocompromised patients become highly susceptible to…”
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Induction of Prostacyclin/PGI2 Synthase Expression After Cerebral Ischemia–Reperfusion by Fang, Yao-Ching, Wu, Jui-Sheng, Chen, Jean-Ju, Cheung, Wai-Mui, Tseng, Ping-Hui, Tarn, Ka-Bik, Shyue, Song-Kun, Chen, Jin-Jer, Lin, Teng-Nan

“…Prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation and leukocyte activation, is crucial in vascular diseases such as stroke…”
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Discovery of thiophene inhibitors of polo-like kinase by Emmitte, Kyle A., Andrews, C. Webb, Badiang, Jennifer G., Davis-Ward, Ronda G., Dickson, Hamilton D., Drewry, David H., Emerson, Holly K., Epperly, Andrea H., Hassler, Daniel F., Knick, Victoria B., Kuntz, Kevin W., Lansing, Timothy J., Linn, James A., Mook, Robert A., Nailor, Kristen E., Salovich, James M., Spehar, Glenn M., Cheung, Mui

“…The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a…”
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