Search Results - "CHESHENKO, Natalia"

Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease by Petro, Christopher, González, Pablo A, Cheshenko, Natalia, Jandl, Thomas, Khajoueinejad, Nazanin, Bénard, Angèle, Sengupta, Mayami, Herold, Betsy C, Jacobs, William R

“…Subunit vaccines comprised of glycoprotein D (gD-2) failed to prevent HSV-2 highlighting need for novel strategies. To test the hypothesis that deletion of…”
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Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry by Cheshenko, Natalia, Pierce, Carl, Herold, Betsy C

“…Herpes simplex virus (HSV) entry is associated with Akt translocation to the outer leaflet of the plasma membrane to promote a complex signaling cascade. We…”
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HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal by Pierce, Carl A, Loh, Lip Nam, Steach, Holly R, Cheshenko, Natalia, Preston-Hurlburt, Paula, Zhang, Fengrui, Stransky, Stephanie, Kravets, Leah, Sidoli, Simone, Philbrick, William, Nassar, Michel, Krishnaswamy, Smita, Herold, Kevan C, Herold, Betsy C

“…Herpes simplex virus type 2 (HSV-2) coinfection is associated with increased HIV-1 viral loads and expanded tissue reservoirs, but the mechanisms are not well…”
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An innate antiviral pathway acting before interferons at epithelial surfaces by Iversen, Marie B, Reinert, Line S, Thomsen, Martin K, Bagdonaite, Ieva, Nandakumar, Ramya, Cheshenko, Natalia, Prabakaran, Thaneas, Vakhrushev, Sergey Y, Krzyzowska, Malgosha, Kratholm, Sine K, Ruiz-Perez, Fernando, Petersen, Steen V, Goriely, Stanislas, Bibby, Bo Martin, Eriksson, Kristina, Ruland, Jürgen, Thomsen, Allan R, Herold, Betsy C, Wandall, Hans H, Frische, Sebastian, Holm, Christian K, Paludan, Søren R

“…Mucosal surfaces often represent the first point of entry for pathogens. Paludan and colleagues demonstrate that disruption of the mucus itself can initiate a…”
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Differential Mechanisms of Tenofovir and Tenofovir Disoproxil Fumarate Cellular Transport and Implications for Topical Preexposure Prophylaxis by Taneva, Ekaterina, Crooker, Kerry, Park, Sung Hyun, Su, Jonathan T, Ott, Adina, Cheshenko, Natalia, Szleifer, Igal, Kiser, Patrick F, Frank, Bruce, Mesquita, Pedro M M, Herold, Betsy C

“…Intravaginal rings releasing tenofovir (TFV) or its prodrug, tenofovir disoproxil fumarate (TDF), are being evaluated for HIV and herpes simplex virus (HSV)…”
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Author Correction: Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2 by Cheshenko, Natalia, Bonanno, Jeffrey B., Hoffmann, Hans-Heinrich, Jangra, Rohit K., Chandran, Kartik, Rice, Charles M., Almo, Steven C., Herold, Betsy C.

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Multiple receptor interactions trigger release of membrane and intracellular calcium stores critical for herpes simplex virus entry by Cheshenko, Natalia, Liu, Wen, Satlin, Lisa M, Herold, Betsy C

“…Herpes simplex viruses (HSV) harness cellular calcium signaling pathways to facilitate viral entry. Confocal microscopy and small interfering RNA (siRNA) were…”
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Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2 by Cheshenko, Natalia, Bonanno, Jeffrey B., Hoffmann, Hans-Heinrich, Jangra, Rohit K., Chandran, Kartik, Rice, Charles M., Almo, Steven C., Herold, Betsy C.

“…Herpes simplex virus (HSV) receptor engagement activates phospholipid scramblase triggering Akt translocation to the outer leaflet of the plasma membrane where…”
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Herpes Simplex Virus Downregulates Secretory Leukocyte Protease Inhibitor: a Novel Immune Evasion Mechanism by FAKIOGLU, Esra, WILSON, Sarah S, MESQUITA, Pedro M. M, HAZRATI, Ehsan, CHESHENKO, Natalia, BLAHO, John A, HEROLD, Betsy C

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θ Defensins Protect Cells from Infection by Herpes Simplex Virus by Inhibiting Viral Adhesion and Entry by Yasin, Bushra, Wang, Wei, Pang, Mabel, Cheshenko, Natalia, Hong, Teresa, Waring, Alan J, Herold, Betsy C, Wagar, Elizabeth A, Lehrer, Robert I

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Bridging the gap between preclinical and clinical microbicide trials: blind evaluation of candidate gels in murine models of efficacy and safety by Segarra, Theodore J, Fakioglu, Esra, Cheshenko, Natalia, Wilson, Sarah S, Mesquita, Pedro M M, Doncel, Gustavo F, Herold, Betsy C

“…Despite significant protection in preclinical studies, cellulose sulfate (CS) failed to protect women against HIV-1/2 and was associated with a trend toward…”
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Access to Nectin Favors Herpes Simplex Virus Infection at the Apical Surface of Polarized Human Epithelial Cells by GALEN, Benjamin, CHESHENKO, Natalia, TUYAMA, Ana, RAMRATNAM, Bharat, HEROLD, Betsy C

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Herpes Simplex Virus Triggers Activation of Calcium-Signaling Pathways by Cheshenko, Natalia, Del Rosario, Brian, Woda, Craig, Marcellino, Daniel, Satlin, Lisa M., Herold, Betsy C.

“…The cellular pathways required for herpes simplex virus (HSV) invasion have not been defined. To test the hypothesis that HSV entry triggers activation of…”
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Focal Adhesion Kinase Plays a Pivotal Role in Herpes Simplex Virus Entry by Cheshenko, Natalia, Liu, Wen, Satlin, Lisa M., Herold, Betsy C.

“…Development of strategies to prevent herpes simplex virus (HSV) infection requires knowledge of cellular pathways harnessed by the virus for invasion. This…”
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NP-1, a Rabbit α-Defensin, Prevents the Entry and Intercellular Spread of Herpes Simplex Virus Type 2 by Sinha, Sara, Cheshenko, Natalia, Lehrer, Robert I, Herold, Betsy C

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HSV usurps eukaryotic initiation factor 3 subunit M for viral protein translation: novel prevention target by Cheshenko, Natalia, Trepanier, Janie B, Segarra, Theodore J, Fuller, A Oveta, Herold, Betsy C

“…Prevention of genital herpes is a global health priority. B5, a recently identified ubiquitous human protein, was proposed as a candidate HSV entry receptor…”
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Candidate Topical Microbicides Bind Herpes Simplex Virus Glycoprotein B and Prevent Viral Entry and Cell-to-Cell Spread by CHESHENKO, Natalia, KELLER, Marla J, ZANEVELD, Lourens J. D, PROFY, Albert T, KLOTMAN, Mary E, HEROLD, Betsy C, MASCASULLO, Veronica, JARVIS, Gary A, HUI CHENG, JOHN, Minnie, LI, Jin-Hua, HOGARTY, Kathleen, ANDERSON, Robert A, WALLER, Donald P

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Molecular Umbrellas: a Novel Class of Candidate Topical Microbicides To Prevent Human Immunodeficiency Virus and Herpes Simplex Virus Infections by PELLETT MADAN, Rebecca, MESQUITA, Pedro M. M, HEROLD, Betsy C, CHESHENKO, Natalia, BINGWEN JING, SHENDE, Vikas, GUZMAN, Esmeralda, HEALD, Taylor, KELLER, Marla J, REGEN, Steven L, SHATTOCK, Robin J

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The Cotton Rat Provides a Novel Model To Study Genital Herpes Infection and To Evaluate Preventive Strategies by YIM, Kevin C, CARROLL, Clifford J, TUYAMA, Ana, CHESHENKO, Natalia, CARLUCCI, Maria Josefina, PORTER, David D, PRINCE, Gregory A, HEROLD, Betsv C

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Amphipathic DNA polymers are candidate vaginal microbicides and block herpes simplex virus binding, entry and viral gene expression by GUZMAN, Esmeralda M, CHESHENKO, Natalia, SHENDE, Vikas, KELLER, Marla J, GOYETTE, Nathalie, JUTEAU, Jean-Marc, BOIVIN, Guy, VAILLANT, Andrew, HEROLD, Betsy C

“…Amphipathic DNA polymers are promising therapies for the prevention of HIV and genital herpes infections. Recent studies on a panel of such compounds indicated…”
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