Search Results - "CHERNY, R. A"

Elevated cortical zinc in Alzheimer disease by RELIGA, D, STROZYK, D, CHERNY, R. A, VOLITAKIS, I, HAROUTUNIAN, V, WINBLAD, B, NASLUND, J, BUSH, A. I

“…To determine whether changes in brain biometals in Alzheimer disease (AD) and in normal brain tissue are tandemly associated with amyloid beta-peptide (Abeta)…”
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Copper and Zinc Binding Modulates the Aggregation and Neurotoxic Properties of the Prion Peptide PrP106−126 by Jobling, Michael F, Huang, Xudong, Stewart, Leanne R, Barnham, Kevin J, Curtain, Cyril, Volitakis, Irene, Perugini, Matthew, White, Anthony R, Cherny, Robert A, Masters, Colin L, Barrow, Colin J, Collins, Steven J, Bush, Ashley I, Cappai, Roberto

“…The abnormal form of the prion protein (PrP) is believed to be responsible for the transmissible spongiform encephalopathies. A peptide encompassing residues…”
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Intracellular Accumulation of Detergent‐Soluble Amyloidogenic Aβ Fragment of Alzheimer's Disease Precursor Protein in the Hippocampus of Aged Transgenic Mice by Li, Qiao‐Xin, Maynard, Christa, Cappai, Roberto, McLean, Catriona A., Cherny, Robert A., Lynch, Toni, Culvenor, Janetta G., Trevaskis, Jim, Tanner, Jane E., Bailey, Karen A., Czech, Christian, Bush, Ashley I., Beyreuther, Konrad, Masters, Colin L.

“…: To study amyloid β‐protein (Aβ) production and aggregation in vivo, we created two transgenic (Tg) mouse lines expressing the C‐terminal 100 amino acids of…”
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Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo: A Novel Therapy for Parkinson's Disease by Kaur, Deepinder, Yantiri, Ferda, Rajagopalan, Subramanian, Kumar, Jyothi, Mo, Jun Qin, Boonplueang, Rapee, Viswanath, Veena, Jacobs, Russell, Yang, Lichuan, Beal, M.Flint, DiMonte, Dino, Volitaskis, Irene, Ellerby, Lisa, Cherny, Robert A, Bush, Ashley I, Andersen, Julie K

“…Studies on postmortem brains from Parkinson's patients reveal elevated iron in the substantia nigra (SN). Selective cell death in this brain region is…”
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Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease by McLean, Catriona A., Cherny, Robert A., Fraser, Fiona W., Fuller, Stephanie J., Smith, Margaret J., Konrad Vbeyreuther, Bush, Ashley I., Masters, Colin L.

“…Genetic evidence strongly supports the view that Aβ amyloid production is central to the cause of Alzheimer's disease. The kinetics, compartmentation, and form…”
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Alzheimer's Disease Amyloid-β Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits by Curtain, Cyril C., Ali, Feda, Volitakis, Irene, Cherny, Robert A., Norton, Raymond S., Beyreuther, Konrad, Barrow, Colin J., Masters, Colin L., Bush, Ashley I., Barnham, Kevin J.

“…Amyloid β peptide (Aβ) is the major constituent of extracellular plaques and perivascular amyloid deposits, the pathognomonic neuropathological lesions of…”
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Targeting the Progression of Parkinsons Disease by George, J L, Mok, S, Moses, D, Wilkins, S, Bush, A I, Cherny, R A, Finkelstein, D I

“…By the time a patient first presents with symptoms of Parkinsons disease at the clinic, a significant proportion (50-70%) of the cells in the substantia nigra…”
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Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice by Cherny, Robert A, Atwood, Craig S, Xilinas, Michel E, Gray, Danielle N, Jones, Walton D, McLean, Catriona A, Barnham, Kevin J, Volitakis, Irene, Fraser, Fiona W, Kim, Young-Seon, Huang, Xudong, Goldstein, Lee E, Moir, Robert D, Lim, James T, Beyreuther, Konrad, Zheng, Hui, Tanzi, Rudolph E, Masters, Colin L, Bush, Ashley I

“…Inhibition of neocortical β-amyloid (Aβ) accumulation may be essential in an effective therapeutic intervention for Alzheimer's disease (AD). Cu and Zn are…”
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Dopamine promotes α‐synuclein aggregation into SDS‐resistant soluble oligomers via a distinct folding pathway by Cappai, Roberto, Leck, Su‐Ling, Tew, Deborah J., Williamson, Nicholas A., Smith, David P., Galatis, Denise, Sharpies, Robyn A., Curtain, Cyril C., Ali, Feda' E., Cherny, Robert A., Culvenor, Janetta G., Bottomley, Stephen P., Masters, Colin L., Barnham, Kevin J., Hill, Andrew F.

“…ABSTRACTDopamine (DA) and α‐synuclein (α‐SN) are two key molecules associated with Parkinson's disease (PD). We have identified a novel action of DA in the…”
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Aqueous Dissolution of Alzheimer's Disease Aβ Amyloid Deposits by Biometal Depletion by Cherny, Robert A., Legg, Jacinta T., McLean, Catriona A., Fairlie, David P., Huang, Xudong, Atwood, Craig S., Beyreuther, Konrad, Tanzi, Rudolph E., Masters, Colin L., Bush, Ashley I.

“…Zn(II) and Cu(II) precipitate Aβ in vitro into insoluble aggregates that are dissolved by metal chelators. We now report evidence that these biometals also…”
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Estrogen Decreases Zinc Transporter 3 Expression and Synaptic Vesicle Zinc Levels in Mouse Brain by Lee, Joo-Yong, Kim, Jung-Hwan, Hong, Seok Ho, Lee, Ji Yoon, Cherny, Robert A., Bush, Ashley I., Palmiter, Richard D., Koh, Jae-Young

“…Previous studies suggest that female sex hormones modulate synaptic zinc levels, which may influence amyloid plaque formation and Alzheimer’s disease…”
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Separation and culture of ovine endometrial epithelial and stromal cells: evidence of morphological and functional polarity by Cherny, R.A. (Monash Medical Centre, Melbourne, Victoria, Australia), Findlay, J.K

“…Epithelial and stromal cells from endometria of ovariectomized estradiol-treated Corriedale ewes were separated and purified after collagenase digestion. The…”
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Neurotoxic, Redox-competent Alzheimer's β-Amyloid Is Released from Lipid Membrane by Methionine Oxidation by Barnham, Kevin J., Ciccotosto, Giuseppe D., Tickler, Anna K., Ali, Feda E., Smith, Danielle G., Williamson, Nicholas A., Lam, Yuen-Han, Carrington, Darryl, Tew, Deborah, Kocak, Gulcan, Volitakis, Irene, Separovic, Frances, Barrow, Colin J., Wade, John D., Masters, Colin L., Cherny, Robert A., Curtain, Cyril C., Bush, Ashley I., Cappai, Roberto

“…The amyloid β peptide is toxic to neurons, and it is believed that this toxicity plays a central role in the progression of Alzheimer's disease. The mechanism…”
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Neuronal Zinc Exchange with the Blood Vessel Wall Promotes Cerebral Amyloid Angiopathy in an Animal Model of Alzheimer's Disease by Friedlich, Avi L, Lee, Joo-Yong, van Groen, Thomas, Cherny, Robert A, Volitakis, Irene, Cole, Toby B, Palmiter, Richard D, Koh, Jae-Young, Bush, Ashley I

“…Cerebral amyloid angiopathy (CAA) is common in Alzheimer's disease (AD) and may contribute to dementia and cerebral hemorrhage. Parenchymal beta-amyloid…”
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Oxidative processes in Alzheimer's disease: the role of Aβ-metal interactions by Lynch, T, Cherny, R.A, Bush, A.I

“…Alzheimer's disease is characterized by signs of a major oxidative stress in the neocortex and the concomitant deposition of Amyloid beta (Aβ). Aβ is a…”
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Immunocytochemical localization of oestrogen receptors in the endometrium of the ewe by Cherny, R A, Salamonsen, L A, Findlay, J K

“…Immunocytochemistry with monoclonal antibodies to the oestrogen receptor (ER) was used to localize ERs in sections of endometrium obtained from cycling and…”
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Strategies for the isolation and characterization of bovine embryonic stem cells by Cherny, R A, Stokes, T M, Merei, J, Lom, L, Brandon, M R, Williams, R L

“…The practical application of advanced breeding technologies and genetic manipulation of domestic animals is dependent on the efficient and routine isolation of…”
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Studies in vitro of effects of steroid hormones and the blastocyst on endometrial function in the sheep by Salamonsen, L A, Cherny, R A, Findlay, J K

“…Normal endometrial function is a result of regulation by the combination of ovarian steroids and local agents arising from within the embryo-maternal unit. We…”
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Chelation and Intercalation: Complementary Properties in a Compound for the Treatment of Alzheimer's Disease by Cherny, Robert A., Barnham, Kevin J., Lynch, Toni, Volitakis, Irene, Li, Qiao-Xin, McLean, Catriona A., Multhaup, Gerd, Beyreuther, Konrad, Tanzi, Rudolph E., Masters, Colin L., Bush, Ashley I.

“…Selective application of metal chelators to homogenates of human Alzheimer's disease (AD) brain has led us to propose that the architecture of aggregated…”
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Quantitative elemental bio-imaging of Mn, Fe, Cu and Zn in 6-hydroxydopamine induced Parkinsonism mouse models by Hare, Dominic, Reedy, Brian, Grimm, Rudolf, Wilkins, Simon, Volitakis, Irene, George, Jessica L, Cherny, Robert A, Bush, Ashley I, Finkelstein, David I, Doble, Philip

“…This study demonstrates the application of quantitative elemental bio-imaging for the determination of the distribution Cu, Mn, Fe and Zn in Parkinsonism mouse…”
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