Search Results - "CHERNUKHIN, Igor"

Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor-positive Breast Cancer by Michaloglou, Chrysiis, Crafter, Claire, Siersbaek, Rasmus, Delpuech, Oona, Curwen, Jon O, Carnevalli, Larissa S, Staniszewska, Anna D, Polanska, Urszula M, Cheraghchi-Bashi, Azadeh, Lawson, Mandy, Chernukhin, Igor, McEwen, Robert, Carroll, Jason S, Cosulich, Sabina C

“…The cyclin dependent kinase (CDK)-retinoblastoma (RB)-E2F pathway plays a critical role in the control of cell cycle in estrogen receptor-positive (ER ) breast…”
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FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3 by Jozwik, Kamila M., Chernukhin, Igor, Serandour, Aurelien A., Nagarajan, Sankari, Carroll, Jason S.

“…FOXA1 is a pioneer factor that binds to enhancer regions that are enriched in H3K4 mono- and dimethylation (H3K4me1 and H3K4me2). We performed a FOXA1 rapid…”
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Comprehensive Genomic Analysis Reveals that the Pioneering Function of FOXA1 Is Independent of Hormonal Signaling by Glont, Silvia-E., Chernukhin, Igor, Carroll, Jason S.

“…Considerable work has linked hormone receptors, such as estrogen receptor-alpha (ER), with the pioneer factor FOXA1. Altered FOXA1 levels contribute to…”
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ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response by Nagarajan, Sankari, Rao, Shalini V., Sutton, Joseph, Cheeseman, Danya, Dunn, Shanade, Papachristou, Evangelia K., Prada, Jose-Enrique Gonzalez, Couturier, Dominique-Laurent, Kumar, Sanjeev, Kishore, Kamal, Chilamakuri, Chandra Sekhar Reddy, Glont, Silvia-Elena, Archer Goode, Emily, Brodie, Cara, Guppy, Naomi, Natrajan, Rachael, Bruna, Alejandra, Caldas, Carlos, Russell, Alasdair, Siersbæk, Rasmus, Yusa, Kosuke, Chernukhin, Igor, Carroll, Jason S.

“…Using genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screens to understand endocrine drug resistance, we discovered ARID1A and…”
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ncRNAseq: simple modifications to RNA-seq library preparation allow recovery and analysis of mid-sized non-coding RNAs by Minshall, Nicola, Chernukhin, Igor, Carroll, Jason S, Git, Anna

“…Despite their abundance, mid-sized RNAs (30–300 nt) have not been extensively studied by high-throughput sequencing, mostly due to selective loss in library…”
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The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver by Hruschka, Natascha, Kalisz, Mark, Subijana, Maria, Graña-Castro, Osvaldo, Del Cano-Ochoa, Francisco, Brunet, Laia Paré, Chernukhin, Igor, Sagrera, Ana, De Reynies, Aurelien, Kloesch, Bernhard, Chin, Suet-Feung, Burgués, Octavio, Andreu, David, Bermejo, Begoña, Cejalvo, Juan Miguel, Sutton, Joe, Caldas, Carlos, Ramón-Maiques, Santiago, Carroll, Jason S., Prat, Aleix, Real, Francisco X., Martinelli, Paola

“…As the catalog of oncogenic driver mutations is expanding, it becomes clear that alterations in a given gene might have different functions and should not be…”
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Elevated ASCL1 activity creates de novo regulatory elements associated with neuronal differentiation by Woods, Laura M, Ali, Fahad R, Gomez, Roshna, Chernukhin, Igor, Marcos, Daniel, Parkinson, Lydia M, Tayoun, Ahmad N Abou, Carroll, Jason S, Philpott, Anna

“…The pro-neural transcription factor ASCL1 is a master regulator of neurogenesis and a key factor necessary for the reprogramming of permissive cell types to…”
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Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation by Redmond, Aisling M, Omarjee, Soleilmane, Chernukhin, Igor, Le Romancer, Muriel, Carroll, Jason S

“…HER2 is a transmembrane receptor tyrosine kinase, which plays a key role in breast cancer due to a common genomic amplification. It is used as a marker to…”
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pepgrep： A Tool for Peptide MS/MS Pattern Matching by Chernukhin, Igor

“…Typically, detection of protein sequences in collision-induced dissociation （CID） tandem MS （MS2） dataset is performed by mapping identified peptide ions back…”
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TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions by Broome, Rebecca, Chernukhin, Igor, Jamieson, Stacey, Kishore, Kamal, Papachristou, Evangelia K., Mao, Shi-Qing, Tejedo, Carmen Gonzalez, Mahtey, Areeb, Theodorou, Vasiliki, Groen, Arnoud J., D’Santos, Clive, Balasubramanian, Shankar, Farcas, Anca Madalina, Siersbæk, Rasmus, Carroll, Jason S.

“…Estrogen receptor-α (ER) drives tumor development in ER-positive (ER+) breast cancer. The transcription factor GATA3 has been closely linked to ER function,…”
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The proapoptotic gene interferon regulatory factor-1 mediates the antiproliferative outcome of paired box 2 gene and tamoxifen by Wang, Shixiong, Somisetty, Venkata S., Bai, Baoyan, Chernukhin, Igor, Niskanen, Henri, Kaikkonen, Minna U., Bellet, Meritxell, Carroll, Jason S., Hurtado, Antoni

“…Tamoxifen is the most prescribed selective estrogen receptor (ER) modulator in patients with ER-positive breast cancers. Tamoxifen requires the transcription…”
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Mutational Analysis of the Poly(ADP-Ribosyl)ation Sites of the Transcription Factor CTCF Provides an Insight into the Mechanism of Its Regulation by Poly(ADP-Ribosyl)ation by Farrar, Dawn, Rai, Sushma, Chernukhin, Igor, Jagodic, Maja, Ito, Yoko, Yammine, Samer, Ohlsson, Rolf, Murrell, Adele, Klenova, Elena

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation by Ohlsson, Rolf, Yu, Wenqiang, Ginjala, Vasudeva, Pant, Vinod, Chernukhin, Igor, Whitehead, Joanne, Docquier, France, Farrar, Dawn, Tavoosidana, Gholamreza, Mukhopadhyay, Rituparna, Kanduri, Chandrasekhar, Oshimura, Mitsuo, Feinberg, Andrew P, Lobanenkov, Victor, Klenova, Elena

“…Chromatin insulators demarcate expression domains by blocking the cis effects of enhancers or silencers in a position-dependent manner. We show that the…”
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CTCF Interacts with and Recruits the Largest Subunit of RNA Polymerase II to CTCF Target Sites Genome-Wide by Chernukhin, Igor, Shamsuddin, Shaharum, Kang, Sung Yun, Bergström, Rosita, Kwon, Yoo-Wook, Yu, WenQiang, Whitehead, Joanne, Mukhopadhyay, Rituparna, Docquier, France, Farrar, Dawn, Morrison, Ian, Vigneron, Marc, Wu, Shwu-Yuan, Chiang, Cheng-Ming, Loukinov, Dmitri, Lobanenkov, Victor, Ohlsson, Rolf, Klenova, Elena

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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In vivo dendritic cell depletion reduces breeding efficiency, affecting implantation and early placental development in mice by Krey, Gesa, Frank, Pierre, Shaikly, Valerie, Barrientos, Gabriela, Cordo-Russo, Rosalia, Ringel, Frauke, Moschansky, Petra, Chernukhin, Igor V., Metodiev, Metodi, Fernández, Nelson, Klapp, Burghard F., Arck, Petra C., Blois, Sandra M.

“…Implantation of mammalian embryos into their mother’s uterus ensures optimal nourishment and protection throughout development. Complex molecular interactions…”
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Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer by Aspros, Kirsten G. M., Carter, Jodi M., Hoskin, Tanya L., Suman, Vera J., Subramaniam, Malayannan, Emch, Michael J., Ye, Zhenqing, Sun, Zhifu, Sinnwell, Jason P., Thompson, Kevin J., Tang, Xiaojia, Rodman, Esther P. B., Wang, Xiyin, Nelson, Adam W., Chernukhin, Igor, Hamdan, Feda H., Bruinsma, Elizabeth S., Carroll, Jason S., Fernandez-Zapico, Martin E., Johnsen, Steven A., Kalari, Krishna R., Huang, Haojie, Leon-Ferre, Roberto A., Couch, Fergus J., Ingle, James N., Goetz, Matthew P., Hawse, John R.

“…Triple Negative Breast Cancer (TNBC) accounts for 15–20% of all breast cancer cases, yet is responsible for a disproportionately high percentage of breast…”
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Decreased Poly(ADP-Ribosyl)ation of CTCF, a Transcription Factor, Is Associated with Breast Cancer Phenotype and Cell Proliferation by DOCQUIER, France, KITA, Georgia-Xanthi, FARRAR, Dawn, JAT, Parmjit, O'HARE, Michael, CHERNUKHIN, Igor, GRETTON, Svetlana, MANDAL, Adhip, ALLDRIDGE, Louise, KLENOVA, Elena

“…Purpose: There is compelling evidence of a relationship between poly(ADP-ribosyl)ation and tumorigenesis; however, much less is known about the role of…”
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CTCF Regulates Growth and Erythroid Differentiation of Human Myeloid Leukemia Cells by Torrano, Verónica, Chernukhin, Igor, Docquier, France, D'Arcy, Vivien, León, Javier, Klenova, Elena, Delgado, M. Dolores

“…CTCF is a transcription factor and a candidate tumor suppressor that contains a DNA-binding domain composed of 11 zinc fingers. We reported previously that…”
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The Potential of BORIS Detected in the Leukocytes of Breast Cancer Patients as an Early Marker of Tumorigenesis by DARCY, Vivien, ABDULLAEV, Ziedulla K, RICHARD, Carlos, DELGADO, M. Dolores, LOBANENKOV, Victor, KLENOVA, Elena, PORE, Naresh, DOCQUIER, France, TORRANO, Veronica, CHERNUKHIN, Igor, SMART, Melissa, FARRAR, Dawn, METODIEV, Metodi, FERNANDEZ, Nelson

“…Purpose: B rother o f the r egulator of i mprinted s ites (BORIS) is a novel member of the cancer-testis antigen gene family. These genes are normally…”
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Profiling of advanced glycation end products uncovers abiotic stress-specific target proteins in Arabidopsis by Chaplin, Amanda K, Chernukhin, Igor, Bechtold, Ulrike

“…General base levels of chloroplast protein glycation were independent of rosette age or stress status. Yet under different abiotic stress treatments, a few…”
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