Search Results - "CHENGSEN XUE"

The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis by CHENGSEN XUE, PLIETH, David, VENKOV, Christo, XU, Carol, NEILSON, Eric G

“…When carcinoma cells metastasize, they change their phenotype to enhance motility. Cells making this switch selectively express S100A4, a p53-associated,…”
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Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis by CHENGSEN XUE, WYCKOFF, Jeffrey, FUBO LIANG, SIDANI, Mazen, VIOLINI, Stefania, TSAI, Kun-Lin, ZHANG, Zhong-Yin, SAHAI, Erik, CONDEELIS, John, SEGALL, Jeffrey E

“…Although overexpression of the epidermal growth factor receptor (EGFR; ErbB1) has been correlated with poor prognosis in breast and other cancers, clinical…”
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ErbB3-dependent motility and intravasation in breast cancer metastasis by CHENGSEN XUE, FUBO LIANG, SEGALL, Jeffrey E, MAHMOOD, Radma, VUOLO, Magalis, WYCKOFF, Jeffrey, HONG QIAN, TSAI, Kun-Lin, KIM, Mimi, LOCKER, Joseph, ZHANG, Zhong-Yin

“…A better understanding of how epidermal growth factor receptor family members (ErbBs) contribute to metastasis is important for evaluating ErbB-directed…”
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Conditional Abatement of Tissue Fibrosis Using Nucleoside Analogs to Selectively Corrupt DNA Replication in Transgenic Fibroblasts by Iwano, Masayuki, Fischer, Andreas, Okada, Hirokazu, Plieth, David, Xue, Chengsen, Danoff, Theodore M., Neilson, Eric G.

“…Progressive tissue fibrosis can compromise epithelial function resulting in organ failure. Appreciating evidence suggests that fibroblasts provide fibrogenic…”
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Abstract 1958: CTC surge by Xue, Chengsen, Amukele, Timothy K.

“…Abstract Circulating Tumor Cells (CTC) are a prognostic biomarker for some types of malignant epithelial cancers and have been correlated with poor clinical…”
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Abstract 512: Tetramer and pentamer assays for antigen-specific lymphocytes: Implementation in clinical trials by Xue, Chengsen, Zhong, Weiguo, Cho, Yeji, Cuomo, Joanne, Swenson, Christina D., Closkey, Thomas W. Mc

“…Abstract The success of inhibiting PD1 on T cells for cancer immunotherapy initiated strong interest in studying therapeutic antibodies to alter the adaptive…”
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Abstract 5588: Uneven distribution of CTCs in magnetic fields following binding with iron nanoparticles by Xue, Chengsen, Swenson, Christina D., Closkey, Thomas W. Mc

“…Abstract Circulating tumor cell (CTC) detection and characterization have recently become an integral part of precision medicine. Several large, multicenter…”
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Abstract 1171: Estimating sensitivity of exploratory cellular biomarkers in oncology clinical trials by Xue, Chengsen, Swenson, Christina D., Mc Closkey, Thomas W.

“…Abstract Background: In the prolonged and complex process of assessing immunotherapeutic oncology drug candidates, flow cytometry plays an essential role. In…”
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Abstract 5593: Identification and characterization of an unusual monocyte subpopulation by Xue, Chengsen, Cuomo, Joanne, Rows, Lucie-Emily, Chen, Kai, Swenson, Chrinstina D., Mc Closkey, Thomas W.

“…Abstract Personalized immunotherapy for cancer has become an effective treatment choice in certain oncology indications. To successfully develop such…”
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Evidence that fibroblasts derive from epithelium during tissue fibrosis by Iwano, Masayuki, Plieth, David, Danoff, Theodore M, Xue, Chengsen, Okada, Hirokazu, Neilson, Eric G

“…Interstitial fibroblasts are principal effector cells of organ fibrosis in kidneys, lungs, and liver. While some view fibroblasts in adult tissues as nothing…”
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Abstract 1608: CTC categorization: Subpopulations of CTCs and their potential clinical significance by Xue, Chengsen, Mc Closkey, Thomas W.

“…Abstract Circulating tumor cells (CTCs) were previously rare events difficult to identify. In clinical practice, CTC enumeration has now been recognized for…”
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Abstract 2605: Improving data quality in oncology immunotherapy clinical research by big data analytics and data visualization by Xue, Chengsen, Cuomo, Joanne, Meyers, Walter, Closkey, Thomas W. Mc

“…Abstract Flow cytometric assessment of cellular and intracellular biomarkers facilitates the development of new classes of cancer immunotherapy therapeutics…”
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Abstract 5115: Enhancing data quality for clinical studies of investigational cancer immunotherapy drug candidates by a new data analytics tool by Xue, Chengsen, Cuomo, Joanne, Baptiste, Melissa L., Chen, Kai, Kurkowski, Danielle L., Closkey, Thomas W. Mc

“…Abstract Cancer immunotherapy is rapidly becoming a treatment of choice in fighting deadly cancers, especially late stage or metastatic cancers. Humanized…”
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Abstract 4821: Circulating tumor cells: A key deliverable in oncology clinical trials by Xue, Chengsen, Cortes, Kasia E., Hura, Dorina, Baptiste, Melissa L., Renato, Paradiso, Cuomo, Joanne, Closkey, Thomas W. Mc

“…Abstract Circulating tumor cell (CTC) enumeration is a new pharmacodynamic biomarker developed from an emerging rare event technology showing prognostic…”
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Interaction of a small molecule Natura-α and STAT3-SH2 domain to block Y705 phosphorylation and inhibit lupus nephritis by Chiao, J.W., Melikian, Maxime, Han, Liying, Xue, Chengsen, Tsao, Allen, Wang, Luxi, Mencher, Simon K., Fallon, John, Solangi, Karim, Bertho, Gildas, Wang, Long G.

“…Natura-α binds SH2 domain of STAT3, forms H-bonds with Glu594 and Arg609, preventing Y705 phosphorylation. The efficacy was evaluated in lupus mice, Natura-α…”
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Probing the microenvironment of mammary tumors using multiphoton microscopy by Sidani, Mazen, Wyckoff, Jeffrey, Xue, Chengsen, Segall, Jeffrey E, Condeelis, John

“…Advances in optical imaging technologies that allow the subcellular resolution of undissected tissue have begun to offer new clues into the biology of…”
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Mitochondrial structure alteration in human prostate cancer cells upon initial interaction with a chemopreventive agent phenethyl isothiocyanate by Xue, Chengsen, Pasolli, Hilda A, Piscopo, Irene, Gros, Daniel J, Liu, Christina, Chen, Yamei, Chiao, Jen Wei

“…Phenethyl isothiocyanate (PEITC), present naturally in cruciferous vegetables, is a chemopreventive agent. It blocks initiation and post-initiation progression…”
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Validation of a flow cytometry-based assay to assess C5aR receptor occupancy on neutrophils and monocytes for use in drug development by Quadrini, Karen J., Hegelund, Anne Charlotte, Cortes, Kasia E., Xue, Chengsen, Kennelly, Susan M., Ji, Hong, Högerkorp, Carl-Magnus, Mc Closkey, Thomas W.

“…The C5a/C5a receptor (C5aR) pathway, a key component in the proinflammatory immune response, is an attractive therapeutic target since its dysregulation is…”
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Probing the microenvironment of mammary tumors using multiphoton microscopy: Imaging of breast and breast cancer by SIDANI, Mazen, WYCKOFF, Jeffrey, CHENGSEN XUE, SEGALL, Jeffrey E, CONDEELIS, John

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Evidence that fibroblasts derive from epithelium during tissue fibrosis by Iwano, Masayuki, Plieth, David, Danoff, Theodore M., Xue, Chengsen, Okada, Hirokazu, Neilson, Eric G.

“…Interstitial fibroblasts are principal effector cells of organ fibrosis in kidneys, lungs, and liver. While some view fibroblasts in adult tissues as nothing…”
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