Search Results - "CHENGQUN HUANG"

Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts by Sin, Jon, Andres, Allen M., Taylor, David J. R., Weston, Thomas, Hiraumi, Yoshimi, Stotland, Aleksandr, Kim, Brandon J., Huang, Chengqun, Doran, Kelly S., Gottlieb, Roberta A.

“…Myogenesis is a crucial process governing skeletal muscle development and homeostasis. Differentiation of primitive myoblasts into mature myotubes requires a…”
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Mitophagy is required for acute cardioprotection by simvastatin by Andres, Allen M, Hernandez, Genaro, Lee, Pamela, Huang, Chengqun, Ratliff, Eric P, Sin, Jon, Thornton, Christine A, Damasco, Marichris V, Gottlieb, Roberta A

“…We have shown that autophagy and mitophagy are required for preconditioning. While statin's cardioprotective effects are well known, the role of…”
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Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1 by Huang, Chengqun, Andres, Allen M, Ratliff, Eric P, Hernandez, Genaro, Lee, Pamela, Gottlieb, Roberta A

“…Autophagy-dependent mitochondrial turnover in response to cellular stress is necessary for maintaining cellular homeostasis. However, the mechanisms that…”
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Notch3 signaling promotes the development of pulmonary arterial hypertension by Li, Xiaodong, Leathers, Robin, Yuan, Jason X-J, Huang, Chengqun, Jamieson, Stuart W, Thistlethwaite, Patricia A, Makino, Ayako, Macias, Jesus, Zhang, Xiaoxue, Parsa, Pouria

“…Notch signaling is known to modulate the phenotype of vascular smooth muscle cells. Xiaodong Li et al . now provide evidence for the importance of signaling…”
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Mesencephalic Astrocyte-derived Neurotrophic Factor Protects the Heart from Ischemic Damage and Is Selectively Secreted upon Sarco/endoplasmic Reticulum Calcium Depletion by Glembotski, Christopher C., Thuerauf, Donna J., Huang, Chengqun, Vekich, John A., Gottlieb, Roberta A., Doroudgar, Shirin

“…Background: Intra- and extracellular MANF are protective; however, the conditions governing MANF secretion are unknown. Results: Of the conditions examined,…”
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Impaired renal reserve contributes to preeclampsia via the kynurenine and soluble fms-like tyrosine kinase 1 pathway by Dupont, Vincent, Berg, Anders H, Yamashita, Michifumi, Huang, Chengqun, Covarrubias, Ambart E, Ali, Shafat, Stotland, Aleksandr, Van Eyk, Jennifer E, Jim, Belinda, Thadhani, Ravi, Karumanchi, S Ananth

“…To understand how kidney donation leads to an increased risk of preeclampsia, we studied pregnant outbred mice with prior uninephrectomy and compared them with…”
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Vascular remodeling of the mouse yolk sac requires hemodynamic force by Lucitti, Jennifer L, Jones, Elizabeth A V, Huang, Chengqun, Chen, Ju, Fraser, Scott E, Dickinson, Mary E

“…The embryonic heart and vessels are dynamic and form and remodel while functional. Much has been learned about the genetic mechanisms underlying the…”
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Intermittent Use of a Short-Course Glucagon-like Peptide-1 Receptor Agonist Therapy Limits Adverse Cardiac Remodeling via Parkin-dependent Mitochondrial Turnover by Germano, Juliana de F., Huang, Chengqun, Sin, Jon, Song, Yang, Tucker, Kyle C., Taylor, David J. R., Saadaeijahromi, Hannaneh, Stotland, Aleksandr, Piplani, Honit, Gottlieb, Roberta A., Mentzer, Robert M., Andres, Allen M.

“…Given that adverse remodeling is the leading cause of heart failure and death in the USA, there is an urgent unmet need to develop new methods in dealing with…”
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Attenuation of Adverse Postinfarction Left Ventricular Remodeling with Empagliflozin Enhances Mitochondria-Linked Cellular Energetics and Mitochondrial Biogenesis by Song, Yang, Huang, Chengqun, Sin, Jon, Germano, Juliana de F, Taylor, David J R, Thakur, Reetu, Gottlieb, Roberta A, Mentzer, Jr, Robert M, Andres, Allen M

“…Sodium-glucose cotransporter 2 (SGLT2) inhibitors such as empagliflozin are known to reduce the risk of hospitalizations related to heart failure irrespective…”
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Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice by CHENGQUN HUANG, XIAOXUE ZHANG, GUSTAFSSON, Asa B, RAMIL, Jennifer M, RIKKA, Shivaji, KIM, Lucy, LEE, Youngil, GUDE, Natalie A, THISTLETHWAITE, Patricia A, SUSSMAN, Mark A, GOTTLIEB, Roberta A

“…The anthracycline doxorubicin is an effective chemotherapeutic agent used to treat pediatric cancers but is associated with cardiotoxicity that can manifest…”
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Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion by Kubli, Dieter A, Quinsay, Melissa N, Huang, Chengqun, Lee, Youngil, Gustafsson, Asa B

“…Bcl-2/adenovirus E1B 19-kDa protein-interacting protein 3 (Bnip3) is a member of the Bcl-2 homology domain 3-only subfamily of proapoptotic Bcl-2 proteins and…”
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A method to measure cardiac autophagic flux in vivo by Iwai-Kanai, Eri, Yuan, Hua, Huang, Chengqun, Sayen, M. Richard, Perry-Garza, Cynthia N., Kim, Lucy, Gottlieb, Roberta A.

“…Autophagy, a highly conserved cellular mechanism wherein various cellular components are broken down and recycled through lysosomes, has been implicated in the…”
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Proteomics of Mouse Heart Ventricles Reveals Mitochondria and Metabolism as Major Targets of a Post-Infarction Short-Acting GLP1Ra-Therapy by de Freitas Germano, Juliana, Sharma, Ankush, Stastna, Miroslava, Huang, Chengqun, Aniag, Marianne, Aceves, Angie, Van Eyk, Jennifer E., Mentzer, Robert M., Piplani, Honit, Andres, Allen M., Gottlieb, Roberta A.

“…Cardiovascular disease is the main cause of death worldwide, making it crucial to search for new therapies to mitigate major adverse cardiac events (MACEs)…”
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Discordant signaling and autophagy response to fasting in hearts of obese mice: Implications for ischemia tolerance by Andres, Allen M, Kooren, Joel A, Parker, Sarah J, Tucker, Kyle C, Ravindran, Nandini, Ito, Bruce R, Huang, Chengqun, Venkatraman, Vidya, Van Eyk, Jennifer E, Gottlieb, Roberta A, Mentzer, Jr, Robert M

“…Autophagy is regulated by nutrient and energy status and plays an adaptive role during nutrient deprivation and ischemic stress. Metabolic syndrome (MetS) is a…”
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Autophagy Induced by Ischemic Preconditioning is Essential for Cardioprotection by Huang, Chengqun, Yitzhaki, Smadar, Perry, Cynthia N., Liu, Wayne, Giricz, Zoltan, Mentzer, Robert M., Gottlieb, Roberta A.

“…Based on growing evidence linking autophagy to preconditioning, we tested the hypothesis that autophagy is necessary for cardioprotection conferred by ischemic…”
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Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole by Huang, Chengqun, Liu, Wayne, Perry, Cynthia N, Yitzhaki, Smadar, Lee, Youngil, Yuan, Hua, Tsukada, Yayoi Tetsuo, Hamacher-Brady, Anne, Mentzer, Jr, Robert M, Gottlieb, Roberta A

“…Previously, we showed that sulfaphenazole (SUL), an antimicrobial agent that is a potent inhibitor of cytochrome P4502C9, is protective against…”
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Correction: The Impact of Juvenile Coxsackievirus Infection on Cardiac Progenitor Cells and Postnatal Heart Development by Sin, Jon, Puccini, Jenna M, Huang, Chengqun, Konstandin, Mathias H, Gilbert, Paul E, Sussman, Mark A, Gottlieb, Roberta A, Feuer, Ralph

“…[This corrects the article DOI: 10.1371/journal.ppat.1004249.]…”
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The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development by Sin, Jon, Puccini, Jenna M, Huang, Chengqun, Konstandin, Mathias H, Gilbert, Paul E, Sussman, Mark A, Gottlieb, Roberta A, Feuer, Ralph

“…Coxsackievirus B (CVB) is an enterovirus that most commonly causes a self-limited febrile illness in infants, but cases of severe infection can manifest in…”
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Reduction of Ischemia and Reperfusion-Induced Myocardial Damage by Cytochrome P450 Inhibitors by Granville, David J., Tashakkor, Babak, Takeuchi, Cindy, Gustafsson, Åsa B., Huang, Chengqun, Sayen, M. Richard, Wentworth, Paul, Yeager, Mark, Gottlieb, Roberta A.

“…Ischemia and reperfusion both contribute to tissue damage after myocardial infarction. Although many drugs have been shown to reduce infarct size when…”
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Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis by Huang, Chengqun, Sheikh, Farah, Hollander, Melinda, Cai, Chengleng, Becker, David, Chu, Po-Hsien, Evans, Sylvia, Chen, Ju

“…The requirement for atrial function in developing heart is unknown. To address this question, we have generated mice deficient in atrial myosin light chain 2…”
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