Search Results - "CHENG, Kenneth K. Y"

Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention by Zhu, Weidong, Cheng, Kenneth K Y, Vanhoutte, Paul M, Lam, Karen S L, Xu, Aimin

“…Adiponectin is a major adipocyte-secreted adipokine abundantly present in the circulation as three distinct oligomeric complexes. In addition to its role as an…”
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Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice by Cheong, Lai Yee, Wang, Baile, Wang, Qin, Jin, Leigang, Kwok, Kelvin H. M., Wu, Xiaoping, Shu, Lingling, Lin, Huige, Chung, Sookja Kim, Cheng, Kenneth K. Y., Hoo, Ruby L. C., Xu, Aimin

“…Lymph nodes (LNs) are always embedded in the metabolically-active white adipose tissue (WAT), whereas their functional relationship remains obscure. Here, we…”
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Adiponectin-Induced Endothelial Nitric Oxide Synthase Activation and Nitric Oxide Production Are Mediated by APPL1 in Endothelial Cells by CHENG, Kenneth K. Y, LAM, Karen S. L, YU WANG, YU HUANG, CARLING, David, DONGHAI WU, CHIWAI WONG, AIMIN XU

“…Adiponectin-Induced Endothelial Nitric Oxide Synthase Activation and Nitric Oxide Production Are Mediated by APPL1 in Endothelial Cells Kenneth K.Y. Cheng 1 2…”
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TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt by Cheng, Kenneth K Y, Lam, Karen S L, Wang, Yu, Wu, Donghai, Zhang, Mingliang, Wang, Baile, Li, Xiaomu, Hoo, Ruby L C, Huang, Zhe, Sweeney, Gary, Xu, Aimin

“…Insulin inhibits hepatic glucose production through activation of the protein kinase Akt, and any defect in this pathway causes fasting hyperglycaemia in Type…”
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PM20D1 is a circulating biomarker closely associated with obesity, insulin resistance and metabolic syndrome by Yang, Ranyao, Hu, Yue, Lee, Chi Ho, Liu, Yan, Diaz-Canestro, Candela, Fong, Carol Ho Yi, Lin, Huige, Cheng, Kenneth K Y, Pravelil, Aparna Padmanabhan, Song, Erfei, Lam, Karen S L, Xu, Aimin

“…Objective Peptidase M20 domain containing 1 (PM20D1), a secreted enzyme catalysing condensation of fatty acids and amino acids into the bioactive lipids N-acyl…”
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The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells by Li, Xiaomu, Cheng, Kenneth K. Y., Liu, Zhuohao, Yang, Jin-Kui, Wang, Baile, Jiang, Xue, Zhou, Yawen, Hallenborg, Philip, Hoo, Ruby L. C., Lam, Karen S. L., Ikeda, Yasuhiro, Gao, Xin, Xu, Aimin

“…Mitochondrial metabolism is pivotal for glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells. However, little is known about the molecular…”
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The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy by Liu, Zhuohao, Jin, Leigang, Yang, Jin-Kui, Wang, Baile, Wu, Kelvin K L, Hallenborg, Philip, Xu, Aimin, Cheng, Kenneth K Y

“…Profound loss and senescence of adipose tissues are hallmarks of advanced age, but the underlying cause and their metabolic consequences remain obscure. Proper…”
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YY1 Regulates Glucose Homeostasis Through Controlling Insulin Transcription in Pancreatic β-Cells by Liu, Di, Yang, Kevin Y, Chan, Vicken W, Ye, Wenchu, Chong, Charing C N, Wang, Chi Chiu, Wang, Huating, Zhou, Bin, Cheng, Kenneth K Y, Lui, Kathy O

“…To date, identification of nonislet-specific transcriptional factors in the regulation of insulin gene expression has been little studied. Here, we report that…”
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PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance by Cao, Mian, Mao, Zhuo, Kam, Chuen, Xiao, Nan, Cao, Xiaoxing, Shen, Chong, Cheng, Kenneth K Y, Xu, Aimin, Lee, Kwong-Man, Jiang, Liwen, Xia, Jun

“…Diabetes is a metabolic disorder characterized by hyperglycemia. Insulin, which is secreted by pancreatic beta cells, is recognized as the critical regulator…”
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APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice by Cheng, Kenneth K. Y., Lam, Karen S. L., Wu, Donghai, Wang, Yu, Sweeney, Gary, Hoo, Ruby L. C., Zhang, Jialiang, Xu, Aimin

“…Insulin resistance and defective insulin secretion are the two major features of type 2 diabetes. The adapter protein APPL1 is an obligatory molecule in…”
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Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy by Hoo, Ruby L. C., Shu, Lingling, Cheng, Kenneth K. Y., Wu, Xiaoping, Liao, Boya, Wu, Donghai, Zhou, Zhiguang, Xu, Aimin

“…Lipotoxicity is implicated in the pathogenesis of obesity-related inflammatory complications by promoting macrophage infiltration and activation. Endoplasmic…”
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APPL2 Negatively Regulates Olfactory Functions by Switching Fate Commitments of Neural Stem Cells in Adult Olfactory Bulb via Interaction with Notch1 Signaling by Gao, Chong, Yan, Tingting, Chen, Xingmiao, Cheng, Kenneth K. Y., Xu, Aimin, Shen, Jiangang

“…Adult olfactory neurogenesis plays critical roles in maintaining olfactory functions. Newly-generated neurons in the subventricular zone migrate to the…”
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APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes by Jiang, Xue, Zhou, Yawen, Wu, Kelvin K. L., Chen, Zhanrui, Xu, Aimin, Cheng, Kenneth K. Y.

“…Aims/hypothesis Beta cell inflammation and demise is a feature of type 1 diabetes. The insulin-sensitising molecule ‘adaptor protein, phosphotyrosine…”
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APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction by Park, Min, Wu, Donghai, Park, Taesik, Choi, Cheol-soo, Li, Ren-Ke, Cheng, Kenneth K Y, Xu, Aimin, Sweeney, Gary

“…APPL1 (adaptor protein containing PH domain, PTB domain, and leucine zipper motif 1) has been established as an important mediator of insulin and adiponectin…”
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Suppression of the Raf/MEK/ERK Signaling Cascade and Inhibition of Angiogenesis by the Carboxyl Terminus of Angiopoietin-Like Protein 4 by Yang, Ying-Hua, Wang, Yu, Lam, Karen S.L, Yau, Ming-Hon, Cheng, Kenneth K.Y, Zhang, Jialiang, Zhu, Weidong, Wu, Donghai, Xu, Aimin

“…OBJECTIVES—Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein that has recently been implicated in the regulation of angiogenesis and metastasis…”
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The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle by Cheng, Kenneth K Y, Zhu, Weidong, Chen, Bin, Wang, Yu, Wu, Donghai, Sweeney, Gary, Wang, Baile, Lam, Karen S L, Xu, Aimin

“…Insulin stimulates glucose uptake by promoting the trafficking of GLUT4 to the plasma membrane in muscle cells, and impairment of this insulin action…”
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Hepatic MDM2 Causes Metabolic Associated Fatty Liver Disease by Blocking Triglyceride‐VLDL Secretion via ApoB Degradation by Lin, Huige, Wang, Lin, Liu, Zhuohao, Long, Kekao, Kong, Mengjie, Ye, Dewei, Chen, Xi, Wang, Kai, Wu, Kelvin KL, Fan, Mengqi, Song, Erfei, Wang, Cunchuan, Hoo, Ruby LC, Hui, Xiaoyan, Hallenborg, Philip, Piao, Hailong, Xu, Aimin, Cheng, Kenneth KY

“…Dysfunctional triglyceride‐very low‐density lipoprotein (TG‐VLDL) metabolism is linked to metabolic‐associated fatty liver disease (MAFLD); however, the…”
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The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic β-cells by Wang, Baile, Lin, Huige, Li, Xiaomu, Lu, Wenqi, Kim, Jae Bum, Xu, Aimin, Cheng, Kenneth K. Y.

“…Filamentous actin (F-actin) cytoskeletal remodeling is critical for glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells, and its dysregulation…”
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Activation of G0/G1 switch gene 2 by endoplasmic reticulum stress enhances hepatic steatosis by Ma, Yunqin, Zhang, Mingliang, Yu, Haoyong, Lu, Junxi, Cheng, Kenneth K.Y., Zhou, Jian, Chen, Haibing, Jia, Weiping

“…Perturbed endoplasmic reticulum (ER) homeostasis and increased levels of G0/G1 Switch Gene 2 (G0S2) have been documented in animal models with fatty liver…”
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Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin by Cheng, Kenneth K.Y., PhD, Lam, Karen S.L., MD, Wang, Baile, BSc, MPhil Student, Xu, Aimin, PhD

“…Adiponectin is an insulin-sensitizing adipokine with protective effects against a cluster of obesity-related metabolic and cardiovascular disorders. The…”
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