Search Results - "CHENEVAL, Olivier"

Fmoc-Based Synthesis of Disulfide-Rich Cyclic Peptides by Cheneval, Olivier, Schroeder, Christina I, Durek, Thomas, Walsh, Phillip, Huang, Yen-Hua, Liras, Spiros, Price, David A, Craik, David J

“…Disulfide-rich cyclic peptides have exciting potential as leads or frameworks in drug discovery; however, their use is faced with some synthetic challenges,…”
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Using the MCoTI-II Cyclotide Scaffold To Design a Stable Cyclic Peptide Antagonist of SET, a Protein Overexpressed in Human Cancer by D’Souza, Charlotte, Henriques, Sónia Troeira, Wang, Conan K, Cheneval, Olivier, Chan, Lai Yue, Bokil, Nilesh J, Sweet, Matthew J, Craik, David J

“…The SET protein is a promising drug target in cancer therapy, because of its ability to inhibit the function of the tumor suppressor gene protein phosphatase…”
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The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells by Spincemaille, Pieter, Alborzinia, Hamed, Dekervel, Jeroen, Windmolders, Petra, van Pelt, Jos, Cassiman, David, Cheneval, Olivier, Craik, David J, Schur, Julia, Ott, Ingo, Wölfl, Stefan, Cammue, Bruno P A, Thevissen, Karin

“…We investigated the effect of the Arabidopsis thaliana-derived decapeptide OSIP108 on human cell tolerance to the chemotherapeutic agent cisplatin (Cp), which…”
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Accurate de novo design of hyperstable constrained peptides by Bhardwaj, Gaurav, Mulligan, Vikram Khipple, Bahl, Christopher D., Gilmore, Jason M., Harvey, Peta J., Cheneval, Olivier, Buchko, Garry W., Pulavarti, Surya V. S. R. K., Kaas, Quentin, Eletsky, Alexander, Huang, Po-Ssu, Johnsen, William A., Greisen, Per Jr, Rocklin, Gabriel J., Song, Yifan, Linsky, Thomas W., Watkins, Andrew, Rettie, Stephen A., Xu, Xianzhong, Carter, Lauren P., Bonneau, Richard, Olson, James M., Coutsias, Evangelos, Correnti, Colin E., Szyperski, Thomas, Craik, David J., Baker, David

“…Naturally occurring, pharmacologically active peptides constrained with covalent crosslinks generally have shapes that have evolved to fit precisely into…”
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Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen by Mueller, Alexander, Starobova, Hana, Morgan, Michael, Dekan, Zoltan, Cheneval, Olivier, Schroeder, Christina I., Alewood, Paul F., Deuis, Jennifer R., Vetter, Irina

“…Pain is the leading cause of disability in the developed world but remains a poorly treated condition. Specifically, postsurgical pain continues to be a…”
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Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7 by Agwa, Akello J., Lawrence, Nicole, Deplazes, Evelyne, Cheneval, Olivier, Chen, Rachel M., Craik, David J., Schroeder, Christina I., Henriques, Sónia T.

“…The human voltage-gated sodium channel sub-type 1.7 (hNaV1.7) is emerging as an attractive target for the development of potent and sub-type selective novel…”
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Where cone snails and spiders meet: design of small cyclic sodium‐channel inhibitors by Peigneur, Steve, Cheneval, Olivier, Maiti, Mohitosh, Leipold, Enrico, Heinemann, Stefan H., Lescrinier, Eveline, Herdewijn, Piet, De Lima, Maria Elena, Craik, David J., Schroeder, Christina I., Tytgat, Jan

“…ABSTRACT A 13 aa residue voltage‐gated sodium (Nav) channel inhibitor peptide, Pn, containing 2 disulfide bridges was designed by using a chimeric approach…”
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Design of a Cyclotide Antagonist of Neuropilin‑1 and -2 That Potently Inhibits Endothelial Cell Migration by Getz, Jennifer A, Cheneval, Olivier, Craik, David J, Daugherty, Patrick S

“…Neuropilin-1 and -2 are critical regulators of angiogenesis, lymphangiogenesis, and cell survival as receptors for multiple growth factors. Disulfide-rich…”
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A designed cyclic analogue of gomesin has potent activity against Staphylococcus aureus biofilms by Dias, Susana, Pinto, Sandra, Silva-Herdade, Ana S., Cheneval, Olivier, Craik, David J, Coutinho, Ana, Castanho, Miguel, Henriques, Sónia T., Veiga, Ana Salome

“…© The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. This is an Open Access article…”
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Cyclic gomesin, a stable redesigned spider peptide able to enter cancer cells by Benfield, Aurélie H., Defaus, Sira, Lawrence, Nicole, Chaousis, Stephanie, Condon, Nicholas, Cheneval, Olivier, Huang, Yen-Hua, Chan, Lai Yue, Andreu, David, Craik, David J., Henriques, Sónia Troeira

“…Anticancer chemo- and targeted therapies are limited in some cases due to strong side effects and/or drug resistance. Peptides have received renascent interest…”
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Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework by Durek, Thomas, Kaas, Quentin, White, Andrew M, Weidmann, Joachim, Fuaad, Abdullah Ahmad, Cheneval, Olivier, Schroeder, Christina I, de Veer, Simon J, Dellsén, Anita, Österlund, Torben, Larsson, Niklas, Knerr, Laurent, Bauer, Udo, Plowright, Alleyn T, Craik, David J

“…We have designed a new class of highly potent bivalent melanocortin receptor ligands based on the nature-derived bicyclic peptide sunflower trypsin inhibitor 1…”
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Small cyclic sodium channel inhibitors by Peigneur, Steve, da Costa Oliveira, Cristina, de Sousa Fonseca, Flávia Cristina, McMahon, Kirsten L., Mueller, Alexander, Cheneval, Olivier, Cristina Nogueira Freitas, Ana, Starobova, Hana, Dimitri Gama Duarte, Igor, Craik, David J., Vetter, Irina, de Lima, Maria Elena, Schroeder, Christina I., Tytgat, Jan

“…[Display omitted] Voltage-gated sodium (NaV) channels play crucial roles in a range of (patho)physiological processes. Much interest has arisen within the…”
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Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties by Troeira Henriques, Sónia, Lawrence, Nicole, Chaousis, Stephanie, Ravipati, Anjaneya S, Cheneval, Olivier, Benfield, Aurélie H, Elliott, Alysha G, Kavanagh, Angela Maria, Cooper, Matthew A, Chan, Lai Yue, Huang, Yen-Hua, Craik, David J

“…Gomesin, a disulfide-rich antimicrobial peptide produced by the Brazilian spider Acanthoscurria gomesiana, has been shown to be potent against Gram-negative…”
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Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions by Philippe, Grégoire, Huang, Yen-Hua, Cheneval, Olivier, Lawrence, Nicole, Zhang, Zhen, Fairlie, David P, Craik, David J., de Araujo, Aline Dantas, Henriques, Sónia Troeira

“…The transcription factor p53 has a tumor suppressor role in leading damaged cells to apoptosis. Its activity is regulated/inhibited in healthy cells by the…”
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Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor‑1 by Durek, Thomas, Cromm, Philipp M, White, Andrew M, Schroeder, Christina I, Kaas, Quentin, Weidmann, Joachim, Ahmad Fuaad, Abdullah, Cheneval, Olivier, Harvey, Peta J, Daly, Norelle L, Zhou, Yang, Dellsén, Anita, Österlund, Torben, Larsson, Niklas, Knerr, Laurent, Bauer, Udo, Kessler, Horst, Cai, Minying, Hruby, Victor J, Plowright, Alleyn T, Craik, David J

“…Ultrastable cyclic peptide frameworks offer great potential for drug design due to their improved bioavailability compared to their linear analogues. Using the…”
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Defense Peptides Engineered from Human Platelet Factor 4 Kill Plasmodium by Selective Membrane Disruption by Lawrence, Nicole, Dennis, Adelaide S M, Lehane, Adele M, Ehmann, Anna, Harvey, Peta J, Benfield, Aurélie H, Cheneval, Olivier, Henriques, Sónia Troeira, Craik, David J, McMorran, Brendan J

“…Malaria is a serious threat to human health and additional classes of antimalarial drugs are greatly needed. The human defense protein, platelet factor 4…”
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Targeted Delivery of Cyclotides via Conjugation to a Nanobody by Kwon, Soohyun, Duarte, Joao N, Li, Zeyang, Ling, Jingjing J, Cheneval, Olivier, Durek, Thomas, Schroeder, Christina I, Craik, David J, Ploegh, Hidde L

“…Many naturally occurring peptides have poor proteolytic stability, which limits their therapeutic applications. Cyclotides are plant-derived cyclic peptides…”
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Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide by Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I., Craik, David J.

“…ABSTRACT Disulfide‐rich peptides isolated from cone snails are of great interest as drug leads due to their high specificity and potency toward therapeutically…”
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Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR by Grage, Stephan L., Sani, Marc-Antoine, Cheneval, Olivier, Henriques, Sónia Troeira, Schalck, Constantin, Heinzmann, Ralf, Mylne, Joshua S., Mykhailiuk, Pavel K., Afonin, Sergii, Komarov, Igor V., Separovic, Frances, Craik, David J., Ulrich, Anne S.

“…Cyclotides are ultra-stable cyclic disulfide-rich peptides from plants. Their biophysical effects and medically interesting activities are related to their…”
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Corrigendum to "Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNa V 1.7" [Biochim. Biophys. Acta 1859(5) (2017) 835-844] by Agwa, Akello J, Lawrence, Nicole, Deplazes, Evelyne, Cheneval, Olivier, Chen, Rachel M, Craik, David J, Schroeder, Christina I, Henriques, Sónia T

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