Search Results - "CHEN-YONG LIN"

Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor‐1 by Yamashita, Fumiki, Kaieda, Takashi, Shimomura, Takeshi, Kawaguchi, Makiko, Lin, Chen‐Yong, Johnson, Michael D, Tanaka, Hiroyuki, Kiwaki, Takumi, Fukushima, Tsuyoshi, Kataoka, Hiroaki

“…Hepatocyte growth factor activator inhibitor‐1 (HAI‐1, also known as SPINT1) is an inhibitor of matriptase, a type‐2 transmembrane protease widely expressed in…”
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Yolo-MSAPF: Multiscale Alignment Fusion With Parallel Feature Filtering Model for High Accuracy Weld Defect Detection by Wang, Guan-Qiang, Zhang, Chi-Zhou, Chen, Ming-Song, Lin, Yong-Cheng, Tan, Xian-Hua, Liang, Pei, Kang, Yu-Xin, Zeng, Wei-Dong, Wang, Qiu

“…This work aims to improve the low accuracy caused by interference information during real-time weld surface detection. First, a weld surface dataset with 7580…”
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Rapid Assessment of Surface Markers on Cancer Cells Using Immuno-Magnetic Separation and Multi-frequency Impedance Cytometry for Targeted Therapy by Lin, Zhongtian, Lin, Siang-Yo, Xie, Pengfei, Lin, Chen-Yong, Rather, Gulam M., Bertino, Joseph R., Javanmard, Mehdi

“…The rapid qualitative assessment of surface markers on cancer cells can allow for point-of-care prediction of patient response to various cancer drugs…”
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Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer‐associated fibroblasts by paracrine activation of protease‐activated receptor 2 by Kanemaru, Ai, Yamamoto, Koji, Kawaguchi, Makiko, Fukushima, Tsuyoshi, Lin, Chen‐Yong, Johnson, Michael D., Camerer, Eric, Kataoka, Hiroaki

“…Cancer‐associated fibroblasts (CAFs) are known to contribute to cancer progression. We have reported that cell surface expression of hepatocyte growth factor…”
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Immunosuppressive and Anti-angiogenic Sphingosine 1-Phosphate Receptor-1 Agonists Induce Ubiquitinylation and Proteasomal Degradation of the Receptor by Oo, Myat Lin, Thangada, Shobha, Wu, Ming-Tao, Liu, Catherine H., Macdonald, Timothy L., Lynch, Kevin R., Lin, Chen-Yong, Hla, Timothy

“…Sphingosine 1-phosphate (S1P), a multifunctional lipid mediator, regulates lymphocyte trafficking, vascular permeability, and angiogenesis by activation of the…”
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Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity by Tseng, Chun-Che, Jia, Bailing, Barndt, Robert, Gu, Yayun, Chen, Chien-Yu, Tseng, I-Chu, Su, Sheng-Fang, Wang, Jehng-Kang, Johnson, Michael D, Lin, Chen-Yong

“…The type 2 transmembrane serine protease matriptase is involved in many pathophysiological processes probably via its enzymatic activity, which depends on the…”
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Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine by Buzza, Marguerite S, Netzel-Arnett, Sarah, Shea-Donohue, Terez, Zhao, Aiping, Lin, Chen-Yong, List, Karin, Szabo, Roman, Fasano, Alessio, Bugge, Thomas H, Antalis, Toni M

“…The intestinal epithelium serves as a major protective barrier between the mammalian host and the external environment. Here we show that the transmembrane…”
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Loss of hepatocyte growth factor activator inhibitor type 1 participates in metastatic spreading of human pancreatic cancer cells in a mouse orthotopic transplantation model by Ye, Jingjia, Kawaguchi, Makiko, Haruyama, Yukihiro, Kanemaru, Ai, Fukushima, Tsuyoshi, Yamamoto, Koji, Lin, Chen‐Yong, Kataoka, Hiroaki

“…Hepatocyte growth factor activator inhibitor type 1 (HAI‐1) is a membrane‐bound serine protease inhibitor that is expressed on the surface of epithelial and…”
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The spatiotemporal control of human matriptase action on its physiological substrates: a case against a direct role for matriptase proteolytic activity in profilaggrin processing and desquamation by Lin, Chen-Yong, Wang, Jehng-Kang, Johnson, Michael D.

“…Studies of human genetic disorders and animal models indicate that matriptase plays essential roles in proteolytic processes associated with profilaggrin…”
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The intracellular seven amino acid motif EEGEVFL is required for matriptase vesicle sorting and translocation to the basolateral plasma membrane by Tseng, Chun-Che, Jia, Bailing, Barndt, Robert B, Dai, Yang-Hong, Chen, Yu Hsin, Du, Po-Wen A, Wang, Jehng-Kang, Tang, Hung-Jen, Lin, Chen-Yong, Johnson, Michael D

“…Matriptase plays important roles in epithelial integrity and function, which depend on its sorting to the basolateral surface of cells, where matriptase…”
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Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation by Lai, Chih-Hsin, Lai, Ying-Jung J, Chou, Feng-Pai, Chang, Hsiang-Hua D, Tseng, Chun-Che, Johnson, Michael D, Wang, Jehng-Kang, Lin, Chen-Yong

“…Significant proteolysis may occur during milk synthesis and secretion, as evidenced by the presence of protease-protease inhibitor complex containing the…”
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Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin by Lee, Shiao-Pieng, Kao, Chen-Yu, Chang, Shun-Cheng, Chiu, Yi-Lin, Chen, Yen-Ju, Chen, Ming-Hsing G, Chang, Chun-Chia, Lin, Yu-Wen, Chiang, Chien-Ping, Wang, Jehng-Kang, Lin, Chen-Yong, Johnson, Michael D

“…The membrane-bound serine proteases prostasin and matriptase and the Kunitz-type protease inhibitors HAI-1 and HAI-2 are all expressed in human skin and may…”
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Selective Inhibition of Prostasin in Human Enterocytes by the Integral Membrane Kunitz-Type Serine Protease Inhibitor HAI-2 by Shiao, Frank, Liu, Li-Ching O, Huang, Nanxi, Lai, Ying-Jung J, Barndt, Robert J, Tseng, Chun-Che, Wang, Jehng-Kang, Jia, Bailing, Johnson, Michael D, Lin, Chen-Yong

“…Mutations of hepatocyte growth factor activator inhibitor (HAI)-2 in humans cause sodium loss in the gastrointestinal (GI) tract in patients with syndromic…”
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Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo by Camerer, Eric, Barker, Adrian, Duong, Daniel N., Ganesan, Rajkumar, Kataoka, Hiroshi, Cornelissen, Ivo, Darragh, Molly R., Hussain, Arif, Zheng, Yao-Wu, Srinivasan, Yoga, Brown, Christopher, Xu, Shan-Mei, Regard, Jean B., Lin, Chen-Yong, Craik, Charles S., Kirchhofer, Daniel, Coughlin, Shaun R.

“…We report an unexpected role for protease signaling in neural tube closure and the formation of the central nervous system. Mouse embryos lacking…”
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HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes by Lu, Dajun D., Huang, Nanxi, Li, Sheng-Wen A., Fang, Jessica R., Lai, Chih-Hsin, Wang, Jehng-Kang, Chan, Khee-Siang, Johnson, Michael D., Lin, Chen-Yong

“…Formation and maintenance of skin barrier function require tightly controlled membrane-associated proteolysis, in which the integral membrane Kunitz-type…”
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N-Glycan Branching Affects the Subcellular Distribution of and Inhibition of Matriptase by HAI-2/Placental Bikunin by Lai, Ying-Jung J, Chang, Hsiang-Hua D, Lai, Hongyu, Xu, Yuan, Shiao, Frank, Huang, Nanxi, Li, Linpei, Lee, Ming-Shyue, Johnson, Michael D, Wang, Jehng-Kang, Lin, Chen-Yong

“…The gene product of SPINT 2, that encodes a transmembrane, Kunitz-type serine protease inhibitor independently designated as HAI-2 or placenta bikunin (PB), is…”
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Potent Inhibition and Global Co-localization Implicate the Transmembrane Kunitz-type Serine Protease Inhibitor Hepatocyte Growth Factor Activator Inhibitor-2 in the Regulation of Epithelial Matriptase Activity by Szabo, Roman, Hobson, John P., List, Karin, Molinolo, Alfredo, Lin, Chen-Yong, Bugge, Thomas H.

“…Hepatocyte growth factor activator inhibitors (HAI)-1 and -2 are recently identified and closely related Kunitz-type transmembrane serine protease inhibitors…”
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Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes by Lu, Dajun D., Gu, Yayun, Li, Sheng-Wen A., Barndt, Robert J., Huang, Shih-Ming, Wang, Jehng-Kang, Su, Hui Chen, Johnson, Michael D., Lin, Chen-Yong

“…Epidermal differentiation and barrier function require well-controlled matriptase and prostasin proteolysis, in which the Kunitz-type serine protease inhibitor…”
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Matriptase activates stromelysin (MMP‐3) and promotes tumor growth and angiogenesis by Jin, Xinlian, Yagi, Motoki, Akiyama, Nagisa, Hirosaki, Tomomi, Higashi, Shouichi, Lin, Chen‐Yong, Dickson, Robert B., Kitamura, Hitoshi, Miyazaki, Kaoru

“…Matriptase/MT‐SP1, a type II membrane serine protease widely expressed in normal epithelial cells and human carcinoma cells, is thought to be involved in…”
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Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation by Jia, Bailing, Thompson, Hamishi A., Barndt, Robert B., Chiu, Yi-Lin, Lee, Mon-Juan, Lee, See-Chi, Wang, Jehng-Kang, Tang, Hung-Jen, Lin, Chen-Yong, Johnson, Michael D.

“…The pathophysiological functions of matriptase, a type 2 transmembrane serine protease, rely primarily on its enzymatic activity, which is under tight control…”
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