Search Results - "CHEN, Sara"
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A potential widespread and important role for sleep-disordered breathing in pressure injury development and delayed healing among those with spinal cord injury
Published in Spinal cord (01-05-2020)“…Soft tissue pressure injuries commonly occur in those with spinal cord injury. They add an immeasurable medical, emotional, and social burden to those who…”
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Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease
Published in EMBO molecular medicine (01-10-2013)“…Identification of tissue‐specific renal stem/progenitor cells with nephrogenic potential is a critical step in developing cell‐based therapies for renal…”
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The Diagnostic Accuracy of Incisional Biopsy in the Oral Cavity
Published in Journal of oral and maxillofacial surgery (01-05-2016)“…Purpose To determine the accuracy of incisional biopsy examination to diagnose oral lesions. Materials and Methods This retrospective cohort study was…”
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Possible donor-dependent differences in efficacy of fresh frozen plasma for treatment of ACE inhibitor–induced angioedema
Published in The journal of allergy and clinical immunology in practice (Cambridge, MA) (01-07-2019)“…Attempts at developing a definitive treatment to reverse or at least block progression of ACE inhibitor–induced angioedema have been unsuccessful. Because…”
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The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets
Published in EMBO molecular medicine (01-01-2013)“…There are considerable differences in tumour biology between adult and paediatric cancers. The existence of cancer initiating cells/cancer stem cells (CIC/CSC)…”
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Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment
Published in Cancer research (Chicago, Ill.) (15-02-2012)“…Hedgehog (Hh) signaling is implicated in bone development and cellular transformation. Here we show that inhibition of Hh pathway activity inhibits tumor…”
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Initial Clinical Experience With Contrast-Enhanced Digital Breast Tomosynthesis
Published in Academic radiology (01-02-2007)“…Rationale and Objectives Contrast-enhanced digital mammography and digital breast tomosynthesis are two imaging techniques that attempt to increase malignant…”
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Whole-body galactose oxidation as a robust functional assay to assess the efficacy of gene-based therapies in a mouse model of Galactosemia
Published in Molecular therapy. Methods & clinical development (14-03-2024)“…Despite the implementation of lifesaving newborn screening programs and a galactose-restricted diet, many patients with classic galactosemia develop long-term…”
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PPARG is central to the initiation and propagation of human angiomyolipoma, suggesting its potential as a therapeutic target
Published in EMBO molecular medicine (01-04-2017)“…Angiomyolipoma ( AML ), the most common benign renal tumor, can result in severe morbidity from hemorrhage and renal failure. While mTORC 1 activation is…”
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Quantification of factors influencing fluorescent protein expression using RMCE to generate an allelic series in the ROSA26 locus in mice
Published in Disease models & mechanisms (01-07-2011)“…Fluorescent proteins (FPs) have great utility in identifying specific cell populations and in studying cellular dynamics in the mouse. To quantify the factors…”
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Fracture Resistance of Various Thickness e.max CAD Lithium Disilicate Crowns Cemented on Different Supporting Substrates: An In Vitro Study
Published in Journal of prosthodontics (01-12-2019)“…Purpose To investigate the influence of abutment material properties on the fracture resistance and failure mode of lithium disilicate (IPS e.max) CAD/CAM…”
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Ex Vivo Expanded 3D Human Kidney Spheres Engraft Long Term and Repair Chronic Renal Injury in Mice
Published in Cell reports (Cambridge) (21-01-2020)“…End-stage renal disease is a worldwide epidemic requiring renal replacement therapy. Harvesting tissue from failing kidneys and autotransplantation of tissue…”
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Peroxisome proliferator‐activated receptor gamma (PPARγ) is central to the initiation and propagation of human angiomyolipoma, suggesting its potential as a therapeutic target
Published in EMBO molecular medicine (01-04-2017)“…Angiomyolipoma (AML), the most common benign renal tumor, can result in severe morbidity from hemorrhage and renal failure. While mTORC1 activation is involved…”
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In Vivo Expansion of Cancer Stemness Affords Novel Cancer Stem Cell Targets: Malignant Rhabdoid Tumor as an Example
Published in Stem cell reports (11-09-2018)“…Cancer stem cell (CSC) identification relies on transplantation assays of cell subpopulations sorted from fresh tumor samples. Here, we attempt to bypass…”
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Anti-Tumorigenic Effect of a Novel Derivative of 2-Hydroxyoleic Acid and the Endocannabinoid Anandamide on Neuroblastoma Cells
Published in Biomedicines (29-06-2022)“…Modulation of the endogenous cannabinoid system has been suggested as a potential anticancer strategy. In the search for novel and less toxic therapeutic…”
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Wilms’ Tumor Blastemal Stem Cells Dedifferentiate to Propagate the Tumor Bulk
Published in Stem cell reports (08-07-2014)“…An open question remains in cancer stem cell (CSC) biology whether CSCs are by definition at the top of the differentiation hierarchy of the tumor. Wilms’…”
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NCAM1/FGF module serves as a putative pleuropulmonary blastoma therapeutic target
Published in Oncogenesis (New York, NY) (02-09-2019)“…Pleuropulmonary blastoma (PPB) is a rare pediatric lung neoplasm that recapitulates developmental pathways of early embryonic lungs. As lung development…”
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Avastin Treatment Reduces Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity
Published in Current eye research (01-07-2012)“…Purpose: This study was designed to evaluate the effect of one intraperitoneal (IP) injection of bevacizumab (Avastin) on the severity of oxygen-induced…”
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Fetal posterior fossa volume: assessment with MR imaging
Published in Radiology (01-03-2006)“…To retrospectively determine the relationship between posterior fossa volume (PFV) and estimated gestational age (EGA) and/or femur length (FL) during…”
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