Search Results - "CHEN, Kathleen"

A sequence-based global map of regulatory activity for deciphering human genetics by Chen, Kathleen M., Wong, Aaron K., Troyanskaya, Olga G., Zhou, Jian

“…Epigenomic profiling has enabled large-scale identification of regulatory elements, yet we still lack a systematic mapping from any sequence or variant to…”
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Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk by Zhou, Jian, Theesfeld, Chandra L., Yao, Kevin, Chen, Kathleen M., Wong, Aaron K., Troyanskaya, Olga G.

“…Key challenges for human genetics, precision medicine and evolutionary biology include deciphering the regulatory code of gene expression and understanding the…”
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Selene: a PyTorch-based deep learning library for sequence data by Chen, Kathleen M., Cofer, Evan M., Zhou, Jian, Troyanskaya, Olga G.

“…To enable the application of deep learning in biology, we present Selene ( https://selene.flatironinstitute.org/ ), a PyTorch-based deep learning library for…”
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Emulsion-templated microparticles with tunable stiffness and topology: Applications as edible microcarriers for cultured meat by Norris, Sam C.P., Kawecki, N. Stephanie, Davis, Ashton R., Chen, Kathleen K., Rowat, Amy C.

“…Cultured meat has potential to diversify methods for protein production, but innovations in production efficiency will be required to make cultured meat a…”
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Deep Learning Sequence Models for Transcriptional Regulation by Sokolova, Ksenia, Chen, Kathleen M, Hao, Yun, Zhou, Jian, Troyanskaya, Olga G

“…Deciphering the regulatory code of gene expression and interpreting the transcriptional effects of genome variation are critical challenges in human genetics…”
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Genome-wide landscape of RNA-binding protein target site dysregulation reveals a major impact on psychiatric disorder risk by Park, Christopher Y., Zhou, Jian, Wong, Aaron K., Chen, Kathleen M., Theesfeld, Chandra L., Darnell, Robert B., Troyanskaya, Olga G.

“…Despite the strong genetic basis of psychiatric disorders, the underlying molecular mechanisms are largely unmapped. RNA-binding proteins (RBPs) are…”
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Genomic analyses implicate noncoding de novo variants in congenital heart disease by Richter, Felix, Morton, Sarah U., Kim, Seong Won, Kitaygorodsky, Alexander, Wasson, Lauren K., Chen, Kathleen M., Zhou, Jian, Qi, Hongjian, Patel, Nihir, DePalma, Steven R., Parfenov, Michael, Homsy, Jason, Gorham, Joshua M., Manheimer, Kathryn B., Velinder, Matthew, Farrell, Andrew, Marth, Gabor, Schadt, Eric E., Kaltman, Jonathan R., Newburger, Jane W., Giardini, Alessandro, Goldmuntz, Elizabeth, Brueckner, Martina, Kim, Richard, Porter, George A., Bernstein, Daniel, Chung, Wendy K., Srivastava, Deepak, Tristani-Firouzi, Martin, Troyanskaya, Olga G., Dickel, Diane E., Shen, Yufeng, Seidman, Jonathan G., Seidman, Christine E., Gelb, Bruce D.

“…A genetic etiology is identified for one-third of patients with congenital heart disease (CHD), with 8% of cases attributable to coding de novo variants…”
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Bottlebrush polymers with flexible enantiomeric side chains display differential biological properties by Nguyen, Hung V.-T., Jiang, Yivan, Mohapatra, Somesh, Wang, Wencong, Barnes, Jonathan C., Oldenhuis, Nathan J., Chen, Kathleen K., Axelrod, Simon, Huang, Zhihao, Chen, Qixian, Golder, Matthew R., Young, Katherine, Suvlu, Dylan, Shen, Yizhi, Willard, Adam P., Hore, Michael J. A., Gómez-Bombarelli, Rafael, Johnson, Jeremiah A.

“…Chirality and molecular conformation are central components of life: biological systems rely on stereospecific interactions between discrete (macro)molecular…”
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Engineering multicomponent tissue by spontaneous adhesion of myogenic and adipogenic microtissues cultured with customized scaffolds by Kawecki, N. Stephanie, Norris, Sam C.P., Xu, Yixuan, Wu, Yifan, Davis, Ashton R., Fridman, Ester, Chen, Kathleen K., Crosbie, Rachelle H., Garmyn, Andrea J., Li, Song, Mason, Thomas G., Rowat, Amy C.

“…[Display omitted] •Approach to engineer multicomponent tissue or marbled cultured meat.•Scaffolds are customized for myogenic and adipogenic cells.•Myogenic…”
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Scalable Processes for Culturing Meat Using Edible Scaffolds by Kawecki, N. Stephanie, Chen, Kathleen K, Smith, Corinne S, Xie, Qingwen, Cohen, Julian M, Rowat, Amy C

“…There is increasing consumer demand for alternative animal protein products that are delicious and sustainably produced to address concerns about the impacts…”
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Healthcare resource utilization and costs associated with psychiatric comorbidities in pediatric patients with attention-deficit/hyperactivity disorder: a claims-based case-cohort study by Schein, Jeff, Cloutier, Martin, Gauthier-Loiselle, Marjolaine, Bungay, Rebecca, Chen, Kathleen, Chan, Deborah, Guerin, Annie, Childress, Ann

“…Attention-deficit/hyperactivity disorder (ADHD) has been shown to pose considerable clinical and economic burden; however, research quantifying the excess…”
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Sex and tissue-specificity of piRNA regulation in adult mice following perinatal lead (Pb) exposure by Perera, Bambarendage P. U., Wang, Kai, Wang, Dongyue, Chen, Kathleen, Dewald, Alisa, Sriram, Swati, Goodrich, Jaclyn M., Svoboda, Laurie K., Sartor, Maureen A., Dolinoy, Dana C.

“…Lead (Pb) is a neurotoxicant with early life exposure linked to long-term health effects. Piwi-interacting RNAs (piRNAs) are small non-coding RNAs that…”
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Mesotrione Conjugation Strategies to Create Proherbicides with Reduced Soil Mobility by Panescu, Priera H, Rose, Douglas A, Chen, Kathleen K, Kashanchi, Glareh Natalie, Maynard, Heather D

“…Proherbicides increase the utilization efficiency of herbicides by reducing their off-site movement and premature degradation. Mesotrione is a prevalent…”
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Effects of trehalose and polyacrylate-based hydrogels on tomato growth under drought by Panescu, Priera H, Browne, Marvin, Chen, Kathleen K, Sack, Lawren, Maynard, Heather D

“…Abstract Hydrophilic amendments can enhance soil moisture content, which, in turn, can improve crop health under drought conditions. Understanding how…”
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Wipe It Off: A Meta-Analytic Review of the Psychological Consequences and Antecedents of Physical Cleansing by Lee, Spike W. S., Chen, Kathleen, Ma, Cecilia, Hoang, Joe

“…Physical cleansing is a human universal. It serves health and survival functions. It also carries rich psychological meanings that interest scholars across…”
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Synthetic Glycomacromolecules of Defined Valency, Absolute Configuration, and Topology Distinguish between Human Lectins by Hartweg, Manuel, Jiang, Yivan, Yilmaz, Gokhan, Jarvis, Cassie M, Nguyen, Hung V.-T, Primo, Gastón A, Monaco, Alessandra, Beyer, Valentin P, Chen, Kathleen K, Mohapatra, Somesh, Axelrod, Simon, Gómez-Bombarelli, Rafael, Kiessling, Laura L, Becer, C. Remzi, Johnson, Jeremiah A

“…Carbohydrate-binding proteins (lectins) play vital roles in cell recognition and signaling, including pathogen binding and innate immunity. Thus, targeting…”
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Safety of Anesthetics in Children by Adler, Adam C., MS, MD, FAAP, Chen, Kathleen, MD, Andropoulos, Dean B., MD, MHCM

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PathCORE-T: identifying and visualizing globally co-occurring pathways in large transcriptomic compendia by Chen, Kathleen M, Tan, Jie, Way, Gregory P, Doing, Georgia, Hogan, Deborah A, Greene, Casey S

“…Investigators often interpret genome-wide data by analyzing the expression levels of genes within pathways. While this within-pathway analysis is routine, the…”
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Systematic review of the association between talc and female reproductive tract cancers by Lynch, Heather N, Lauer, Daniel J, Leleck, Olivia Messina, Freid, Rachel D, Collins, Justin, Chen, Kathleen, Thompson, William J, Ierardi, A Michael, Urban, Ania, Boffetta, Paolo, Mundt, Kenneth A

“…Talc is a hydrous magnesium sheet silicate used in cosmetic powders, ceramics, paints, rubber, and many other products. We conducted a systematic review of the…”
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Systematic review of the scientific evidence of the pulmonary carcinogenicity of talc by Lynch, Heather N, Lauer, Daniel J, Thompson, William J, Leleck, Olivia, Freid, Rachel D, Collins, Justin, Chen, Kathleen, Ierardi, A Michael, Urban, Ania M, Cappello, Michael A, Boffetta, Paolo, Mundt, Kenneth A

“…We conducted a systematic review to assess the potential pulmonary carcinogenicity of inhaled talc in humans. Our systematic review methods adhere to Preferred…”
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