Search Results - "CHEFER, Vladimir I"

Kappa Opioid Receptors on Dopaminergic Neurons Are Necessary for Kappa-Mediated Place Aversion by CHEFER, Vladimir I, BÄCKMAN, Cristina M, GIGANTE, Eduardo D, SHIPPENBERG, Toni S

“…Kappa-opioid receptor (KOR) agonists have dysphoric properties in humans and are aversive in rodents. This has been attributed to the activation of KORs within…”
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Dopamine in the Dorsal Hippocampus Impairs the Late Consolidation of Cocaine-Associated Memory by KRAMAR, Cecilia P, CHEFER, Vladimir I, WISE, Roy A, MEDINA, Jorge H, BARBANO, M. Flavia

“…Cocaine is thought to be addictive because it elevates dopamine levels in the striatum, reinforcing drug-seeking habits. Cocaine also elevates dopamine levels…”
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κ Opioids Selectively Control Dopaminergic Neurons Projecting to the Prefrontal Cortex by Margolis, Elyssa B., Lock, Hagar, Chefer, Vladimir I., Shippenberg, Toni S., Hjelmstad, Gregory O., Fields, Howard L.

“…Dopaminergic afferents arising from the ventral tegmental area (VTA) are crucial elements in the neural circuits that mediate arousal, motivation, and…”
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NMDA receptors on non-dopaminergic neurons in the VTA support cocaine sensitization by Luo, Yu, Good, Cameron H, Diaz-Ruiz, Oscar, Zhang, YaJun, Hoffman, Alexander F, Shan, Lufei, Kuang, Serena Y, Malik, Nasir, Chefer, Vladimir I, Tomac, Andreas C, Lupica, Carl R, Bäckman, Cristina M

“…The initiation of behavioral sensitization to cocaine and other psychomotor stimulants is thought to reflect N-methyl-D-aspartate receptor (NMDAR)-mediated…”
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Overview of brain microdialysis by Chefer, Vladimir I, Thompson, Alexis C, Zapata, Agustin, Shippenberg, Toni S

“…The technique of microdialysis enables sampling and collecting of small-molecular-weight substances from the interstitial space. It is a widely used method in…”
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Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease by Good, Cameron H., Hoffman, Alexander F., Hoffer, Barry J., Chefer, Vladimir I., Shippenberg, Toni S., Bäckman, Cristina M., Larsson, Nils‐Göran, Olson, Lars, Gellhaar, Sandra, Galter, Dagmar, Lupica, Carl R.

“…ABSTRACT Parkinson's disease (PD) involves progressive loss of nigrostriatal dopamine (DA) neurons over an extended period of time. Mitochondrial damage may…”
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Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism by Robinson, J Elliott, Vardy, Eyal, DiBerto, Jeffrey F, Chefer, Vladimir I, White, Kate L, Fish, Eric W, Chen, Meng, Gigante, Eduardo, Krouse, Michael C, Sun, Hui, Thorsell, Annika, Roth, Bryan L, Heilig, Markus, Malanga, C J

“…The OPRM1 A118G polymorphism is the most widely studied μ-opioid receptor (MOR) variant. Although its involvement in acute alcohol effects is well…”
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Basolateral Amygdala-Driven Augmentation of Medial Prefrontal Cortex GABAergic Neurotransmission in Response to Environmental Stimuli Associated with Cocaine Administration by CHEFER, Vladimir I, RUIZHONG WANG, SHIPPENBERG, Toni S

“…Basolateral amygdala (BLA) and medial prefrontal cortex (mPFC) interactions have been implicated in cue-elicited craving and drug seeking. However, the…”
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Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors by Bagley, Elena E, Hacker, Jennifer, Chefer, Vladimir I, Mallet, Christophe, McNally, Gavan P, Chieng, Billy C H, Perroud, Julie, Shippenberg, Toni S, Christie, MacDonald J

“…The authors report that GABA transporter 1 (GAT-1) cation currents directly increase GABAergic neuronal excitability and synaptic GABA release in the…”
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Effects of acute and repeated administration of salvinorin A on dopamine function in the rat dorsal striatum by Gehrke, Brenda J., Chefer, Vladimir I., Shippenberg, Toni S.

“…Rationale Acute systemic administration of salvinorin A, a naturally occurring κ-opioid receptor (KOPr) agonist, decreases locomotion and striatal dopamine…”
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Delta-Opioid Receptor Antagonists Prevent Sensitization to the Conditioned Rewarding Effects of Morphine by Shippenberg, Toni S, Chefer, Vladimir I, Thompson, Alexis C

“…Background Functional interactions between μ- and δ-opioid receptors (MOPr and DOPr, respectively) are implicated in morphine tolerance and dependence. The…”
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Endogenous kappa-opioid receptor systems regulate mesoaccumbal dopamine dynamics and vulnerability to cocaine by Chefer, Vladimir I, Czyzyk, Traci, Bolan, Elizabeth A, Moron, Jose, Pintar, John E, Shippenberg, Toni S

“…Genetic and pharmacological approaches were used to examine kappa-opioid receptor (KOR-1) regulation of dopamine (DA) dynamics in the nucleus accumbens and…”
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The effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat by Tejeda, Hugo A., Chefer, Vladimir I., Zapata, Agustin, Shippenberg, Toni S.

“…Rationale Kappa-opioid receptor (KOR) agonists produce dysphoria and psychotomimesis in humans. KORs are enriched in the prefrontal cortex and other brain…”
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Quantitative no-net-flux microdialysis permits detection of increases and decreases in dopamine uptake in mouse nucleus accumbens by Chefer, Vladimir I., Zapata, Agustin, Shippenberg, Toni S., Bungay, Peter M.

“…A number of investigators are using the quantitative no-net-flux microdialysis technique to monitor basal neurotransmitter dynamics in discrete brain regions…”
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Detection and quantification of neurotransmitters in dialysates by Zapata, Agustin, Chefer, Vladimir I, Shippenberg, Toni S, Denoroy, Luc

“…Sensitive analytical methods are needed for the separation and quantification of neurotransmitters obtained in microdialysate studies. This unit describes…”
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Microdialysis in rodents by Zapata, Agustin, Chefer, Vladimir I, Shippenberg, Toni S

“…Microdialysis is an in vivo sampling technique that permits the quantification of various substances (e.g., neurotransmitters, peptides, electrolytes) in blood…”
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Enhanced Responsiveness to Novelty and Cocaine Is Associated with Decreased Basal Dopamine Uptake and Release in the Nucleus Accumbens: Quantitative Microdialysis in Rats under Transient Conditions by Chefer, Vladimir I, Zakharova, Irina, Shippenberg, Toni S

“…Male rats were screened for their response to a novel environment and designated as high responders (HRs) or low responders (LRs). They then received daily…”
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Detection and quantification of neurotransmitters in dialysates by Zapata, Agustin, Chefer, Vladimir I, Parrot, Sandrine, Denoroy, Luc

“…Sensitive analytical methods are needed for the separation and quantification of neurotransmitters obtained in microdialysate studies. This unit describes…”
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Behavioural sensitization and enhanced dopamine response in the nucleus accumbens after intravenous cocaine self-administration in mice by Zapata, Agustin, Chefer, Vladimir I., Ator, Robert, Shippenberg, Toni S., Rocha, Beatriz A.

“…The behavioural effects of cocaine are enhanced in animals with a prior history of repeated cocaine administration. This phenomenon, referred to as…”
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Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-knockout mice by Chefer, Vladimir I., Kieffer, Brigitte L., Shippenberg, Toni S.

“…Conventional and no net flux microdialysis were used to quantify basal and morphine‐induced extracellular dopamine (DA) levels and the basal extraction…”
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