Search Results - "CHEETHAM, Janet"

Report From the NEI/FDA Endpoints Workshop on Age-Related Macular Degeneration and Inherited Retinal Diseases by Csaky, Karl, Ferris, 3rd, Frederick, Chew, Emily Y, Nair, Prashant, Cheetham, Janet K, Duncan, Jacque L

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Double-Masked, Randomized, Phase 2 Evaluation of Abicipar Pegol (an Anti-VEGF DARPin Therapeutic) in Neovascular Age-Related Macular Degeneration by Callanan, David, Kunimoto, Derek, Maturi, Raj K, Patel, Sunil S, Staurenghi, Giovanni, Wolf, Sebastian, Cheetham, Janet K, Hohman, Thomas C, Kim, Kimmie, López, Francisco J, Schneider, Susan

“…To evaluate safety and efficacy of the vascular endothelial growth factor binding protein abicipar pegol (abicipar) versus ranibizumab for neovascular…”
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Visual Acuity Change over 12 Months in the Prospective Progression of Atrophy Secondary to Stargardt Disease (ProgStar) Study: ProgStar Report Number 6 by Kong, Xiangrong, Strauss, Rupert W, Cideciyan, Artur V, Michaelides, Michel, Sahel, José-Alain, Munoz, Beatriz, Ahmed, Mohamed, Ervin, Ann M, West, Sheila K, Cheetham, Janet K, Scholl, Hendrik P N

“…To estimate the yearly rate of change of best-corrected visual acuity (BCVA) and the risk of loss 1 line or more over 1 year and to identify risk factors for…”
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Baseline Visual Field Findings in the RUSH2A Study: Associated Factors and Correlation With Other Measures of Disease Severity by Duncan, Jacque L., Liang, Wendi, Maguire, Maureen G., Audo, Isabelle, Ayala, Allison R., Birch, David G., Carroll, Joseph, Cheetham, Janet K., Esposti, Simona Degli, Durham, Todd A., Erker, Laura, Farsiu, Sina, Ferris, Frederick L., Heon, Elise, Hufnagel, Robert B., Iannaccone, Alessandro, Jaffe, Glenn J., Kay, Christine N., Michaelides, Michel, Pennesi, Mark E., Sahel, José-Alain

“…To report baseline visual fields in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study. Cross-sectional study within a natural…”
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The RUSH2A Study: Dark-Adapted Visual Fields in Patients With Retinal Degeneration Associated With Biallelic Variants in the USH2A Gene by Birch, David G, Samarakoon, Lassana, Melia, Michele, Duncan, Jacque L, Ayala, Allison R, Audo, Isabelle, Cheetham, Janet K, Durham, Todd A, Iannaccone, Alessandro, Pennesi, Mark E, Stingl, Katarina

“…To measure visual fields using two-color dark-adapted chromatic perimetry in a subset of participants in the Rate of Progression of USH2A-related Retinal…”
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Functional Vision in Patients With Biallelic USH2A Variants by Heon, Elise, Melia, Michele, Bocchino, Laura E., Samarakoon, Lassana, Duncan, Jacque L., Ayala, Allison R., Audo, Isabelle, Bradley, Chris, Cheetham, Janet K., Dagnelie, Gislin, Durham, Todd A., Hoyng, Carel B., Jain, Nieraj, Jayasundera, Kanishka T., Pennesi, Mark E., Weng, Christina Y.

“…•ARRP and USH2 participants reported similar functional vision.•Overall FV score was moderately correlated with VA and visual field hill of vision.•The…”
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Baseline Microperimetry and OCT in the RUSH2A Study: Structure−Function Association and Correlation With Disease Severity by Lad, Eleonora M., Duncan, Jacque L., Liang, Wendi, Maguire, Maureen G., Ayala, Allison R., Audo, Isabelle, Birch, David G., Carroll, Joseph, Cheetham, Janet K., Durham, Todd A., Fahim, Abigail T., Loo, Jessica, Deng, Zengtian, Mukherjee, Dibyendu, Heon, Elise, Hufnagel, Robert B., Guan, Bin, Iannaccone, Alessandro, Jaffe, Glenn J., Kay, Christine N., Michaelides, Michel, Pennesi, Mark E., Vincent, Ajoy, Weng, Christina Y., Farsiu, Sina

“…•Baseline microperimetry and spectral domain OCT were analyzed in the RUSH2A study.•Better best corrected visual acuity and larger subfield thickness were…”
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Visual Acuity Change over 12 Months in the Prospective Progression of Atrophy Secondary to Stargardt Disease (ProgStar) Study by Kong, Xiangrong, PhD, Strauss, Rupert W., MD, Cideciyan, Artur V., PhD, Michaelides, Michel, MD, Sahel, José-Alain, MD, Munoz, Beatriz, MS, Ahmed, Mohamed, MD, Ervin, Ann M., PhD, West, Sheila K., PhD, Cheetham, Janet K., PharmD, Scholl, Hendrik P.N., MD, MA

“…Purpose To estimate the yearly rate of change of best-corrected visual acuity (BCVA) and the risk of loss 1 line or more over 1 year and to identify risk…”
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Static Perimetry in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) Study: Assessment Through 2 Years by Duncan, Jacque L., Cheng, Peiyao, Maguire, Maureen G., Ayala, Allison A., Birch, David G., Cheetham, Janet K., Durham, Todd A., Fahim, Abigail T., Hoyng, Carel B., Ishikawa, Hiroshi, Michaelides, Michel, Pennesi, Mark E., Sahel, José-Alain, Stingl, Katarina, Weng, Christina Y.

“…•Static perimetry declined over 2 years in USH2A-related retinal degeneration.•Annual percentage rate of change was greater for peripheral than central…”
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Self-Reported Functional Vision in USH2A-Associated Retinal Degeneration as Measured by the Michigan Retinal Degeneration Questionnaire by Parekh, Bela, Duncan, Jacque L, Samarakoon, Lassana, Melia, Michele, Abalem, Maria Fernanda, Andrews, Chris A, Audo, Isabelle, Ayala, Allison R, Bradley, Chris, Cheetham, Janet K, Dagnelie, Gislin, Durham, Todd A, Huckfeldt, Rachel M, Lacy, Gabrielle D, Malbin, Brett, Michaelides, Michel, Musch, David C, Peck-Dimit, Nicholas, Stingl, Katarina, Weng, Christina Y, Zmejkoski, Alex Z, Jayasundera, K Thiran

“…The purpose of this study was to evaluate self-reported functional vision (FV) and the impact of vision loss in patients with USH2A-associated retinal…”
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Solvent-Free Dynamic Nuclear Polarization of Amorphous and Crystalline ortho-Terphenyl by Ong, Ta-Chung, Mak-Jurkauskas, Melody L, Walish, Joseph J, Michaelis, Vladimir K, Corzilius, Björn, Smith, Albert A, Clausen, Andrew M, Cheetham, Janet C, Swager, Timothy M, Griffin, Robert G

“…Dynamic nuclear polarization (DNP) of amorphous and crystalline ortho-terphenyl (OTP) in the absence of glass forming agents is presented in order to gauge the…”
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Tissue‐specific genotype–phenotype correlations among USH2A‐related disorders in the RUSH2A study by Hufnagel, Robert B., Liang, Wendi, Duncan, Jacque L., Brewer, Carmen C., Audo, Isabelle, Ayala, Allison R., Branham, Kari, Cheetham, Janet K., Daiger, Stephen P., Durham, Todd A., Guan, Bin, Heon, Elise, Hoyng, Carel B., Iannaccone, Alessandro, Kay, Christine N., Michaelides, Michel, Pennesi, Mark E., Singh, Mandeep S., Ullah, Ehsan

“…We assessed genotype–phenotype correlations among the visual, auditory, and olfactory phenotypes of 127 participants with Usher syndrome (USH2) (n =80) or…”
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Hepcidin Revisited, Disulfide Connectivity, Dynamics, and Structure by Jordan, John B., Poppe, Leszek, Haniu, Mitsuru, Arvedson, Tara, Syed, Rashid, Li, Vivian, Kohno, Hiko, Kim, Helen, Schnier, Paul D., Harvey, Timothy S., Miranda, Les P., Cheetham, Janet, Sasu, Barbra J.

“…Hepcidin is a tightly folded 25-residue peptide hormone containing four disulfide bonds, which has been shown to act as the principal regulator of iron…”
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Auditory and olfactory findings in patients with USH2A‐related retinal degeneration—Findings at baseline from the rate of progression in USH2A‐related retinal degeneration natural history study (RUSH2A) by Iannaccone, Alessandro, Brewer, Carmen C., Cheng, Peiyao, Duncan, Jacque L., Maguire, Maureen G., Audo, Isabelle, Ayala, Allison R., Bernstein, Paul S., Bidelman, Gavin M., Cheetham, Janet K., Doty, Richard L., Durham, Todd A., Hufnagel, Robert B., Myers, Mark H., Stingl, Katarina, Zein, Wadih M.

“…Sensorineural hearing loss (SNHL) is characteristic of Usher syndrome type 2 (USH2), but less is known about SNHL in nonsyndromic autosomal recessive retinitis…”
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Overcoming the Challenges to Clinical Development of X-Linked Retinitis Pigmentosa Therapies: Proceedings of an Expert Panel by Birch, David G, Cheetham, Janet K, Daiger, Stephen P, Hoyng, Carel, Kay, Christine, MacDonald, Ian M, Pennesi, Mark E, Sullivan, Lori S

“…X-linked retinitis pigmentosa (XLRP) is a rare inherited retinal disease manifesting as impaired night vision and peripheral vision loss that progresses to…”
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The RUSH2A Study: Best-Corrected Visual Acuity, Full-Field Electroretinography Amplitudes, and Full-Field Stimulus Thresholds at Baseline by Birch, David G, Cheng, Peiyao, Duncan, Jacque L, Ayala, Allison R, Maguire, Maureen G, Audo, Isabelle, Cheetham, Janet K, Durham, Todd A, Fahim, Abigail T, Ferris, 3rd, Frederick L, Heon, Elise, Huckfeldt, Rachel M, Iannaccone, Alessandro, Khan, Naheed W, Lad, Eleonora M, Michaelides, Michel, Pennesi, Mark E, Stingl, Katarina, Vincent, Ajoy, Weng, Christina Y

“…The purpose of this study was to evaluate baseline best corrected visual acuity (BCVA), full-field electroretinography (ERG), full-field stimulus thresholds…”
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Endpoints and Design for Clinical Trials in USH2A-Related Retinal Degeneration: Results and Recommendations From the RUSH2A Natural History Study by Maguire, Maureen G, Birch, David G, Duncan, Jacque L, Ayala, Allison R, Ayton, Lauren N, Cheetham, Janet K, Cheng, Peiyao, Durham, Todd A, Ferris, 3rd, Frederick L, Hoyng, Carel B, Huckfeldt, Rachel M, Jaffe, Glenn J, Kay, Christine, Lad, Eleonora M, Leroy, Bart P, Liang, Wendi, McDaniel, Lee S, Melia, Michele, Michaelides, Michel, Pennesi, Mark E, Sahel, José-Alain, Samarakoon, Lassana

“…To evaluate functional and structural assessments as endpoints for clinical trials for USH2A-related retinal degeneration. People with biallelic…”
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Discovery and Characterization of a Photo-Oxidative Histidine-Histidine Cross-Link in IgG1 Antibody Utilizing 18O‑Labeling and Mass Spectrometry by Liu, Min, Zhang, Zhongqi, Cheetham, Janet, Ren, Da, Zhou, Zhaohui Sunny

“…A novel photo-oxidative cross-linking between two histidines (His-His) has been discovered and characterized in an IgG1 antibody via the workflow of…”
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Tackling the Challenges of Product Development Through a Collaborative Rare Disease Network: The Foundation Fighting Blindness Consortium by Durham, Todd A, Duncan, Jacque L, Ayala, Allison R, Birch, David G, Cheetham, Janet K, Ferris, 3rd, Frederick L, Hoyng, Carel B, Pennesi, Mark E, Sahel, José-Alain

“…The Foundation Fighting Blindness, a 501(c)(3) nonprofit organization, established an international consortium of inherited retinal disease specialists in…”
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A Workshop on Measuring the Progression of Atrophy Secondary to Stargardt Disease in the ProgStar Studies: Findings and Lessons Learned by Ervin, Ann-Margret, Strauss, Rupert W, Ahmed, Mohamed I, Birch, David, Cheetham, Janet, Ferris, 3rd, Frederick L, Ip, Michael S, Jaffe, Glenn J, Maguire, Maureen G, Schönbach, Etienne M, Sadda, SriniVas R, West, Sheila K, Scholl, Hendrik P N

“…The Progression of Atrophy Secondary to Stargardt Disease (ProgStar) studies were designed to measure the progression of Stargardt disease through the use of…”
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