Search Results - "CHEAH, PEH YEAN"

A Susceptibility Gene Set for Early Onset Colorectal Cancer That Integrates Diverse Signaling Pathways: Implication for Tumorigenesis by Hong, Yi, Ho, Kok Sun, Eu, Kong Weng, Cheah, Peh Yean

“…Purpose: The causative genes for autosomal dominantly inherited familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer have been…”
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The emerging role of RBL2/p130 in multi-step retinoblastoma tumorigenesis by Cheah, Peh-Yean

“…Commentary to: High incidence of allelic loss at 16q12.2 region spanning RB2/p130 gene in retinoblastoma Priya Kadam , Thuan Chong Quah, Srinivasa Rao Jada,…”
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metastasis-prone' signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics by Hong, Yi, Downey, Thomas, Eu, Kong Weng, Koh, Poh Koon, Cheah, Peh Yean

“…Metastasis is the major cause of cancer mortality. We aimed to find a metastasis-prone signature for early stage mismatch-repair proficient sporadic colorectal…”
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Singapore familial adenomatous polyposis (FAP) patients with classical adenomatous polyposis but undetectable APC mutations have accelerated cancer progression by XIA CAO, YI HONG, KONG WENG EU, LOI, Carol, PEH YEAN CHEAH

“…Germline mutation in adenomatous polyposis coli (APC) is detected in up to 80% of familial adenomatous polyposis (FAP) patients worldwide. In this study, we…”
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GG genotype of cyclin D1 G870A polymorphism is associated with increased risk and advanced colorectal cancer in patients in Singapore by Hong, Yi, Eu, Kong Weng, Seow-Choen, Francis, Fook-Chong, Stephanie, Cheah, Peh Yean

“…Recent studies have implicated cyclin D1 G870A single-nucleotide polymorphism (SNP) in susceptibility to and early onset of colorectal cancers (CRC). We…”
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Metabolic Profiling of Human Colorectal Cancer Using High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance (HR-MAS NMR) Spectroscopy and Gas Chromatography Mass Spectrometry (GC/MS) by Chan, Eric Chun Yong, Koh, Poh Koon, Mal, Mainak, Cheah, Peh Yean, Eu, Kong Weng, Backshall, Alexandra, Cavill, Rachel, Nicholson, Jeremy K, Keun, Hector C

“…Current clinical strategy for staging and prognostication of colorectal cancer (CRC) relies mainly upon the TNM or Duke system. This clinicopathological stage…”
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KRAS mutation‐independent downregulation of MAPK/PI3K signaling in colorectal cancer by Lam, Kuen Kuen, Tang, Choong Leong, Tan, Emile, Wong, Siew Heng, Cheah, Peh Yean

“…KRAS is a gatekeeper gene in human colorectal tumorigenesis. KRAS is ‘undruggable’; hence, efforts have been diverted to inhibit downstream RAF/MEK/ERK and…”
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Recent advances in colorectal cancer genetics and diagnostics by Cheah, Peh Yean

“…Abstract Colorectal cancer (CRC) is one of the most prevalent cancers and leading cause of cancer mortality worldwide. It is also one of the most curable…”
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Targeting the 'Undruggable' Driver Protein, KRAS, in Epithelial Cancers: Current Perspective by Lam, Kuen Kuen, Wong, Siew Heng, Cheah, Peh Yean

“…This review summarizes recent development in synthetic drugs and biologics targeting intracellular driver genes in epithelial cancers, focusing on KRAS, and…”
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Mesenteric desmoid tumors in singapore familial adenomatous polyposis patients : Clinical course and genetic profile in a predominantly chinese population by KOH, Poh-Koon, LOI, Carol, XIA CAO, CHEAH, Peh-Yean, HO, Kok-Sun, OOI, Boon-Swee, TANG, Choong-Leong, EU, Kong-Weng

“…This study examined the mutational profile of the adenomatous polyposis coli gene in relation to the development of desmoid tumors in familial adenomatous…”
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Metabotyping of human colorectal cancer using two-dimensional gas chromatography mass spectrometry by Mal, Mainak, Koh, Poh Koon, Cheah, Peh Yean, Chan, Eric Chun Yong

“…Colorectal cancer (CRC) is the fourth most common cause of death from cancer in the world. The limitations of the currently available methods and biomarkers…”
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Enhancer-derived long non-coding RNAs CCAT1 and CCAT2 at rs6983267 has limited predictability for early stage colorectal carcinoma metastasis by Thean, Lai Fun, Blöcker, Christopher, Li, Hui Hua, Lo, Michelle, Wong, Michelle, Tang, Choong Leong, Tan, Emile K. W., Rozen, Steven G., Cheah, Peh Yean

“…Up-regulation of long non-coding RNAs (lncRNAs), colon-cancer associated transcript ( CCAT ) 1 and 2 , was associated with worse prognosis in colorectal cancer…”
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Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis by Phang, Beng Hooi, Othman, Rashidah, Bougeard, Gaelle, Chia, Ren Hui, Frebourg, Thierry, Tang, Choong Leong, Cheah, Peh Yean, Sabapathy, Kanaga

“…Whereas most mutations inp53occur in the DNA-binding domain and lead to its functional inactivation, their relevance in the amino-terminal transactivation…”
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KRAS-specific antibody binds to KRAS protein inside colorectal adenocarcinoma cells and inhibits its localization to the plasma membrane by Lam, Kuen Kuen, Low, Yee Syuen, Lo, Michelle, Wong, Michelle, Leong Tang, Choong, Tan, Emile, Chok, Aik Yong, Seow-En, Isaac, Wong, Siew Heng, Cheah, Peh Yean

“…Colorectal cancer (CRC) is the third highest incidence cancer and a leading cause of cancer mortality worldwide. To date, chemotherapeutic treatment of…”
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Global gas chromatography/time-of-flight mass spectrometry (GC/TOFMS)-based metabonomic profiling of lyophilized human feces by Phua, Lee Cheng, Koh, Poh Koon, Cheah, Peh Yean, Ho, Han Kiat, Chan, Eric Chun Yong

“…•A GC/TOFMS method was developed and validated for the metabotyping of human feces.•Feces demonstrated a more comprehensive metabolic coverage than fecal…”
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Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients by Thean, Lai Fun, Wong, Yu Hui, Lo, Michelle, Loi, Carol, Chew, Min Hoe, Tang, Choong Leong, Cheah, Peh Yean

“…Familial adenomatous polyposis (FAP) is an autosomal-dominantly inherited form of colorectal cancer (CRC) caused by mutation in the adenomatous polyposis coli…”
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Genome‐wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians by Zhang, Ben, Jia, Wei‐Hua, Matsuo, Keitaro, Shin, Aesun, Xiang, Yong‐Bing, Matsuda, Koichi, Jee, Sun Ha, Kim, Dong‐Hyun, Cheah, Peh Yean, Ren, Zefang, Cai, Qiuyin, Long, Jirong, Shi, Jiajun, Wen, Wanqing, Yang, Gong, Ji, Bu‐Tian, Pan, Zhi‐Zhong, Matsuda, Fumihiko, Gao, Yu‐Tang, Oh, Jae Hwan, Ahn, Yoon‐Ok, Kubo, Michiaki, Thean, Lai Fun, Park, Eun Jung, Li, Hong‐Lan, Park, Ji Won, Jo, Jaeseong, Jeong, Jin‐Young, Hosono, Satoyo, Nakamura, Yusuke, Shu, Xiao‐Ou, Zeng, Yi‐Xin, Zheng, Wei

“…Genome‐wide association studies (GWAS) of colorectal cancer (CRC) have been conducted primarily in European descendants. In a GWAS conducted in East Asians, we…”
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Ultra-pressure liquid chromatography/tandem mass spectrometry targeted profiling of arachidonic acid and eicosanoids in human colorectal cancer by Mal, Mainak, Koh, Poh Koon, Cheah, Peh Yean, Chan, Eric Chun Yong

“…Cumulative evidence shows that eicosanoids such as prostaglandins, leukotrienes, thromboxanes and hydroxy eicosatetraenoic acids play an important role in…”
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Proteomic Analysis of Colorectal Cancer Reveals Alterations in Metabolic Pathways by Bi, Xuezhi, Lin, Qingsong, Foo, Tet Wei, Joshi, Shashikant, You, Tao, Shen, Han-Ming, Ong, Choon Nam, Cheah, Peh Yean, Eu, Kong Weng, Hew, Choy-Leong

“…Colorectal cancer is the second leading killer cancer worldwide and presently the most common cancer among males in Singapore. The study aimed to detect…”
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A novel indel in exon 9 of APC upregulates a 'skip exon 9' isoform and causes very severe familial adenomatous polyposis by Cheah, Peh Yean, Wong, Yu Hui, Koh, Poh Koon, Loi, Carol, Chew, Min Hoe, Tang, Choong Leong

“…Germline mutation in the adenomatous polyposis coli (APC) gene causes the majority (80%) of familial adenomatous polyposis (FAP), an autosomal dominantly…”
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