Search Results - "CHAVRE, Satish"

5- and 6-Exocyclic Products, cis-2,3,5-Trisubstituted Tetrahydrofurans, and cis-2,3,6-Trisubstituted Tetrahydropyrans via Prins-Type Cyclization by Chavre, Satish. N, Choo, Hyunah, Lee, Jae Kyun, Pae, Ae Nim, Kim, Youseung, Cho, Yong Seo

“…Exocyclic products having cis-2,5 and cis-2,6 substitution were synthesized from terminally substituted alkynyl alcohols with various aldehydes via Prins-type…”
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Chutes and ladders in hepatitis C nucleoside drug development by Coats, Steven J., Garnier-Amblard, Ethel C., Amblard, Franck, Ehteshami, Maryam, Amiralaei, Sheida, Zhang, Hongwang, Zhou, Longhu, Boucle, Sebastien R.L., Lu, Xiao, Bondada, Lavanya, Shelton, Jadd R., Li, Hao, Liu, Peng, Li, Chengwei, Cho, Jong Hyun, Chavre, Satish N., Zhou, Shaoman, Mathew, Judy, Schinazi, Raymond F.

“…•Nucleoside analogs target the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.•At least twelve nucleoside analogs have reached clinical study for…”
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Stereocontrolled Synthesis of Oxaspirobicycles via Prins-Pinacol Annulation by Chavre, Satish N, Ullapu, Punna Reddy, Min, Sun-Joon, Lee, Jae Kyun, Pae, Ae Nim, Kim, Youseung, Cho, Yong Seo

“…We have developed the stereoselective synthesis of 2-oxaspiro[m,n]alkane derivatives using the Prins-pinacol annulation of alkene diols with a wide range of…”
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2′-Fluoro-6′-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: In vitro anti-HBV activity against the lamivudine–entecavir resistant triple mutant and its mechanism of action by Rawal, Ravindra K, Singh, Uma S, Chavre, Satish N, Wang, Jianing, Sugiyama, Masaya, Hung, Wai, Govindarajan, Rajgopal, Korba, Brent, Tanaka, Yasuhito, Chu, Chung K

“…Novel 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA) monophosphate prodrug (FMCAP) was synthesized and evaluated for its in vitro anti-HBV potency against…”
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5-Exocyclic Products, 2,3,5-Trisubstituted Tetrahydrofurans via Prins-Type Cyclization by Chavre, Satish N, Choo, Hyunah, Cha, Joo Hwan, Pae, Ae Nim, Choi, Kyung Il, Cho, Yong Seo

“…5-Exocyclic products, 2,3,5-trisubstituted tetrahydrofurans, were synthesized from homopropargylic alcohols with terminally substituted alkynes and various…”
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Intermolecular Double Prins-Type Cyclization: A Facile and Efficient Synthesis of 1,6-Dioxecanes by Ullapu, Punna Reddy, Min, Sun-Joon, Chavre, Satish N, Choo, Hyunah, Lee, Jae Kyun, Pae, Ae Nim, Kim, Youseung, Chang, Moon Ho, Cho, Yong Seo

“…Double or nothing: The title reaction converts a range of aromatic aldehydes and allenylmethyl/allyl silanes into 1,6-dioxecane derivatives in good to…”
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Highly Stereoselective Synthesis of 2,5-Disubstituted 3-Vinylidene Tetetrahydrofurans via Prins-Type Cyclization by Shin, Chul, Chavre, Satish N, Pae, Ae Nim, Cha, Joo Hwan, Koh, Hun Yeong, Chang, Moon Ho, Choi, Jung Hoon, Cho, Yong Seo

“…A novel synthetic methodology for 2,5-disubstituted tetrahydrofurans having an allenyl group at the 3-position via Prins-type cyclization was developed. The…”
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5- and 6-Exocyclic Products, cis-2,3,5-Trisubstituted Tetrahydrofurans, and cis-2,3,6-Trisubstituted Tetrahydrofurans via Prins-Type Cyclization by Chavre, Satish N, Choo, Hyunah, Lee, Jay Kyun, Pae, Ae Nim, Kim, Youseng, Cho, Yong Seo

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Intermolecular Double Prins-Type Cyclization: A Facile and Efficient Synthesis of 1,6-Dioxecanes by Ullapu, Punna Reddy, Min, Sun-Joon, Chavre, Satish N, Choo, Hyunah, Lee, Jae Kyun, Pae, Ae Nim, Kim, Youseung, Chang, Moon Ho, Cho, Yong Seo

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[2-(4-Chloro-phen-yl)-5-phenyl-oxolan-3-yl](cyclo-penten-yl)methanone by Lee, Jae Kyun, Chavre, Satish N, Cho, Yong Seo, Lee, Yeonhee, Cha, Joo Hwan

“…In the title compound, C(22)H(21)ClO(2), the oxolane ring adopts a twisted conformation. The dihedral angles between the mean plane of the oxolane ring and the…”
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Synthesis and evaluation of non-dimeric HCV NS5A inhibitors by Amblard, Franck, Zhang, Hongwang, Zhou, Longhu, Shi, Junxing, Bobeck, Drew R., Nettles, James H., Chavre, Satish, McBrayer, Tamara R., Tharnish, Philip, Whitaker, Tony, Coats, Steven J., Schinazi, Raymond F.

“…Based on the symmetrical bidentate structure of the NS5A inhibitor BMS-790052, a series of new monodentate molecules were designed. The synthesis of 36 new…”
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Dioxolane l-Nucleoside Analogs Prevent Varicella-Zoster Virus Replication in Fibroblasts and Skin Organ Culture by De, Chandrav, Chavre, Satish, Chu, Chung. K., Moffat, Jennifer

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β-L-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (L-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism by DE, Chandrav, DONGMEI LIU, BO ZHENG, SINGH, Uma S, CHAVRE, Satish, WHITE, Catherine, ARNOLD, Robert D, HAGEN, Fred K, CHU, Chung K, MOFFAT, Jennifer F

“…The alphaherpesvirus varicella-zoster virus (VZV) causes chickenpox and shingles. Current treatments are acyclovir (ACV) and its derivatives, foscarnet and…”
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2a2-Fluoro-6a2-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: In vitro anti-HBV activity against the lamivudineaentecavir resistant triple mutant and its mechanism of action by Rawal, Ravindra K, Singh, Uma S, Chavre, Satish N, Wang, Jianing, Sugiyama, Masaya, Hung, Wai, Govindarajan, Rajgopal, Korba, Brent, Tanaka, Yasuhito, Chu, Chung K

“…Novel 2a2-fluoro-6a2-methylene-carbocyclic adenosine (FMCA) monophosphate prodrug (FMCAP) was synthesized and evaluated for its in vitro anti-HBV potency…”
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Intermolecular Double Prins‐Type Cyclization: A Facile and Efficient Synthesis of 1,6‐Dioxecanes by Ullapu, Punna Reddy, Min, Sun‐Joon, Chavre, Satish N., Choo, Hyunah, Lee, Jae Kyun, Pae, Ae Nim, Kim, Youseung, Chang, Moon Ho, Cho, Yong Seo

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Intermolecular Double Prins‐Type Cyclization: A Facile and Efficient Synthesis of 1,6‐Dioxecanes by Ullapu, Punna Reddy, Min, Sun‐Joon, Chavre, Satish N., Choo, Hyunah, Lee, Jae Kyun, Pae, Ae Nim, Kim, Youseung, Chang, Moon Ho, Cho, Yong Seo

“…Verdoppelter Einsatz: Die Titelreaktion überführt eine Reihe aromatischer Aldehyde in 26–85 % Ausbeute mithilfe von Allenylmethyl‐/Allylsilanen in…”
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Intermolecular Double Prins-Type Cyclization: A Facile and Efficient Synthesis of 1,6-Dioxecanes by Ullapu, Punna Reddy, Min, Sun-Joon, Chavre, Satish N., Choo, Hyunah, Lee, Jae Kyun, Pae, Ae Nim, Kim, Youseung, Chang, Moon Ho, Cho, Yong Seo

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Intermolecular Double Prins‐Type Cyclization: A Facile and Efficient Synthesis of 1,6‐Dioxecanes by Ullapu, Punna Reddy, Min, Sun‐Joon, Chavre, Satish N., Choo, Hyunah, Lee, Jae Kyun, Pae, Ae Nim, Kim, Youseung, Chang, Moon Ho, Cho, Yong Seo

“…Abstract Verdoppelter Einsatz : Die Titelreaktion überführt eine Reihe aromatischer Aldehyde in 26–85 % Ausbeute mithilfe von Allenylmethyl‐/Allylsilanen in…”
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