Search Results - "CHAVATTE, Philippe"

Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N‑Acylethanolamine Acid Amidase Inhibitors by Tuo, Wei, Leleu-Chavain, Natascha, Spencer, John, Sansook, Supojjanee, Millet, Régis, Chavatte, Philippe

“…Fatty acid ethanolamides (FAEs) and endocannabinoids (ECs) have been shown to alleviate pain and inflammation, regulate motility and appetite, and produce…”
Get full text

GED-0507 attenuates lung fibrosis by counteracting myofibroblast transdifferentiation in vivo and in vitro by Speca, Silvia, Dubuquoy, Caroline, Rousseaux, Christel, Chavatte, Philippe, Desreumaux, Pierre, Spagnolo, Paolo

“…The development of more effective, better tolerated drug treatments for progressive pulmonary fibrosis (of which idiopathic pulmonary fibrosis is the most…”
Get full text

Targeting Peroxisome Proliferator-Activated Receptors (PPARs): Development of Modulators by Pirat, Céline, Farce, Amaury, Lebègue, Nicolas, Renault, Nicolas, Furman, Christophe, Millet, Régis, Yous, Saı̈d, Speca, Silvia, Berthelot, Pascal, Desreumaux, Pierre, Chavatte, Philippe

Get full text

GED-0507 is a novel potential antifibrotic treatment option for pulmonary fibrosis by Speca, Silvia, Dubuquoy, Caroline, Rousseaux, Christel, Chavatte, Philippe, Desreumaux, Pierre, Spagnolo, Paolo

Get full text

Synthesis and Structure–Activity Relationships of (Aryloxy)quinazoline Ureas as Novel, Potent, and Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitors by Garofalo, Antonio, Farce, Amaury, Ravez, Séverine, Lemoine, Amélie, Six, Perrine, Chavatte, Philippe, Goossens, Laurence, Depreux, Patrick

“…In our continuing search for medicinal agents to treat proliferative diseases, quinazoline derivatives were synthesized and evaluated pharmacologically as…”
Get full text

Polycyclic nitrogen heterocycles as potential thymidine phosphorylase inhibitors: synthesis, biological evaluation, and molecular docking study by Aknin, Karen, Bontemps, Alexis, Farce, Amaury, Merlet, Eric, Belmont, Philippe, Helissey, Philippe, Chavatte, Philippe, Sari, Marie-Agnès, Giorgi-Renault, Sylviane, Desbène-Finck, Stéphanie

“…New polycyclic heterocycles were synthesised and evaluated as potential inhibitors of thymidine phosphorylase (TP). Inspired by the pharmacophoric…”
Get full text

Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50 by Clement, Nathalie, Renault, Nicolas, Guillaume, Jean‐Luc, Cecon, Erika, Journé, Anne‐Sophie, Laurent, Xavier, Tadagaki, Kenjiro, Cogé, Francis, Gohier, Arnaud, Delagrange, Philippe, Chavatte, Philippe, Jockers, Ralf

“…Background and Purpose Recent crystal structures of GPCRs have emphasized the previously unappreciated role of the second extracellular (E2) loop in ligand…”
Get full text

Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: meta-analysis of CD1d-glycolipids dynamics simulations by Laurent, Xavier, Renault, Nicolas, Farce, Amaury, Chavatte, Philippe, Hénon, Eric

“…A number of potentially bioactive molecules can be found in nature. In particular, marine organisms are a valuable source of bioactive compounds. The activity…”
Get full text

Novel structural insights for drug design of selective 5-HT2C inverse agonists from a ligand-biased receptor model by RENAULT, Nicolas, GOHIER, Arnaud, CHAVATTE, Philippe, FARCE, Amaury

Get full text

Three-Dimensional Quantitative Structure−Activity Relationships of Cyclo-oxygenase-2 (COX-2) Inhibitors: A Comparative Molecular Field Analysis by Chavatte, Philippe, Yous, Saïd, Marot, Christophe, Baurin, Nicolas, Lesieur, Daniel

“…The three-dimensional quantitative structure−activity relationship (3D-QSAR) approach using comparative molecular field analysis (CoMFA) was applied to an…”
Get full text

Synthesis and Structure−Affinity−Activity Relationships of Novel Benzofuran Derivatives as MT2 Melatonin Receptor Selective Ligands by Wallez, Valérie, Durieux-Poissonnier, Sophie, Chavatte, Philippe, Boutin, Jean A, Audinot, Valérie, Nicolas, Jean-Paul, Bennejean, Caroline, Delagrange, Philippe, Renard, Pierre, Lesieur, Daniel

“…A series of N-(2-phenylbenzofuran-3-yl) ethyl amide and N-(2-arylalkylbenzofuran-3-yl) ethyl amide derivatives were synthesized and evaluated as melatonin…”
Get full text

2,6-Diphenylthiazolo[3,2- b][1,2,4]triazoles as telomeric G-quadruplex stabilizers by El Bakali, Jamal, Klupsch, Frédérique, Guédin, Aurore, Brassart, Bertrand, Fontaine, Gaëlle, Farce, Amaury, Roussel, Pascal, Houssin, Raymond, Bernier, Jean-Luc, Chavatte, Philippe, Mergny, Jean-Louis, Riou, Jean-François, Hénichart, Jean-Pierre

“…Two of the title compounds ( 14a, 19) bearing cationic side chains present high selectivity for telomeric G-quadruplex over duplex DNA. The design and…”
Get full text

A computational view of COX-2 inhibition by Chavatte, Philippe, Farce, Amaury

“…Selective inhibition of COX-2 provided a new class of anti-inflammatory, analgesic and antipyretic drugs with significantly reduced side effects and could also…”
Get more information

Investigations of new lead structures for the design of novel cyclooxygenase-2 inhibitors by Park, Chang Ha, Siomboing, Xavier, Yous, Saı̈d, Gressier, Bernard, Luyckx, Michel, Chavatte, Philippe

“…On the basis of molecular modelling studies, five new compounds were synthesised and studied in an attempt to design new lead structures as selective COX-2…”
Get full text

Docking study of ligands into the colchicine binding site of tubulin by Farce, Amaury, Loge, Cedric, Gallet, Sebastien, Lebegue, Nicolas, Carato, Pascal, Chavatte, Philippe, Berthelot, Pascal, Lesieur, Daniel

“…Cancer is a major cause of mortality in developed countries, following only cardiovascular diseases. Death of cancerous cells can be achieved by stopping…”
Get more information

2D QSAR Consensus Prediction for High-Throughput Virtual Screening. An Application to COX-2 Inhibition Modeling and Screening of the NCI Database by Baurin, Nicolas, Mozziconacci, Jean-Christophe, Arnoult, Eric, Chavatte, Philippe, Marot, Christophe, Morin-Allory, Luc

“…Using classification (SOM, LVQ, Binary, Decision Tree) and regression algorithms (PLS, BRANN, k-NN, Linear), this paper details the building of eight 2D-QSAR…”
Get full text

SINAPs: A Software Tool for Analysis and Visualization of Interaction Networks of Molecular Dynamics Simulations by Bedart, Corentin, Renault, Nicolas, Chavatte, Philippe, Porcherie, Adeline, Lachgar, Abderrahim, Capron, Monique, Farce, Amaury

“…As long as the structural study of molecular mechanisms requires multiple molecular dynamics reflecting contrasted bioactive states, the subsequent analysis of…”
Get full text

Chitin-glucan improves important pathophysiological features of irritable bowel syndrome by Valibouze, Caroline, Dubuquoy, Caroline, Chavatte, Philippe, Genin, Michaël, Maquet, Veronique, Modica, Salvatore, Desreumaux, Pierre, Rousseaux, Christel

“…Irritable bowel syndrome (IBS) is one of the most frequent and debilitating conditions leading to gastroenterological referrals. However, recommended…”
Get full text

Pharmacophoric Search and 3D-QSAR Comparative Molecular Field Analysis Studies on Agonists of Melatonin Sheep Receptors by Marot, Christophe, Chavatte, Philippe, Morin-Allory, Luc, Viaud, Marie Claude, Guillaumet, Gérald, Renard, Pierre, Lesieur, Daniel, Michel, André

“…Conformational analysis was used to characterize the agonist pharmacophore for melatonin sheep brain receptor recognition and activation. The molecular…”
Get full text

Design, Synthesis, and Pharmacological Evaluation of New Farnesyl Protein Transferase Inhibitors by Houssin, Raymond, Pommery, Jean, Salaün, Marie-Catherine, Deweer, Sophie, Goossens, Jean-François, Chavatte, Philippe, Hénichart, Jean-Pierre

“…New CA1A2X peptidomimetics are described as Ras farnesyl transferase inhibitors (FTIs). They include cysteine and methionine as mimetics of the C-terminus…”
Get full text