Search Results - "CHAVAN, A. J"

Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes by SEGAL, A. W, WEST, I, WIENTJES, F, NUGENT, J. H. A, CHAVAN, A. J, HALEY, B, GARCIA, R. C, ROSEN, H, SCRACE, G

“…The NADPH oxidase of phagocytic cells is important for the efficient killing and digestion of ingested microbes. A very unusual low-potential cytochrome b…”
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The Novel Silatecan 7-tert-Butyldimethylsilyl-10-hydroxycamptothecin Displays High Lipophilicity, Improved Human Blood Stability, and Potent Anticancer Activity by Bom, David, Curran, Dennis P, Kruszewski, Stefan, Zimmer, Stephen G, Thompson Strode, J, Kohlhagen, Glenda, Du, Wu, Chavan, Ashok J, Fraley, Kimberly A, Bingcang, Alex L, Latus, Lori J, Pommier, Yves, Burke, Thomas G

“…We describe the rational design and synthesis of B- and A,B-ring-modified camptothecins. The key α-hydroxy-δ-lactone pharmacophore in…”
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Dictyostelium, a microbial model for brain disease by Annesley, S.J., Chen, S., Francione, L.M., Sanislav, O., Chavan, A.J., Farah, C., De Piazza, S.W., Storey, C.L., Ilievska, J., Fernando, S.G., Smith, P.K., Lay, S.T., Fisher, P.R.

“…Most neurodegenerative diseases are associated with mitochondrial dysfunction. In humans, mutations in mitochondrial genes result in a range of phenotypic…”
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Novel A,B,E-Ring-Modified Camptothecins Displaying High Lipophilicity and Markedly Improved Human Blood Stabilities by Bom, David, Curran, Dennis P, Chavan, Ashok J, Kruszewski, Stefan, Zimmer, Stephen G, Fraley, Kimberly A, Burke, Thomas G

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NAD+ binding site of Clostridium botulinum C3 ADP-ribosyltransferase. Identification of peptide in the adenine ring binding domain using 2-azido NAD by CHAVAN, A. J, NEMOTO, Y, NARUMIYA, S, KOZAKI, S, HALEY, B. E

“…C3 ADP-ribosyltransferase is an exoenzyme produced by certain strains of Clostridium botulinum types C and D, which specifically ADP-ribosylates rho proteins…”
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Synthesis and application of bidentate photoaffinity cross-linking reagents. Nucleotide photoaffinity probes with two photoactive groups by RAJAGOPALAN, K, CHAVAN, A. J, HALEY, B. E, WATT, D. S

“…Two "targeted bidentate" photoaffinity cross-linking reagents, the monoanhydride of 8-N3ADP with N-(4-(benzoyl)phenylmethyl)phosphoramide ([gamma-32P]8-N3ATP…”
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Identification of peptides from the adenine binding domains of ATP and AMP in adenylate kinase: isolation of photoaffinity-labeled peptides by metal chelate chromatography by Salvucci, Michael E, Chavan, Ashok J, Haley, Boyd E

“…Photoaffinity labeling with azidoadenine nucleotides was used to identify peptides from the ATP and AMP binding domains on chicken muscle adenylate kinase…”
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Photoaffinity labeling of human placental NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase with [alpha-32P]2N3NAD+. Identification of a peptide in the adenine ring binding domain by Chavan, A J, Ensor, C M, Wu, P, Haley, B E, Tai, H H

“…Oxidation of many prostaglandins at C-15 results in the formation of 15-keto metabolites, which have reduced biological activity. This reaction is catalyzed by…”
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Photoaffinity labeling of rat liver microsomal steroid 5 alpha-reductase by 2-azido-NADP by Bhattacharyya, A K, Chavan, A J, Shuffett, M, Haley, B E, Collins, D C

“…Preincubation of female rat liver microsomal preparations with [2'-32P]2N3-NADP+ followed by photolysis with UV light (254 nm) and analysis by…”
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Identification and characterization of a nucleotide binding site of ovine prolactin with 2-azido-NAD by Trad, C H, Chavan, A J, Clemens, J, Haley, B E

“…Photoaffinity labeling of ovine prolactin with the NAD+ photoaffinity analog [alpha-32P]nicotinamide-2-azidoadenine dinucleotide has been used to identify an…”
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Identification and characterization of a nucleotide binding site on recombinant murine granulocyte/macrophage-colony stimulating factor by Doukas, Michael A, Chavan, Ashok J, Gass, Cecelia, Boone, Thomas, Haley, Boyd E

“…Granulocyte/macrophage-colony stimulating factor (GM-CSF) is a regulatory cytokine important in the proliferative and functional activation of hematopoietic…”
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Forskolin photoaffinity probes for the evaluation of tubulin binding sites by Chavan, Ashok J, Richardson, Stewart K, Kim, Hyuntae, Haley, Boyd E, Watt, David S

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Phenyl azide substituted and benzophenone-substituted phosphonamides of 7-methylguanosine 5'-triphosphate as photoaffinity probes for protein synthesis initiation factor eIF-4E and a proteolytic fragment containing the cap-binding site by Chavan, Ashok J, Rychlik, Wojciech, Blaas, Dieter, Kuechler, Ernst, Watt, David S, Rhoads, Robert E

“…Three photoactive derivatives of the 7-methylguanosine-containing cap of eukaryotic mRNA were used to investigate protein synthesis initiation factor eIF-4E…”
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New multipetalous variety G. Ad.2 in Adenium obesum by Alka Singh, S. K. Chavan, A. J. Bhandari, Vipulkumar Parekh, H. P. Shah, A. I. Patel and B. N. Patel

“…Research was conducted on Adenium obesum, a popular flowering pot plant with the basic objective for genetic improvement at Advance Technology Centre of…”
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Identification of Adenine Binding Domain Peptides of the NADP+ Active Site within Porcine Heart NADP+-Dependent Isocitrate Dehydrogenase by Sankaran, Banumathi, Chavan, Ashok J, Haley, Boyd E

“…Photoaffinity labeling with [2‘-32P]2N3NADP+ and [32P]2N3NAD+ was used to identify two overlapping tryptic and chymotryptic generated peptides within the…”
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Identification of the NADP(H) binding site of rat liver microsomal 5 alpha-reductase (isozyme-1): purification of a photolabeled peptide corresponding to the adenine binding domain by Bhattacharyya, A K, Chavan, A J, Haley, B E, Taylor, M F, Collins, D C

“…We have previously shown that [2'-32P]-2-azido-NADP+ is an effective probe of the NADP-(H) binding site of rat liver microsomal 5 alpha-reductase (5 alpha R-1)…”
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Interaction of Nucleotides with Acidic Fibroblast Growth Factor (FGF-1) by Chavan, Ashok J, Haley, Boyd E, Volkin, David B, Marfia, Kimberly E, Verticelli, Adeline M, Bruner, Mark W, Draper, Jerome P, Burke, Carl J, Middaugh, C. Russell

“…A wide variety of nucleotides are shown to bind to acidic fibroblast growth factor (aFGF) as demonstrated by their ability to (1) inhibit the heat-induced…”
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Photoaffinity labeling of the ATP binding domain of Rubisco activase and a separate domain involved in the activation of ribulose-1,5-bisphosphate carboxylase/oxygenase by Salvucci, Michael E, Chavan, Ashok J, Klein, Robert R, Rajagopolan, Krishnan, Haley, Boyd E

“…Photoaffinity labeling of Rubisco activase with 2- and 8-N3ATP was used to identify the adenine binding domain for ATP. Rubisco activase hydrolyzed both of…”
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Identification of N-Terminus Peptide of Human Granulocyte/Macrophage Colony-Stimulating Factor as the Site of Nucleotide Interaction by Chavan, A.J., Gass, C., Haley, B.E., Boone, T., Doukas, M.A.

“…The interaction of nucleotides with recombinant human granulocyte/macrophage colony stimulating factor (rhGM-CSF) has been investigated. Utilizing nucleotide…”
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Photoaffinity labeling of human placental NAD+-linked 15-hydroxyprostaglandin dehydrogenase with [α-32P]2N3NAD by CHAVAN, A. J, ENSOR, C. M, PING WU, HALEY, B. E, HSIN-HSIUNG TAI

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