Search Results - "CHATENOUD, Lucienne"

CD3-specific antibodies: a portal to the treatment of autoimmunity by Chatenoud, Lucienne, Bluestone, Jeffrey A

“…Targeted immunotherapies hold great promise for the treatment and cure of autoimmune diseases. The efficacy of CD3-specific monoclonal antibody therapy in mice…”
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CD3-specific antibody-induced active tolerance: from bench to bedside by Chatenoud, Lucienne

“…Although they were used initially as non-specific immunosuppressants in transplantation, CD3-specific monoclonal antibodies have elicited renewed interest…”
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Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling by Lepelley, Alice, Martin-Niclós, Maria José, Le Bihan, Melvin, Marsh, Joseph A, Uggenti, Carolina, Rice, Gillian I, Bondet, Vincent, Duffy, Darragh, Hertzog, Jonny, Rehwinkel, Jan, Amselem, Serge, Boulisfane-El Khalifi, Siham, Brennan, Mary, Carter, Edwin, Chatenoud, Lucienne, Chhun, Stéphanie, Coulomb l'Hermine, Aurore, Depp, Marine, Legendre, Marie, Mackenzie, Karen J, Marey, Jonathan, McDougall, Catherine, McKenzie, Kathryn J, Molina, Thierry Jo, Neven, Bénédicte, Seabra, Luis, Thumerelle, Caroline, Wislez, Marie, Nathan, Nadia, Manel, Nicolas, Crow, Yanick J, Frémond, Marie-Louise

“…Heterozygous missense mutations in coatomer protein subunit α, COPA, cause a syndrome overlapping clinically with type I IFN-mediated disease due to…”
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Antibiotics in early life alter the gut microbiome and increase disease incidence in a spontaneous mouse model of autoimmune insulin-dependent diabetes by Candon, Sophie, Perez-Arroyo, Alicia, Marquet, Cindy, Valette, Fabrice, Foray, Anne-Perrine, Pelletier, Benjamin, Milani, Christian, Milani, Cristian, Ventura, Marco, Bach, Jean-François, Chatenoud, Lucienne

“…Insulin-dependent or type 1 diabetes is a prototypic autoimmune disease whose incidence steadily increased over the past decades in industrialized countries…”
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TGFβ-dependent expression of PD-1 and PD-L1 controls CD8(+) T cell anergy in transplant tolerance by Baas, Marije, Besançon, Alix, Goncalves, Tania, Valette, Fabrice, Yagita, Hideo, Sawitzki, Birgit, Volk, Hans-Dieter, Waeckel-Enée, Emmanuelle, Rocha, Benedita, Chatenoud, Lucienne, You, Sylvaine

“…CD8(+) T cell anergy is a critical mechanism of peripheral tolerance, poorly investigated in response to immunotherapy. Here, using a pancreatic islet…”
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Cutting Edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients by Hutchinson, James A, Riquelme, Paloma, Sawitzki, Birgit, Tomiuk, Stefan, Miqueu, Patrick, Zuhayra, Maaz, Oberg, Hans H, Pascher, Andreas, Lützen, Ulf, Janssen, Uwe, Broichhausen, Christiane, Renders, Lutz, Thaiss, Friedrich, Scheuermann, Ernst, Henze, Eberhard, Volk, Hans-Dieter, Chatenoud, Lucienne, Lechler, Robert I, Wood, Kathryn J, Kabelitz, Dieter, Schlitt, Hans J, Geissler, Edward K, Fändrich, Fred

“…Regulatory macrophages (M regs) were administered to two living-donor renal transplant recipients. Both patients were minimized to low-dose tacrolimus…”
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Restricted specificity of peripheral alloreactive memory B cells in HLA-sensitized patients awaiting a kidney transplant by Snanoudj, Renaud, Claas, Frans H J, Heidt, Sebastiaan, Legendre, Christophe, Chatenoud, Lucienne, Candon, Sophie

“…The contribution of memory B cells in alloreactive humoral responses remains poorly understood. Here we tested the presence of circulating alloreactive memory…”
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Concise Review: Pluripotent Stem Cell‐Derived Cardiac Cells, A Promising Cell Source for Therapy of Heart Failure: Where Do We Stand? by Gouadon, Elodie, Moore‐Morris, Thomas, Smit, Nicoline W., Chatenoud, Lucienne, Coronel, Ruben, Harding, Sian E., Jourdon, Philippe, Lambert, Virginie, Rucker‐Martin, Catherine, Pucéat, Michel

“…Heart failure is still a major cause of hospitalization and mortality in developed countries. Many clinical trials have tested the use of multipotent stem…”
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Adaptive TGF-β-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment by You, Sylvaine, Leforban, Bertrand, Garcia, Corinne, Bach, Jean-François, Bluestone, Jeffrey A, Chatenoud, Lucienne

“…Previous results have shown that CD4⁺CD25⁺ regulatory T cells (Tregs) control autoimmunity in a spontaneous model of type 1 diabetes, the nonobese diabetic…”
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Inducing and Administering Tregs to Treat Human Disease by Perdigoto, Ana Luisa, Chatenoud, Lucienne, Bluestone, Jeffrey A, Herold, Kevan C

“…Regulatory T cells (Tregs) control unwanted immune responses, including those that mediate tolerance to self as well as to foreign antigens. Their mechanisms…”
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IL-4 and IL-17 Are Required for House Dust Mite-Driven Airway Hyperresponsiveness in Autoimmune Diabetes-Prone Non-Obese Diabetic Mice by Foray, Anne-Perrine, Dietrich, Céline, Pecquet, Coralie, Machavoine, François, Chatenoud, Lucienne, Leite-de-Moraes, Maria

“…Allergic asthma is characterized by airway inflammation with a Th2-type cytokine profile, hyper-IgE production, mucus hypersecretion, and airway…”
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Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice by Chatenoud, Lucienne, Marquet, Cindy, Valette, Fabrice, Scott, Lindsay, Quan, Jiexia, Bu, Chun Hui, Hildebrand, Sara, Moresco, Eva Marie Y, Bach, Jean-François, Beutler, Bruce

“…Genetic association studies of type 1 diabetes (T1D) in humans, and in congenic non-obese diabetic (NOD) mice harboring DNA segments from T1D-resistant mice,…”
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CD8+ T-Cell Responses Identify β-Cell Autoimmunity in Human Type 1 Diabetes by Mallone, Roberto, Martinuzzi, Emanuela, Blancou, Philippe, Novelli, Giulia, Afonso, Georgia, Dolz, Manuel, Bruno, Graziella, Chaillous, Lucy, Chatenoud, Lucienne, Bach, Jean-Marie, van Endert, Peter

“…CD8 + T-Cell Responses Identify β-Cell Autoimmunity in Human Type 1 Diabetes Roberto Mallone 1 2 , Emanuela Martinuzzi 1 2 , Philippe Blancou 3 4 , Giulia…”
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A historical view from thirty eventful years of immunotherapy in autoimmune diabetes by Bach, Jean-François, Chatenoud, Lucienne

“…Highlights ► Adequate immunotherapy strategies can halt the progression of Type 1 diabetes. ► CD3 antibodies are able to restore immune tolerance in Type 1…”
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Understanding Pathogenesis and Care Challenges of Immune Reconstitution Inflammatory Syndrome in Fungal Infections by Dellière, Sarah, Guery, Romain, Candon, Sophie, Rammaert, Blandine, Aguilar, Claire, Lanternier, Fanny, Chatenoud, Lucienne, Lortholary, Olivier

“…Immune deficiency of diverse etiology, including human immunodeficiency virus (HIV), antineoplastic agents, immunosuppressive agents used in solid organ…”
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Efficacy of BAFF inhibition and B-cell depletion in non-obese diabetic mice as a spontaneous model for Sjögren’s disease by Felten, Renaud, Foray, Anne-Perrine, Schneider, Pascal, Marquet, Cindy, Pecquet, Coralie, Monneaux, Fanny, Dumortier, Hélène, Sibilia, Jean, Valette, Fabrice, Chatenoud, Lucienne, Gottenberg, Jacques-Eric

“…IntroductionThe therapeutic interest of targeting B-cell activating factor (BAFF) in Sjögren’s disease (SjD) can be suspected from the results of two phase II…”
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Therapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes by You, Sylvaine, Piali, Luca, Kuhn, Chantal, Steiner, Beat, Sauvaget, Virginia, Valette, Fabrice, Clozel, Martine, Bach, Jean-François, Chatenoud, Lucienne

“…In the present study, we investigated the therapeutic potential of a selective S1P1 receptor modulator, ponesimod, to protect and reverse autoimmune diabetes…”
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The Frequency and Immunodominance of Islet-Specific CD8+ T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment by Martinuzzi, Emanuela, Novelli, Giulia, Scotto, Matthieu, Blancou, Philippe, Bach, Jean-Marie, Chaillous, Lucy, Bruno, Graziella, Chatenoud, Lucienne, van Endert, Peter, Mallone, Roberto

“…The Frequency and Immunodominance of Islet-Specific CD8 + T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment Emanuela Martinuzzi 1 2 ,…”
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Autoimmune Diabetes Onset Results From Qualitative Rather Than Quantitative Age-Dependent Changes in Pathogenic T-Cells by YOU, Sylvaine, BELGHITH, Mériam, COBBOLD, Stephen, ALYANAKIAN, Marie-Alexandra, GOUARIN, Christine, BARRIOT, Samia, GARCIA, Corinne, WALDMANN, Herman, BACH, Jean-Frangois, CHATENOUD, Lucienne

“…Autoimmune Diabetes Onset Results From Qualitative Rather Than Quantitative Age-Dependent Changes in Pathogenic T-Cells Sylvaine You 1 2 , Mériam Belghith 1 2…”
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Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance by Kuhn, Chantal, You, Sylvaine, Valette, Fabrice, Hale, Geoff, van Endert, Peter, Bach, Jean-François, Waldmann, Herman, Chatenoud, Lucienne

“…Monoclonal antibodies have proven to be potent agents to promote immunological tolerance in animal models of autoimmune disease and transplantation. However,…”
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