Search Results - "CHATEAUNEUF, Anne"

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    Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP by Gervais, Francois G., Cruz, Rani P.G., Chateauneuf, Anne, Gale, Stephen, Sawyer, Nicole, Nantel, Francois, Metters, Kathleen M., O'Neill, Gary P.

    Published in Journal of allergy and clinical immunology (01-12-2001)
    “…Background: PGD2 is the major prostanoid released by mast cells during an allergic response. Its role in the allergic response, however, remains unclear…”
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    Journal Article
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    Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: Discovery of MK-5286 by Li, Lianhai, Berthelette, Carl, Chateauneuf, Anne, Ouellet, Marc, Sturino, Claudio F., Wang, Zhaoyin

    Published in Bioorganic & medicinal chemistry letters (15-12-2010)
    “…The strategy and SAR studies that led to the discovery of a novel potent and orally available 5-lipoxygenase (5-LO) inhibitor 3-(4-fluorophenyl)-6-({4-[(1…”
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    A Role for Ultraviolet A in solar Mutagenesis by Drobetsky, Elliot A., Turcotte, Johanne, Chateauneuf, Anne

    “…It is well established that exposure to solar UVB (290-320 nm) gives rise to mutations in oncogenes and tumor suppressor genes that initiate the molecular…”
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    Discovery of a potent and selective agonist of the prostaglandin EP4 receptor by BILLOT, Xavier, CHATEAUNEUF, Anne, CHAURET, Nathalie, DENIS, Danielle, GREIG, Gillian, MATHIEU, Marie-Claude, METTERS, Kathleen M, SLIPETZ, Deborah M, YOUNG, Robert N

    Published in Bioorganic & medicinal chemistry letters (24-03-2003)
    “…Analogues of PGE(2) wherein the hydroxycyclopentanone ring has been replaced by a lactam have been prepared and evaluated as ligands for the EP(4) receptor. An…”
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    The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor by Ducharme, Yves, Blouin, Marc, Brideau, Christine, Châteauneuf, Anne, Gareau, Yves, Grimm, Erich L, Juteau, Hélène, Laliberté, Sébastien, MacKay, Bruce, Massé, Frédéric, Ouellet, Marc, Salem, Myriam, Styhler, Angela, Friesen, Richard W

    Published in ACS medicinal chemistry letters (08-07-2010)
    “…The discovery of novel and selective inhibitors of human 5-lipoxygenase (5-LO) is described. These compounds are potent, orally bioavailable, and active at…”
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    Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2 by Sawyer, Nicole, Cauchon, Elizabeth, Chateauneuf, Anne, Cruz, Rani P G, Nicholson, Donald W, Metters, Kathleen M, O'Neill, Gary P, Gervais, Francois G

    Published in British journal of pharmacology (01-12-2002)
    “…The recombinant human prostaglandin D2 (PGD2) receptor, hCRTH2, has been expressed in HEK293(EBNA) and characterized with respect to radioligand binding and…”
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    Identification of a GABAB Receptor Subunit, gb2, Required for Functional GABAB Receptor Activity by Ng, G Y, Clark, J, Coulombe, N, Ethier, N, Hebert, T E, Sullivan, R, Kargman, S, Chateauneuf, A, Tsukamoto, N, McDonald, T, Whiting, P, Mezey, E, Johnson, M P, Liu, Q, Kolakowski, Jr, L F, Evans, J F, Bonner, T I, O'Neill, G P

    Published in The Journal of biological chemistry (19-03-1999)
    “…G protein-coupled receptors are commonly thought to bind their cognate ligands and elicit functional responses primarily as monomeric receptors. In studying…”
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    Molecular pharmacology of the human prostaglandin D 2 receptor, CRTH2 by Sawyer, Nicole, Cauchon, Elizabeth, Chateauneuf, Anne, Cruz, Rani P G, Nicholson, Donald W, Metters, Kathleen M, O'Neill, Gary P, Gervais, Francois G

    Published in British journal of pharmacology (01-12-2002)
    “…The recombinant human prostaglandin D 2 (PGD 2 ) receptor, hCRTH2, has been expressed in HEK293(EBNA) and characterized with respect to radioligand binding and…”
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    Journal Article
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    2,3-Diarylthiophenes as selective EP1 receptor antagonists by DUCHARME, Yves, BLOUIN, Marc, MARTINS, Evelyn, NANTEL, Francois, O'NEILL, Gary, SAWYER, Nicole, METTERS, Kathleen M, FRIESEN, Richard W, CARRIERE, Marie-Claude, CHATEAUNEUF, Anne, COTE, Bernard, DENIS, Danielle, FRENETTE, Richard, GREIG, Gillian, KARGMAN, Stacia, LAMONTAGNE, Sonia

    Published in Bioorganic & medicinal chemistry letters (15-02-2005)
    “…The synthesis and the EP(1) receptor binding affinity of 2,3-diarylthiophene derivatives are described. The evaluation of the structure-activity relationship…”
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    Discovery of a potent and selective agonist of the prostaglandin EP 4 receptor by Billot, Xavier, Chateauneuf, Anne, Chauret, Nathalie, Denis, Danielle, Greig, Gillian, Mathieu, Marie-Claude, Metters, Kathleen M, Slipetz, Deborah M, Young, Robert N

    “…Analogues of PGE 2 wherein the hydroxycyclopentanone ring has been replaced by a lactam have been prepared and evaluated as ligands for the EP 4 receptor. An…”
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    Journal Article
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