Search Results - "CHASTAIN, Michael"
-
1
A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors
Published in BMC genomics (30-06-2010)“…Hyperactivation of the Ras signaling pathway is a driver of many cancers, and RAS pathway activation can predict response to targeted therapies. Therefore,…”
Get full text
Journal Article -
2
Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors
Published in PloS one (08-02-2010)“…Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other…”
Get full text
Journal Article -
3
oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions
Published in Proceedings of the National Academy of Sciences - PNAS (14-10-2008)“…The conserved oligomannose epitope, Man₉GlcNAc₂, recognized by the broadly neutralizing human mAb 2G12 is an attractive prophylactic vaccine candidate for the…”
Get full text
Journal Article -
4
Fully Synthetic Carbohydrate HIV Antigens Designed on the Logic of the 2G12 Antibody
Published in Journal of the American Chemical Society (12-09-2007)“…Di- and trivalent glycopeptide mimics of the HIV 2G12 epitope have been synthesized and evaluated for their comparative 2G12 binding characteristics. The…”
Get full text
Journal Article -
5
Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys
Published in Vaccine (13-08-2004)“…A universal influenza virus vaccine that does not require frequent updates and/or annual immunizations will offer significant advantages over current seasonal…”
Get full text
Journal Article -
6
Universal Influenza B Vaccine Based on the Maturational Cleavage Site of the Hemagglutinin Precursor
Published in Journal of Virology (01-06-2005)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text
Journal Article -
7
Heterologous Human Immunodeficiency Virus Type 1 Priming-Boosting Immunization Strategies Involving Replication-Defective Adenovirus and Poxvirus Vaccine Vectors
Published in Journal of Virology (01-10-2004)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text
Journal Article -
8
Talimogene Laherparepvec in Combination With Ipilimumab in Previously Untreated, Unresectable Stage IIIB-IV Melanoma
Published in Journal of clinical oncology (01-08-2016)“…Combining immunotherapeutic agents with different mechanisms of action may enhance efficacy. We describe the safety and efficacy of talimogene laherparepvec…”
Get full text
Journal Article -
9
Vaccine-Induced Immune Responses in Rodents and Nonhuman Primates by Use of a Humanized Human Immunodeficiency Virus Type 1 pol Gene
Published in Journal of Virology (01-01-2002)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text
Journal Article -
10
Abstract B13: A phase 2, randomized, open-label trial assessing efficacy and safety of talimogene laherparepvec (T-VEC) neoadjuvant treatment (tx) plus surgery vs. surgery for resectable stage IIIB-IVM1a melanoma
Published in Cancer research (Chicago, Ill.) (15-07-2015)“…Abstract Background: The risk of recurrence and death in patients (pts) with stages IIIB to IVM1a melanoma following resection is high. T-VEC is an HSV-1…”
Get full text
Journal Article -
11
Phase 2, multicenter, randomized, open-label trial assessing efficacy and safety of talimogene laherparepvec (T-VEC) neoadjuvant treatment (tx) plus surgery vs surgery for resectable stage IIIB/C and IVM1a melanoma (MEL)
Published in Journal of clinical oncology (20-05-2015)“…Abstract only…”
Get full text
Journal Article -
12
Comparative Immunogenicity in Rhesus Monkeys of DNA Plasmid, Recombinant Vaccinia Virus, and Replication-Defective Adenovirus Vectors Expressing a Human Immunodeficiency Virus Type 1 gag Gene
Published in Journal of Virology (01-06-2003)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text
Journal Article -
13
Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination
Published in Science (American Association for the Advancement of Science) (20-10-2000)“…With accumulating evidence indicating the importance of cytotoxic T lymphocytes (CTLs) in containing human immunodeficiency virus-1 (HIV-1) replication in…”
Get full text
Journal Article -
14
Primary analysis of a phase 1b multicenter trial to evaluate safety and efficacy of talimogene laherparepvec (T-VEC) and ipilimumab (ipi) in previously untreated, unresected stage IIIB-IV melanoma
Published in Journal of clinical oncology (20-05-2014)“…Abstract only…”
Get full text
Journal Article -
15
A novel MHC- dextramer assay to identify melanoma antigen-specific CD8+ T cells from solid tumor disaggregates and matched peripheral blood
Published in Journal for immunotherapy of cancer (04-11-2015)“…BackgroundCytotoxic CD8+ T lymphocytes (CTL) mediate target cell killing of tumor cells. New technological advances in multi-parameter flow cytometry have…”
Get full text
Journal Article -
16
Enhanced in vivo transgene expression and immunogenicity from plasmid vectors following electrostimulation in rodents and primates
Published in Vaccine (19-09-2008)“…Abstract Safe and efficient methods for in vivo delivery of transgenes of interest must be developed so that the promise of these therapies can be practically…”
Get full text
Journal Article Conference Proceeding -
17
Enhancedin vivotransgene expression and immunogenicity from plasmid vectors following electrostimulation in rodents and primates
Published in Vaccine (19-09-2008)“…Safe and efficient methods forin vivodelivery of transgenes of interest must be developed so that the promise of these therapies can be practically used in the…”
Get full text
Journal Article -
18
Distinct expression profiles of Notch-1 protein in human solid tumors : implications for development of targeted therapeutic monoclonal antibodies
Published in Biologics (24-06-2010)“…Reports the results of immunohistochemistry performed on tissue microarrays to determine whether the Notch-1 receptor is overexpressed in tumour cells as…”
Get full text
Journal Article -
19
Vaccination of mice with replication-defective human immunodeficiency virus induces cellular and humoral immunity and protects against vaccinia virus-gag challenge
Published in Molecular therapy (01-09-2006)“…Here we describe as a potential vaccine candidate a replication-defective HIV that encodes multiple viral genes in addition to a cassette that includes both…”
Get full text
Journal Article -
20
Poly(rA) ioinos poly(rG) poly(rC) to form a tripie helix
Published in Nucleic acids research (25-01-1992)“…Poly(rA) blinds poIy(rG).poly(rC) to form a triple helix. Evidence for this structure includes ultraviolet absorbance mixing curves and melting curves, and…”
Get full text
Journal Article