Search Results - "CHARPENTIER, Monica S"

α-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration by Boggs, Amanda E, Vitolo, Michele I, Whipple, Rebecca A, Charpentier, Monica S, Goloubeva, Olga G, Ioffe, Olga B, Tuttle, Kimberly C, Slovic, Jana, Lu, Yiling, Mills, Gordon B, Martin, Stuart S

“…Metastatic cases of breast cancer pose the primary challenge in clinical management of this disease, demanding the identification of effective therapeutic…”
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Curcumin Targets Breast Cancer Stem-like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment by CHARPENTIER, Monica S, WHIPPLE, Rebecca A, VITOLO, Michele I, BOGGS, Amanda E, SLOVIC, Jana, THOMPSON, Keyata N, BHANDARY, Lekhana, MARTIN, Stuart S

“…Cancer stem-like cells (CSC) and circulating tumor cells (CTC) have related properties associated with distant metastasis, but the mechanisms through which…”
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Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibition by Whipple, Rebecca A, Vitolo, Michele I, Boggs, Amanda E, Charpentier, Monica S, Thompson, Keyata, Martin, Stuart S

“…Detyrosinated tubulin, a post-translational modification of α-tubulin and a hallmark of stable microtubules, has gained recent attention given its association…”
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ROCK inhibition promotes microtentacles that enhance reattachment of breast cancer cells by Bhandary, Lekhana, Whipple, Rebecca A, Vitolo, Michele I, Charpentier, Monica S, Boggs, Amanda E, Chakrabarti, Kristi R, Thompson, Keyata N, Martin, Stuart S

“…The presence of circulating tumor cells (CTCs) in blood predicts poor patient outcome and CTC frequency is correlated with higher risk of metastasis. Recently…”
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The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence by Thompson, Keyata N, Whipple, Rebecca A, Yoon, Jennifer R, Lipsky, Michael, Charpentier, Monica S, Boggs, Amanda E, Chakrabarti, Kristi R, Bhandary, Lekhana, Hessler, Lindsay K, Martin, Stuart S, Vitolo, Michele I

“…A high proportion of human tumors maintain activation of both the PI3K and Ras/MAPK pathways. In basal-like breast cancer (BBC), PTEN expression is…”
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Abstract 2161: Activation of the MAPK pathway in combination with PTEN loss leads to aggressive primary tumor formation by Thompson, Keyata N., Whipple, Rebecca A., Yoon, Jennifer R., Charpentier, Monica S., Boggs, Amanda E., Bhandary, Lekhana, Chakrabarti, Kristi R., Martin, Stuart S., Vitolo, Michele I.

“…Breast cancer is the most frequent malignancy in women, and although many breast cancers are curable via surgery, approximately one quarter maintain a latent…”
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Abstract A32: Cell dormancy and tumorigenicity due to PTEN loss by Thompson, Keyata N., Whipple, Rebecca A., Charpentier, Monica S., Boggs, Amanda E., Bhandray, Lekhana, Chakrabarti, Kristi R., Martin, Stuart S., Vitolo, Michele I.

“…Breast cancer is the most frequent malignancy in women, and although many breast cancers are curable via surgery, approximately one quarter maintain a latent…”
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Abstract 3160: ROCK inhibition promotes microtentacle formation and reattachment of breast cancer cells by Bhandary, Lekhana, Vitolo, Michele I., Bettes, Rebecca A., Charpentier, Monica S., Boggs, Amanda E., Slovic, Jana, Thompson, Keyata, Martin, Stuart S.

“…Circulating Tumor Cells (CTCs) predict poor patient outcome and increased CTC detection is correlated with higher risk of metastasis. The efficiency of cancers…”
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Abstract 1480: The effect of Metformin on microtentacle formation and stabilization in breast cancer cells by Chakrabarti, Kristi, Whipple, Rebecca A., Boggs, Amanda E., Charpentier, Monica S., Slovic, Jana, Vitolo, Michele I., Martin, Stuart S.

“…Metastasis is one of the main causes of mortality in women with breast cancer. Epithelial-to-mesenchymal transition (EMT) has emerged to be a key mediator of…”
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Abstract 2627: Acetylation of α-tubulin contributes to microtentacle formation and re-attachment in suspended breast tumor cells by Boggs, Amanda E., Vitolo, Michele I., Bettes, Rebecca A., Slovic, Jana, Charpentier, Monica S., Martin, Stuart S.

“…Circulating tumor cells (CTCs) seed distant and recurrent metastases, the leading cause of breast cancer-related death. However, few laboratories are…”
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Abstract 276: Microtentacle stabilization during TGFβ-induced EMT as a new therapeutic target to reduce circulating tumor cell metastasis by Slovic, Jana, Vitolo, Michele I., Whipple, Rebbecca A., Boggs, Amanda E., Charpentier, Monica S., Bhandary, Lekhana, Thompson, Keyata, Martin, Stuart S.

“…Circulating tumor cells (CTCs) have been identified as a predictive factor of patient outcome and disease progression in breast cancer. Solid tumor metastasis…”
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Abstract 3772: The role of microtentacles in the metastatic potential of breast tumor stem cells by Charpentier, Monica S., Bettes, Rebecca A., Vitolo, Michele I., Boggs, Amanda E., Slovic, Jana, Thompson, Keyata, Bhandary, Lekhana, Yoon, Jennifer, Martin, Stuart S.

“…Breast cancer is the 2nd leading cause of cancer-related death among women; however, the majority of deaths arise as complications from metastasis, rather than…”
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Abstract 3122: PTEN loss disrupts the actin cortex to promote tubulin microtentacle formation and increased metastatic potential by Vitolo, Michele I., Boggs, Amanda E., Thompson, Keyata, Whipple, Rebecca A., Yoon, Jennifer R., Slovic, Jana, Charpentier, Monica S., Matrone, Michael A., Martin, Stuart S.

“…Breast cancer is the most frequent malignancy in women, and although many breast cancers are curable via surgery, approximately one quarter maintain a latent…”
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