Search Results - "CHARIOT, A"

Editorial Expression of Concern: Restoration of SHIP-1 activity in human leukemic cells modifies NF-jB activation pathway and cellular survival upon oxidative stress by Gloire, G., Charlier, E., Rahmouni, S., Volanti, C., Chariot, A., Erneux, C., Piette, J.

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TLR-4, IL-1R and TNF-R signaling to NF-κB: variations on a common theme by Verstrepen, L, Bekaert, T, Chau, T.-L, Tavernier, J, Chariot, A, Beyaert, R

“…Toll-like receptors (TLRs) as well as the receptors for tumor necrosis factor (TNF-R) and interleukin-1 (IL-1R) play an important role in innate immunity by…”
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Differential usage of NF-κB activating signals by IL-1β and TNF-α in pancreatic beta cells by Ortis, F., Miani, M., Colli, M.L., Cunha, D.A., Gurzov, E.N., Allagnat, F., Chariot, A., Eizirik, D.L.

“…► Differential usage of IKK complex components by IL-1β and TNF-α in beta cells. ► The IKK complex induced by IL-1β in beta cells lacks the IKKβ subunit. ►…”
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Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells by Ortis, F, Pirot, P, Naamane, N, Kreins, A. Y, Rasschaert, J, Moore, F, Théâtre, E, Verhaeghe, C, Magnusson, N. E, Chariot, A, Ørntoft, T. F, Eizirik, D. L

“…Aims/hypothesis IL-1β and TNF-α contribute to pancreatic beta cell death in type 1 diabetes. Both cytokines activate the transcription factor nuclear factor-κB…”
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PO-168 IKBKE regulates TSC1 for the activation of mTOR/S6K pathway in tumour cells by Göktuna, S, Chariot, A

“…IntroductionIKBKE (IKKε) has emerged as an oncogenic protein which has diverse substrate selectivity in tumorigenic pathways in multiple malignancies. mTOR…”
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MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation by Shostak, K, Patrascu, F, Göktuna, S I, Close, P, Borgs, L, Nguyen, L, Olivier, F, Rammal, A, Brinkhaus, H, Bentires-Alj, M, Marine, J-C, Chariot, A

“…Restoration of p53 tumor suppressor function through inhibition of its interaction and/or enzymatic activity of its E3 ligase, MDM2, is a promising therapeutic…”
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IKKε/IKBKE integrates LPS and IL-17A signaling cascades to establish an inflammatory microenvironment in intestinal tumors by Goktuna, S, Shostak, K, Chau, T.L, Heukamp, L, Close, P, Rahmouni, S, Van Loo, G, Buttner, R, Greten, F, Chariot, A

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Restoration of SHIP-1 activity in human leukemic cells modifies NF-κB activation pathway and cellular survival upon oxidative stress by GLOIRE, G, CHARLIER, E, RAHMOUNI, S, VOLANTI, C, CHARIOT, A, ERNEUX, C, PIETTE, J

“…Nuclear factor-kappa B (NF-κB) is an important prosurvival transcription factor activated in response to a large array of external stimuli, including reactive…”
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NF-κB2/p100 induces Bcl-2 expression by VIATOUR, P, BENTIRES-ALJ, M, CHARIOT, A, DEREGOWSKI, V, DE LEVAL, L, MERVILLE, M-P, BOURS, V

“…The NF-kappaB2/p100 and bcl-3 genes are involved in chromosomal translocations described in chronic lymphocytic leukemias (CLL) and non-Hodgkin's lymphomas,…”
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SHIP-1 inhibits CD95 APO-1 Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity by Charlier, E, Condé, C, Zhang, J, Deneubourg, L, Di Valentin, E, Rahmouni, S, Chariot, A, Agostinis, P, Pang, P-C, Haslam, S M, Dell, A, Penninger, J, Erneux, C, Piette, J, Gloire, G

“…SHIP-1 (SH2 (Src homology 2)-containing inositol 5′-phosphatase-1) functions as a negative regulator of immune responses by hydrolyzing…”
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Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB by BENOIT, V, DE MORAES, E, MERVILLE, M.-P, HAINAUT, P, DAR, N. A, TARANCHON, E, BOURS, V, HAUTEFEUILLE, A, TANIERE, P, CHARIOT, A, SCOAZEC, J.-Y, DE MOURA GALLO, C. V

“…Overexpression of cyclooxygenase-2 (Cox-2) is thought to exert antiapoptotic effects in cancer. Here we show that the tumor suppressor p53 upregulated Cox-2 in…”
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Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-[kappa]B2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes by Robert, I, Aussems, M, Keutgens, A, Zhang, X, Hennuy, B, Viatour, P, Vanstraelen, G, Merville, M-p, Chapelle, J-p, De Leval, L, Lambert, F, Dejardin, E, Gothot, A, Chariot, A

“…Constitutive nuclear factor (NF)-kappaB activation in haematological malignancies is caused in several cases by loss of function mutations within the coding…”
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Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-κB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes by Robert, I, Aussems, M, Keutgens, A, Zhang, X, Hennuy, B, Viatour, P, Vanstraelen, G, Merville, M-P, Chapelle, J-P, de Leval, L, Lambert, F, Dejardin, E, Gothot, A, Chariot, A

“…Constitutive nuclear factor (NF)-κB activation in haematological malignancies is caused in several cases by loss of function mutations within the coding…”
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Screening of 14 alkaloids isolated from Haplophyllum A. Juss. for their cytotoxic properties by Jansen, Olivia, Akhmedjanova, V., Angenot, L., Balansard, G., Chariot, A., Ollivier, E., Tits, M., Frédérich, M.

“…Further to a systematic chemotaxonomic study of Uzbek Haplophyllum A. Juss. plants selected on ethnopharmacological data, 14 alkaloids were screened for their…”
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Deregulated expression of TANK in glioblastomas triggers pro-tumorigenic ERK1/2 and AKT signaling pathways by Stellzig, J, Chariot, A, Shostak, K, Ismail Göktuna, S, Renner, F, Acker, T, Pagenstecher, A, Schmitz, M L

“…Signal transmission by the noncanonical IkappaB kinases (IKKs), TANK-binding kinase 1 (TBK1) and IKKɛ, requires interaction with adapter proteins such as TRAF…”
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Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation by Viatour, Patrick, Merville, Marie-Paule, Bours, Vincent, Chariot, Alain

“…Nuclear factor-κB (NF-κB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis. Activation of NF-κB…”
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Elongator Controls the Migration and Differentiation of Cortical Neurons through Acetylation of α-Tubulin by Creppe, Catherine, Malinouskaya, Lina, Volvert, Marie-Laure, Gillard, Magali, Close, Pierre, Malaise, Olivier, Laguesse, Sophie, Cornez, Isabelle, Rahmouni, Souad, Ormenese, Sandra, Belachew, Shibeshih, Malgrange, Brigitte, Chapelle, Jean-Paul, Siebenlist, Ulrich, Moonen, Gustave, Chariot, Alain, Nguyen, Laurent

“…The generation of cortical projection neurons relies on the coordination of radial migration with branching. Here, we report that the multisubunit histone…”
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Retinoic Acid Induces Three Newly Cloned HOXA1 Transcripts in MCF7 Breast Cancer Cells by Chariot, A., Moreau, L., Senterre, G., Sobel, M.E., Castronovo, V.

“…Coordinated expression of genes involved in development, differentiation and malignant transformation is regulated by transcription factors including…”
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Are the IKKs and IKK-related kinases TBK1 and IKK-ε similarly activated ? by Chau, Tieu-Lan, Gioia, Romain, Gatot, Jean-Stéphane, Patrascu, Felicia Alina, Carpentier, Isabelle, Chapelle, Jean-Paul, O'Neill, Luke, Beyaert, Rudi, Piette, Jacques, Chariot, Alain

“…The IkappaB kinases (IKKs) IKK-alpha and IKK-beta, and the IKK-related kinases TBK1 and IKK-epsilon, have essential roles in innate immunity through…”
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Cemip is a new key regulator of chondrocytes transdifferentiation involved in osteoarthritic cartilage fibrosis by Deroyer, C., Charlier, E., Neuville, S., Malaise, O., Relic, B., Chariot, A., Malaise, M., de Seny, D.

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