Search Results - "CHAPPLE, Charles"

VarSome: the human genomic variant search engine by Kopanos, Christos, Tsiolkas, Vasilis, Kouris, Alexandros, Chapple, Charles E, Albarca Aguilera, Monica, Meyer, Richard, Massouras, Andreas

“…VarSome.com is a search engine, aggregator and impact analysis tool for human genetic variation and a community-driven project aiming at sharing global…”
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Extreme multifunctional proteins identified from a human protein interaction network by Chapple, Charles E., Robisson, Benoit, Spinelli, Lionel, Guien, Céline, Becker, Emmanuelle, Brun, Christine

“…Moonlighting proteins are a subclass of multifunctional proteins whose functions are unrelated. Although they may play important roles in cells, there has been…”
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Multifunctional proteins revealed by overlapping clustering in protein interaction network by Becker, Emmanuelle, Robisson, Benoît, Chapple, Charles E., Guénoche, Alain, Brun, Christine

“…Motivation: Multifunctional proteins perform several functions. They are expected to interact specifically with distinct sets of partners, simultaneously or…”
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Relaxation of selective constraints causes independent selenoprotein extinction in insect genomes by Chapple, Charles E, Guigó, Roderic

“…Selenoproteins are a diverse family of proteins notable for the presence of the 21st amino acid, selenocysteine. Until very recently, all metazoan genomes…”
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Redefining protein moonlighting by Chapple, Charles E, Brun, Christine

“…We recently presented the first computational method for the large-scale identification of what we have termed "extreme multifunctional proteins" (EMF) [1]…”
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Relationships between predicted moonlighting proteins, human diseases, and comorbidities from a network perspective by Zanzoni, Andreas, Chapple, Charles E, Brun, Christine

“…Moonlighting proteins are a subset of multifunctional proteins characterized by their multiple, independent, and unrelated biological functions. We recently…”
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Clust&See: A Cytoscape plugin for the identification, visualization and manipulation of network clusters by Spinelli, Lionel, Gambette, Philippe, Chapple, Charles E., Robisson, Benoît, Baudot, Anaïs, Garreta, Henri, Tichit, Laurent, Guénoche, Alain, Brun, Christine

“…Large networks, such as protein interaction networks, are extremely difficult to analyze as a whole. We developed Clust&See, a Cytoscape plugin dedicated to…”
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short motif in Drosophila SECIS Binding Protein 2 provides differential binding affinity to SECIS RNA hairpins by Takeuchi, Akiko, Schmitt, David, Chapple, Charles, Babaylova, Elena, Karpova, Galina, Guigo, Roderic, Krol, Alain, Allmang, Christine

“…Selenoproteins contain the amino acid selenocysteine which is encoded by a UGA Sec codon. Recoding UGA Sec requires a complex mechanism, comprising the…”
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SECISaln, a web-based tool for the creation of structure-based alignments of eukaryotic SECIS elements by Chapple, Charles E., Guigó, Roderic, Krol, Alain

“…Selenoproteins contain the 21st amino acid selenocysteine which is encoded by an inframe UGA codon, usually read as a stop. In eukaryotes, its co-translational…”
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PrOnto database : GO term functional dissimilarity inferred from biological data by Chapple, Charles E, Herrmann, Carl, Brun, Christine

“…Moonlighting proteins are defined by their involvement in multiple, unrelated functions. The computational prediction of such proteins requires a formal method…”
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comparison of random sequence reads versus 16S rDNA sequences for estimating the biodiversity of a metagenomic library by Manichanh, Chaysavanh, Chapple, Charles E, Frangeul, Lionel, Gloux, Karine, Guigo, Roderic, Dore, Joel

“…The construction of metagenomic libraries has permitted the study of microorganisms resistant to isolation and the analysis of 16S rDNA sequences has been used…”
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Diversity and Functional Plasticity of Eukaryotic Selenoproteins: Identification and Characterization of the SelJ Family by Castellano, Sergi, Lobanov, Alexey V., Charles Chapple, Novoselov, Sergey V., Mario Albrecht, Deame Hua, Alain Lescure, Lengauer, Thomas, Alain Krol, Gladyshev, Vadim N., Guigó, Roderic

“…Selenoproteins are a diverse group of proteins that contain selenocysteine (Sec), the 21st amino acid. In the genetic code, UGA serves as a termination signal…”
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Nematode selenoproteome: the use of the selenocysteine insertion system to decode one codon in an animal genome? by Taskov, Kalin, Chapple, Charles, Kryukov, Gregory V., Castellano, Sergi, Lobanov, Alexey V., Korotkov, Konstantin V., Guigó, Roderic, Gladyshev, Vadim N.

“…Selenocysteine (Sec) is co-translationally inserted into selenoproteins in response to codon UGA with the help of the selenocysteine insertion sequence (SECIS)…”
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Correction: Relaxation of Selective Constraints Causes Independent Selenoprotein Extinction in Insect Genomes by Chapple, Charles E., Guigó, Roderic

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Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution by Elsik, Christine G, Tellam, Ross L, Worley, Kim C

“…To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of…”
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Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype by Weissenbach, Jean, Jaillon, Olivier, Aury, Jean-Marc, Brunet, Frédéric, Petit, Jean-Louis, Stange-Thomann, Nicole, Mauceli, Evan, Bouneau, Laurence, Fischer, Cécile, Ozouf-Costaz, Catherine, Bernot, Alain, Nicaud, Sophie, Jaffe, David, Fisher, Sheila, Lutfalla, Georges, Dossat, Carole, Segurens, Béatrice, Dasilva, Corinne, Salanoubat, Marcel, Levy, Michael, Boudet, Nathalie, Castellano, Sergi, Anthouard, Véronique, Jubin, Claire, Castelli, Vanina, Katinka, Michael, Vacherie, Benoît, Biémont, Christian, Skalli, Zineb, Cattolico, Laurence, Poulain, Julie, de Berardinis, Véronique, Cruaud, Corinne, Duprat, Simone, Brottier, Philippe, Coutanceau, Jean-Pierre, Gouzy, Jérôme, Parra, Genis, Lardier, Guillaume, Chapple, Charles, McKernan, Kevin J, McEwan, Paul, Bosak, Stephanie, Kellis, Manolis, Volff, Jean-Nicolas, Guigó, Roderic, Zody, Michael C, Mesirov, Jill, Lindblad-Toh, Kerstin, Birren, Bruce, Nusbaum, Chad, Kahn, Daniel, Robinson-Rechavi, Marc, Laudet, Vincent, Schachter, Vincent, Quétier, Francis, Saurin, William, Scarpelli, Claude, Wincker, Patrick, Lander, Eric S, Roest Crollius, Hugues

“…Tetraodon nigroviridis is a freshwater puffer fish with the smallest known vertebrate genome. Here, we report a draft genome sequence with long-range linkage…”
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Hyaline membrane syndrome by CHAPPLE, C C

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A duosyndrome of the laryngeal nerve by CHAPPLE, C C

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Genome duplication in the teleost fish Tetraodon nigroviddis reveals the eddy vertebrate proto-karyotype by JAILLON, Olivier, AURY, Jean-Marc, NICAUD, Sophie, JAFFE, David, FISHER, Sheila, LUTFALLA, Georges, DOSSAT, Carole, SEGURENS, Béatrice, DASILVA, Corinne, SALANOUBAT, Marcel, LEVY, Michael, BOUDET, Nathalie, BRUNET, Frédéric, CASTELLANO, Sergi, ANTHOUARD, Véronique, JUBIN, Claire, CASTELLI, Vanina, KAFINKA, Michael, VACHERIE, Benoit, BIEMONT, Christian, SKALLI, Zineb, CATTOLLICO, Laurence, POULAIN, Julie, PETIT, Jean-Louis, DE BERARDINIS, Véronique, CRUAUD, Corinne, DUPRAT, Simone, BROTTIER, Philippe, COUTANCEAU, Jean-Pierre, GOUZY, Jérome, PARRA, Genis, LARDIER, Guillaume, CHAPPLE, Charles, MCKERNAN, Kevin J, STANGE-THOMANN, Nicole, MCEWAN, Paul, BOSAK, Stephanie, KELLIS, Manolis, VOLFF, Jean-Nicolas, GUIGO, Roderic, ZODY, Michael C, MESIROV, Jill, LINDBLAD-TOH, Kerstin, BIRREN, Bruce, NUSBAUM, Chad, MAUCELI, Evan, KAHN, Daniel, ROBINSON-RECHAVI, Marc, LAUDET, Vincent, SCHACHTER, Vincent, QUETIER, Francis, SAURIN, William, SCARPELLI, Claude, WINCKER, Patrick, LANDER, Eric S, WELSSENBACH, Jean, BOUNEAU, Laurence, FISCHER, Cécile, OZOUF-COSTAZ, Catherine, BERNOT, Alain

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Phenotypic Similarities and Differences Between CALLA-Positive Acute Lymphoblastic Leukemia Cells and Normal Marrow CALLA-Positive B Cell Precursors by Ryan, Daniel H., Chapple, Charles W., Kossover, Stuart A., Sandberg, Avery A., Cohen, Harvey J.

“…Expression of differentiation markers in common acute lymphoblastic leukemia (cALL) cells from 25 patients was compared with subpopulations of normal common…”
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