Search Results - "CHAPPELL, M. J"

Predicting QRS and PR interval prolongations in humans using nonclinical data by Bergenholm, L, Parkinson, J, Mettetal, J, Evans, N D, Chappell, M J, Collins, T

“…Background and Purpose Risk of cardiac conduction slowing (QRS/PR prolongations) is assessed prior to clinical trials using in vitro and in vivo studies…”
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A mathematical model characterising Achilles tendon dynamics in flexion by Chatzistefani, N., Chappell, M.J., Hutchinson, C., Kletzenbauer, S., Evans, N.D.

“…•A novel coupled dynamic foot and Achilles tendon model is presented.•Achilles tendon model permits identification of key elasticity constant.•Whole model…”
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Structural identifiability of surface binding reactions involving heterogeneous analyte: Application to surface plasmon resonance experiments by Evans, N.D., Moyse, H.A.J., Lowe, D., Briggs, D., Higgins, R., Mitchell, D., Zehnder, D., Chappell, M.J.

“…Binding affinities are useful measures of target interaction and have an important role in understanding biochemical reactions that involve binding mechanisms…”
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Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment by Collins, TA, Bergenholm, L, Abdulla, T, Yates, JWT, Evans, N, Chappell, MJ, Mettetal, JT

“…Systems pharmacology modeling and pharmacokinetic‐pharmacodynamic (PK/PD) analysis of drug‐induced effects on cardiovascular (CV) function plays a crucial role…”
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Structural identifiability and indistinguishability analyses of the Minimal Model and a Euglycemic Hyperinsulinemic Clamp model for glucose–insulin dynamics by Chin, S.V, Chappell, M.J

“…Abstract Many mathematical models have been developed to describe glucose–insulin kinetics as a means of analysing the effective control of diabetes. This…”
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Kinetic modelling of haemodialysis removal of myoglobin in rhabdomyolysis patients by Keir, R, Evans, N.D, Hutchison, C.A, Vigano, M.R, Stella, A, Fabbrini, P, Storr, M, Chappell, M.J

“…Abstract An extended two compartment model is proposed to describe the dynamics of myoglobin in rhabdomyolysis patients undergoing dialysis. Before using…”
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A new general glucose homeostatic model using a proportional-integral-derivative controller by Watson, E.M, Chappell, M.J, Ducrozet, F, Poucher, S.M, Yates, J.W.T

“…Abstract The glucose–insulin system is a challenging process to model due to the feedback mechanisms present, hence the implementation of a model-based…”
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Evaluation of frequency and time-frequency spectral analysis of heart rate variability as a diagnostic marker of the sleep apnoea syndrome by HILTON, M. F, BATES, R. A, GODFREY, K. R, CHAPPELL, M. J, CAYTON, R. M

“…The sleep apnoea/hypopnoea syndrome (SAHS) elicits a unique heart rate rhythm that may provide the basis for an effective screening tool. The study uses the…”
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Describing the effectiveness of immunosuppression drugs and apheresis in the treatment of transplant patients by Hattersley, J.G, Chappell, M.J, Zehnder, D, Higgins, R.M, Evans, N.D

“…Highlights ► Mathematical models to describe antibody (IgG, IgA and IgM) in vivo kinetics. ► Method to predict the immune response and treatment effectiveness…”
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Combined index of heart rate variability and oximetry in screening for the sleep apnoea/hypopnoea syndrome by Raymond, Ben, Cayton, R. M, Chappell, M. J.

“…SUMMARY Many sleep centres employ a preliminary screening test in order to reduce the number of polysomnographies required in the routine diagnosis of the…”
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The use of a formal sensitivity analysis on epidemic models with immune protection from maternally acquired antibodies by Chapman, J.D, Chappell, M.J, Evans, N.D

“…Abstract This paper considers the outcome of a formal sensitivity analysis on a series of epidemic model structures developed to study the population level…”
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Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis by Hattersley, J.G, Pérez-Velázquez, J, Chappell, M.J, Bearup, D, Roper, D, Dowson, C, Bugg, T, Evans, N.D

“…Abstract An important question in Systems Biology is the design of experiments that enable discrimination between two (or more) competing chemical pathway…”
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Identifiability of uncontrolled nonlinear rational systems by Evans, N.D., Chapman, M.J., Chappell, M.J., Godfrey, K.R.

“…In this paper an approach for the identifiability analysis of uncontrolled rational systems is provided. The method is based on the use of a local smooth state…”
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Kinetic modelling of the role of the aldehyde dehydrogenase enzyme and the breast cancer resistance protein in drug resistance and transport by Atari, M.I, Chappell, M.J, Errington, R.J, Smith, P.J, Evans, N.D

“…Abstract A compartmental model for the in vitro uptake kinetics of the anti-cancer agent topotecan (TPT) has been extended from a previously published model…”
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The sleep apnoea/hypopnoea syndrome depresses waking vagal tone independent of sympathetic activation by Hilton, M.F, Chappell, M.J, Bartlett, W.A, Malhotra, A, Beattie, J.M, Cayton, R.M

“…The modest daytime hypertension and sympathetic upregulation associated with the sleep apnoea/hypopnoea syndrome (SAHS), does not explain the relatively large…”
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A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan by Chappell, M.J, Evans, N.D, Errington, R.J, Khan, I.A, Campbell, L, Ali, R, Godfrey, K.R, Smith, P.J

“…Abstract A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented…”
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The transmission and control of mastitis in dairy cows: A theoretical approach by White, L.J., Lam, T.J.G.M., Schukken, Y.H., Green, L.E., Medley, G.F., Chappell, M.J.

“…A multispecies model that incorporates the transmission of both major and minor mastitis pathogens as well as the interaction between them via coinfection of a…”
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Data reduction in headspace analysis of blood and urine samples for robust bacterial identification by Yates, J.W. T., Chappell, M.J., Gardner, J.W., Dow, C.S., Dowson, C., Hamood, A., Bolt, F., Beeby, L.

“…This paper demonstrates the application of chemical headspace analysis to the problem of classifying the presence of bacteria in biomedical samples by using…”
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A multispecies model for the transmission and control of mastitis in dairy cows by WHITE, L. J., SCHUKKEN, Y. H., LAM, T. J. G. M., MEDLEY, G. F., CHAPPELL, M. J.

“…Mastitis in dairy cows is a significant economic and animal welfare issue in the dairy industry. The bacterial pathogens responsible for infection of the…”
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The structural identifiability and parameter estimation of a multispecies model for the transmission of mastitis in dairy cows by White, L.J., Evans, N.D., Lam, T.J.G.M., Schukken, Y.H., Medley, G.F., Godfrey, K.R., Chappell, M.J.

“…A structural identifiability analysis is performed on a mathematical model for the coupled transmission of two classes of pathogen. The pathogens, classified…”
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