Search Results - "CHAPPELL, Cynthia L"

Fecal Indole as a Biomarker of Susceptibility to Cryptosporidium Infection by Chappell, Cynthia L, Darkoh, Charles, Shimmin, Lawrence, Farhana, Naveed, Kim, Do-Kyun, Okhuysen, Pablo C, Hixson, James

“…Cryptosporidium causes significant diarrhea worldwide, especially among children and immunocompromised individuals, and no effective drug treatment is…”
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Cryptosporidium meleagridis: Infectivity in Healthy Adult Volunteers by CHAPPELL, Cynthia L, OKHUYSEN, Pablo C, LANGER-CURRY, Rebecca C, AKIYOSHI, Donna E, WIDMER, Giovanni, TZIPORI, Saul

“…Most Cryptosporidium infections in humans are caused by C. parvum or C. hominis. However, genotyping techniques have identified infections caused by unusual…”
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Virulence of Three Distinct Cryptosporidium parvum Isolates for Healthy Adults by Okhuysen, Pablo C., Chappell, Cynthia L., Crabb, Joseph H., Sterling, Charles R., DuPont, Herbert L.

“…The infectivity of three Cryptosporidium parvum isolates (Iowa [calf], UCP [calf], and TAMU [horse]) of the C genotype was investigated in healthy adults…”
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High Levels of CXCL10 Are Produced by Intestinal Epithelial Cells in AIDS Patients with Active Cryptosporidiosis but Not after Reconstitution of Immunity by Wang, Heuy-Ching, Dann, Sara M, Okhuysen, Pablo C, Lewis, Dorothy E, Chappell, Cynthia L, Adler, Douglas G, White, A. Clinton Jr

“…Chemokines play key roles in attracting immune cells to sites of infections. However, few data on chemokine expression in the gut during human infections are…”
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Infectivity of a Cryptosporidium parvum Isolate of Cervine Origin for Healthy Adults and Interferon-γ Knockout Mice by Okhuysen, Pablo C., Rich, Stephen M., Chappell, Cynthia L., Grimes, Kevin A., Widmer, Giovanni, Feng, Xiaochuan, Tzipori, Saul

“…The infectivity of a Cryptosporidium parvum isolate of cervine origin (type 2, Moredun) propagated in calves was investigated simultaneously in healthy adult…”
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Cryptosporidium muris: infectivity and illness in healthy adult volunteers by Chappell, Cynthia L, Okhuysen, Pablo C, Langer-Curry, Rebecca C, Lupo, Philip J, Widmer, Giovanni, Tzipori, Saul

“…Although Cryptosporidium parvum and C. hominis cause the majority of human cryptosporidiosis cases, other Cryptosporidium species are also capable of infecting…”
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Comment on "Cryptosporidium Infection Risk: Results of New Dose-Response Modeling" - Discussion of Underlying Assumptions and Their Implications by Schmidt, Philip J., Chappell, Cynthia L.

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Cryptosporidium Dose-Response Studies: Variation Between Hosts by Teunis, Peter F. M., Chappell, Cynthia L., Okhuysen, Pablo C.

“…The issue of variation is highly important in dose‐response analysis: variation among genetically related pathogens infecting the same host, but also variation…”
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Substance P Expression Correlates with Severity of Diarrhea in Cryptosporidiosis by Robinson, Prema, Okhuysen, Pablo C., Chappell, Cynthia L., Weinstock, Joel V., Lewis, Dorothy E., Actor, Jeffrey K., White, A. Clinton

“…Cryptosporidiosis, caused by Cryptosporidium parvum, is self-limited in immunocompetent hosts but may cause chronic diarrhea in patients with acquired…”
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Cryptosporidium hominis: experimental challenge of healthy adults by Chappell, Cynthia L, Okhuysen, Pablo C, Langer-Curry, Rebecca, Widmer, Giovanni, Akiyoshi, Donna E, Tanriverdi, Sultan, Tzipori, Saul

“…Cryptosporidium hominis causes diarrhea in humans and has been associated with community outbreaks. This study describes the infectivity, illness, and…”
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Cryptosporidium parvum: Intensity of Infection and Oocyst Excretion Patterns in Healthy Volunteers by Chappell, Cynthia L., Okhuysen, Pablo C., Sterling, Charles R., DuPont, Herbert L.

“…Data about human Cryptosporidium parvum infection have originated from travelers, community and day care center outbreaks, and persons infected with the human…”
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Adenovirus 36 antibody detection: Improving the standard serum neutralization assay by Chappell, Cynthia L., Dickerson, Mary, Day, R. Sue, Dubuisson, Olga, Dhurandhar, Nikhil V.

“…•Adenovirus 36 is linked to human obesity but evidence for causation is needed.•The serum neutralization assay for specific antibody is the lengthy and…”
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Combination Drug Therapy for Cryptosporidiosis in AIDS by Smith, Nathaniel H., Cron, Stanley, Valdez, Luis M., Chappell, Cynthia L., White, A. Clinton

“…Aside from effective antiretroviral therapy, there is no consistently effective antiparasitic therapy for cryptosporidiosis in AIDS. The purpose of this study…”
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Combined use of enzyme-linked immunosorbent assay and flow cytometry to detect antibodies to Trypanosoma cruzi in domestic canines in Texas by Shadomy, Sean V, Waring, Stephen C, Martins-Filho, Olindo Assis, Oliveira, Rodrigo Corrêa, Chappell, Cynthia L

“…Canines may be sentinels and/or reservoirs for human Trypanosoma cruzi exposures. This study adapted a method originally designed for human diagnostics to…”
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Fully resolved assembly of Cryptosporidium parvum by Menon, Vipin K, Okhuysen, Pablo C, Chappell, Cynthia L, Mahmoud, Medhat, Mahmoud, Medhat, Meng, Qingchang, Doddapaneni, Harsha, Vee, Vanesa, Han, Yi, Salvi, Sejal, Bhamidipati, Sravya, Kottapalli, Kavya, Weissenberger, George, Shen, Hua, Ross, Matthew C, Hoffman, Kristi L, Cregeen, Sara Javornik, Muzny, Donna M, Metcalf, Ginger A, Gibbs, Richard A, Petrosino, Joseph F, Sedlazeck, Fritz J

“…Abstract Background Cryptosporidium parvum is an apicomplexan parasite commonly found across many host species with a global infection prevalence in human…”
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Evaluation of recombinant oocyst protein CP41 for detection of cryptosporidium-specific antibodies by Kjos, Sonia A, Jenkins, Mark, Okhuysen, Pablo C, Chappell, Cynthia L

“…Cryptosporidium is an important cause of diarrhea in developed and developing countries, and its epidemiology is of interest. The methodologies used in the…”
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Opportunities and Challenges in Developing a Cryptosporidium Controlled Human Infection Model for Testing Antiparasitic Agents by Jumani, Rajiv S, Blais, Johanne, Tillmann, Hanns-Christian, Segal, Florencia, Wetty, Dean, Ostermeier, Christian, Nuber, Natko, Lakshman, Jay, Aziz, Natasha, Chandra, Richa, Chen, Wilbur H, Chappell, Cynthia L, Diagana, Thierry T, Manjunatha, Ujjini H

“…Cryptosporidiosis is a leading cause of moderate-to-severe diarrhea in low- and middle-income countries, responsible for high mortality in children younger…”
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Antibody response of healthy adults to recombinant thrombospondin-related adhesive protein of cryptosporidium 1 after experimental exposure to cryptosporidium oocysts by Okhuysen, Pablo C, Rogers, G Aaron, Crisanti, Andrea, Spano, Furio, Huang, David B, Chappell, Cynthia L, Tzipori, Saul

“…Thrombospondin-related adhesive protein of Cryptosporidium 1 (TRAP-C1) belongs to a group of proteins that are also found in Toxoplasma gondii, Eimeria…”
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Molecular cloning and analysis of the Cryptosporidium parvum aminopeptidase N gene by PADDA, Ranjit S, TSAI, An, CHAPPELL, Cynthia L, OKHUYSEN, Pablo C

“…Cryptosporidium parvum proteases have been associated with release of infective sporozoites from oocysts, and their specific inhibition blocks parasite…”
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The Infectivity of Cryptosporidium parvum in Healthy Volunteers by DuPont, Herbert L, Chappell, Cynthia L, Sterling, Charles R, Okhuysen, Pablo C, Rose, Joan B, Jakubowski, Walter

“…C ryptosporidium parvum is a coccidian parasite of many animal species. The agent is a common cause of diarrhea in virtually all human populations, and it has…”
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