Search Results - "CHAPKIN, Robert S"

Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness by Levental, Kandice R., Malmberg, Eric, Symons, Jessica L., Fan, Yang-Yi, Chapkin, Robert S., Ernst, Robert, Levental, Ilya

“…Proper membrane physiology requires maintenance of biophysical properties, which must be buffered from external perturbations. While homeostatic adaptation of…”
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Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development by Kumar, Ritesh, Herold, Jennifer L, Schady, Deborah, Davis, Jennifer, Kopetz, Scott, Martinez-Moczygemba, Margarita, Murray, Barbara E, Han, Fang, Li, Yu, Callaway, Evelyn, Chapkin, Robert S, Dashwood, Wan-Mohaiza, Dashwood, Roderick H, Berry, Tia, Mackenzie, Chris, Xu, Yi

“…Streptococcus gallolyticus subsp. gallolyticus (Sg) has long been known to have a strong association with colorectal cancer (CRC). This knowledge has important…”
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Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs) by Safe, Stephen, Jin, Un-Ho, Park, Hyejin, Chapkin, Robert S, Jayaraman, Arul

“…The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that bound and mediated the toxic effects of…”
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Membrane lipid raft organization is uniquely modified by n-3 polyunsaturated fatty acids by Turk, Harmony F, Chapkin, Robert S

“…Abstract Fish oil, enriched in bioactive n-3 polyunsaturated fatty acids (PUFA), has been shown to play a role in prevention of colon cancer. The effects of…”
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Gene knockout inference with variational graph autoencoder learning single-cell gene regulatory networks by Yang, Yongjian, Li, Guanxun, Zhong, Yan, Xu, Qian, Chen, Bo-Jia, Lin, Yu-Te, Chapkin, Robert S, Cai, James J

“…Abstract In this paper, we introduce Gene Knockout Inference (GenKI), a virtual knockout (KO) tool for gene function prediction using single-cell RNA…”
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Flavonoids: structure–function and mechanisms of action and opportunities for drug development by Safe, Stephen, Jayaraman, Arul, Chapkin, Robert S., Howard, Marcell, Mohankumar, Kumaravel, Shrestha, Rupesh

“…Flavonoids are polyphenolic phytochemicals produced in fruits, nuts and vegetables and dietary consumption of these structurally diverse compounds is…”
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Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action by Safe, Stephen, Kothari, Jainish, Hailemariam, Amanuel, Upadhyay, Srijana, Davidson, Laurie A, Chapkin, Robert S

“…Coffee is one of the most widely consumed beverages worldwide, and epidemiology studies associate higher coffee consumption with decreased rates of mortality…”
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Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells by Jin, Un-Ho, Cheng, Yating, Park, Hyejin, Davidson, Laurie A., Callaway, Evelyn S., Chapkin, Robert S., Jayaraman, Arul, Asante, Andrew, Allred, Clinton, Weaver, Evelyn A., Safe, Stephen

“…Aryl hydrocarbon receptor (AhR) ligands are important for gastrointestinal health and play a role in gut inflammation and the induction of T regulatory cells,…”
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Ghrelin Alleviates Experimental Ulcerative Colitis in Old Mice and Modulates Colonocyte Metabolism via PPARγ Pathway by Muthyala, Srilakshmi, Chapkin, Robert S, Wu, Chaodong, Wu, Chia-Shan

“…There is a growing prevalence of inflammatory bowel disease (IBD), a chronic inflammatory condition of the gastrointestinal tract, among the aging population…”
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Shift work cycle‐induced alterations of circadian rhythms potentiate the effects of high‐fat diet on inflammation and metabolism by Kim, Sam-Moon, Neuendorff, Nichole, Alaniz, Robert C., Sun, Yuxiang, Chapkin, Robert S., Earnest, David J.

“…ABSTRACT Based on genetic models with mutation or deletion of core clock genes, circadian disruption has been implicated in the pathophysiology of metabolic…”
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Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes by Cheng, Yating, Jin, Un-Ho, Allred, Clint D, Jayaraman, Arul, Chapkin, Robert S, Safe, Stephen

“…The tryptophan microbiota metabolites indole-3-acetate, indole-3-aldehyde, indole, and tryptamine are aryl hydrocarbon receptor (AhR) ligands, and in this…”
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Dietary docosahexaenoic and eicosapentaenoic acid: Emerging mediators of inflammation by Chapkin, Robert S, Kim, Wooki, Lupton, Joanne R, McMurray, David N

“…Abstract The inflammatory response is designed to help fight and clear infection, remove harmful chemicals, and repair damaged tissue and organ systems…”
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From crypts to enteroids: establishment and characterization of avian intestinal organoids by Zhao, Dan, Farnell, Morgan B., Kogut, Michael H., Genovese, Kenneth J., Chapkin, Robert S., Davidson, Laurie A., Berghman, Luc R., Farnell, Yuhua Z.

“…Intestinal organoids (IO), known as “mini-guts”, derived from intestinal crypts, are self-organizing three-dimensional (3D) multicellular ex vivo models that…”
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Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis by Monk, Jennifer M, Hou, Tim Y, Turk, Harmony F, Weeks, Brad, Wu, Chaodong, McMurray, David N, Chapkin, Robert S

“…Clinical and experimental evidence suggests that obesity-associated inflammation increases disease activity during colitis, attributed in part to the effects…”
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A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells by Fan, Yang-Yi, Davidson, Laurie A, Callaway, Evelyn S, Wright, Gus A, Safe, Stephen, Chapkin, Robert S

“…Evidence suggests that targeting cancer cell energy metabolism might be an effective therapeutic approach for selective ablation of malignancies. Using a…”
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Involvement of Intestinal Epithelium Aryl Hydrocarbon Receptor Expression and 3, 3'-Diindolylmethane in Colonic Tertiary Lymphoid Tissue Formation by Garcia-Villatoro, Erika L, Bomstein, Zachary S, Allred, Kimberly F, Callaway, Evelyn S, Safe, Stephen, Chapkin, Robert S, Jayaraman, Arul, Allred, Clinton D

“…Tertiary lymphoid tissues (TLTs) are adaptive immune structures that develop during chronic inflammation and may worsen or lessen disease outcomes in a…”
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Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self‐renewal of colonic stem and progenitor cells by Han, Huajun, Davidson, Laurie A, Fan, Yang‐Yi, Goldsby, Jennifer S, Yoon, Grace, Jin, Un‐Ho, Wright, Gus A, Landrock, Kerstin K, Weeks, Bradley R, Wright, Rachel C, Allred, Clinton D, Jayaraman, Arul, Ivanov, Ivan, Roper, Jatin, Safe, Stephen H, Chapkin, Robert S

“…The aryl hydrocarbon receptor (AhR), a ligand‐activated transcription factor that senses xenobiotics, diet, and gut microbial‐derived metabolites, is…”
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Single-cell RNA Sequencing Reveals How the Aryl Hydrocarbon Receptor Shapes Cellular Differentiation Potency in the Mouse Colon by Yang, Yongjian, Osorio, Daniel, Davidson, Laurie A, Han, Huajun, Mullens, Destiny A, Jayaraman, Arul, Safe, Stephen, Ivanov, Ivan, Cai, James J, Chapkin, Robert S

“…Despite recent progress recognizing the importance of aryl hydrocarbon receptor (Ahr)-dependent signaling in suppressing colon tumorigenesis, its role in…”
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AdipoRon Attenuates Wnt Signaling by Reducing Cholesterol-Dependent Plasma Membrane Rigidity by Salinas, Michael L., Fuentes, Natividad R., Choate, Rachel, Wright, Rachel C., McMurray, David N., Chapkin, Robert S.

“…The increasing prevalence of adult and adolescent obesity and its associated risk of colorectal cancer reinforces the urgent need to elucidate the underlying…”
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Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin by Erazo-Oliveras, Alfredo, Muñoz-Vega, Mónica, Mlih, Mohamed, Thiriveedi, Venkataramana, Salinas, Michael L., Rivera-Rodríguez, Jaileen M., Kim, Eunjoo, Wright, Rachel C., Wang, Xiaoli, Landrock, Kerstin K., Goldsby, Jennifer S., Mullens, Destiny A., Roper, Jatin, Karpac, Jason, Chapkin, Robert S.

“…Although the role of the Wnt pathway in colon carcinogenesis has been described previously, it has been recently demonstrated that Wnt signaling originates…”
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