Search Results - "CHAPKIN, R. S"

Integrated analysis of gut metabolome, microbiome, and exfoliome data in an equine model of intestinal injury by Whitfield-Cargile, C M, Chung, H C, Coleman, M C, Cohen, N D, Chamoun-Emanuelli, A M, Ivanov, I, Goldsby, J S, Davidson, L A, Gaynanova, I, Ni, Y, Chapkin, R S

“…The equine gastrointestinal (GI) microbiome has been described in the context of various diseases. The observed changes, however, have not been linked to host…”
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Obesity promotes colonic stem cell expansion during cancer initiation by DeClercq, V, McMurray, D.N, Chapkin, R.S

“…Highlights • Colonic stem cell number is significantly higher in obese AOM-injected mice. • Apoptotic response to AOM injection is reduced in high fat fed…”
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The Microbiome and Colorectal Neoplasia: Environmental Modifiers of Dysbiosis by Turner, N. D., Ritchie, L. E., Bresalier, R. S., Chapkin, R. S.

“…The etiology of colon cancer is complex, yet it is undoubtedly impacted by intestinal microbiota. Whether the contribution to colon carcinogenesis is generated…”
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Importance of dietary gamma-linolenic acid in human health and nutrition by Fan, Y Y, Chapkin, R S

“…Considerable debate remains regarding the distinct biological activities of individual polyunsaturated fatty acids (PUFA). One of the most interesting yet…”
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Aryl hydrocarbon receptor activity in intestinal epithelial cells in the formation of colonic tertiary lymphoid tissues by Garcia-Villatoro, E L, Ufondu, A, Callaway, E S, Allred, K F, Safe, S H, Chapkin, R S, Jayaraman, A, Allred, C D

“…After birth, the development of secondary lymphoid tissues (SLTs) in the colon is dependent on the expression of the aryl hydrocarbon receptor (AhR) in immune…”
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Dietary n‐3 polyunsaturated fatty acids modulate purified murine T‐cell subset activation by Arrington, J. L., Chapkin, R. S., Switzer, K. C., Morris, J. S., Mcmurray, D. N.

“…Studies in humans and murine disease models have clearly shown dietary fish oil to possess anti‐inflammatory properties, apparently mediated by the n‐3…”
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Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis by CHANG, W.-C. L, CHAPKIN, R. S, LUPTON, J. R

“…In order to determine the prognostic significance of proliferation, differentiation, and apoptosis as intermediate markers for colon tumor development, these…”
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Dietary n‐3 polyunsaturated fatty acids suppress splenic CD4+ T cell function in interleukin (IL)‐10–/– mice by Ly, L. H., Smith, R., Chapkin, R. S., McMurray, D. N.

“…Summary Our laboratory has demonstrated that down‐regulation of proliferation and cytokine synthesis by CD4+ T cells in mice fed diets rich in n‐3…”
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Dietary (n-3) polyunsaturated fatty acids suppress murine lymphoproliferation, interleukin-2 secretion, and the formation of diacylglycerol and ceramide by Jolly, C A, Jiang, Y H, Chapkin, R S, McMurray, D N

“…Elucidation of the mechanism(s) by which dietary fish oil, enriched in eicosapentaenoic acid (EPA, 20:5(n-3)] and docosahexaenoic acid [DHA, 22:6(n-3)],…”
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Protein kinase C zeta isoform is critical for mitogenic signal transduction by Berra, E, Diaz-Meco, M T, Dominguez, I, Municio, M M, Sanz, L, Lozano, J, Chapkin, R S, Moscat, J

“…The requirement of protein kinase C zeta (zeta PKC) for maturation of X. laevis oocytes in response to insulin, p21ras, and phosphatidylcholine-hydrolyzing…”
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Differential effects of 2- and 3-series E-prostaglandins on in vitro expansion of Lgr5+ colonic stem cells by Fan, Yang-Yi, Davidson, Laurie A, Callaway, Evelyn S, Goldsby, Jennifer S, Chapkin, Robert S

“…Arachidonic acid (20:4(Δ5,8,11,14), AA)-derived prostaglandin E2 (PGE2) promotes colon cancer development. In contrast, chemoprotective n-3 polyunsaturated…”
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Dietary n‐3 PUFA affect TcR‐mediated activation of purified murine T cells and accessory cell function in co‐cultures by CHAPKIN, R. S., ARRINGTON, J. L., APANASOVICH, T. V., CARROLL, R. J., MCMURRAY, D. N.

“…Summary Diets enriched in n‐3 polyunsaturated fatty acids (PUFA) suppress several functions of murine splenic T cells by acting directly on the T cells and/or…”
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Dietary Fish Oil Reduces O6-Methylguanine DNA Adduct Levels in Rat Colon in Part by Increasing Apoptosis during Tumor Initiation by MEE YOUNG HONG, LUPTON, J. R, MORRIS, J. S, NAISYIN WANG, CARROLL, R. J, DAVIDSON, L. A, ELDER, R. H, CHAPKIN, R. S

“…There is epidemiological, clinical, and experimental evidence that dietary fish oil, containing n-3 polyunsaturated fatty acids, protects against colon tumor…”
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Wheat bran diet reduces tumor incidence in a rat model of colon cancer independent of effects on distal luminal butyrate concentrations by Zoran, D L, Turner, N D, Taddeo, S S, Chapkin, R S, Lupton, J R

“…To investigate the effects of dietary fibers in colonic luminal physiology and their role in the prevention of colon cancer, a study was conducted using two…”
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Effects of Dietary n-3 Fatty Acids on T Cell Activation and T Cell Receptor-Mediated Signaling in a Murine Model by McMurray, David N., Jolly, Christopher A., Chapkin, Robert S.

“…A short-term feeding paradigm in mice, with diets enriched with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), was used to study the modulation of…”
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Dietary fish oil and pectin enhance colonocyte apoptosis in part through suppression of PPARδ/PGE2 and elevation of PGE3 by Vanamala, J., Glagolenko, A., Yang, P., Carroll, R.J., Murphy, M.E., Newman, R.A., Ford, J.R., Braby, L.A., Chapkin, R.S., Turner, N.D., Lupton, J.R.

“…We have shown that dietary fish oil and pectin (FP) protects against radiation-enhanced colon cancer by upregulating apoptosis in colonic mucosa. To…”
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Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics by Davidson, Laurie A., Lupton, Joanne R., Jiang, Yi-Hai, Chapkin, Robert S.

“…Epidemiological and experimental data suggest that dietary fiber and fat are major determinants of colorectal cancer. However, the mechanisms by which these…”
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Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor α expression in activated murine lymphocytes by Jolly, C.A., McMurray, D.N., Chapkin, R.S.

“…Dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) suppress interleukin-2 (IL-2) secretion and impair T-lymphocyte proliferation. To determine…”
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Influence of dietary n-3 fatty acids on macrophage glycerophospholipid molecular species and peptidoleukotriene synthesis by Chapkin, RS, Akoh, CC, Miller, CC

“…The study examined the ability of dietary n-3 fatty acids to modify mouse peritoneal macrophage glycerophospholipid molecular species and peptidoleukotriene…”
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Effects of purified dietary n-3 ethyl esters on murine T lymphocyte function by Fowler, KH, Chapkin, RS, McMurray, DN

“…To precisely determine the biologic role of fish oil-derived constituents (n-3 polyunsaturated fatty acids), it is imperative that information on highly…”
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