Search Results - "CHAPIN, D. S"

Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia by Schmidt, C J, Chapin, D S, Cianfrogna, J, Corman, M L, Hajos, M, Harms, J F, Hoffman, W E, Lebel, L A, McCarthy, S A, Nelson, F R, Proulx-LaFrance, C, Majchrzak, M J, Ramirez, A D, Schmidt, K, Seymour, P A, Siuciak, J A, Tingley, 3rd, F D, Williams, R D, Verhoest, P R, Menniti, F S

“…We have recently proposed the hypothesis that inhibition of the cyclic nucleotide phosphodiesterase (PDE) 10A may represent a new pharmacological approach to…”
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Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits by SIUCIAK, Judith A, MCCARTHY, Sheryl A, MARTIN, A. N, CHAPIN, D. S, STOCK, J, NADEAU, D. M, KANTESARIA, S, BRYCE-PRITT, D, MCLEAN, S

“…The structurally related neuropeptides, substance P, neurokinin A, and neurokinin B, belong to a family of molecules termed tachykinins and are widely…”
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Reduction of brain kynurenic acid improves cognitive function by Kozak, Rouba, Campbell, Brian M, Strick, Christine A, Horner, Weldon, Hoffmann, William E, Kiss, Tamas, Chapin, Douglas S, McGinnis, Dina, Abbott, Amanda L, Roberts, Brooke M, Fonseca, Kari, Guanowsky, Victor, Young, Damon A, Seymour, Patricia A, Dounay, Amy, Hajos, Mihaly, Williams, Graham V, Castner, Stacy A

“…The elevation of kynurenic acid (KYNA) observed in schizophrenic patients may contribute to core symptoms arising from glutamate hypofunction, including…”
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Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-1B (PDE1B) enzyme by Siuciak, J.A., McCarthy, S.A., Chapin, D.S., Reed, T.M., Vorhees, C.V., Repaske, D.R.

“…PDE1B is a calcium-dependent cyclic nucleotide phosphodiesterase that is highly expressed in the striatum. In order to investigate the physiological role of…”
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Novel Benzisoxazole Derivatives as Potent and Selective Inhibitors of Acetylcholinesterase by Villalobos, Anabella, Blake, James F, Biggers, C. Kelly, Butler, Todd W, Chapin, Douglas S, Chen, Yuhpyng L, Ives, Jeffrey L, Jones, Shawn B, Liston, Dane R

“…A series of N-benzylpiperidine benzisoxazoles has been developed as potent and selective inhibitors of the enzyme acetylcholinesterase (AChE). The…”
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Teaching sacrospinous colpopexy by Chapin, David S.

“…OBJECTIVE: A method is described by which residents can perform transvaginal sacrospinous colpopexy simply, quickly, safely, and effectively. STUDY DESIGN:…”
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Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase by Lowe, John A, Archer, Robert L, Chapin, Douglas S, Cheng, John B, Helweg, David, Johnson, Jonathan L, Koe, B. Kenneth, Lebel, Lorraine A, Moore, Peter F

“…A series of quinazolinediones and azaquinazolinediones is described which possess potent inhibitory activity toward the calcium-independent phosphodiesterase…”
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Exogenous tryptophan increases synthesis, storage, and intraneuronal metabolism of 5-hydroxytryptamine in the rat hypothalamus by Lookingland, K J, Shannon, N J, Chapin, D S, Moore, K E

“…The effects of tryptophan administration on neurochemical estimates of synthesis [5-hydroxytryptophan (5-HTP) accumulation following administration of a…”
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Sertraline, a serotonin-uptake inhibitor, reduces food intake and body weight in lean rats and genetically obese mice by Nielsen, JA, Chapin, DS, Johnson, JL, Torgersen, LK

“…Sertraline was found to inhibit weight gain and decrease food intake without affecting locomotion in rats and genetically obese (ob/ob) mice. Doses of 10,…”
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Comparative effects of the neurotoxins N-chloroethyl-N-ethyl-2-bromobenzylamine hydrochloride (DSP4) and 6-hydroxydopamine on hypothalamic noradrenergic, dopaminergic and 5-hydroxytryptaminergic neurons in the male rat by Lookingland, K J, Chapin, D S, McKay, D W, Moore, K E

“…The intracerebroventricular (i.c.v.) administration of 6-hydroxydopamine (6-OHDA; 50 micrograms X 3) and the systemic administration of DSP4 (50 mg/kg X 2;…”
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Calcium-independent phosphodiesterase inhibitors as putative antidepressants : [3-(bicycloakyloxy)-4-methoxyphenyl]-2-imidazolidinones by SACCOMANO, N. A, VINICK, F. J, LEBEL, L. A, RUSSO, L. L, HELWEG, D. A, JOHNSON, J. L, IVES, J. L, WILLIAMS, I. H, KOE, B. K, NIELSEN, J. A, WHALEN, W. M, MELTZ, M, PHILLIPS, D, THADIEO, P. F, JUNG, S, CHAPIN, D. S

“…The synthesis and biological properties of a novel series of selective calcium-independent phosphodiesterase inhibitors are described. These compounds also…”
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Differential effects of d-amphetamine, beta-phenylethylamine, cocaine and methylphenidate on the rate of dopamine synthesis in terminals of nigrostriatal and mesolimbic neurons and on the efflux of dopamine metabolites into cerebroventricular perfusates of rats by Nielsen, J A, Chapin, D S, Moore, K E

“…The in vivo effects of four psychomotor stimulants (d-amphetamine, beta-phenylethylamine, cocaine and methylphenidate) were determined on: 1) the rate of…”
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Chest-wall reconstruction for spondylocostal dysostosis by Nichter, L S, Chapin, S D, Wells, W, Downey, S E

“…A child with respiratory insufficiency due to a lethal syndrome known as spondylocostal dysostosis is described. Severe chest-wall deformities with resultant…”
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The effects of continuous androgen secretion on the hypothalamic-pituitary axis in woman: evidence from a luteinized thecoma of the ovary by Dunaif, A, Scully, R E, Andersen, R N, Chapin, D S, Crowley, Jr, W F

“…Hyperandrogenic states in women are often accompanied by disruption of gonadotropin secretion. However, the role of androgens per se in the pathogenesis of…”
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5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety by Villalobos, A, Butler, T W, Chapin, D S, Chen, Y L, DeMattos, S B, Ives, J L, Jones, S B, Liston, D R, Nagel, A A, Nason, D M

“…A series of N-benzylpiperidines (2a-d, 10) with novel isoxazole-containing tricycles has been prepared. This series has shown potent in vitro inhibition of the…”
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Laparoscopically assisted vaginal hysterectomy in female-to-male transsexuals by Chapin, D S

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Electrical Properties of Ferromagnetic CrOx (1.89 < x < 2.02) by Chapin, D. S, Kafalas, J. A, Honig, J. M

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Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme by Siuciak, Judith A., McCarthy, Sheryl A., Chapin, Douglas S., Martin, Ashley N.

“…Rationale Phosphodiesterases (PDEs) belonging to the PDE4 family control intracellular concentrations of cyclic adenosine monophosphate (cAMP) by catalyzing…”
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Pontine myelinolysis after correction of hyponatremia during burn resuscitation by Cohen, B J, Jordan, M H, Chapin, S D, Cape, B, Laureno, R

“…Central pontine myelinolysis is a neurologic disease produced by the rapid correction of hyponatremia. This report describes the occurrence of central pontine…”
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Antipsychotic profile of rolipram : efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4b (PDE4B) enzyme by SIUCIAK, Judith A, CHAPIN, Douglas S, MCCARTHY, Sheryl A, MARTIN, Ashley N

“…Recent studies provide evidence for reduced phosphodiesterase-4B (PDE4B) as a genetic susceptibility factor as well as suggesting an association of several…”
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