Search Results - "CHAOYONG HE"

Dissociation of Bcl-2―Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes by CHAOYONG HE, HUAIPING ZHU, HONGLIANG LI, ZOU, Ming-Hui, ZHONGLIN XIE

“…Diabetic cardiomyopathy is associated with suppression of cardiac autophagy, and activation of AMP-activated protein kinase (AMPK) restores cardiac autophagy…”
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Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice by Li, Hongliang, Xu, Mingjiang, Lee, Jiyeon, He, Chaoyong, Xie, Zhonglin

“…Leucine supplementation has been shown to prevent high-fat diet (HFD)-induced obesity, hyperglycemia, and dyslipidemia in animal models, but the underlying…”
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AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy by Xie, Zhonglin, He, Chaoyong, Zou, Ming-Hui

“…We have recently shown that in diabetic OVE26 mice (type I diabetes), the AMP-activated protein kinase (AMPK) is reduced along with cardiac dysfunction and…”
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AMPK Suppresses Vascular Inflammation In Vivo by Inhibiting Signal Transducer and Activator of Transcription-1 by He, Chaoyong, Li, Hongliang, Viollet, Benoit, Zou, Ming-Hui, Xie, Zhonglin

“…Activation of AMPK suppresses inflammation, but the underlying mechanisms remain poorly understood. This study was designed to characterize the molecular…”
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AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response by Li, Hongliang, Min, Qing, Ouyang, Changhan, Lee, Jiyeon, He, Chaoyong, Zou, Ming-Hui, Xie, Zhonglin

“…Lipid accumulation is a central event in the development of chronic metabolic diseases, including obesity and type 2 diabetes, but the mechanisms responsible…”
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Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acids by Li, Hongliang, Lee, Jiyeon, He, Chaoyong, Zou, Ming-Hui, Xie, Zhonglin

“…Nutrient overload is associated with the development of obesity, insulin resistance, and type 2 diabetes. However, the underlying mechanisms for developing…”
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AMPKα2 Deletion Exacerbates Neointima Formation by Upregulating Skp2 in Vascular Smooth Muscle Cells by Song, Ping, Wang, Shuangxi, He, Chaoyong, Wang, Shaobin, Liang, Bin, Viollet, Benoit, Zou, Ming-Hui

“…RATIONALE:Adenosine monophosphate-activated protein kinase (AMPK), a metabolic and redox sensor, is reported to suppress cell proliferation of nonmalignant and…”
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Dysregulated mesenchymal PDGFR‐β drives kidney fibrosis by Buhl, Eva M, Djudjaj, Sonja, Klinkhammer, Barbara M, Ermert, Katja, Puelles, Victor G, Lindenmeyer, Maja T, Cohen, Clemens D, He, Chaoyong, Borkham‐Kamphorst, Erawan, Weiskirchen, Ralf, Denecke, Bernd, Trairatphisan, Panuwat, Saez‐Rodriguez, Julio, Huber, Tobias B, Olson, Lorin E, Floege, Jürgen, Boor, Peter

“…Kidney fibrosis is characterized by expansion and activation of platelet‐derived growth factor receptor‐β (PDGFR‐β)‐positive mesenchymal cells. To study the…”
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MiR-483-5p downregulation alleviates ox-LDL induced endothelial cell injury in atherosclerosis by Zhu, Hezhong, Liang, Hui, Gao, Zhen, Zhang, Xiaoqiao, He, Qian, He, Chaoyong, Cai, Chao, Chen, Jiajuan

“…Abstract Background In light of the abnormal expression of microRNA (miR-483-5p) in patients with atherosclerosis (AS), its role in vascular endothelial cell…”
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Exosomes from uterine fluid promote capacitation of human sperm by Deng, Renbin, Wu, Zhao, He, Chaoyong, Lu, Chuncheng, He, Danpeng, Li, Xi, Duan, Zhenling, Zhao, Hui

“…Extracellular vesicles (EVs) are membrane-bound vesicles containing various proteins, lipids, and nucleic acids. EVs are found in many body fluids, such as…”
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Chronic Stress-Induced Gene Changes In Vitro and In Vivo: Potential Biomarkers Associated With Depression and Cancer Based on circRNA- and lncRNA-Associated ceRNA Networks by Zhou, Ting, Li, Mingming, Xiao, Zhijun, Cai, Jian, Zhao, Weiwei, Duan, Jingjing, Yang, Zhen, Guo, Zhijun, Chen, Yitian, Cai, Weijia, Huang, Piaopiao, He, Chaoyong, Xu, Feng

“…Circular RNAs (circRNAs) and long noncoding RNAs (lncRNAs) have been considered as biomarkers or regulators in many diseases. However, the exact role of…”
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Activation of STING Pathway Contributed to Cisplatin-Induced Cardiac Dysfunction via Promoting the Activation of TNF-α-AP-1 Signal Pathway by Wang, Lintao, Zhang, Suya, Han, Jibo, Nie, Xiaoyan, Qi, Yajun, Han, Yingying, Chen, Xiong, He, Chaoyong

“…Cardiovascular complications are a well-documented limitation of conventional cancer chemotherapy. As a notable side effect of cisplatin, cardiotoxicity…”
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Polypyrimidine tract binding protein 1 exacerbates cardiac fibrosis by regulating fatty acid‐binding protein 5 by Chen, Zhen, He, Chaoyong, Gao, Zhen, Li, Yu, He, Qian, Wang, Yiyan, Cai, Chao

“…Aims The activation of cardiac fibroblasts (CFs) leads to overproduction of collagens and subsequently cardiac fibrosis. However, the regulatory mechanism of…”
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A long noncoding RNA GTF2IRD2P1 suppresses cell proliferation in bladder cancer by inhibiting the Wnt/β‑catenin signaling pathway by Huang, Zhuo, Gao, Hongbin, Qing, Liangliang, Wang, Biao, He, Chaoyong, Luo, Ning, Lu, Chuncheng, Fan, Shipeng, Gu, Peng, Zhao, Hui

“…There is growing evidence that long non-coding RNAs (LncRNAs) are key in the development of a variety of human tumors. However, the role of lncRNA GTF2IRD2P1…”
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Link between sterile inflammation and cardiovascular diseases: Focus on cGAS-STING pathway in the pathogenesis and therapeutic prospect by Du, Yao, Zhang, Hui, Nie, Xiaoyan, Qi, Yajun, Shi, Shi, Han, Yingying, Zhou, Wenchen, He, Chaoyong, Wang, Lintao

“…Sterile inflammation characterized by unresolved chronic inflammation is well established to promote the progression of multiple autoimmune diseases, metabolic…”
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Enhanced Tyrosine Nitration of Prostacyclin Synthase Is Associated with Increased Inflammation in Atherosclerotic Carotid Arteries from Type 2 Diabetic Patients by He, Chaoyong, Chul Choi, Hyoung, Xie, Zhonglin

“…Prostacyclin synthase (PGIS) is tyrosine nitrated in diseased animals. Whether PGIS nitration occurs in human diabetic atherosclerotic arteries has not been…”
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Tyrosine Nitration of Prostacyclin Synthase Is Associated with Enhanced Retinal Cell Apoptosis in Diabetes by Zou, Ming-Hui, Li, Hongliang, He, Chaoyong, Lin, Mingkai, Lyons, Timothy J, Xie, Zhonglin

“…The risk of diabetic retinopathy is associated with the presence of both oxidative stress and toxic eicosanoids. Whether oxidative stress actually causes…”
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Single-Cell Analysis Reveals Cxcl14+ Fibroblast Accumulation in Regenerating Diabetic Wounds Treated by Hydrogel-Delivering Carbon Monoxide by Li, Ya, Sun, Lu, Chen, Ranxi, Ni, Wenpeng, Liang, Yuyun, Zhang, Hexu, He, Chaoyong, Shi, Bi, Petropoulos, Sophie, Zhao, Cheng, Shi, Liyang

“…Nonhealing skin wounds are a problematic complication associated with diabetes. Therapeutic gases delivered by biomaterials have demonstrated powerful wound…”
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Wnt/β-Catenin Signaling in Liver Cancers by Wang, Wenhui, Smits, Ron, Hao, Haiping, He, Chaoyong

“…Liver cancer is among the leading global healthcare issues associated with high morbidity and mortality. Liver cancer consists of hepatocellular carcinoma…”
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Signal transducer and transcriptional activation 1 protects against pressure overload‐induced cardiac hypertrophy by Zhen, Changlin, Liu, Hongxia, Gao, Li, Tong, Yuanyuan, He, Chaoyong

“…Signal transducers and transcriptional activation 1 (Stat1) is a member of the STATs family, and its role in various biological responses, including cell…”
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