Search Results - "CHANG, JASON"

Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor by Ma, Leyuan, Dichwalkar, Tanmay, Chang, Jason Y H, Cossette, Benjamin, Garafola, Daniel, Zhang, Angela Q, Fichter, Michael, Wang, Chensu, Liang, Simon, Silva, Murillo, Kumari, Sudha, Mehta, Naveen K, Abraham, Wuhbet, Thai, Nikki, Li, Na, Wittrup, K Dane, Irvine, Darrell J

“…Chimeric antigen receptor-T cell (CAR-T) therapy has been effective in the treatment of hematologic malignancies, but it has shown limited efficacy against…”
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Hydrogel-Coated Microneedle Arrays for Minimally Invasive Sampling and Sensing of Specific Circulating Nucleic Acids from Skin Interstitial Fluid by Al Sulaiman, Dana, Chang, Jason Y. H, Bennett, Nitasha R, Topouzi, Helena, Higgins, Claire A, Irvine, Darrell J, Ladame, Sylvain

“…Minimally invasive technologies that can sample and detect cell-free nucleic acid biomarkers from liquid biopsies have recently emerged as clinically useful…”
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Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers by Tokatlian, Talar, Read, Benjamin J, Jones, Christopher A, Kulp, Daniel W, Menis, Sergey, Chang, Jason Y H, Steichen, Jon M, Kumari, Sudha, Allen, Joel D, Dane, Eric L, Liguori, Alessia, Sangesland, Maya, Lingwood, Daniel, Crispin, Max, Schief, William R, Irvine, Darrell J

“…In vaccine design, antigens are often arrayed in a multivalent nanoparticle form, but in vivo mechanisms underlying the enhanced immunity elicited by such…”
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Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma by Chandrawati, Rona, Chang, Jason Y. H., Reina‐Torres, Ester, Jumeaux, Coline, Sherwood, Joseph M., Stamer, W. Daniel, Zelikin, Alexander N., Overby, Darryl R., Stevens, Molly M.

“…Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location‐ and dose‐dependent. A NO…”
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Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in EGFR -Mutant Lung Cancer by Schoenfeld, Adam J, Chan, Joseph M, Kubota, Daisuke, Sato, Hiroki, Rizvi, Hira, Daneshbod, Yahya, Chang, Jason C, Paik, Paul K, Offin, Michael, Arcila, Maria E, Davare, Monika A, Shinde, Ujwal, Pe'er, Dana, Rekhtman, Natasha, Kris, Mark G, Somwar, Romel, Riely, Gregory J, Ladanyi, Marc, Yu, Helena A

“…Patterns of resistance to first-line osimertinib are not well-established and have primarily been evaluated using plasma assays, which cannot detect histologic…”
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Subnanomolar Detection of Oligonucleotides through Templated Fluorogenic Reaction in Hydrogels: Controlling Diffusion to Improve Sensitivity by Al Sulaiman, Dana, Chang, Jason Y. H., Ladame, Sylvain

“…Oligonucleotide‐templated reactions are valuable tools for nucleic acid sensing both in vitro and in vivo. They are typically carried out under conditions that…”
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Pathologic Assessment and Staging of Multiple Non–Small Cell Lung Carcinomas: A Paradigm Shift with the Emerging Role of Molecular Methods by Chang, Jason C., Rekhtman, Natasha

“…Non–small cell lung carcinomas (NSCLCs) commonly present as 2 or more separate tumors. Biologically, this encompasses 2 distinct processes: separate primary…”
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Oligonucleotide-templated lateral flow assays for amplification-free sensing of circulating microRNAs by Pavagada, Suraj, Channon, Robert B, Chang, Jason Y H, Kim, Sung Hye, MacIntyre, David, Bennett, Phillip R, Terzidou, Vasso, Ladame, Sylvain

“…Herein we demonstrate the first example of oligonucleotide-templated reaction (OTR) performed on paper, using lateral flow to capture and concentrate specific…”
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The Role of Matrix Metalloproteinase Polymorphisms in Ischemic Stroke by Chang, Jason J, Stanfill, Ansley, Pourmotabbed, Tayebeh

“…Stroke remains the fifth leading cause of mortality in the United States with an annual rate of over 128,000 deaths per year. Differences in incidence,…”
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Role of nitric oxide in murine conventional outflow physiology by Chang, Jason Y H, Stamer, W Daniel, Bertrand, Jacques, Read, A Thomas, Marando, Catherine M, Ethier, C Ross, Overby, Darryl R

“…Elevated intraocular pressure (IOP) is the main risk factor for glaucoma. Exogenous nitric oxide (NO) decreases IOP by increasing outflow facility, but whether…”
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Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity by Agarwal, Yash, Milling, Lauren E., Chang, Jason Y. H., Santollani, Luciano, Sheen, Allison, Lutz, Emi A., Tabet, Anthony, Stinson, Jordan, Ni, Kaiyuan, Rodrigues, Kristen A., Moyer, Tyson J., Melo, Mariane B., Irvine, Darrell J., Wittrup, K. Dane

“…Anti-tumour inflammatory cytokines are highly toxic when administered systemically. Here, in multiple syngeneic mouse models, we show that the intratumoural…”
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Admission Neutrophil-to-Lymphocyte Ratio as a Prognostic Biomarker of Outcomes in Large Vessel Occlusion Strokes by Goyal, Nitin, Tsivgoulis, Georgios, Chang, Jason J, Malhotra, Konark, Pandhi, Abhi, Ishfaq, Muhammad F, Alsbrook, Diana, Arthur, Adam S, Elijovich, Lucas, Alexandrov, Andrei V

“…BACKGROUND AND PURPOSE—The purpose of this study is to evaluate the relationship between neutrophil-to-lymphocyte ratio (NLR) at admission with safety and…”
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The Global Phosphorylation Landscape of SARS-CoV-2 Infection by Bouhaddou, Mehdi, Memon, Danish, Meyer, Bjoern, White, Kris M., Rezelj, Veronica V., Correa Marrero, Miguel, Polacco, Benjamin J., Melnyk, James E., Ulferts, Svenja, Kaake, Robyn M., Batra, Jyoti, Richards, Alicia L., Stevenson, Erica, Gordon, David E., Rojc, Ajda, Obernier, Kirsten, Fabius, Jacqueline M., Soucheray, Margaret, Miorin, Lisa, Moreno, Elena, Koh, Cassandra, Tran, Quang Dinh, Hardy, Alexandra, Robinot, Rémy, Vallet, Thomas, Nilsson-Payant, Benjamin E., Hernandez-Armenta, Claudia, Dunham, Alistair, Weigang, Sebastian, Knerr, Julian, Modak, Maya, Quintero, Diego, Zhou, Yuan, Dugourd, Aurelien, Valdeolivas, Alberto, Patil, Trupti, Li, Qiongyu, Hüttenhain, Ruth, Cakir, Merve, Muralidharan, Monita, Kim, Minkyu, Jang, Gwendolyn, Tutuncuoglu, Beril, Hiatt, Joseph, Guo, Jeffrey Z., Xu, Jiewei, Bouhaddou, Sophia, Mathy, Christopher J.P., Gaulton, Anna, Manners, Emma J., Félix, Eloy, Shi, Ying, Goff, Marisa, Lim, Jean K., McBride, Timothy, O’Neal, Michael C., Cai, Yiming, Chang, Jason C.J., Broadhurst, David J., Klippsten, Saker, De wit, Emmie, Leach, Andrew R., Kortemme, Tanja, Shoichet, Brian, Ott, Melanie, Saez-Rodriguez, Julio, tenOever, Benjamin R., Mullins, R. Dyche, Fischer, Elizabeth R., Kochs, Georg, Grosse, Robert, García-Sastre, Adolfo, Vignuzzi, Marco, Johnson, Jeffery R., Shokat, Kevan M., Swaney, Danielle L., Beltrao, Pedro, Krogan, Nevan J.

“…The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions…”
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SMARCA4-Deficient Thoracic Sarcomatoid Tumors Represent Primarily Smoking-Related Undifferentiated Carcinomas Rather Than Primary Thoracic Sarcomas by Rekhtman, Natasha, Montecalvo, Joseph, Chang, Jason C, Alex, Deepu, Ptashkin, Ryan N, Ai, Ni, Sauter, Jennifer L, Kezlarian, Brie, Jungbluth, Achim, Desmeules, Patrice, Beras, Amanda, Bishop, Justin A, Plodkowski, Andrew J, Gounder, Mrinal M, Schoenfeld, Adam J, Namakydoust, Azadeh, Li, Bob T, Rudin, Charles M, Riely, Gregory J, Jones, David R, Ladanyi, Marc, Travis, William D

“…Highly aggressive thoracic neoplasms characterized by SMARCA4 (BRG1) deficiency and undifferentiated round cell or rhabdoid morphology have been recently…”
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Neurogenic Stunned Myocardium in Subarachnoid Hemorrhage by Kerro, Ali, MD, Woods, Timothy, MD, Chang, Jason J, MD

“…Abstract “Stunned myocardium”, characterized by reversible left ventricular dysfunction, was first described via animal models utilizing transient coronary…”
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Engineering autoreactive T and B cell responses toward active immunotherapy for inflammatory diseases by Chang, Jason Y. H., Irvine, Darrell J.

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Circulating microRNAs as Potential Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma by Jin, Yu, Wong, Ye Shen, Goh, Brian K. P., Chan, Chung Yip, Cheow, Peng Chung, Chow, Pierce K. H., Lim, Tony K. H., Goh, George B. B., Krishnamoorthy, Thinesh Lee, Kumar, Rajneesh, Ng, Tze Pin, Chong, Samuel S., Tan, Hwee Huang, Chung, Alexander Y. F., Ooi, London Lucien P. J., Chang, Jason P. E., Tan, Chee Kiat, Lee, Caroline G. L.

“…Hepatocellular carcinoma (HCC) is the fifth most common cancer with high mortality, due to late diagnosis and limited treatment options. Blood miRNAs, which…”
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A cutaneous epithelioid vascular tumor harboring a TPM3::ALK fusion by Linos, Konstantinos, Chang, Jason C., Busam, Klaus J.

“…Substantial progress has been made in understanding the molecular pathways associated with vascular tumors over the last two decades. In addition to mutations…”
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Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials by Malhotra, Konark, Chang, Jason J., Khunger, Arjun, Blacker, David, Switzer, Jeffrey A., Goyal, Nitin, Hernandez, Adrian V., Pasupuleti, Vinay, Alexandrov, Andrei V., Tsivgoulis, Georgios

“…Background Various randomized-controlled clinical trials (RCTs) have investigated the neuroprotective role of minocycline in acute ischemic stroke (AIS) or…”
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Engineered immunogen binding to alum adjuvant enhances humoral immunity by Moyer, Tyson J., Kato, Yu, Abraham, Wuhbet, Chang, Jason Y. H., Kulp, Daniel W., Watson, Nicki, Turner, Hannah L., Menis, Sergey, Abbott, Robert K., Bhiman, Jinal N., Melo, Mariane B., Simon, Hayley A., Herrera-De la Mata, Sara, Liang, Shu, Seumois, Gregory, Agarwal, Yash, Li, Na, Burton, Dennis R., Ward, Andrew B., Schief, William R., Crotty, Shane, Irvine, Darrell J.

“…Adjuvants are central to the efficacy of subunit vaccines. Aluminum hydroxide (alum) is the most commonly used vaccine adjuvant, yet its adjuvanticity is often…”
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