Search Results - "CHANG, Audrey"
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Purity Independent Subtyping of Tumors (PurIST), A Clinically Robust, Single-sample Classifier for Tumor Subtyping in Pancreatic Cancer
Published in Clinical cancer research (01-01-2020)“…Molecular subtyping for pancreatic cancer has made substantial progress in recent years, facilitating the optimization of existing therapeutic approaches to…”
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2
PP1cβ dephosphorylates cardiac myosin by MYPT‐dependent and independent mechanisms
Published in The FASEB journal (01-05-2022)“…In beating hearts, cardiac muscle myosin is phosphorylated at its regulatory light chain (RLC) at 0.4 mol phosphate/mol RLC. This level of constitutive…”
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3
A prospective study of the incidence of myocarditis/pericarditis and new onset cardiac symptoms following smallpox and influenza vaccination
Published in PloS one (20-03-2015)“…Although myocarditis/pericarditis (MP) has been identified as an adverse event following smallpox vaccine (SPX), the prospective incidence of this reaction and…”
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4
Myosin light chain phosphatase catalytic subunit dephosphorylates cardiac myosin via mechanisms dependent and independent of the MYPT regulatory subunits
Published in The Journal of biological chemistry (01-09-2022)“…Cardiac muscle myosin regulatory light chain (RLC) is constitutively phosphorylated at ∼0.4 mol phosphate/mol RLC in normal hearts, and phosphorylation is…”
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5
Association of the Female Athlete Triad Risk Assessment Stratification to the Development of Bone Stress Injuries in Collegiate Athletes
Published in The American journal of sports medicine (01-02-2017)“…Background: The female athlete triad (referred to as the triad) contributes to adverse health outcomes, including bone stress injuries (BSIs), in female…”
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6
Sport and Triad Risk Factors Influence Bone Mineral Density in Collegiate Athletes
Published in Medicine and science in sports and exercise (01-12-2018)“…PURPOSEAthletes in weight-bearing sports may benefit from higher bone mineral density (BMD). However, some athletes are at risk for impaired BMD with female…”
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7
Recombinant neuregulin 1 does not activate cardiomyocyte DNA synthesis in normal or infarcted adult mice
Published in PloS one (29-12-2014)“…Neuregulin 1 signaling plays an important role in cardiac trabecular development, and in sustaining functional integrity in adult hearts. Treatment with…”
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8
Accuracy and Safety of the Cytosponge for Assessing Histologic Activity in Eosinophilic Esophagitis: A Two-Center Study
Published in The American journal of gastroenterology (01-10-2017)“…Management of eosinophilic esophagitis (EoE) requires repeated endoscopic mucosal sampling to assess disease activity. A less invasive and expensive means of…”
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9
Natural Variation in plep-1 Causes Male-Male Copulatory Behavior in C. elegans
Published in Current biology (19-10-2015)“…In sexual species, gametes have to find and recognize one another. Signaling is thus central to sexual reproduction and involves a rapidly evolving interplay…”
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10
Striated muscle MLCP is regulated by MYPT2 to limit baseline cardiac myosin phosphorylation
Published in Biophysical journal (10-02-2023)Get full text
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11
Role of myosin light chain phosphatase in cardiac physiology and pathophysiology
Published in Journal of molecular and cellular cardiology (01-12-2016)“…Maintenance of contractile performance of the heart is achieved in part by the constitutive 40% phosphorylation of myosin regulatory light chain (RLC) in…”
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The MYPT2-regulated striated muscle-specific myosin light chain phosphatase limits cardiac myosin phosphorylation in vivo
Published in The Journal of biological chemistry (01-02-2024)“…The physiological importance of cardiac myosin regulatory light chain (RLC) phosphorylation by its dedicated cardiac myosin light chain kinase has been…”
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13
Higher odds of meniscectomy compared with meniscus repair in a young patient population with increased neighbourhood disadvantage
Published in British journal of sports medicine (01-06-2024)“…To investigate the impact of demographic and socioeconomic factors on the management of isolated meniscus tears in young patients and to identify trends in…”
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14
Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities
Published in Proceedings of the National Academy of Sciences - PNAS (05-07-2016)“…The well-known, muscle-specific smooth muscle myosin light chain kinase (MLCK) (smMLCK) and skeletal muscle MLCK (skMLCK) are dedicated protein kinases…”
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15
Formal Radiologist Interpretations of Intraoperative Spine Radiographs Have Low Clinical Value
Published in Spine (Philadelphia, Pa. 1976) (01-07-2024)“…Retrospective cohort. To evaluate the clinical relevance, usefulness, and financial implications of intraoperative radiograph interpretation by radiologists in…”
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16
Mild sleep restriction increases endothelial oxidative stress in female persons
Published in Scientific reports (16-09-2023)“…Sleep restriction is associated with increased cardiovascular risk, which is more pronounced in female than male persons. We reported recently first causal…”
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17
Kidney Injury Stimulates Apical Translocation of NHERF1
Published in The FASEB journal (01-05-2022)“…Background NHERF1 (Na+‐hydrogen exchanger regulatory factor isoform 1), recognized as a scaffold protein that regulates proximal tubule phosphate transport,…”
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18
Mutations in Troponin that cause HCM, DCM AND RCM: What can we learn about thin filament function?
Published in Journal of molecular and cellular cardiology (01-05-2010)“…Abstract Troponin (Tn) is a critical regulator of muscle contraction in cardiac muscle. Mutations in Tn subunits are associated with hypertrophic, dilated and…”
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Ascorbic acid, nitrate, and nitrite concentration relationship to the 24 hour light/dark cycle for spinach grown in different conditions
Published in Food chemistry (01-05-2013)Get full text
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20
Constitutive Phosphorylation of Cardiac Myosin Regulatory Light Chain in Vivo
Published in The Journal of biological chemistry (24-04-2015)“…In beating hearts, phosphorylation of myosin regulatory light chain (RLC) at a single site to 0.45 mol of phosphate/mol by cardiac myosin light chain kinase…”
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