Search Results - "CHANDY, K. George"

Antibodies and venom peptides: new modalities for ion channels by Wulff, Heike, Christophersen, Palle, Colussi, Paul, Chandy, K. George, Yarov-Yarovoy, Vladimir

“…Ion channels play fundamental roles in both excitable and non-excitable tissues and therefore constitute attractive drug targets for myriad neurological,…”
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Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug by Tyagi, Anu, Ahmed, Tofayel, Jian, Shi, Bajaj, Saumya, Ong, Seow Theng, Goay, Stephanie Shee Min, Zhao, Yue, Vorobyov, Igor, Tian, Changlin, Chandy, K George, Bhushan, Shashi

“…We report two structures of the human voltage-gated potassium channel (Kv) Kv1.3 in immune cells alone (apo-Kv1.3) and bound to an immunomodulatory drug called…”
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International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels by Kaczmarek, Leonard K, Aldrich, Richard W, Chandy, K George, Grissmer, Stephan, Wei, Aguan D, Wulff, Heike

“…A subset of potassium channels is regulated primarily by changes in the cytoplasmic concentration of ions, including calcium, sodium, chloride, and protons…”
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Obstacles for T-lymphocytes in the tumour microenvironment: Therapeutic challenges, advances and opportunities beyond immune checkpoint by Verma, Navin Kumar, Wong, Brandon Han Siang, Poh, Zhi Sheng, Udayakumar, Aiswarya, Verma, Ritu, Goh, Ryan Kwang Jin, Duggan, Shane P., Shelat, Vishalkumar G., Chandy, K. George, Grigoropoulos, Nicholas Francis

“…The tumour microenvironment (TME) imposes a major obstacle to infiltrating T-lymphocytes and suppresses their function. Several immune checkpoint proteins that…”
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Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads by Chandy, K George, Sanches, Karoline, Norton, Raymond S

“…The voltage-gated potassium channel KV1.3 is an important therapeutic target for the treatment of autoimmune and neuroinflammatory diseases. The recent…”
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CD4 + T Cells Mediate the Development of Liver Fibrosis in High Fat Diet-Induced NAFLD in Humanized Mice by Her, Zhisheng, Tan, Joel Heng Loong, Lim, Yee-Siang, Tan, Sue Yee, Chan, Xue Ying, Tan, Wilson Wei Sheng, Liu, Min, Yong, Kylie Su Mei, Lai, Fritz, Ceccarello, Erica, Zheng, Zhiqiang, Fan, Yong, Chang, Kenneth Tou En, Sun, Lei, Chang, Shih Chieh, Chin, Chih-Liang, Lee, Guan Huei, Dan, Yock Young, Chan, Yun-Shen, Lim, Seng Gee, Chan, Jerry Kok Yen, Chandy, K George, Chen, Qingfeng

“…Non-alcoholic fatty liver disease (NAFLD) has been on a global rise. While animal models have rendered valuable insights to the pathogenesis of NAFLD,…”
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Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels by Ong, Seow Theng, Tyagi, Anu, Chandy, K. George, Bhushan, Shashi

“…Voltage-gated potassium (Kv) channels modulate the function of electrically-excitable and non-excitable cells by using several types of “gates” to regulate ion…”
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Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases by Chi, Victor, Pennington, Michael W., Norton, Raymond S., Tarcha, Eric J., Londono, Luz M., Sims-Fahey, Brian, Upadhyay, Sanjeev K., Lakey, Jonathan T., Iadonato, Shawn, Wulff, Heike, Beeton, Christine, Chandy, K. George

“…Electrophysiological and pharmacological studies coupled with molecular identification have revealed a unique network of ion channels—Kv1.3, KCa3.1, CRAC…”
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International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels by Gutman, George A, Chandy, K George, Grissmer, Stephan, Lazdunski, Michel, McKinnon, David, Pardo, Luis A, Robertson, Gail A, Rudy, Bernardo, Sanguinetti, Michael C, Stühmer, Walter, Wang, Xiaoliang

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Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking by Galea, Charles A., Nguyen, Hai M., George Chandy, K., Smith, Brian J., Norton, Raymond S.

“…MMP23 is a member of the matrix metalloprotease family of zinc- and calcium-dependent endopeptidases, which are involved in a wide variety of cellular…”
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Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis by Mkhikian, Haik, Grigorian, Ani, Li, Carey F., Chen, Hung-Lin, Newton, Barbara, Zhou, Raymond W., Beeton, Christine, Torossian, Sevan, Tatarian, Gevork Grikor, Lee, Sung-Uk, Lau, Ken, Walker, Erin, Siminovitch, Katherine A., Chandy, K. George, Yu, Zhaoxia, Dennis, James W., Demetriou, Michael

“…How environmental factors combine with genetic risk at the molecular level to promote complex trait diseases such as multiple sclerosis (MS) is largely…”
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Kv1.3 Channels Are a Therapeutic Target for T Cell-Mediated Autoimmune Diseases by Beeton, Christine, Wulff, Heike, Standifer, Nathan E., Azam, Philippe, Mullen, Katherine M., Pennington, Michael W., Kolski-Andreaco, Aaron, Wei, Eric, Grino, Alexandra, Counts, Debra R., Wang, Ping H., LeeHealey, Christine J., Andrews, Brian S., Sankaranarayanan, Ananthakrishnan, Homerick, Daniel, Roeck, Werner W., Tehranzadeh, Jamshid, Stanhope, Kimber L., Zimin, Pavel, Havel, Peter J., Griffey, Stephen, Knaus, Hans-Guenther, Nepom, Gerald T., Gutman, George A., Calabresi, Peter A., Chandy, K. George

“…Autoreactive memory T lymphocytes are implicated in the pathogenesis of autoimmune diseases. Here we demonstrate that disease-associated autoreactive T cells…”
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International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels by Wei, Aguan D, Gutman, George A, Aldrich, Richard, Chandy, K George, Grissmer, Stephan, Wulff, Heike

“…The second major group of six/seven transmembrane potassium-selective channels consists of the KCa channels (for reviews, see Lingle, 2002; Magleby, 2003;…”
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Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma by Liu, Min, Bertolazzi, Giorgio, Sridhar, Shruti, Lee, Rui Xue, Jaynes, Patrick, Mulder, Kevin, Syn, Nicholas, Hoppe, Michal Marek, Fan, Shuangyi, Peng, Yanfen, Thng, Jocelyn, Chua, Reiya, Jayalakshmi, Batumalai, Yogeshini, De Mel, Sanjay, Poon, Limei, Chan, Esther Hian Li, Lee, Joanne, Hue, Susan Swee-Shan, Chang, Sheng-Tsung, Chuang, Shih-Sung, Chandy, K. George, Ye, Xiaofei, Pan-Hammarström, Qiang, Ginhoux, Florent, Chee, Yen Lin, Ng, Siok-Bian, Tripodo, Claudio, Jeyasekharan, Anand D.

“…Macrophages are abundant immune cells in the microenvironment of diffuse large B-cell lymphoma (DLBCL). Macrophage estimation by immunohistochemistry shows…”
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The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans by Toyama, Kazuyoshi, Wulff, Heike, Chandy, K George, Azam, Philippe, Raman, Girija, Saito, Takashi, Fujiwara, Yoshimasa, Mattson, David L, Das, Satarupa, Melvin, James E, Pratt, Phillip F, Hatoum, Ossama A, Gutterman, David D, Harder, David R, Miura, Hiroto

“…Atherosclerosis remains a major cause of death in the developed world despite the success of therapies that lower cholesterol and BP. The…”
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Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics by Lioudyno, Maria I, Birch, Alexandra M, Tanaka, Brian S, Sokolov, Yuri, Goldin, Alan L, Chandy, K George, Hall, James E, Alkire, Michael T

“…The molecular targets and neural circuits that underlie general anesthesia are not fully elucidated. Here, we directly demonstrate that Kv1-family…”
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Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance by Upadhyay, Sanjeev Kumar, Eckel-Mahan, Kristin L, Mirbolooki, M Reza, Tjong, Indra, Griffey, Stephen M, Schmunk, Galina, Koehne, Amanda, Halbout, Briac, Iadonato, Shawn, Pedersen, Brian, Borrelli, Emiliana, Wang, Ping H, Mukherjee, Jogeshwar, Sassone-Corsi, Paolo, Chandy, K George

“…Obesity is an epidemic, calling for innovative and reliable pharmacological strategies. Here, we show that ShK-186, a selective and potent blocker of the…”
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Modulation of voltage-gated K⁺ channels by the sodium channel β1 subunit by Nguyen, Hai M, Miyazaki, Haruko, Hoshi, Naoto, Smith, Brian J, Nukina, Nobuyuki, Goldin, Alan L, Chandy, K. George

“…Voltage-gated sodium (Na V) and potassium (K V) channels are critical components of neuronal action potential generation and propagation. Here, we report that…”
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A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue by Hou, Aihua, Bose, Tanima, Chandy, K George, Tong, Louis

“…Dry eye disease is a very common condition that causes morbidity and healthcare burden and decreases the quality of life. There is a need for a suitable dry…”
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Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis by Markakis, Ioannis, Charitakis, Ioannis, Beeton, Christine, Galani, Melpomeni, Repousi, Elpida, Aggeloglou, Stella, Sfikakis, Petros P, Pennington, Michael W, Chandy, K George, Poulopoulou, Cornelia

“…Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary…”
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