Search Results - "CHANDRARATNA, ROSHANTHA A. S"

Mechanism of asymmetric ovarian development in chick embryos by Ishimaru, Yoshiyasu, Komatsu, Tomoko, Kasahara, Megumi, Katoh-Fukui, Yuko, Ogawa, Hidesato, Toyama, Yoshiro, Maekawa, Mamiko, Toshimori, Kiyotaka, Chandraratna, Roshantha A S, Morohashi, Ken-ichirou, Yoshioka, Hidefumi

“…In most animals, the gonads develop symmetrically, but most birds develop only a left ovary. A possible role for estrogen in this asymmetric ovarian…”
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Vitamin A Enhances in Vitro Th2 Development Via Retinoid X Receptor Pathway by Stephensen, Charles B, Rasooly, Reuven, Jiang, Xiaowen, Ceddia, Michael A, Weaver, Casey T, Chandraratna, Roshantha A. S, Bucy, R. Patterson

“…Vitamin A deficiency diminishes Th2-mediated Ab responses, and high-level dietary vitamin A or treatment with the vitamin A metabolite retinoic acid (RA)…”
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Dorsoventral patterning of the Xenopus eye: a collaboration of Retinoid, Hedgehog and FGF receptor signaling by Lupo, Giuseppe, Liu, Ying, Qiu, Rong, Chandraratna, Roshantha A S, Barsacchi, Giuseppina, He, Rong-Qiao, Harris, William A

“…In the developing spinal cord and telencephalon, ventral patterning involves the interplay of Hedgehog (Hh), Retinoic Acid (RA) and Fibroblast Growth Factor…”
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Retinoid X Receptor Agonists Increase Bcl2a1 Expression and Decrease Apoptosis of Naive T Lymphocytes by Rasooly, R, Gregg, J.P, Xiao, J.H, Chandraratna, R.A.S, Stephensen, C.B

“…Vitamin A affects many aspects of T lymphocyte development and function. The vitamin A metabolites all-trans- and 9-cis-retinoic acid regulate gene expression…”
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Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme by Lupo, Giuseppe, Gestri, Gaia, O'Brien, Matthew, Denton, Ross M, Chandraratna, Roshantha A.S, Ley, Steven V, Harris, William A, Wilson, Stephen W

“…Retinoic acid receptor (RAR) signaling is required for morphogenesis of the ventral optic cup and closure of the choroid fissure, but the mechanisms by which…”
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A novel transglutaminase activator forms a complex with type 1 transglutaminase by STURNIOLO, Michael T, CHANDRARATNA, Roshantha A. S, ECKERT, Richard L

“…Type I transglutaminase is a plasma membrane-anchored intracellular protein-protein crosslinking enzyme that is responsible for assembly of the keratinocyte…”
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Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lung carcinoma cells and its association with suppression of the transformed phenotype by HIGUCHI, Eisaku, CHANDRARATNA, Roshantha A. S, HONG, Waun K, LOTAN, Reuben

“…Retinoids can regulate the proliferation and differentiation of various tumor cells. It is thought that nuclear retinoid receptors mediate these effects by…”
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A novel retinoid-related molecule inhibits pancreatic cancer cell proliferation by a retinoid receptor independent mechanism via suppression of cell cycle regulatory protein function and induction of caspase-associated apoptosis by BALASUBRAMANIAN, Sivaprakasam, CHANDRARATNA, Roshantha A. S, ECKERT, Richard L

“…Retinoid-related molecules are important potential agents for the treatment of cancer. In the present study, we test the effect of a novel retinoid-related…”
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Active repression by RARγ signaling is required for vertebrate axial elongation by Janesick, Amanda, Nguyen, Tuyen T L, Aisaki, Ken-ichi, Igarashi, Katsuhide, Kitajima, Satoshi, Chandraratna, Roshantha A S, Kanno, Jun, Blumberg, Bruce

“…Retinoic acid receptor gamma 2 (RARγ2) is the major RAR isoform expressed throughout the caudal axial progenitor domain in vertebrates. During a microarray…”
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Multiple points of interaction between retinoic acid and FGF signaling during embryonic axis formation by Shiotsugu, Jason, Katsuyama, Yu, Arima, Kayo, Baxter, Allison, Koide, Tetsuya, Song, Jihwan, Chandraratna, Roshantha A S, Blumberg, Bruce

“…Anteroposterior (AP) patterning of the developing CNS is crucial for both regional specification and the timing of neurogenesis. Several important factors are…”
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Requirement for RAR-Mediated Gene Repression in Skeletal Progenitor Differentiation by Weston, Andrea D., Roshantha A. S. Chandraratna, Torchia, Joseph, Underhill, T. Michael

“…Chondrogenesis is a multistep process culminating in the establishment of a precisely patterned template for bone formation. Previously, we identified a loss…”
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A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands by Crowe, David L, Chandraratna, Roshantha A S

“…Certain lipids have been shown to be ligands for a subgroup of the nuclear hormone receptor superfamily known as the peroxisome proliferator-activated…”
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Combination Therapy of Insulin-Like Growth Factor Binding Protein-3 and Retinoid X Receptor Ligands Synergize on Prostate Cancer Cell Apoptosis In vitro and In vivo by BINGRONG LIU, LEE, Kuk-Wha, HEJU LI, LIQUN MA, LIN, George L, CHANDRARATNA, Roshantha A. S, COHEN, Pinchas

“…We have previously identified the retinoid X receptor-α (RXRα) as an insulin-like growth factor binding protein-3 (IGFBP-3) nuclear binding partner, which is…”
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Identification of the molecular requirements for an RARα-mediated cell cycle arrest during granulocytic differentiation by Walkley, Carl R., Purton, Louise E., Snelling, Hayley J., Yuan, Yang-Dar, Nakajima, Hideaki, Chambon, Pierre, Chandraratna, Roshantha A.S., McArthur, Grant A.

“…Retinoids are potent inducers of cell cycle arrest and differentiation of numerous cell types, notably granulocytes. However the mechanisms by which retinoids…”
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Retinoids Inhibit Proliferation of Human Coronary Smooth Muscle Cells by Modulating Cell Cycle Regulators by Wakino, Shu, Kintscher, Ulrich, Kim, Sarah, Jackson, Simon, Yin, Fen, Nagpal, Sunil, Chandraratna, Roshantha A.S, Hsueh, Willa A, Law, Ronald E

“…ABSTRACT—Retinoids inhibit rat vascular smooth muscle cell (VSMC) proliferation in vitro and intimal hyperplasia in vivo. We examined the mechanism of the…”
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Effects of Retinoid Ligands on RIP140:  Molecular Interaction with Retinoid Receptors and Biological Activity by Farooqui, Mariya, Franco, Peter J, Thompson, Jim, Kagechika, Hiroyuki, Chandraratna, Roshantha A. S, Banaszak, Len, Wei, Li-Na

“…Receptor interacting protein 140 (RIP140) interacts with retinoic acid receptor (RAR) and retinoid X receptor (RXR) constitutively, but hormone binding…”
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RARγ is a negative regulator of osteoclastogenesis by Green, Alanna C., Poulton, Ingrid J., Vrahnas, Christina, Häusler, Karl D., Walkley, Carl R., Wu, Joy Y., Martin, T. John, Gillespie, Matthew T., Chandraratna, Roshantha A.S., Quinn, Julian M.W., Sims, Natalie. A., Purton, Louise E.

“…•We analysed the bone phenotype of RARγ knockout mice.•RARγ null mice have less bone than wildtype mice.•Activation of RARγ using a selective agonist inhibits…”
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New Dermatological Agents for the Treatment of Psoriasis by Thacher, Scott M, Vasudevan, Jayasree, Tsang, Kwok-Yin, Nagpal, Sunil, Chandraratna, Roshantha A. S

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BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect by Olson, James M, Hallahan, Andrew R, Pritchard, Joel I, Chandraratna, Roshantha A S, Ellenbogen, Richard G, Geyer, J Russel, Overland, Ryan P, Strand, Andrew D, Tapscott, Stephen J

“…The mechanisms of retinoid activity in tumors remain largely unknown. Here we establish that retinoids cause extensive apoptosis of medulloblastoma cells. In a…”
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N-(4-hydroxyphenyl)retinamide induces apoptosis in human retinal pigment epithelial cells: Retinoic acid receptors regulate apoptosis, reactive oxygen species generation, and the expression of heme oxygenase-1 and Gadd153 by Samuel, William, Kutty, R. Krishnan, Nagineni, Sahrudaya, Vijayasarathy, Camasamudram, Chandraratna, Roshantha A.S., Wiggert, Barbara

“…N‐(4‐hydroxyphenyl)retinamide (4HPR, fenretinide), a retinoic acid (RA) derivative and a potential cancer preventive agent, is known to exert its…”
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