Search Results - "CHANDRAN, Prasant"

Pharmacological modulation of movement-evoked pain in a rat model of osteoarthritis by Chandran, Prasant, Pai, Madhavi, Blomme, Eric A., Hsieh, Gin C., Decker, Michael W., Honore, Prisca

“…This study was conducted to characterize movement-induced pain in a rat model of knee joint osteoarthritis and validate this behavioral assessment by…”
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A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat by Honore, Prisca, Donnelly-Roberts, Diana, Namovic, Marian T, Hsieh, Gin, Zhu, Chang Z, Mikusa, Joe P, Hernandez, Gricelda, Zhong, Chengmin, Gauvin, Donna M, Chandran, Prasant, Harris, Richard, Medrano, Arturo Perez, Carroll, William, Marsh, Kennan, Sullivan, James P, Faltynek, Connie R, Jarvis, Michael F

“…ATP-sensitive P2X(7) receptors are localized on cells of immunological origin including glial cells in the central nervous system. Activation of P2X(7)…”
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Default-mode-like network activation in awake rodents by Upadhyay, Jaymin, Baker, Scott J, Chandran, Prasant, Miller, Loan, Lee, Younglim, Marek, Gerard J, Sakoglu, Unal, Chin, Chih-Liang, Luo, Feng, Fox, Gerard B, Day, Mark

“…During wakefulness and in absence of performing tasks or sensory processing, the default-mode network (DMN), an intrinsic central nervous system (CNS) network,…”
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Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity by Frost, Jennifer M, Dart, Michael J, Tietje, Karin R, Garrison, Tiffany R, Grayson, George K, Daza, Anthony V, El-Kouhen, Odile F, Yao, Betty B, Hsieh, Gin C, Pai, Madhavi, Zhu, Chang Z, Chandran, Prasant, Meyer, Michael D

“…Several 3-acylindoles with high affinity for the CB2 cannabinoid receptor and selectivity over the CB1 receptor have been prepared. A variety of 3-acyl…”
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Central and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats by Hsieh, Gin C, Pai, Madhavi, Chandran, Prasant, Hooker, Bradley A, Zhu, Chang Z, Salyers, Anita K, Wensink, Erica J, Zhan, CenChen, Carroll, William A, Dart, Michael J, Yao, Betty B, Honore, Prisca, Meyer, Michael D

“…BACKGROUND AND PURPOSE Cannabinoid CB2 receptor activation by selective agonists has been shown to produce analgesic effects in preclinical models of…”
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Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia by Honore, Prisca, Chandran, Prasant, Hernandez, Gricelda, Gauvin, Donna M., Mikusa, Joseph P., Zhong, Chengmin, Joshi, Shailen K., Ghilardi, Joseph R., Sevcik, Molly A., Fryer, Ryan M., Segreti, Jason A., Banfor, Patricia N., Marsh, Kennan, Neelands, Torben, Bayburt, Erol, Daanen, Jerome F., Gomtsyan, Arthur, Lee, Chih-Hung, Kort, Michael E., Reilly, Regina M., Surowy, Carol S., Kym, Philip R., Mantyh, Patrick W., Sullivan, James P., Jarvis, Michael F., Faltynek, Connie R.

“…Transient receptor potential vanilloid type 1 (TRPV1) is a ligand-gated ion channel that functions as an integrator of multiple pain stimuli including heat,…”
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TRPV1-related modulation of spinal neuronal activity and behavior in a rat model of osteoarthritic pain by Chu, Katharine L, Chandran, Prasant, Joshi, Shailen K, Jarvis, Michael F, Kym, Philip R, McGaraughty, Steve

“…Abstract The TRPV1 receptor functions as a molecular integrator, and blockade of this receptor modulates enhanced somatosensitivity across several animal…”
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Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging by Yao, Betty B, Hsieh, Gin, Daza, Anthony V, Fan, Yihong, Grayson, George K, Garrison, Tiffany Runyan, El Kouhen, Odile, Hooker, Bradley A, Pai, Madhavi, Wensink, Erica J, Salyers, Anita K, Chandran, Prasant, Zhu, Chang Z, Zhong, Chengmin, Ryther, Keith, Gallagher, Megan E, Chin, Chih-Liang, Tovcimak, Ann E, Hradil, Vincent P, Fox, Gerard B, Dart, Michael J, Honore, Prisca, Meyer, Michael D

“…Studies demonstrating the antihyperalgesic and antiallodynic effects of cannabinoid CB(2) receptor activation have been largely derived from the use of…”
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Pharmacological modulation of brain activity in a preclinical model of osteoarthritis by Upadhyay, Jaymin, Baker, Scott J., Rajagovindan, Rajasimhan, Hart, Michelle, Chandran, Prasant, Hooker, Bradley A., Cassar, Steven, Mikusa, Joseph P., Tovcimak, Ann, Wald, Michael J., Joshi, Shailen K., Bannon, Anthony, Medema, Jeroen K., Beaver, John, Honore, Prisca, Kamath, Rajesh V., Fox, Gerard B., Day, Mark

“…The earliest stages of osteoarthritis are characterized by peripheral pathology; however, during disease progression chronic pain emerges—a major symptom of…”
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Central and peripheral sites of action for CB 2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats by Hsieh, Gin C, Pai, Madhavi, Chandran, Prasant, Hooker, Bradley A, Zhu, Chang Z, Salyers, Anita K, Wensink, Erica J, Zhan, CenChen, Carroll, William A, Dart, Michael J, Yao, Betty B, Honore, Prisca, Meyer, Michael D

“…BACKGROUND AND PURPOSE Cannabinoid CB 2 receptor activation by selective agonists has been shown to produce analgesic effects in preclinical models of…”
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The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1αβ knockout mice by Honore, Prisca, Donnelly-Roberts, Diana, Namovic, Marian, Zhong, Chengmin, Wade, Carrie, Chandran, Prasant, Zhu, Chang, Carroll, William, Perez-Medrano, Arturo, Iwakura, Yoichiro, Jarvis, Michael F.

“…The pro-inflammatory cytokine interleukin-1β (IL-1β) has been implicated in both inflammatory processes and nociceptive neurotransmission. Activation of P2X7…”
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H 4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats by Hsieh, Gin C., Chandran, Prasant, Salyers, Anita K., Pai, Madhavi, Zhu, Chang Z., Wensink, Erica J., Witte, David G., Miller, Thomas R., Mikusa, Joe P., Baker, Scott J., Wetter, Jill M., Marsh, Kennan C., Hancock, Arthur A., Cowart, Marlon D., Esbenshade, Timothy A., Brioni, Jorge D., Honore, Prisca

“…The histamine H 4 receptor (H 4R) is expressed primarily on cells involved in inflammation and immune responses. To determine the potential role of H 4R in…”
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Potentiation of analgesic efficacy but not side effects: Co-administration of an alpha 4 beta 2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats by Zhu, Chang Z, Chin, Chih-Liang, Rustay, Nathan R, Zhong, Chengmin, Mikusa, Joe, Chandran, Prasant, Salyers, Anita, Gomez, Erica, Simler, Gricelda, Lewis, La Geisha, Gauvin, Donna, Baker, Scott, Pai, Madhavi, Tovcimak, Ann, Brown, Jordan, Komater, Victoria, Fox, Gerard B, Decker, Michael W, Jacobson, Peer B, Gopalakrishnan, Murali, Lee, Chih-Hung, Honore, Prisca

“…Positive modulation of the neuronal nicotinic acetylcholine receptor (nAChR) alpha 4 beta 2 subtype by selective positive allosteric modulator NS-9283 has…”
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Potentiation of analgesic efficacy but not side effects: Co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats by Zhu, Chang Z., Chin, Chih-liang, Rustay, Nathan R., Zhong, Chengmin, Mikusa, Joe, Chandran, Prasant, Salyers, Anita, Gomez, Erica, Simler, Gricelda, Lewis, La Geisha, Gauvin, Donna, Baker, Scott, Pai, Madhavi, Tovcimak, Ann, Brown, Jordan, Komater, Victoria, Fox, Gerard B., Decker, Michael W., Jacobson, Peer B., Gopalakrishnan, Murali, Lee, Chih-Hung, Honore, Prisca

“…Positive allosteric modulator NS-9283 enhances NNR α4β2 agonist ABT-594 (up to 100 nmol/kg)-induced analgesic efficacy in animal models of pain, and cortical…”
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Antinociceptive effects of histamine H 3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems by Hsieh, Gin C., Honore, Prisca, Pai, Madhavi, Wensink, Erica J., Chandran, Prasant, Salyers, Anita K., Wetter, Jill M., Zhao, Chen, Liu, Huaqing, Decker, Michael W., Esbenshade, Timothy A., Cowart, Marlon D., Brioni, Jorge D.

“…The histamine H 3 receptor is predominantly expressed in the central nervous system and plays a role in diverse physiological mechanisms. In the present study,…”
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Development of opioid tolerance with repeated transcutaneous electrical nerve stimulation administration by Chandran, Prasant, Sluka, Kathleen A

“…The analgesia produced by low and high frequency transcutaneous electrical nerve stimulation (TENS) is mediated by the release of μ- or δ-opioids, respectively…”
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H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats by HSIEH, Gin C, CHANDRAN, Prasant, WETTER, Jill M, MARSH, Kennan C, HANCOCK, Arthur A, COWART, Marlon D, ESBENSHADE, Timothy A, BRIONI, Jorge D, HONORE, Prisca, SALYERS, Anita K, PAI, Madhavi, ZHU, Chang Z, WENSINK, Erica J, WITTE, David G, MILLER, Thomas R, MIKUSA, Joe P, BAKER, Scott J

“…The histamine H(4) receptor (H(4)R) is expressed primarily on cells involved in inflammation and immune responses. To determine the potential role of H(4)R in…”
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Indol-3-yl-tetramethylcyclopropyl Ketones: Effects of Indole Ring Substitution on CB2 Cannabinoid Receptor Activity by Frost, Jennifer M, Dart, Michael J, Tietje, Karin R, Garrison, Tiffany R, Grayson, George K, Daza, Anthony V, El-Kouhen, Odile F, Miller, Loan N, Li, Lanlan, Yao, Betty B, Hsieh, Gin C, Pai, Madhavi, Zhu, Chang Z, Chandran, Prasant, Meyer, Michael D

“…A series of potent indol-3-yl-tetramethylcyclopropyl ketones have been prepared as CB2 cannabinoid receptor ligands. Two unsubstituted indoles (5, 32) were the…”
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Paradigm shift in translational neuroimaging of CNS disorders by Sakoğlu, Ünal, Upadhyay, Jaymin, Chin, Chih-Liang, Chandran, Prasant, Baker, Scott J., Cole, Todd B., Fox, Gerard B., Day, Mark, Luo, Feng

“…Structural MRI, task-evoked functional MRI and resting-state functional MRI in preclinical and clinical settings provide the capability of translational…”
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Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems by Hsieh, Gin C, Honore, Prisca, Pai, Madhavi, Wensink, Erica J, Chandran, Prasant, Salyers, Anita K, Wetter, Jill M, Zhao, Chen, Liu, Huaqing, Decker, Michael W, Esbenshade, Timothy A, Cowart, Marlon D, Brioni, Jorge D

“…Abstract The histamine H3 receptor is predominantly expressed in the central nervous system and plays a role in diverse physiological mechanisms. In the…”
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