Search Results - "CHANDRAKESAN, Parthasarathy"

Alternative splice variants of DCLK1 mark cancer stem cells, promote self‐renewal and drug‐resistance, and can be targeted to inhibit tumorigenesis in kidney cancer by Ge, Yang, Weygant, Nathaniel, Qu, Dongfeng, May, Randal, Berry, William L., Yao, Jiannan, Chandrakesan, Parthasarathy, Zheng, Wei, Zhao, Lichao, Zhao, Karena L., Drake, Michael, Vega, Kenneth J., Bronze, Michael S., Tomasek, James J., An, Guangyu, Houchen, Courtney W.

“…Renal cell carcinoma (RCC) is a common and devastating disease characterized by a hypoxic microenvironment, epithelial‐mesenchymal transition and potent…”
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XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism by Sureban, Sripathi M, May, Randal, Weygant, Nathaniel, Qu, Dongfeng, Chandrakesan, Parthasarathy, Bannerman-Menson, Eddie, Ali, Naushad, Pantazis, Panayotis, Westphalen, Christoph B, Wang, Timothy C, Houchen, Courtney W

“…Highlights • Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a poor survival rate. • Doublecortin-like kinase1 (DCLK1) is upregulated in…”
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DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer by Sureban, Sripathi M, May, Randal, Qu, Dongfeng, Weygant, Nathaniel, Chandrakesan, Parthasarathy, Ali, Naushad, Lightfoot, Stan A, Pantazis, Panayotis, Rao, Chinthalapally V, Postier, Russell G, Houchen, Courtney W

“…Stem cell pluripotency, angiogenesis and epithelial-mesenchymal transition (EMT) have been shown to be significantly upregulated in pancreatic ductal…”
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Inflammatory Mediators and Gut Microbial Toxins Drive Colon Tumorigenesis by IL-23 Dependent Mechanism by Panneerselvam, Janani, Madka, Venkateshwar, Rai, Rajani, Morris, Katherine T, Houchen, Courtney W, Chandrakesan, Parthasarathy, Rao, Chinthalapally V

“…Obesity-associated chronic inflammation predisposes colon cancer risk development. Interleukin-23 (IL-23) is a potential inflammatory mediator linking obesity…”
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Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1 by Weygant, Nathaniel, Qu, Dongfeng, Berry, William L, May, Randal, Chandrakesan, Parthasarathy, Owen, Daniel B, Sureban, Sripathi M, Ali, Naushad, Janknecht, Ralf, Houchen, Courtney W

“…Doublecortin-like kinase 1 (DCLK1) is emerging as a tumor specific stem cell marker in colorectal and pancreatic cancer. Previous in vitro and in vivo studies…”
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Bufalin Inhibits Tumorigenesis, Stemness, and Epithelial–Mesenchymal Transition in Colorectal Cancer through a C-Kit/Slug Signaling Axis by Ding, Ling, Yang, Yuning, Lu, Qin, Qu, Dongfeng, Chandrakesan, Parthasarathy, Feng, Hailan, Chen, Hong, Chen, Xuzheng, Liao, Zhuhui, Du, Jian, Cao, Zhiyun, Weygant, Nathaniel

“…Colorectal cancer (CRC) is a major source of morbidity and mortality, characterized by intratumoral heterogeneity and the presence of cancer stem cells (CSCs)…”
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Brief Report: Dclk1 Deletion in Tuft Cells Results in Impaired Epithelial Repair After Radiation Injury by May, Randal, Qu, Dongfeng, Weygant, Nathaniel, Chandrakesan, Parthasarathy, Ali, Naushad, Lightfoot, Stanley A., Li, Linheng, Sureban, Sripathi M., Houchen, Courtney W.

“…The role of Dclk1+ tuft cells in the replacement of intestinal epithelia and reestablishing the epithelial barrier after severe genotoxic insult is completely…”
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Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis by Qu, Dongfeng, Weygant, Nathaniel, May, Randal, Chandrakesan, Parthasarathy, Madhoun, Mohammad, Ali, Naushad, Sureban, Sripathi M, An, Guangyu, Schlosser, Michael J, Houchen, Courtney W

“…Doublecortin-like kinase 1 (Dclk1), a microtubule-associated kinase, marks the fifth lineage of intestinal epithelial cells called tuft cells that function as…”
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Critical Roles of Notch and Wnt/β-Catenin Pathways in the Regulation of Hyperplasia and/or Colitis in Response to Bacterial Infection by AHMED, Ishfaq, CHANDRAKESAN, Parthasarathy, TAWFIK, Ossama, LIJUN XIA, ANANT, Shrikant, UMAR, Shahid

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury by Chandrakesan, Parthasarathy, May, Randal, Weygant, Nathaniel, Qu, Dongfeng, Berry, William L., Sureban, Sripathi M., Ali, Naushad, Rao, Chinthalapally, Huycke, Mark, Bronze, Michael S., Houchen, Courtney W.

“…Crypt epithelial survival and regeneration after injury require highly coordinated complex interplay between resident stem cells and diverse cell types. The…”
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Doublecortin-like kinase 1 promotes hepatocyte clonogenicity and oncogenic programming via non-canonical β-catenin-dependent mechanism by Ali, Naushad, Nguyen, Charles B., Chandrakesan, Parthasarathy, Wolf, Roman F., Qu, Dongfeng, May, Randal, Goretsky, Tatiana, Fazili, Javid, Barrett, Terrence A., Li, Min, Huycke, Mark M., Bronze, Michael S., Houchen, Courtney W.

“…Chronic liver injury is a risk factor for cirrhosis and hepatocellular carcinoma (HCC). The molecular mechanisms that regulate the decision between normal…”
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DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition by Chandrakesan, Parthasarathy, Weygant, Nathaniel, May, Randal, Qu, Dongfeng, Chinthalapally, Harisha R, Sureban, Sripathi M, Ali, Naushad, Lightfoot, Stan A, Umar, Shahid, Houchen, Courtney W

“…Doublecortin-like kinase 1 (Dclk1) is overexpressed in many cancers including colorectal cancer (CRC) andit specifically marks intestinal tumor stem cells…”
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DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma by Weygant, Nathaniel, Qu, Dongfeng, May, Randal, Tierney, Ryan M, Berry, William L, Zhao, Lichao, Agarwal, Shweta, Chandrakesan, Parthasarathy, Chinthalapally, Harisha R, Murphy, Nicholas T, Li, James D, Sureban, Sripathi M, Schlosser, Michael J, Tomasek, James J, Houchen, Courtney W

“…Renal clear cell carcinoma (RCC) is the most common type of kidney cancer and the 8th most common cancer overall in the US. RCC survival rates drop…”
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Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer by Lightfoot, Stan, Wang, Timothy C., An, Guangyu, Clendenin, Cynthia, Stanger, Ben Z., Houchen, Courtney W., Husain, Sanam, Pitts, Kamille, May, Randal, Berry, William L., Chandrakesan, Parthasarathy, Yao, Jiannan, Weygant, Nathaniel, Qu, Dongfeng, Li, Min

“…Oncogenic KRAS mutation plays a key role in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis with nearly 95% of PDAC harboring mutation-activated KRAS,…”
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DCLK1 Regulates Tumor Stemness and Cisplatin Resistance in Non-small Cell Lung Cancer via ABCD-Member-4 by Panneerselvam, Janani, Mohandoss, Priyanga, Patel, Ravi, Gillan, Hamza, Li, Michael, Kumar, Kirtana, Nguyen, DangHuy, Weygant, Nathaniel, Qu, Dongfeng, Pitts, Kamille, Lightfoot, Stanley, Rao, Chinthalapally, Houchen, Courtney, Bronze, Michael, Chandrakesan, Parthasarathy

“…Chemoresistance cells have features similar to cancer stem cells. Elimination of these cells is an effective therapeutic strategy to clinically combat…”
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Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells by Qu, Dongfeng, Johnson, Jeremy, Chandrakesan, Parthasarathy, Weygant, Nathaniel, May, Randal, Aiello, Nicole, Rhim, Andrew, Zhao, Lichao, Zheng, Wei, Lightfoot, Stanley, Pant, Shubham, Irvan, Jeremy, Postier, Russell, Hocker, James, Hanas, Jay S, Ali, Naushad, Sureban, Sripathi M, An, Guangyu, Schlosser, Michael J, Stanger, Ben, Houchen, Courtney W

“…Doublecortin-like kinase 1 (DCLK1) is a putative pancreatic stem cell marker and is upregulated in pancreatic cancer, colorectal cancer, and many other solid…”
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Dietary Pectin Increases Intestinal Crypt Stem Cell Survival following Radiation Injury by Sureban, Sripathi M, May, Randal, Qu, Dongfeng, Chandrakesan, Parthasarathy, Weygant, Nathaniel, Ali, Naushad, Lightfoot, Stan A, Ding, Kai, Umar, Shahid, Schlosser, Michael J, Houchen, Courtney W

“…Gastrointestinal (GI) mucosal damage is a devastating adverse effect of radiation therapy. We have recently reported that expression of Dclk1, a Tuft cell and…”
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Differential effects of β-catenin and NF-κB interplay in the regulation of cell proliferation, inflammation and tumorigenesis in response to bacterial infection by Chandrakesan, Parthasarathy, Jakkula, Laxmi Uma Maheswar Rao, Ahmed, Ishfaq, Roy, Badal, Anant, Shrikant, Umar, Shahid

“…Both β-catenin and NF-κB have been implicated in our laboratory as candidate factors in driving proliferation in an in vivo model of Citrobacter rodentium…”
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Distinct Compartmentalization of NF-κB Activity in Crypt and Crypt-Denuded Lamina Propria Precedes and Accompanies Hyperplasia and/or Colitis following Bacterial Infection by CHANDRAKESAN, Parthasarathy, AHMED, Ishfaq, CHINTHALAPALLY, Anisha, SINGH, Pomila, AWASTHI, Shanjana, ANANT, Shrikant, UMAR, Shahid

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal by Chandrakesan, Parthasarathy, May, Randal, Qu, Dongfeng, Weygant, Nathaniel, Taylor, Vivian E, Li, James D, Ali, Naushad, Sureban, Sripathi M, Qante, Michael, Wang, Timothy C, Bronze, Michael S, Houchen, Courtney W

“…To date, no discrete genetic signature has been defined for isolated Dclk1+ tuft cells within the small intestine. Furthermore, recent reports on the…”
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