Search Results - "CHANDORKAR, Gurudatt"

Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease by PERNI, Robert B, ALMQUIST, Susan J, HEISER, Angela, KALKERI, Gururaj, KOLACZKOWSKI, Elaine, KAI LIN, LUONG, Yu-Ping, GOVINDA RAO, B, TAYLOR, William P, THOMSON, John A, TUNG, Roger D, YUNYI WEI, BYRN, Randal A, KWONG, Ann D, CHAO LIN, CHANDORKAR, Gurudatt, CHATURVEDI, Pravin R, COURTNEY, Lawrence F, DECKER, Caroline J, DINEHART, Kirk, GATES, Cynthia A, HARBESON, Scott L

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Effect of Telaprevir on the Pharmacokinetics of Midazolam and Digoxin by Garg, Varun, Chandorkar, Gurudatt, Farmer, H. Frank, Smith, Frances, Alves, Katia, van Heeswijk, Rolf P. G.

“…In this open-label study, 24 healthy volunteers received a single intravenous (IV) dose of 0.5 mg of midazolam on day 1 and a single oral dose each of 2 mg of…”
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Pharmacokinetics of surotomycin from phase 1 single and multiple ascending dose studies in healthy volunteers by Chandorkar, Gurudatt, Zhan, Qiao, Donovan, Julie, Rege, Shruta, Patino, Hernando

“…Surotomycin, a novel, orally administered, cyclic, lipopeptide antibacterial in development for the treatment of Clostridium difficile-associated diarrhea, has…”
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Merimepodib, pegylated interferon, and ribavirin in genotype 1 chronic hepatitis C pegylated interferon and ribavirin nonresponders by Rustgi, Vinod K., Lee, William M., Lawitz, Eric, Gordon, Stuart C., Afdhal, Nezam, Poordad, Fred, Bonkovsky, Herbert L., Bengtsson, Leif, Chandorkar, Gurudatt, Harding, Matthew, McNair, Lindsay, Aalyson, Molly, Alam, John, Kauffman, Robert, Gharakhanian, Shahin, McHutchison, John G.

“…Merimepodib (MMPD) is an orally administered, inosine monophosphate dehydrogenase inhibitor that has shown antiviral activity in nonresponders with chronic…”
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Impact of Renal Function on the Pharmacokinetics and Safety of Ceftolozane-Tazobactam by WOOLEY, Myra, MILLER, Benjamin, KRISHNA, Gopal, HERSHBERGER, Ellie, CHANDORKAR, Gurudatt

“…Ceftolozane-tazobactam is a novel antipseudomonal cephalosporin with a β-lactamase inhibitor. We investigated the pharmacokinetics (PK) and safety of…”
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Transport and metabolism of opioid peptides across BeWo cells, an in vitro model of the placental barrier by Ampasavate, Chadarat, Chandorkar, Gurudatt A, Vande Velde, David G, Stobaugh, John F, Audus, Kenneth L

“…In keeping with the advance of biotechnology, cell culture becomes an important tool for investigating the transport and the metabolism phenomena. A cell line…”
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Population pharmacokinetics of ceftolozane/tazobactam in healthy volunteers, subjects with varying degrees of renal function and patients with bacterial infections by Chandorkar, Gurudatt, Xiao, Alan, Mouksassi, Mohamad-Samer, Hershberger, Ellie, Krishna, Gopal

“…Ceftolozane/tazobactam is a novel antipseudomonal cephalosporin and β‐lactamase inhibitor in clinical development for treatment of complicated urinary tract…”
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Peptide transport and metabolism across the placenta by Chandorkar, Gurudatt A, Ampasavate, Chadarat, Stobaugh, John F, Audus, Kenneth L

“…Advances made in the field of DNA and recombinant technology have led to the emergence of peptides and proteins as an important class of therapeutic compounds…”
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SP322A DRUG-DRUG INTERACTION STUDY TO EVALUATE THE EFFECT OF VADADUSTAT ON THE PHARMACOKINETICS OF CELECOXIB, A CYP2C9 SUBSTRATE IN HEALTHY VOLUNTEERS by Chandorkar, Gurudatt A, Farzaneh-Far, Ramin, Buch, Akshay, Maroni, Bradley

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Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects by CHANDORKAR, Gurudatt, HUNTINGTON, Jennifer A, GOTFRIED, Mark H, RODVOLD, Keith A, UMEH, Obiamiwe

“…Appropriate antibiotic exposure at the site of infection is important for clinically effective therapy. This study compared the epithelial lining fluid (ELF)…”
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Functional expression of P-glycoprotein in primary cultures of human cytotrophoblasts and BeWo cells by Utoguchi, Naoki, Chandorkar, Gurudatt A., Avery, Michael, Audus, Kenneth L.

“…The objective of this study was to investigate the functional expression of the efflux transporter, P-glycoprotein (P-gp), in primary cultures of human…”
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The effect of CYP3A inhibitors and inducers on the pharmacokinetics of telaprevir in healthy volunteers by Garg, Varun, Chandorkar, Gurudatt, Yang, Yijun, Adda, Nathalie, McNair, Lindsay, Alves, Katia, Smith, Frances, Heeswijk, Rolf P. G.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Telaprevir is a hepatitis C virus protease inhibitor for the treatment of genotype 1 chronic hepatitis C in adult…”
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Single-dose Pharmacokinetics and Tolerability of Daptomycin 8 to 10 mg/kg in Children Aged 2 to 6 Years With Suspected or Proved Gram-positive Infections by Abdel-Rahman, Susan M., Chandorkar, Gurudatt, Akins, Ronda L., Bradley, John S., Jacobs, Richard F., Donovan, Julie, Benziger, David P.

“…A pharmacokinetic analysis was performed for single intravenous doses of daptomycin 8 or 10 mg/kg in subjects aged 2 to 6 years. Proportional increases in…”
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Phase 1 study of IMGN853, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC) in patients (Pts) with epithelial ovarian cancer (EOC) and other FRA-positive solid tumors by Borghaei, Hossein, O'Malley, David M., Seward, Shelly Marie, Bauer, Todd Michael, Perez, Raymond P., Oza, Amit M., Jeong, Woondong, Michenzie, Mary F., Kirby, Maurice William, Chandorkar, Gurudatt, Ruiz-Soto, Rodrigo, Birrer, Michael J., Moore, Kathleen N.

“…Abstract only…”
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403Ceftolozane/Tazobactam (C/T) Dose Optimization in Patients with End Stage Renal Disease (ESRD) Requiring Hemodialysis (HD) Using Population Pharmacokinetics (pPK) and Monte Carlo Simulations (MCS) by Xiao, Alan, Chandorkar, Gurudatt, Krishna, Gopal, Hershberger, Ellie

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Inhibitors of hepatitis C virus NS3·4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics by Perni, Robert B., Chandorkar, Gurudatt, Cottrell, Kevin M., Gates, Cynthia A., Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P., Murcko, Mark A., Pitlik, Janos, Rao, Govinda, Schairer, Wayne C., Drie, John Van, Wei, Yunyi

“…A series of tetrapeptide HCV NS34A protease inhibitors with varying P4 capping groups were prepared. The SAR and pharmacokinetic properties of these inhibitors…”
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Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics by Perni, Robert B, Chandorkar, Gurudatt, Cottrell, Kevin M, Gates, Cynthia A, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, Govinda, Schairer, Wayne C, Van Drie, John, Wei, Yunyi

“…Reversible tetrapeptide-based compounds have been shown to effectively inhibit the hepatitis C virus NS3.4A protease. Inhibition of viral replicon RNA…”
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Mechanisms of blood-brain and blood-cerebrospinal fluid transport of aluminum in rats by Chandorkar, Gurudatt Ajay

“…Aluminum (Al) is a neurotoxin implicated in several neurological disorders. However, the mechanisms of its transport across the blood-brain barrier remain…”
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Mechanisms of blood-brain and blood-cerebrospinal fluid transport of aluminum in rats by Chandorkar, Gurudatt Ajay

“…Aluminum (Al) is a neurotoxin implicated in several neurological disorders. However, the mechanisms of its transport across the blood-brain barrier remain…”
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972 VX-950: the discovery of an inhibitor of the hepatitis C NS3·4A protease and a potential hepatitis C virus therapeutic by Perni, Robert B., Chandorkar, Gurudatt, Chaturvedi, Pravin R., Courtney, Lawrence F., Decker, Caroline J., Gates, Cynthia A., Harbeson, Scott L., Kwong, Ann D., Lin, Chao, Luong, Yu-Ping, Markland, William, Rao, Govinda, Tung, Roger D., Thomson, John A.

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