Search Results - "CHANDER, S. K"

Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents by IRESON, C. R, CHANDER, S. K, PUROHIT, A, PERERA, S, NEWMAN, S. P, PARISH, D, LEESE, M. P, SMITH, A. C, POTTER, B. V. L, REED, M. J

“…2-Methoxyoestradiol (2-MeOE2) is an endogenous oestrogen metabolite that inhibits the proliferation of cancer cells in vitro, and it is also antiangiogenic. In…”
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In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer by Stengel, C, Newman, S P, Day, J M, Chander, S K, Jourdan, F L, Leese, M P, Ferrandis, E, Regis-Lydi, S, Potter, B V L, Reed, M J, Purohit, A, Foster, P A

“…Background: STX2484 is a novel non-steroidal compound with potent anti-proliferative activity. These studies aimed to identify STX2484’s mechanism of action,…”
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In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol by CHANDER, S. K, FOSTER, P. A, LEESE, M. P, NEWMAN, S. P, POTTER, B. V. L, PUROHIT, A, REED, M. J

“…Drugs that inhibit growth of tumours and their blood supply could have considerable therapeutic potential. 2-Methoxyoestradiol-3,17-O,O-bis-sulphamate…”
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Steroid sulphatase inhibitors for breast cancer therapy by Purohit, A, Woo, L.W.L, Chander, S.K, Newman, S.P, Ireson, C, Ho, Y, Grasso, A, Leese, M.P, Potter, B.V.L, Reed, M.J

“…In contrast to aromatase inhibitors, which are now in clinical use, the development of steroid sulphatase (STS) inhibitors for breast cancer therapy is still…”
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The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer by Parsons, M F C, Foster, P A, Chander, S K, Jhalli, R, Newman, S P, Leese, M P, Potter, B V L, Purohit, A, Reed, M J

“…The steroidal-based drug 2-ethyloestradiol-3,17- O , O - bis -sulphamate (STX243) has been developed as a potent antiangiogenic and antitumour compound. The…”
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Pharmacokinetics of the nonsteroidal steroid sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats by IRESON, C. R, CHANDER, S. K, PUROHIT, A, PARISH, D. C, WOO, L. W. L, POTTER, B. V. L, REED, M. J

“…Breast cancer is a major cause of mortality in Western countries and there is an urgent requirement for novel treatment strategies. The nonsteroidal sulphatase…”
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Inhibition of Steroid Sulphatase Activity via the Percutaneous Route: A New Option for Breast Cancer Therapy by PUROHIT, A, CHANDER, S. K, WOO, L. W. L, PARSONS, M. F. C, JHALLI, R, POTTER, B. V. L, REED, M. J

“…Steroid sulphatase (STS) inhibitors have been developed primarily for the treatment of hormone-dependent breast cancer, but may also have utility for the…”
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The effects of 2-methoxyoestrogen sulphamates on the in vitro and in vivo proliferation of breast cancer cells by Utsumi, T., Leese, M.P., Chander, S.K., Gaukroger, K., Purohit, A., Newman, S.P., Potter, B.V.L., Reed, M.J.

“…2-Methoxyoestrogen sulphamates are a new class of compounds, which inhibit breast cancer cell proliferation and are also potent inhibitors of steroid…”
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Clinical and biological significance of HSP89 alpha in human breast cancer by Jameel, A, Skilton, R A, Campbell, T A, Chander, S K, Coombes, R C, Luqmani, Y A

“…In order to isolate and characterize genes whose expression may be altered in breast malignancy, we screened a cDNA library with a polyclonal anti-serum…”
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Pyrrolidino-4-iodotamoxifen and 4-iodotamoxifen, new analogues of the antiestrogen tamoxifen for the treatment of breast cancer by CHANDER, S. K, MCCAGUE, R, LUQMANI, Y, NEWTON, C, DOWSETT, M, JARMAN, M, COOMBES, R. C

“…New tamoxifen analogues were tested for their antiproliferative activity both in vitro and in vivo. Binding studies showed that both 4-iodotamoxifen and…”
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Effectiveness of combined limonene and 4-hydroxyandrostenedione in the treatment of NMU-induced rat mammary tumours by CHANDER, S. K, LANSDOWN, A. G. B, LUQMANI, Y. A, GOMM, J. J, COOPE, R. C, GOULD, N, COOMBES, R. C

“…Limonene, a monocyclic monoterpene, occurs naturally in orange peel oil. It has been shown to exhibit both chemopreventive and chemotherapeutic activity…”
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Effects of synthetic vitamin D analogues on breast cancer cell proliferation in vivo and in vitro by Colston, K W, Chander, S K, Mackay, A G, Coombes, R C

“…Calcipotriol (MC903) is a novel vitamin D analogue which effects cellular differentiation and proliferation in vitro and has reduced effects on calcium…”
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The regulation and inhibition of 17β-hydroxysteroid dehydrogenase in breast cancer by Purohit, A., Tutill, H.J., Day, J.M., Chander, S.K., Lawrence, H.R., Allan, G.M., Fischer, D.S., Vicker, N., Newman, S.P., Potter, B.V.L., Reed, M.J.

“…17β-Hydroxysteroid dehydrogenase Type 1 (17β-HSD1) has a pivotal role in regulating the synthesis of oestradiol (E2) within breast tumours. In whole body…”
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Oestrone sulphatase activity in mammary tumours and the liver of N-nitrosomethylurea treated rats by EVANS, T. R. J, CHANDER, S. K, ROWLANDS, M. G, COOMBES, R. C

“…Oestrone sulphatase may be an important means of production of intra-tumoural oestrogens in breast cancer cells. The N-nitrosomethylurea induced rat mammary…”
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Detection of breast cancer-associated estrone sulfatase in breast cancer biopsies and cell lines using polymerase chain reaction by Evans, T R, Rowlands, M G, Luqmani, Y A, Chander, S K, Coombes, R C

“…Steroid sulfatase (STS) is a single enzyme with a range of substrate specificities, including estrone sulfate. Using a 2.4 kb cDNA clone, expression of human…”
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An in vivo model for screening peptidomimetic inhibitors of gelatinase A by Chander, S K, Antoniw, P, Beeley, N R, Boyce, B, Crabbe, T, Docherty, A J, Leonard, J, Mason, B, Millar, K, Millican, A T

“…Gelatinase A, a matrix metalloproteinase, is frequently associated with human solid tumors, and its secretion and activation in the tumor milieu is considered…”
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Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor by An, Z, Wang, X, Willmott, N, Chander, S K, Tickle, S, Docherty, A J, Mountain, A, Millican, A T, Morphy, R, Porter, J R, Epemolu, R O, Kubota, T, Moossa, A R, Hoffman, R M

“…In this study, we describe the activity of CT1746, an orally-active synthetic MMP inhibitor that has a greater specificity for gelatinase A, gelatinase B and…”
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The biological evaluation of novel antioestrogens for the treatment of breast cancer by Chander, S K, Sahota, S S, Evans, T R, Luqmani, Y A

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The effect of endocrine therapy on fibroblast growth factor-like activity in nitrosomethylurea-induced rat mammary tumours by Smith, J, Chander, S K, Baillie, R, Coombes, R C

“…Tumour regression following ovariectomy of rats bearing nitrosomethylurea-induced mammary tumours has been well characterised as a model for oestrogen receptor…”
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New endocrine agents for the treatment of breast cancer by Coombes, R C, Jarman, M, Dowsett, M, Chander, S K, Rowlands, M G, Di Salle, E, Evans, T J

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