Search Results - "CHAN, Weng C"

Look who's talking: communication and quorum sensing in the bacterial world by Williams, Paul, Winzer, Klaus, Chan, Weng C, Cámara, Miguel

“…For many years bacteria were considered primarily as autonomous unicellular organisms with little capacity for collective behaviour. However, we now appreciate…”
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Actinomadura graeca sp. nov.: A novel producer of the macrocyclic antibiotic zelkovamycin by Tarantini, Francesco Saverio, Brunati, Mara, Taravella, Anna, Carrano, Lucia, Parenti, Francesco, Hong, Kar Wai, Williams, Paul, Chan, Kok Gan, Heeb, Stephan, Chan, Weng C

“…As part of a screening programme for antibiotic-producing bacteria, a novel Actinomadura species was discovered from a soil sample collected in Santorini,…”
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Regulation of Neurotoxin Production and Sporulation by a Putative agrBD Signaling System in Proteolytic Clostridium botulinum by Cooksley, Clare M, Davis, Ian J, Winzer, Klaus, Chan, Weng C, Peck, Michael W, Minton, Nigel P

“…A significant number of genome sequences of Clostridium botulinum and related species have now been determined. In silico analysis of these data revealed the…”
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Thermoresponsive Polymer Colloids for Drug Delivery and Cancer Therapy by Abulateefeh, Samer R., Spain, Sebastian G., Aylott, Jonathan W., Chan, Weng C., Garnett, Martin C., Alexander, Cameron

“…Many difficulties in treating cancer arise from the problems in directing highly cytotoxic agents to the deseased tissues, cells and intracellular…”
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Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate by Bardelang, Philip, Murray, Ewan J, Blower, Isobel, Zandomeneghi, Sara, Goode, Alice, Hussain, Rohanah, Kumari, Divya, Siligardi, Giuliano, Inoue, Katsuaki, Luckett, Jeni, Doutch, James, Emsley, Jonas, Chan, Weng C, Hill, Philip, Williams, Paul, Bonev, Boyan B

“…Virulence gene expression in the human pathogen, is regulated by the (accessory gene regulator) quorum sensing (QS) system which is conserved in diverse…”
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Molecular Mechanism of Target Recognition by Subtilin, a Class I Lanthionine Antibiotic by PARISOT, Judicaël, CAREY, Sarah, BREUKINK, Eefjan, CHAN, Weng C, NARBAD, Arjan, BONEV, Boyan

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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End-stapled homo and hetero collagen triple helices: a click chemistry approach by Byrne, Cillian, McEwan, Paul A, Emsley, Jonas, Fischer, Peter M, Chan, Weng C

“…A CuAAC reaction was established for modular synthesis of end-stapled homo- and hetero-triple helical peptides, generating "clicked" macro-assemblies with…”
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Quorum-sensing, intra- and inter-species competition in the staphylococci by Williams, Paul, Hill, Phil, Bonev, Boyan, Chan, Weng C

“…In Gram-positive bacteria such as and the coagulase-negative staphylococci (CoNS), the accessory gene regulator ( ) is a highly conserved but polymorphic…”
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Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC by Jensen, Rasmus O., Winzer, Klaus, Clarke, Simon R., Chan, Weng C., Williams, Paul

“…Virulence in Staphylococcus aureus is regulated via agr-dependent quorum sensing in which an autoinducing peptide (AIP) activates AgrC, a histidine protein…”
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New Found Hope for Antibiotic Discovery: Lipid II Inhibitors by Ng, Vivian, Chan, Weng C.

“…Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of antimicrobial resistance. The development of modern tools…”
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Attenuating Staphylococcus aureus Virulence Gene Regulation: A Medicinal Chemistry Perspective by Gordon, Christopher P, Williams, Paul, Chan, Weng C

“…Virulence gene expression in Staphylococcus aureus is tightly regulated by intricate networks of transcriptional regulators and two-component signal…”
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A facile method to clickable sensing polymeric nanoparticles by Welser, Katharina, Perera, M D Ayal, Aylott, Jonathan W, Chan, Weng C

“…Clickable biocompatible nanoparticles were prepared in a one-pot process by microemulsion polymerization using acrylamide, N,N'-methylene bisacrylamide and…”
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Virulence Regulation and Quorum Sensing in Staphylococcal Infections:  Competitive AgrC Antagonists as Quorum Sensing Inhibitors by Chan, Weng C, Coyle, Barry J, Williams, Paul

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A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin by Murray, Ewan J, Dubern, Jean-Frédéric, Chan, Weng C, Chhabra, Siri Ram, Williams, Paul

“…As single- and mixed-species biofilms, Staphylococcus aureus and Pseudomonas aeruginosa cause difficult-to-eradicate chronic infections. In P. aeruginosa,…”
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Poly( l-lysine)–GRGDS as a biomimetic surface modifier for poly(lactic acid) by Quirk, Robin A., Chan, Weng C., Davies, Martyn C., Tendler, Saul J.B., Shakesheff, Kevin M.

“…The immobilization of adhesion peptide sequences (such as RGD) at the surfaces of poly( α-hydroxyacid)s, including poly(lactic acid) (PLA), is complicated by…”
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Rational Design and Synthesis of Modified Teixobactin Analogues: In Vitro Antibacterial Activity against Staphylococcus aureus, Propionibacterium acnes and Pseudomonas aeruginosa by Ng, Vivian, Kuehne, Sarah A., Chan, Weng C.

“…Teixobactin, a recently discovered depsipeptide that binds to bacterial lipid II and lipid III, provides a promising molecular scaffold for the design of new…”
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Timing Is Everything: Impact of Naturally Occurring Staphylococcus aureus AgrC Cytoplasmic Domain Adaptive Mutations on Autoinduction by Sloan, Tim J, Murray, Ewan, Yokoyama, Maho, Massey, Ruth C, Chan, Weng C, Bonev, Boyan B, Williams, Paul

“…Mutations in the polymorphic locus responsible for quorum sensing (QS)-dependent virulence gene regulation occur frequently during host adaptation. In two…”
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Nasal Immunization with Homogenate and Peptide Antigens Induces Protective Immunity against Trichinella spiralis by MCGUIRE, Carolann, CHAN, Weng C, WAKELIN, Derek

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A facile approach to tryptophan derivatives for the total synthesis of argyrin analogues by Chen, Chou-Hsiung, Genapathy, Sivaneswary, Fischer, Peter M, Chan, Weng C

“…A facile route has been established for the synthesis of indole-substituted (S)-tryptophans from corresponding indoles, which utilizes a chiral…”
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Methicillin Resistance Reduces the Virulence of Healthcare-Associated Methicillin-Resistant Staphylococcus aureus by Interfering With the agr Quorum Sensing System by Rudkin, Justine K., Edwards, Andrew M., Bowden, Maria G., Brown, Eric L., Pozzi, Clarissa, Waters, Elaine M., Chan, Weng C., Williams, Paul, O'Gara, James P., Massey, Ruth C.

“…The difficulty in successfully treating infections caused by methicillin-resistant Staphylococcus aureus (MRSA) has led to them being referred to as highly…”
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